KARACHI: The State Bank of Pakistan (SBP) on Friday allowed subsidised financing for setting up of new plants and expansion of existing units while the maximum amount for a single unit has been set at Rs5 billion to boost economic activities in the manufacturing sector.

The SBP on Friday said it has opened up its subsidised Temporary Economic Relief Facility (TERF) for Balancing, Modernization and Replacement (BMR) and expansion of existing projects.

Under this scheme, the SBP provides refinance to banks for their onward extension of financing at maximum end-user rate of seven per cent for 10 years.

“The maximum financing for a single project under the scheme is Rs5bn. The objective of this facility is to boost economic activity through investments in manufacturing units,” said the SBP.

While allowing the BMR and expansion of existing projects, the SBP has permitted financing for purchase of new-imported and locally-manufactured plant and machinery against foreign letter of credit (LC) and inland LC.

“The funding under the facility cannot be used for procurement of second-hand machinery, land or carrying out civil works,” said the SBP.

According to the circular issued by the central bank, in addition to new projects, existing projects and businesses are being allowed to avail financing under these facilities for BMR and expansion of their projects or businesses.

“This measure has been taken to provide further stimulus to the economy in the context of Covid-19’s impact on the economy, to support investment in the country for modernising or expanding manufacturing and production units, and in response from feedback from stakeholders,” said the SBP.

The central bank said that, it has taken several measures since the outbreak of Covid-19 to safeguard economic activity in the country. On Mar 17, the SBP introduced TERF and its shariah-compliant version to stimulate new investment in the manufacturing sector.

With expansion in scope of the facility, the SBP expects that existing businesses will avail subsidised funding to improve productivity leading to higher economic activity and employment generation.

The banks and development finance institutions will be required to make disbursements to their customers on the basis of certificates of their internal audit confirming that financing is within the terms and conditions laid down in the facilities.

Borrowers will be required to submit a report from the Pakistan Banks Association-approved surveyors with regard to confirmation that the newly-purchased plant and machinery has been installed as per their initial request or proposal for BMR and expansion. In case of installation and fixation in part, this report will be required at first and final installation of the plant and equipment.

Published in Dawn, May 9th, 2020

ADB today announced a $400,000 grant to the Government of Fiji to help fund priority recovery activities following Tropical Cyclone Harold, which hit Fiji's western, central, and eastern divisions on 8 and 9 April.

ADB today approved a $200,000 (460,000 pa’anga) grant to the Government of Tonga to help restore life-sustaining services following the damage from Tropical Cyclone Harold.

Alastair Hughes, CEO (Asia Pacific) of Jones Lang LaSalle (JLL), who was in Bangalore to hold a board meeting of the Asia Pacific region comprising China, Japan, Australia, South East Asia and India, spoke to BusinessLine to share the real estate market sentiment and key issues on corporate leasing. How is the realty market in India as compared to other countries in Asia Pacific ? India has seen a dramatic recovery. The hangover did not last very long as it had in 2010-2011. The market is very dynamic here right now. While Asia-Pacific began to recover in 2012-2013, India went through a lull, largely due to lack of business confidence, […]

Today’s companies see the importance of design as more consumers demand elegance alongside flawless functionality and exceptional user experience. As a company that has created countless ingenious product designs in different markets all over the ...

BENGALURU, INDIA, FEBRUARY 11, 2020 – Expect fireworks as JBL unveils its new brand film featuring superstar and youth icon Ranveer Singh, urging consumers to ‘Live it real and Live it raw’.  Featuring striking visuals and inspiring rap vocals by the...

Here are the key milestones in the history of quantum computing, as well as New Scientist's predictions for the future 

* LILLY RECEIVES U.S. FDA APPROVAL FOR RETEVMO™ (SELPERCATINIB), THE FIRST THERAPY SPECIFICALLY FOR PATIENTS WITH ADVANCED RET-DRIVEN LUNG AND THYROID CANCERS

Despite the growing possibility of a total wipeout of professional tennis this year due to the coronavirus pandemic, ATP Tour chief Andrea Gaudenzi is refusing to give up on 2020 just yet.

Amsterdam's Schiphol Airport was closed briefly as police investigated a suspicious situation. Julie Noce reports.

Title: Folic Acid Might Offer Allergy Relief
Category: Health News
Created: 5/1/2009 2:00:00 AM
Last Editorial Review: 5/1/2009 12:00:00 AM

Title: FDA Approves New Device for Asthma Relief
Category: Health News
Created: 4/30/2010 11:31:00 AM
Last Editorial Review: 4/30/2010 11:31:14 AM

Title: Gentle Yoga May Deliver Migraine Relief
Category: Health News
Created: 5/6/2020 12:00:00 AM
Last Editorial Review: 5/7/2020 12:00:00 AM

People suffering from regular migraines despite medication might consider investing in a yoga mat.

Title: Trump Signs Massive Relief Package Into Law as U.S. Coronavirus Cases Reach 9,000
Category: Health News
Created: 3/19/2020 12:00:00 AM
Last Editorial Review: 3/19/2020 12:00:00 AM

Massachusetts rallies for health equity

As the U.S. COVID-19 outbreak worsened in March, the Massachusetts Public Health Association took swift action, rallying state health advocates and pushing policymakers to make equity-focused decisions.

Mental health focus of Alabama program

A new pubic health campaign in Alabama is working to reduce stigma related to mental health illness, substance and opioid use disorders, HIV and hepatitis C.

Medicaid expansion helps pregnant women

Fewer women are dying from pregnancy-related complications in states that have expanded Medicaid, new research finds.

The past decade has increased our understanding of how genome topology controls RAG endonuclease-mediated assembly of lymphocyte AgR genes. New technologies have illuminated how the large IgH, Ig, TCRα/, and TCRβ loci fold into compact structures that place their numerous V gene segments in similar three-dimensional proximity to their distal recombination center composed of RAG-bound (D)J gene segments. Many studies have shown that CTCF and cohesin protein–mediated chromosome looping have fundamental roles in lymphocyte lineage- and developmental stage–specific locus compaction as well as broad usage of V segments. CTCF/cohesin–dependent loops have also been shown to direct and restrict RAG activity within chromosome domains. We summarize recent work in elucidating molecular mechanisms that govern three-dimensional chromosome organization and in investigating how these dynamic mechanisms control V(D)J recombination. We also introduce remaining questions for how CTCF/cohesin–dependent and –independent genome architectural mechanisms might regulate compaction and recombination of AgR loci.

We investigated whether cycloheximide (CHX) would induce amnesia for the stress-induced impairment of extinction retrieval. First, a single restraint stress session was demonstrated to impair extinction retrieval, but not fear conditioning. A second experiment showed that when CHX was administered immediately after restraint, rats exhibited significant extinction retrieval at test (i.e., retrograde amnesia for the stress). In a third experiment, the stress session impaired various amounts of extinction durations, suggesting that the stress inhibited extinction retrieval rather than enhancing the original fear learning. These results suggest memories for acute stress are susceptible to disruption, which could have clinical implications.

BackgroundA brief intervention whereby GPs opportunistically facilitate an NHS-funded referral to a weight loss programme is clinically and cost-effective.AimTo test the acceptability of a brief intervention and attendance at a weight loss programme when GPs facilitate a referral that requires patients to pay for the service.Design and settingAn observational study of the effect of a GP encouraging attendance at a weight loss programme requiring self-payment in the West Midlands from 16 October 2018 to 30 November 2018, to compare with a previous trial in England in which the service was NHS-funded.MethodSixty patients with obesity who consecutively attended primary care appointments received an opportunistic brief intervention by a GP to endorse and offer a referral to a weight loss programme at the patient’s own expense. Participants were randomised to GPs who either stated the weekly monetary cost of the programme (basic cost) or who compared the weekly cost to an everyday discretionary item (cost comparison). Participants were subsequently asked to report whether they had attended a weight loss programme.ResultsOverall, 47% of participants (n = 28) accepted the referral; 50% (n = 15) in the basic cost group and 43% (n = 13) in the cost comparison group. This was significantly less than in a previous study when the programme was NHS-funded (77%, n = 722/940; P<0.0001). Most participants reported the intervention to be helpful/very helpful and appropriate/very appropriate (78%, n = 46/59 and 85%, n = 50/59, respectively) but scores were significantly lower than when the programme was NHS-funded (92% n = 851/922 and 88% n = 813/922, respectively; P = 0.004). One person (2%) attended the weight loss programme, which is significantly lower than the 40% of participants who attended when the programme was NHS-funded (P<0.0001).ConclusionGP referral to a weight loss programme that requires patients to pay rather than offering an NHS-funded programme is acceptable; however, it results in almost no attendance.

The American Board of Family Medicine routinely surveys its Diplomates in each national graduating cohort 3 years out of training. These data were used to characterize early career family physicians whose services include management of pregnancy and prescribing buprenorphine. A total of 261 (5.1%) respondents both provide maternity care and prescribe buprenorphine. Family physicians who care for pregnant women and also prescribe buprenorphine represented 50.4% of all buprenorphine prescribers. The family physicians in this group were trained in a small number of residency programs, with only 15 programs producing at least 25% of graduates who do this work.

Plasma DNA fragmentomics is an emerging area of research covering plasma DNA sizes, end points, and nucleosome footprints. In the present study, we found a significant increase in the diversity of plasma DNA end motifs in patients with hepatocellular carcinoma (HCC). Compared with patients without HCC, patients with HCC showed a preferential pattern of 4-mer end motifs. In particular, the abundance of plasma DNA motif CCCA was much lower in patients with HCC than in subjects without HCC. The aberrant end motifs were also observed in patients with other cancer types, including colorectal cancer, lung cancer, nasopharyngeal carcinoma, and head and neck squamous cell carcinoma. We further observed that the profile of plasma DNA end motifs originating from the same organ, such as the liver, placenta, and hematopoietic cells, generally clustered together. The profile of end motifs may therefore serve as a class of biomarkers for liquid biopsy in oncology, noninvasive prenatal testing, and transplantation monitoring.

BRAF^V600 mutations occur in a wide range of tumor types, and RAF inhibition has become standard in several of these cancers. Despite this progress, BRAF^V600 mutations have historically been considered a clear demonstration of tumor lineage context–dependent oncogene addiction, based predominantly on the insensitivity to RAF inhibition in colorectal cancer. However, the true broader activity of RAF inhibition pan-cancer remains incompletely understood. To address this, we conducted a multicohort "basket" study of the BRAF inhibitor vemurafenib in non-melanoma BRAF^V600 mutation–positive solid tumors. In total, 172 patients with 26 unique cancer types were treated, achieving an overall response rate of 33% and median duration of response of 13 months. Responses were observed in 13 unique cancer types, including historically treatment-refractory tumor types such as cholangiocarcinoma, sarcoma, glioma, neuroendocrine carcinoma, and salivary gland carcinomas. Collectively, these data demonstrate that single-agent BRAF inhibition has broader clinical activity than previously recognized.

A collection of recently published news items.

A large international study found that the composition of the intestinal microbiome can predict clinical outcomes in patients undergoing allogenic hematopoietic-cell transplant (HCT) for blood cancers. The findings may help assess patients' transplantation-related mortality risk and aid in developing interventions to prevent or mitigate microbiome changes that affect HCT outcomes.

Chlorotoxin, a small peptide component of scorpion venom, may help pinpoint glioblastoma cells for destruction when engineered into a chimeric antigen receptor T-cell therapy. The concept has shown efficacy in mice, without off-target toxicity, and will soon be assessed in patients.

Human macrophages equipped with chimeric antigen receptor constructs infiltrate solid tumors, ingest malignant tissue, and stimulate adaptive immunity in mouse models. Several new biotech companies are racing to bring the technology into clinical trials.

Thermo Fisher Scientific announced plans in March to acquire Qiagen in a $11.5 billion deal that could bring morediagnostic offeringsand sample-preparation technologies to one of the world's leading manufacturers of scientific instruments, research services, and laboratory consumables.

As the COVID-19 pandemic worsens, the clinical cancer community is grappling with how to continue providing access to experimental but potentially lifesaving therapies while keeping immunocompromised patients safe. To that end, cancer centers are making changes to their clinical trial programs, while pharmaceutical companies are deciding how—or whether—trials should continue.

Antoni Ribas, MD, PhD, and Gillian Leng, MBChB, are featured.

In the plasmaMATCH trial, researchers performed circulating tumor DNA testing on patients with advanced breast cancer and matched those with ESR1, HER2, or AKT1 alterations to targeted therapies. Patients with HER2 and AKT1 mutations experienced response rates greater than 22% with durable benefit.

As COVID-19 continues to surge, cancer scientists engaged in basic research face unique challenges. At centers throughout the United States, investigators are confronting difficult decisions about which experiments to continue, while securing supplies and creating contingency plans for a complete shutdown.

Since 2018, the FDA has required that U.S. clinical trial results be reported to clinicaltrials.gov within a year of trial completion, but this mandate is often ignored. A recent study found that less than half of U.S. trials submitted results to the site by the deadline. Industry-led trials were the most likely to be reported on time.

In a draft guidance, the FDA urges researchers to take steps to increase enrollment of adults age 65 and older in clinical trials of investigational of cancer drugs. Noting that a drug's risk–benefit profile can vary significantly across age groups, the FDA recommends including older adults in early-phase studies and modifying trial designs and recruitment strategies to make it easier for them to participate.

Publisher Microsoft and developer 343 Industries announced Halo 2: Anniversary will launch for the Windows PC version of Halo: The Master Chief Collection via Steam and Microsoft Store on Tuesday, May 12.

Here is an overview of the game:

Halo 2: Anniversary comes to PC as the next installment in Halo: The Master Chief Collection. Now optimized for PC, experience the impeccably remastered edition of the original Halo 2 game. Following the destruction of Halo, humankind experiences a short-lived victory. Eager for revenge, the Covenant launches a surprise attack on Earth, but they find themselves ill-prepared to defeat the UNSC’s home fleet and are forced to flee into slipspace. When the Master Chief pursues his overzealous enemies, they discover yet another Halo ring, uncovering long-buried secrets, including an unlikely ally, that will dramatically alter the course of the Human-Covenant Conflict forever.

Key Features:

• PC Settings/Optimizations: Halo 2: Anniversary is now optimized for PC and looking better than ever at up to 4k UHD and at 60+ FPS.* Other PC native settings include customizable mouse and keyboard support, ultrawide support, FOV customization, and more.
• Campaign: Experience the next chapter in the Halo saga and fight your way through 15 unforgettable missions. Play as both Spartan-117, the Master Chief, and for the first time, the Covenant Elite, known as the Arbiter, and experience the Human-Covenant Conflict in a whole new way.
• Anniversary Edition/Update: Toggle between the remastered graphics in the Anniversary edition and the graphics from the original Halo 2 campaign. In the Anniversary edition, view Blur Studio’s spectacularly remastered cutscenes from the original Halo 2 game.
• Multiplayer: Continue your Halo adventure with 7 remastered multiplayer maps from Halo 2: Anniversary and 25 multiplayer maps from the original Halo 2, featuring a completely updated progression system.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443396/halo-2-anniversary-for-halo-the-master-chief-collection-for-pc-launches-may-12/

As US-Iran tensions rise following the assassination of an Iranian general and missile attacks on US troops, UN diplomat Neil Walsh warns cyberattacks can be just as impactful

His cause of death is unknown.

U.S. Chief Justice John Roberts on Friday put a temporary hold on the disclosure to a Democratic-led House of Representatives committee of grand jury material redacted from former Special Counsel Robert Mueller's report on Russian interference in the 2016 election.

Defying congressional oversight concerns, U.S. President Donald Trump’s acting director of national intelligence on Friday unveiled organizational changes to his agency.

The last Formula One season was a disappointing one for Daniel Ricciardo, who retains a burning desire to win the world title.

The legendary Bafana Bafana striker has backed the Amakhosi midfielder, who is facing stiff competition in midfield

President Donald Trump said on Thursday his administration was considering further economic measures, possibly via executive orders, to provide help against the economic fallout from the novel coronavirus pandemic.

Defying congressional oversight concerns, U.S. President Donald Trump’s acting director of national intelligence on Friday unveiled organizational changes to his agency.

Three cheers for them

The first charity the band is highlighting is Feeding America, which partners with food banks across the U.S.