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Diastereoselective synthesis of functionalized spiroindolines via intramolecular ipso-iodocyclization/nucleophile addition cascade reactions of indole-tethered ynones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00112E, Paper
Debojyoti Bag, Sanghapal D. Sawant
Herein, we describe a highly diastereoselective approach for synthesizing polyfunctionalized spiroindolines from indolyl-ynones involving an ipso-iodocyclization/nucleophile addition cascade.
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Selective recognition between aromatics and aliphatics by cage-shaped borates supported by a machine learning approach

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00408F, Paper
Open Access
Yuya Tsutsui, Issei Yanaka, Kazuhiro Takeda, Masaru Kondo, Shinobu Takizawa, Ryosuke Kojima, Akihito Konishi, Makoto Yasuda
Exploration of a Lewis acid with high selectivity for hydrocarbon moieties is assisted by a machine learning approach. Molecular polarizability is an essential factor, leading to design guidelines for Lewis acid catalysts with dispersion forces.
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Stereoselective Synthesis of gem-Dihalopiperidines via Halo-Aza-Prins Cyclization Reaction: Access to Piperidin-4-ones and Pyridines

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00338A, Paper
Anil Kumar Saikia, Surjya Kumar Bora, Subhamoy Biswas, Bipin Kumar Behera
An efficient methodology for the synthesis of 4,4-dihalopiperidine derivatives has been developed from N-(3-halobut-3-en-1-yl)-4-methylbenzenesulfonamide and aldehyde catalyzed by In(OTf)3 in excellent yields. The reaction involves an initial formation of six...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Vinylogous and stereoselective domino synthesis of pyrano[2,3-c]pyrroles from alkylidene meldrum's acids

Org. Biomol. Chem., 2024, 22,2948-2952
DOI: 10.1039/D4OB00233D, Communication
Mariia Savchuk, Giang Vo-Thanh, Sylvain Oudeyer, Hélène Beucher, Jean-François Brière
An expeditious diatereoselective synthesis of pyrano[2,3-c]pyrroles thanks to a domino Vinylogous aza-Michael-Aldol-Cyclocondensation (aza-VMAC) reaction to alkylidene Meldrum's acid derivatives.
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Selective synthesis of an elusive C-functional bis-cyclam and study of its inhibition of the CXCR4 chemokine receptor

Org. Biomol. Chem., 2024, 22,3059-3067
DOI: 10.1039/D3OB02050A, Paper
Marie M. Le Roy, Sandra Claes, Nathalie Saffon-Merceron, Dominique Schols, Thibault Troadec, Raphaël Tripier
A rare example of C,C'-linked bis-cyclam has been synthesized with controlled manner in mild conditions thanks to the “bis-aminal” tool, and its good CXCR4-recognition properties could be demonstated in vitro.
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Palladium-catalyzed (Z)-selective allylation of phosphine oxides with vinylethylene carbonates to construct phosphorus allyl alcohols

Org. Biomol. Chem., 2024, 22,3068-3072
DOI: 10.1039/D4OB00354C, Paper
Hua Huang, Yi-Qi Wu, Lu-Yao Han, Lu Jiang, Zhuo-Zhuo Zhang, Xiang Zhang, Bo Han, Wei Huang, Jun-Long Li
A general and efficient method for the highly stereoselective synthesis of (Z)-phosphorus allylalcohols has been developed using the Pd-catalyzed cross-coupling of phosphine oxides with vinylethylene carbonates.
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Stereoselective synthesis of (R)- and (S)-1,2-diazetidine-3-carboxylic acid derivatives for peptidomimetics

Org. Biomol. Chem., 2024, 22,2974-2977
DOI: 10.1039/D4OB00278D, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Matthew Nutter, Henry Stone, Michael Shipman, Stefan Roesner
Stereoselective synthesis of both enantiomers of orthogonally protected 1,2-diazetidine-3-carboxylic acid (aAze) from homochiral glycidol and its application in peptidomimetics.
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Selective enhancement of (6–4) photoproduct formation in dithymine dinucleotides driven by specific sugar puckering

Org. Biomol. Chem., 2024, 22,3025-3034
DOI: 10.1039/D4OB00279B, Paper
Jouda Jakhlal, Clément Denhez, Stéphanie Coantic-Castex, Agathe Martinez, Dominique Harakat, Thierry Douki, Dominique Guillaume, Pascale Clivio
Evidence is presented that (6–4) photoproduct formation between two thymine residues in dinucleotide analogues is significantly and specifically enhanced when the 5''- and 3''-end sugar puckering are mainly north and south, respectively.
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Iron-catalyzed selective construction of indole derivatives via oxidative C(sp3)–H functionalization of indolin-2-ones

Org. Biomol. Chem., 2024, 22,3073-3079
DOI: 10.1039/D4OB00133H, Paper
Wei Chen, Lang-Qi Wen, Xiao-Bing Lu, Hui Zhou
We have developed a clean and efficient iron-catalyzed C(sp3)–H functionalization of indolin-2-ones for the chemodivergent synthesis of value-added indole derivatives, including isatins, and symmetrical and non-symmetrical isoindigos.
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Direct access to pyrrole anhydrides via oxidative self-coupling of pyrrole carboxaldehydes

Org. Biomol. Chem., 2024, 22,3045-3052
DOI: 10.1039/D4OB00052H, Paper
Surabhi Panday, Tapas Maity, Pratibha Bhatti, Joydev K. Laha
An elegant synthesis of pyrrole-2-carboxylic acid anhydrides from pyrrole-2-carboxaldehydes using TBAI as a catalyst and tert-butyl hydroperoxide (TBHP) as an oxidant is described herein.
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Nickel-catalysed regio- and stereoselective hydrocyanation of alkynoates and its mechanistic insights proposed by DFT calculations

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00380B, Communication
Shigeru Arai, Koichi Nakazawa, Xiao-Fei Yang, Masaya Nakajima, Shinji Harada, Atsushi Nishida
This work discloses the origin of regio- and stereoselectivity of hydrocyanation of alkynoates.
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Cu(OTf)2/HFIP catalyzed regioselective cycloisomerization of indole-C3-functionalized alkynols to carbazoles

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00421C, Communication
Srinivasarao Yaragorla, Tabassum Khan, Sayonika Chakroborty
We report here a simple and atom economic cycloisomerization reaction of indole-tethered alkynols for constructing diverse carbazoles via 1,2-alkly migration using Cu(OTf)2/HFIP as the excellent promoter system.
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Discovery of selective monosaccharide receptors via dynamic combinatorial chemistry

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00015C, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Miguel Alena-Rodriguez, Marcos Fernandez-Villamarin, Ignacio Alfonso, Paula M. Mendes
An effective workflow to discover selective saccharide receptors by combining dynamic combinatorial chemistry with isothermal titration calorimetry and NMR.
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A Highly Diastereoselective One-Pot Ugi/Radical Spirocyclization/Aza-Michael Addition Sequence

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00610K, Communication
Chandra Volla, Salman Khan, Abhradeep Chatterjee, Akshay Murali Nair
We hereby report a highly diastereoselective synthesis of chalcogenated azaspirotricycles via a one-pot Ugi/spirocyclization/ aza-Michael addition sequence. The reaction proceeded via a key visible light mediated spirocyclization step under mild,...
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Regioselective synthesis of 4-arylamino-1,2-naphthoquinones in eutectogel as a confined reaction medium using LED light

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00140K, Communication
R. Vara Prasad, Yogendra Kumar, R. Arun Kumar, Tohira Banoo, Subbiah Nagarajan
The use of a simple carbohydrate-derived eutectogel facilitating a LED-light-induced regioselective synthesis of 4-arylamino-1,2-naphthoquinones in good yields is reported.
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Selecting the right candidate

Building a team or an institution requires both courtesy and common sense




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Counselling: Overcoming the defences of your mind for peace, productivity

Learning to recognise the impact past experiences have on present behaviour can unlock your true potential




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Designing organisations as ‘selfless’ collectives

Reducing complexity and friction between members is important




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Of commitment and self-fulfilment, the Harman way

Vinita Shrivastava, Senior Director at Harman India, on how to ensure loyalty while helping employees reach personal goals




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Basel: What to watch out for

Baselworld, one of the most important watch fairs in the world that hosts brands like Rolex, Omega and Breitling was held in Basel this month from March 22-27. Here’s a Luxe review of some of the novelties to watch out for




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The best gizmos from Basel

Notes from Baselworld 2018, keeping an eye out for top innovations in watchmaking




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Baselworld 2018: For him

Every year just before Easter, Basel hosts the world’s biggest and most important watch show where some of the most prominent watchmakers arrive to boast of their latest creations. As this year’s Baselworld went off successfully, we bring you the top five men’s timepieces from the Messe Basel exhibition centre




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Baselworld 2018: For her

The 2018 Baselworld focusses anew on women’s watches. Watch manufacturers are now no longer emphasising on just bejewelled timepieces but also offering complications. Here is our pick of the top four timepieces that stand out from the rest




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The malfunction of US education policy : elite misinformation, disinformation, and selfishness / Richard P. Phelps.

Lanham : Rowman & Littlefield, [2023]




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Embracing relational teaching [electronic resource] : how strong relationships promote student self-regulation and efficacy / Anthony R. Reibel.

Bloomington, IN : Solution Tree Press, [2023]




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How Kalki penned Ponniyin Selvan dipping into archival books in an old steel trunk

For the historical book, the author travelled widely across Tamil Nadu and Sri Lanka




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Actor Althaf Manaf on making a space for himself in Malayalam films

The actor will be seen in upcoming releases Kapp and Kunjammini’s Hospital




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Early Apple computer that helped launch $3T company sells at auction for $223,000

The Apple-1 has been restored to a fully operational state and came with a custom case with a built-in keyboard




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Short stories by Ernest Hemingway / selected and with an introduction by David Hughes ; illustrations by Ian Beck.

London : The Folio Society, 1986




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Oh, to be a painter! / Virginia Woolf ; introduced and selected by Claudia Tobin.

New York, New York : David Zwirner Books, [2021]




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Travelling with a bitter melon : selected poems (1973-1998) / Leung Ping-kwan ; edited by Martha P.Y. Cheung = Dai yi mei ku gua lü xing / Liang Bingjun.

Hong Kong : Asia 2000 Ltd., [2002]




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Non-person singular : selected poems / Yang Lian ; translated by Brian Holton.

London : Wellsweep, 1994.




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The rubaiyat of Omar Khayyam ; Bird parliament / Farrid ud-Din Attar ; translated by Edward FitzGerald ; selected and edited by A.D.P. Briggs, University of Birmingham.

London : J.M. Dent, 1998.




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Doctor Atomic : [opera in two acts] (2007) / composer, John Adams ; libretto, Peter Sellars from original sources ; stage director, Peter Sellars ; a co-production of De Nederlandse Opera and the NPS [DVD].

Waldron, Heathfield, East Sussex, U.K. : Opus Arte, [2008]




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The Court of King's Bench in law and history : Selden Society lecture delivered in the Hall of the Inner Temple, March 1959 / by George O. Sayles.

London : B. Quaritch, 1959.




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Challenges and contradictions of world order : a reader : selected papers published on the occasion of the 50th anniversary of the foundation of the International Progress Organization / Hans Köchler.

Vienna : International Progress Organization, 2022.




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La sangre, la lengua y el apellido / Yásnaya Aguilar Gil ; [selección de textos a cargo de Marc Delcan Albors].

Buenos Aires : Madreselva, 2021.




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Die spätaltbabylonische Zeit : Abiešuḫ bis Samsuditana : Quellen, Jahresdaten, Geschichte. [Teile 1+2] / Rosel Pientka.

Münster : Rhema, 1998.




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The bookseller of Kabul / Åsne Seierstad ; translated by Ingrid Christophersen.

London : Virago, 2004.




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Local elites and local coinage : elite self-representation on the provincial coinage of Asia, 31 BC to AD 275 / Robert Bennett.

London : Royal Numismatic Society, 2014.




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Edith Stein : essential writings / selected with an introduction by John Sullivan.

New York : Orbis Books, [2002]




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A polar multilayered two-dimensional hybrid perovskite for self-driven X-ray photodetection with a low detection limit

Mater. Chem. Front., 2024, 8,3807-3816
DOI: 10.1039/D4QM00582A, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Jingtian Zhang, Wuqian Guo, Haojie Xu, Qingshun Fan, Linjie Wei, Xianmei Zhao, Zhihua Sun, Junhua Luo
We have designed a polar multilayered hybrid perovskite by alloying large cations into the distorted cage, in which a crystal-based photodetector enables dramatic self-powered X-ray detection performance.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Self-assembled phthalocyanine-based nano-photosensitizers in photodynamic therapy for hypoxic tumors

Mater. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QM00602J, Review Article
Lin He, Ding Ma
This paper reviews the potential of self-assembled phthalocyanine-based nano-photosensitizers for overcoming the limitations of photodynamic therapy (PDT) in treating hypoxic tumors.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Lucy Yu | Think like a human: Self-driving vehicles and the rules of the road

Lucy Yu, Director of Public Policy at FiveAI, is focusing on how to translate the rules of the road – designed and written with human drivers in mind – to the language of computers. Autonomous vehicles may have better sensors than humans, but their ability to reason in ambiguous or new situations is limited. To codify the intuitions many humans rely on when driving, FiveAI starts by providing rules for the car to follow in the most standard conditions, then gives it experience in a controlled version of real world driving. ABOUT WIRED PULSE: AI AT THE BARBICAN 450 business executives, technologists and enthusiasts gathered at The Barbican Centre’s Concert Hall in London, for WIRED Pulse: AI at the Barbican on June 15, 2019. Discover some of the fascinating insights from speakers here: http://wired.uk/ai-event ABOUT WIRED PULSE AND WIRED EVENTS The WIRED Pulse series offers an engaging, top-level perspective on how disruptive technology and fast-changing industries - such as artificial intelligence, deep tech and health - are impacting the human experience. The aim is to distill the most pertinent strands of themes within each complex topic and to share it with the wider public as a thought-provoking conversation-starter. WIRED events shine a spotlight on the innovators, inventors and entrepreneurs who are changing our world for the better. Explore this channel for videos showing on-stage talks, behind-the-scenes action, exclusive interviews and performances from our roster of events. Join us as we uncover the most relevant, up-and-coming trends and meet the people building the future. ABOUT WIRED WIRED brings you the future as it happens - the people, the trends, the big ideas that will change our lives. An award-winning printed monthly and online publication. WIRED is an agenda-setting magazine offering brain food on a wide range of topics, from science, technology and business to pop-culture and politics. CONNECT WITH WIRED Events: http://wired.uk/events Web: http://po.st/WiredVideo Twitter: http://po.st/TwitterWired Facebook: http://po.st/FacebookWired Google+: http://po.st/GoogleWired Instagram: http://po.st/InstagramWired Magazine: http://po.st/MagazineWired Newsletter: http://po.st/NewslettersWired




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Autocomplete Interview - Russell Crowe Answers the Web's Most Searched Questions

'Unhinged' star Russell Crowe answers the internet's most searched questions about himself. What is Russell Crowe doing right now? How old was Russell when he made 'Gladiator'? What band was Russell in? What color are his eyes? What did he win an Oscar for? Russell answers all these questions and more! 'Unhinged' releases July 10




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11 Levels of Self-Portraiture: Easy to Complex

Artist TM Davy explains how to draw a self-portrait in 11 levels of increasing complexity. Starting off with the ubiquitous "solar head" and moving on to portraits that implement light, shadow and color, TM Davy deftly describes how a drawing evolves through materials and techniques. TM Davy is an New York-based artist and a professor at the School of Visual Arts. To see more of his work visit: http://www.tmdavy.com/ and @tmdavy on Instagram.




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WIRED25 2020: Matt Mitchell on Protecting Yourself From Digital Surveillance

Matt Mitchell, founder of CryptoHarlem, joined WIRED25 to discuss online surveillance, "digital stop-and-frisk," and how law enforcement continues to target people of color.




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How a Nat Geo Photographer Selects the Best Images from a Shoot

Steve Winter has been a contributing wildlife photographer with National Geographic for over 20 years. As a wildlife photographer, Steve always has tons of photographs to sift through, and eventually whittle down. Watch as Steve lays out how he actually goes about choosing the perfect photograph.




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Obsessed - Meet the Self-Taught Medicinal Mushroom Cultivator

You think you like mushrooms? William Padilla-Brown might just have a step up on you. As the founder of MycoSymbiotics, William has cultivated hundreds of thousands of mushrooms from dozens of species; he's barcoded them, and turned them into various extracts and tinctures. William sits down with WIRED to break down his mushroom obsession.