Once ranked as the world's sixth-richest, this man is now facing financial challenges but continues a lavish lifestyle in Mumbai with his family.

Meenaakshi Chaudhary looks just as great in a simple cotton sari as she does when she is red-carpet ready.

The government needs to answer the critical question of whether it has accepted any restrictions on its infrastructure creation activities, asserts Ajai Shukla.

The Brampton Triveni temple in Canada has cancelled a consular event after the Canadian police warned them of an "extremely high and imminent" threat level of violent protests. The Life Certificate event, organised by the Consulate General of India, Toronto, was scheduled for November 17 at the temple premises. The cancellation comes almost a week after protestors carrying Khalistani flags clashed with devotees at a Hindu Sabha temple and disrupted an event co-organised by the temple authorities and the Indian Consulate at Brampton. India condemned the attack and called for the prosecution of those involved. Relations between India and Canada have been strained since Prime Minister Justin Trudeau's allegations in September last year of a potential involvement of Indian agents in Khalistan extremist Hardeep Singh Nijjar's killing.

Mohd Ali, Haji Anayat Ali of Kargil and their assistants Shero Ali and Nazir Ahmad of Kathua had gone to the higher reaches of Warwan in J-K's Kishtwar district to purchase livestock in August 1998 but did not return to their homes.

Pappadams are a must for the grand Onam feast and units selling handmade pappadams in Thiruvananthapuram have a steady clientele

On this World Environment Day, a look at the boom in biodegradable cutlery and crockery made from agricultural residue

'While my generation carries with it the memory of the Chinese perfidy of 1962, this generation will carry the memory of Chinese perfidy in Galwan.'

• Dresden players sent home after two test positive
• ‘We are not changing our plans,’ says Christian Seifert

The Bundesliga is keen to press ahead with plans to restart the season for the top two tiers next weekend, despite Dynamo Dresden’s squad being quarantined for two weeks.

Dresden’s players were sent home after two tested positive for coronavirus. This means the second tier club cannot play their first two games of the restart – against Hannover on 17 May and against Fürth the following weekend.

44AD and 44ADA require payment of advanced tax by 15th of march. And if a person (say individual) who is is eligibe for 44AD or 44ADA is having income from other heads (say house property and capital gain) what happens to the requirement of advance tax with respect to such income.

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Company: P & I Management Consultants
Experience: 6 to 9
location: India, Ludhiana
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சென்னை: இஸ்லாமியர்களின் புனித மாதம் ரமலான். இஸ்லாமியர்களின் காலண்டரின் ஒன்பதாவது மாதம் புனித ரமலான் மாதம். நிலவின் நிலைகளை அடிப்படையாகக் கொண்ட சந்திர நாள்காட்டியை இஸ்லாமிய மக்கள் பின்பற்றுகின்றனர். அமாவாசை முடிந்து பிறை தெரியும் நாளில் இருந்து மாதம் தொடங்கும். இந்த ஆண்டு புனித ரமலான் மாதம் ஏப்ரல் 23ஆம் தேதி தொடங்குகிறது. மே 23ஆம் தேதிவரை

Alia Bhatt's traditional outfits have been aced by a number of brides. Recently, her Sabyasachi saree also inspired a bride-to-be. Sonia Wahlla wore the same Sabyasachi saree for her pre-engagement celebration in Vancouver, Canada. She looked elegant and let's

On digital drive to boost staff productivity; taking steps for their safety too

KIDS NOWADAYS they grow up so fast

Dark, handsome bearded and tattooed, Latin Lucca Santanna can’t get enough of brown Brazilian top Cesar Dotadao. Starting at his nips and chest Lucca works down till he’s faced with cramming Cesar’s big fat 9-incher down his throat. He gags a little but gets it good and wet. See more at RawHole.

The post RawHole: Lucca Santanna and Cesar Dotadao appeared first on QueerClick.

(MEXICO CITY) – Today, U.S. Environmental Protection Agency Administrator Andrew Wheeler wrapped up trilateral meetings with Canada and Mexico as part of the 25th Anniversary of the Commission for Environmental Cooperation (CEC) Council meetings in Mexico City.

Visit CTVNews.ca for an interactive record of the COVID-19 outbreak in Canada.

After more than a month at sea, isolated to their cabins, dozens of Canadian cruise ship workers have arrived back on home soil.

Prime Minister Justin Trudeau called Saturday for caution and expressed concern about loosening lockdown measures in Montreal, the epicenter of Canada's coronavirus outbreak. While several Canadian provinces, including Quebec, are preparing reopening measures and a gradual revival of their economies, Trudeau stressed prudence and said that the country is not yet out of danger. Quebec is the worst-hit province in Canada, with more than half of both the country's 67,000 cases of coronavirus and 4,700 deaths.

Extracellular matrix-evoked angiostasis and autophagy within the tumor microenvironment represent two critical, but unconnected, functions of the small leucine-rich proteoglycan, decorin. Acting as a partial agonist of vascular endothelial growth factor 2 (VEGFR2), soluble decorin signals via the energy sensing protein, AMP-activated protein kinase (AMPK), in the autophagic degradation of intracellular vascular endothelial growth factor A (VEGFA). Here, we discovered that soluble decorin evokes intracellular catabolism of endothelial VEGFA that is mechanistically independent of mTOR, but requires an autophagic regulator, paternally expressed gene 3 (PEG3). We found that administration of autophagic inhibitors such as chloroquine or bafilomycin A1, or depletion of autophagy-related 5 (ATG5), results in accumulation of intracellular VEGFA, indicating that VEGFA is a basal autophagic substrate. Mechanistically, decorin increased the VEGFA clearance rate by augmenting autophagic flux, a process that required RAB24 member RAS oncogene family (RAB24), a small GTPase that facilitates the disposal of autophagic compartments. We validated these findings by demonstrating the physiological relevance of this process in vivo. Mice starved for 48 h exhibited a sharp decrease in overall cardiac and aortic VEGFA that could be blocked by systemic chloroquine treatment. Thus, our findings reveal a unified mechanism for the metabolic control of endothelial VEGFA for autophagic clearance in response to decorin and canonical pro-autophagic stimuli. We posit that the VEGFR2/AMPK/PEG3 axis integrates the anti-angiogenic and pro-autophagic bioactivities of decorin as the molecular basis for tumorigenic suppression. These results support future therapeutic use of decorin as a next-generation protein therapy to combat cancer.

Contact between inflammatory cells and endothelial cells (ECs) is a crucial step in vascular inflammation. Recently, we demonstrated that the cell-surface level of endomucin (EMCN), a heavily O-glycosylated single-transmembrane sialomucin, interferes with the interactions between inflammatory cells and ECs. We have also shown that, in response to an inflammatory stimulus, EMCN is cleared from the cell surface by an unknown mechanism. In this study, using adenovirus-mediated overexpression of a tagged EMCN in human umbilical vein ECs, we found that treatment with tumor necrosis factor α (TNF-α) or the strong oxidant pervanadate leads to loss of cell-surface EMCN and increases the levels of the C-terminal fragment of EMCN 3- to 4-fold. Furthermore, treatment with the broad-spectrum matrix metalloproteinase inhibitor batimastat (BB94) or inhibition of ADAM metallopeptidase domain 10 (ADAM10) and ADAM17 with two small-molecule inhibitors, GW280264X and GI254023X, or with siRNA significantly reduced basal and TNFα-induced cell-surface EMCN cleavage. Release of the C-terminal fragment of EMCN by TNF-α treatment was blocked by chemical inhibition of ADAM10 alone or in combination with ADAM17. These results indicate that cell-surface EMCN undergoes constitutive cleavage and that TNF-α treatment dramatically increases this cleavage, which is mediated predominantly by ADAM10 and ADAM17. As endothelial cell-surface EMCN attenuates leukocyte–EC interactions during inflammation, we propose that EMCN is a potential therapeutic target to manage vascular inflammation.

04/13/2020 to 06/12/2020 Daytime intermittent lane closures for milling, patching, paving, and ADA improvements.

Looks like Honda's Multistrada V4 challenger will come with a breathtaking design! Find all details here.

What happens when you take nine Tata UVs including Hexa and Harrier and put them on the road to the world's highest motorable road? Come, witness, how this epic journey unfolded over a course of 10 days.

Small cardamom exports to Saudi Arabia are likely to increase during the current Ramadan season with the Saudi authorities agreeing to accept the globally accepted Codex Food Standards of the United Nations.

Adani Enterprises (AEL), the parent company for the group’s airports and renewable energy businesses, is covered for 12 months of payments amid the lockdown-related economic disruptions, the management said.

Kuldeep Yadav performed brilliantly in the first T20 against the Windies to ensure India registered a comfortable win over the visitors.

The lockdown has added significant impetus, however, to e-sports or online sports, which are fast becoming a mainstream activity.