State lawmakers must create a plan to improve rural schools in response to a 2014 state Supreme Court ruling.

The state's supreme court ruled that it is not its role to tell the legislature how to spend its money, ending a 24-year school-funding battle.

School districts have "unconscionably and impermissibly shifted operating costs of the classrooms directly on the financial backs of our teachers," the lawsuit alleges.

A state leader shares how research helped raise important considerations for increasing college success and completion in Indiana.

Controversy over an intiative aimed a reducing inequities in Lee's Summit, Mo., schools led the police department to provide security protection for the district's first African-American superintendent. Now the school board has reversed course.

Many are whipsawed by shutdown recommendations aimed at stemming the coronavirus, and the logistical and financial consequences of those actions.

The supreme court put an end to five years of legal wrangling that landed the state's public school system with millions more dollars from the state and teachers with a pay raise.

The state's highest court ruled that Washington's charter school law is mostly constitutional, and that charter schools can continue to receive public money.

Nearly 45 percent of children in rural McDowell County, West Virginia do not live with their parents and many are being raised by grandparents.

Michael Martirano led the state's schools through dramatic budget cuts, academic challenges, and a state-versus-local battle over school construction.

David Schuler, the superintendent of Township High School District 214 in Arlington Heights, Ill., has been named 2018 National Superintendent of the Year.

The court declined to take up an appeal backed by school groups of a ruling allowing some property taxpayers challenge their assessments in federal court.

Injuries to the central nervous system (CNS) can cause severe neurological deficits. Axonal regrowth is a fundamental process for the reconstruction of compensatory neuronal networks after injury; however, it is extremely limited in the adult mammalian CNS. In this study, we conducted a loss-of-function genetic screen in cortical neurons, combined with a Web resource-based phenotypic screen, and identified synaptotagmin 4 (Syt4) as a novel regulator of axon elongation. Silencing Syt4 in primary cultured cortical neurons inhibits neurite elongation, with changes in gene expression involved in signaling pathways related to neuronal development. In a spinal cord injury model, inhibition of Syt4 expression in cortical neurons prevented axonal sprouting of the corticospinal tract, as well as neurological recovery after injury. These results provide a novel therapeutic approach to CNS injury by modulating Syt4 function.

The superior colliculus receives a direct projection from retinal ganglion cells. In primates, it remains unknown if the same ganglion cells also supply the lateral geniculate nucleus. To address this issue, a double-label experiment was performed in two male macaques. The animals fixated a target while injection sites were scouted in the superior colliculus by recording and stimulating with a tetrode. Once suitable sites were identified, cholera toxin subunit B-Alexa Fluor 488 was injected via an adjacent micropipette. In a subsequent acute experiment, cholera toxin subunit B-Alexa Fluor 555 was injected into the lateral geniculate nucleus at matching retinotopic locations. After a brief survival period, ganglion cells were examined in retinal flatmounts. The percentage of double-labeled cells varied locally, depending on the relative efficiency of retrograde transport by each tracer and the precision of retinotopic overlap of injection sites in each target nucleus. In counting boxes with extensive overlap, 76–98% of ganglion cells projecting to the superior colliculus were double labeled. Cells projecting to the superior colliculus constituted 4.0–6.7% of the labeled ganglion cell population. In one particularly large zone, there were 5,746 cells labeled only by CTB-AF555, 561cells double labeled by CTB-AF555 and CTB-AF488, but no cell labeled only by CTB-AF488. These data indicate that retinal input to the macaque superior colliculus arises from a collateral axonal branch supplied by ~5% of the ganglion cells that project to the lateral geniculate nucleus. Surprisingly, there exist no ganglion cells that project exclusively to the SC.

Systemic study of pathogenic pathways and interrelationships underlying genes associated with Alzheimer's disease (AD) facilitates the identification of new targets for effective treatments. Recently available large-scale multiomics datasets provide opportunities to use computational approaches for such studies. Here, we devised a novel disease gene identification (digID) computational framework that consists of a semi-supervised deep learning classifier to predict AD-associated genes and a protein–protein interaction (PPI) network-based analysis to prioritize the importance of these predicted genes in AD. digID predicted 1,529 AD-associated genes and revealed potentially new AD molecular mechanisms and therapeutic targets including GNAI1 and GNB1, two G-protein subunits that regulate cell signaling, and KNG1, an upstream modulator of CDC42 small G-protein signaling and mediator of inflammation and candidate coregulator of amyloid precursor protein (APP). Analysis of mRNA expression validated their dysregulation in AD brains but further revealed the significant spatial patterns in different brain regions as well as among different subregions of the frontal cortex and hippocampi. Super-resolution STochastic Optical Reconstruction Microscopy (STORM) further demonstrated their subcellular colocalization and molecular interactions with APP in a transgenic mouse model of both sexes with AD-like mutations. These studies support the predictions made by digID while highlighting the importance of concurrent biological validation of computationally identified gene clusters as potential new AD therapeutic targets.

Santiago, Chile- The declaration of the XXI Specialized Meeting on Family Farming of MERCOSUR (REAF, in Spanish) held last week in Argentina, acknowledged the advances promoted by FAO’s Director General, [...]

Milan - European governments must help combat [...]

I am convinced that the only path to lasting peace in Colombia consists of dialogue, negotiation, cooperation, inclusion and fairness – which is also the high road to sustainable development [...]

Rome - The Food and Agriculture Organization of the United Nations (FAO) and Grow Asia, a multi-stakeholder partnership platform that brings together farmers, the private sector, governments, [...]

Team on ground regrouped; strengthened with surge personnel; Declaration of corporate scale-up response

Watch a course video excerpt from Rise of the Superheroes: The legendary Stan Lee, creator of the Avengers, Spiderman and Iron Man, has partnered with the Smithsonian National Museum of American History to launch the first global online course about superheroes to fans around the world.

The legendary Stan Lee, creator of the Avengers, Spiderman and Iron Man, has partnered with the Smithsonian National Museum of American History to launch the first global online course about superheroes to fans around the world. Register now: smithsonian.com/edx/superheroes

Henry Ford spent the majority of the war as a pacifist. By 1917, however, his state-of-the-art assembly line was churning out vital engine parts to feed the war machine.

The legendary Stan Lee, creator of the Avengers, Spiderman and Iron Man, has partnered with the Smithsonian National Museum of American History to launch the first global online course about superheroes to fans around the world. Taught by "The Dark Knight" producer Michael Uslan, students will go into the vaults of the Smithsonian collection and hear from industry experts. Register now (http://bit.ly/1DsdJ3W) and beginning May 5, 2015, you can become a certified expert on superheroes. Sign up for the verified certificate to earn an original piece of artwork from top artist Phil Jimenez (Wonder Woman, New X-Men) with Phil's, Stan Lee’s, and Michael Uslan’s signatures.

A new “health check” for our planet sounds an alarm bell on rising ocean acidification, which is driven by carbon dioxide levels in the atmosphere

This week's supermoon is closer to Earth than any other in 2024

Since her birth in 1909, Francis lived through two world wars, segregation, the fall of the Soviet Union, multiple pandemics and the invention of the cellphone

Introduced in 1934, the federal duck stamp contest has raised more than $1.2 billion and protected at least 6.5 million acres across the nation. Now, an art exhibition at Connecticut’s Bruce Museum honors the competition’s history

In summer months above the North and South Poles, glowing clouds occasionally form naturally at sunset under the right conditions

The 1898 Wilmington massacre left dozens of Black North Carolinians dead. Conspirators also forced the city's multiracial government to resign at gunpoint

An opioid replacement program in downtown Fredericton will continue to operate at the River Stone Recovery Centre until March 2025 after it got a one-year extension from Health Canada, despite increased opposition to the clinic.

The Prince Edward Island Fire Marshals Office has concluded its investigation into a massive fire at Valley Truss and Metal in Kensington in October.

The large urban mayors of Northern Ontario are advocating for increased provincial and federal support, prioritizing the establishment of Homelessness and Addiction Recovery Treatment Hubs and the expansion of the Rural Community Immigration Pilot.

In the new year, Ontario is supposed to be fully accessible for disabled people, but advocates say the province is ‘nowhere near’ meeting standards it created 20 years ago.

The last time a snowfall was recorded at the Winnipeg airport was on April 19, making it 206 days without any snow. Normally, Winnipeggers would see the first snowfall in October.

That Figure Skating Show previews the final Grand Prix stop of the season. The Russian skaters are expected to dominate, but the biggest showdown is in the women's event.

Falkland locals are still wrapping their heads around the raid of the rural property, likened to a scene out of Breaking Bad, which was part of an RCMP operation that seized drugs and guns worth almost half a billion dollars.

Israeli airstrikes have killed at least 46 people in the Gaza Strip over the past 24 hours — including 11 in an Israeli-declared humanitarian zone, medics said — as the country missed a deadline set by Washington to allow more humanitarian aid into the Palestinian enclave. 

The Calgary-based team beat Hamilton Forge FC in a 2-1 nail-biter at home on Saturday, in front of a sold-out crowd of over 7,000 fans at Spruce Meadows.

Business-Critical Solutions are Now Free to any Subscriber for an Additional Year

DWGgateway plug-in lets AutoCAD users share designs with virtually anyone

Cometal builds on successful investment in COSMOS design analysis software

SolidWorks software helps cut Crenshaw's new product development time and costs in half

Company provides SolidWorks Student Edition software to 100 winners of the Presidential Awards for Excellence in Mathematics and Science Teaching

Both state and national high school and college winners received 3D CAD software to fuel engineering interest and prepare for professional careers

Technology Student Association middle and high school winners received SolidWorks 3D CAD software

Software donation to help fuel engineering enthusiasm for students solving real-world challenges

SOLIDWORKS design and COSMOS analysis software and technical support bring engineering fun, 3D CAD understanding to contests