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Sometimes the best hacks are the ones hiding in plain sight, just waiting for a bright spark to shine light on it. Süreyya Tuncer of @sues_daily took a simple IKEA MOSSLANDA picture ledge and turned it into an affordable curtain pelmet. I’ve come across lots of picture ledge hacks over the years but this is the first time I’ve seen it used this way. It’s a straightforward repurposing of the ledge yet this simple twist made a stark difference. Süreyya […]

The post Elevate Your Curtains Instantly with This Simple Pelmet DIY appeared first on IKEA Hackers.

BrandyPoshie says: "Here`s my Manx mix, Stanly!"

Stanly has a super squee Manx mustache!

-Sally Squeeps

Do you have a squee pet that you want to share with the world? Send us your pet pictures and stories, and they could end up on Daily Squee!

My girlfriend works for a state-funded company and was the lead on the re-design of their website. They already had a developer lined up, but his design skills were not on-par with what they had in mind. As a web designer, I was naturally my girlfriend’s first selection for the job. After five minutes of discussing what they need to be done, I know I will have to turn down the job to save our relationship. 

Client: “So we need you to design three different options for the website and it needs to be designed in HTML and CSS.”

Me: “Okay, but if I’m just designing it, what do you need me to do with the HTML and CSS? Am I designing and developing the site?”

Client: “Just designing it, what’s the problem?”

Me: “Well, if I am designing it, why do you need me to use HTML or CSS? I can develop the site too if that’s what you’re asking?”

Client: “No! You’re not listening! You’re just designing the page, but we need it to be designed in CSS and HTML so it can be developed by[Developer’s Name] for our website.”

Me: “I don’t think you understand what HTML and CSS are.”

Client: “Yes I do! I took a marketing class!”

Me: “…”

The discovery of an impeccably preserved Celtic burial chamber in southern Germany is a "stroke of luck for archaeology," scientists say.

The post 1980-1990s in Uzbekistan appeared first on English Russia.

Scientists have long known that magnetic fields probably extract energy from spinning black holes — they just didn’t know how.

An international team of researchers and gamers, led by Princeton’s Mala Murthy and Sebastian Seung, mapped every neuron and every synaptic connection in an adult fruit fly's brain, building a comprehensive “connectome” that represents a massive step toward understanding the human brain.

Kenneth Strother Jr., director of operations in Princeton University's Department of Public Safety (DPS), has been named assistant vice president for public safety, effective June 1.

ⓒ keico has added a photo to the pool:

'roid week 2024, day 1

found old polaroids and i didn't even remember these existed.

In this talk, Graham Neubig will discuss a new frontier in AI models, vision-language models that understand the world's cultures. The talk will be in two parts. First, Neubig will discuss training of multilingual multimodal multicultural models that understand images and text, and have increased ability to answer culture-specific questions about multimodal data. Second, he will discuss work on "image transcreation", where models have been developed that can transform images to make them more relevant to a particular culture. This work has applications in a number of areas, such as cultural localization of educational materials (to accompany translated text). While these methods cover many languages, African and not, the talk will focus on examples specifically from the African context, and challenges we currently face therein.

It goes without saying that ChatGPT has become a prominent figure in today’s online community. Its impressive debut left a lasting impression on everyone, and there are numerous reasons for this. One of the key features of ChatGPT is its innovative technology, which enables it to comprehend the context of users’ messages and respond accordingly. […]

The post Meet Your New Best Friend: ChatGPT Assistant for Personal Feeds appeared first on RSSground.com.

Two minute video looks at the differences between Repeat Signage Standard edition and the Standalone edition. The former has full features and is ideal for displaying engaging content on any display screen anywhere in the world, whilst the latter is ideal for any application where the Internet is not possible, for example, military, army manoevers, evacuation, outdoor events, etc.

The man was pronounced dead at the scene after CPR efforts from cabin crew

Over 100,000 passengers passed through the airport on 27 October

Pakistan crush world champions Australia by nine wickets in Adelaide to set up a one-day international series decider.

Pakistan thrash Australia by eight wickets in Perth to claim their first one-day series win in the country for 22 years.

1. 'There's a guy in Indian team whose Test average is 63...': Tim Paine wants Rohit and Gambhir to open their eyes  Hindustan Times
2. EXCLUSIVE | Dhruv Jurel can be the X-factor India are looking for in Australia, says Suresh Raina  The Times of India
3. Former Australia captain tips India youngster to shine Down Under  ICC Cricket
4. Not Rishabh Pant or Yashasvi Jaiswal; Ex- Australian captain backs this Indian young player to impress everyone in Border-Gavaskar Trophy, says 'class above all his teammates on this tour'  SportsTak
5. Why India should play Jurel as a specialist batsman at Perth  The Indian Express

1. iPhone SE 4 expected to launch in March 2025, supply chain data suggests  Business Standard
2. iPhone SE4 is likely to launch soon and here are 5 big upgrades we are expecting  India Today
3. Apple iPhone SE 4 to launch next year, likely to become the cheapest iPhone to support Apple Intelligence...  Moneycontrol
4. iPhone SE 4 may spell trouble for iPhone 16 and premium Android phones, here’s why  Hindustan Times
5. iPhone SE 4 Camera Production to Begin Soon Ahead of Anticipated Debut in March 2025: Report  Gadgets 360

1. Pakistani TikToker Imsha Rehman deactivates social media accounts after explicit video leaked online  Hindustan Times
2. Pakistani Influencer Imsha Rehman Deactivates Social Media Accounts After Private Video Leaks  NDTV
3. Now Pakistani TikToker Imsha Rehman’s alleged obscene video leaked online  The Times of India
4. After Minahil Malik, another Pakistani TikTok star Imsha Rehman’s X-rated video goes viral; here's how she  The Economic Times
5. Imsha Rehman viral video: Why Pakistani TikToker has deactivated her account? What’s there in the ‘explicit’ clip?  Mint

velocityconf: If you don't understand your ppl, you don't understand #Ops http://t.co/DQTBLJlWza New #velocityconf interview w/ @katemats

velocityconf: RT @oreillyanimals Vote Instant Wild's Digital Eyes & Ears for Wildlife Protection to win Google Global Impact Award http://t.co/Z0EetiQshZ

War is back in daily headlines. It’s devastating to think about the impact on children here and where the actual fighting is taking place.

Morgan Stanley analysts say Tesla will surge if it can expand to be an AI giant, which may be more likely if Elon Musk exerts influence in a second Trump term.

Sure, some airlines let you work in a free stopover. But Turkish Airlines goes one step further and offers up a free city tour on a stopover as short as six hours. Maybe getting into a shuttle bus and tooling around Istanbul after seven hours on an Airbus isn’t your cup of tea, but if […]

Elon Musk could have a role in Donald Trump’s White House, and this could mean stricter AI standards. It’s no… Continue reading Musk and Trump’s relationship could lead to tougher AI standards

The post Musk and Trump’s relationship could lead to tougher AI standards appeared first on ReadWrite.

Microsoft on Tuesday doubled down on deploying artificial intelligence to consumers, releasing an updated version of its Copilot chatbot that can hold voice conversations and interpret images.

IVT released its latest upgrades to its MediaPlatform software.

Click to view the announcement.

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An important mechanism of resistance to β-lactam antibiotics is via their β-lactamase–catalyzed hydrolysis. Recent work has shown that, in addition to the established hydrolysis products, the reaction of the class D nucleophilic serine β-lactamases (SBLs) with carbapenems also produces β-lactones. We report studies on the factors determining β-lactone formation by class D SBLs. We show that variations in hydrophobic residues at the active site of class D SBLs (i.e. Trp105, Val120, and Leu158, using OXA-48 numbering) impact on the relative levels of β-lactones and hydrolysis products formed. Some variants, i.e. the OXA-48 V120L and OXA-23 V128L variants, catalyze increased β-lactone formation compared with the WT enzymes. The results of kinetic and product studies reveal that variations of residues other than those directly involved in catalysis, including those arising from clinically observed mutations, can alter the reaction outcome of class D SBL catalysis. NMR studies show that some class D SBL variants catalyze formation of β-lactones from all clinically relevant carbapenems regardless of the presence or absence of a 1β-methyl substituent. Analysis of reported crystal structures for carbapenem-derived acyl-enzyme complexes reveals preferred conformations for hydrolysis and β-lactone formation. The observation of increased β-lactone formation by class D SBL variants, including the clinically observed carbapenemase OXA-48 V120L, supports the proposal that class D SBL-catalyzed rearrangement of β-lactams to β-lactones is important as a resistance mechanism.

Jacek R. Wiśniewski
Dec 1, 2014; 13:3497-3506
Research

Lys234 is one of the residues present in class A β-lactamases that is under selective pressure due to antibiotic use. Located adjacent to proton shuttle residue Ser130, it is suggested to play a role in proton transfer during catalysis of the antibiotics. The mechanism underpinning how substitutions in this position modulate inhibitor efficiency and substrate specificity leading to drug resistance is unclear. The K234R substitution identified in several inhibitor-resistant β-lactamase variants is associated with decreased potency of the inhibitor clavulanic acid, which is used in combination with amoxicillin to overcome β-lactamase–mediated antibiotic resistance. Here we show that for CTX-M-14 β-lactamase, whereas Lys234 is required for hydrolysis of cephalosporins such as cefotaxime, either lysine or arginine is sufficient for hydrolysis of ampicillin. Further, by determining the acylation and deacylation rates for cefotaxime hydrolysis, we show that both rates are fast, and neither is rate-limiting. The K234R substitution causes a 1500-fold decrease in the cefotaxime acylation rate but a 5-fold increase in kcat for ampicillin, suggesting that the K234R enzyme is a good penicillinase but a poor cephalosporinase due to slow acylation. Structural results suggest that the slow acylation by the K234R enzyme is due to a conformational change in Ser130, and this change also leads to decreased inhibition potency of clavulanic acid. Because other inhibitor resistance mutations also act through changes at Ser130 and such changes drastically reduce cephalosporin but not penicillin hydrolysis, we suggest that clavulanic acid paired with an oxyimino-cephalosporin rather than penicillin would impede the evolution of resistance.

The aftermath: Navigating a Taliban-led Afghanistan Expert comment NCapeling 20 August 2021

In the coming weeks, governments and international organizations must work through an approach to the Taliban takeover of Afghanistan. It will not be simple.

A failure to acknowledge that the legitimate, elected representatives of Afghanistan are no longer in control of territory or institutions, and to refuse to deal with those that are, will only make for further misery for a population which has already endured decades of violence and poverty.

But to recognize the Taliban risks condemning tens of thousands of Afghan women, children, and men to brutal repression and, for some, potential death, as well as mocking the human rights and rule of law which the US and its allies sought to promote in Afghanistan, and globally, as cornerstones of values-based foreign policies.

The dilemma western governments find themselves in is one they have studiously sought to avoid despite mounting evidence that, without a negotiated deal, a Taliban takeover was only a matter of time. As late as 6 August, the UN Security Council refused to countenance appeals by the UN mission and Afghan civil society activists to press the Taliban and the government to negotiate a ceasefire.

The US reiterated its refrain that it ‘will not accept a military takeover of Afghanistan’ and the UK stressed the Taliban’s only route to power was through meaningful engagement in a peace process. Meanwhile, not until 11 August did Germany and the Netherlands stop deporting Afghan migrants despite the pleas of Afghan authorities and refugee organizations that the country was on the brink of crisis.

Delaying the inevitable

Belief that a military takeover was still some months away may have led diplomats to view dealing with the Taliban as a distant task. The unilateral nature of the US deal with the Taliban and the resistance of the Ghani government to any suggestion of power-sharing arrangements compounded a lack of international coordination and planning on what the conditions for engagement might be.

It cannot be delayed further. The scale of the humanitarian crisis in Afghanistan is daunting, with more than half a million displaced by fighting in 2021 alone, almost 17 million facing crisis levels of food insecurity, and nearly half of all children under five malnourished as a consequence of drought and the COVID-19 pandemic.

With one of the highest global refugee populations and an estimated up 20-30,000 Afghans fleeing the country weekly – even before the government collapsed – Afghanistan evokes still raw memories of the 2015 Syria migrant crisis for Europe. Pakistan and Turkey, home to some of the largest Afghan refugee communities, have already closed their borders to more.

The ongoing chaos at Kabul airport highlights the challenges ahead. But there is a small window – before the UN Security Council is scheduled to review the mandate of the UN mission in Afghanistan by 17 September – for the US and its allies to craft an approach to dealing with the Taliban.

Formal recognition of a Taliban-led government is simply not an option, even for those maintaining a diplomatic presence in Kabul such as China, Iran, Pakistan, and Russia. Technically the Afghan republic has not yet dissolved with vice-president Amrullah Saleh, reportedly in hiding in the Panjshir valley, claiming he is the country’s ‘caretaker’ president.

Conditions for international acceptance

Afghanistan’s ‘enduring partners’ must now focus on building a consensus around five conditions for international acceptance of a Taliban-administered Afghanistan and prevent the Taliban again reaping the benefits of international divisions. The G7 began to articulate some of these conditions but they need to be set out and negotiated with Afghanistan’s neighbours before being formally articulated by the UN Security Council.

1. Adherence to Afghanistan’s human rights obligations. This must specify the rights of women and girls to education and work, the protection of ethnic and religious minorities, and safe passage for all Afghans and internationals leaving the country.
2. Amnesty for all individuals who worked for the Afghan government or international embassies, forces, or aid organizations since 2001.
3. No harbouring of terrorist groups. This has been the central condition for the US deal with the Taliban, and the overriding concern for both China and Russia.
4. Non-lethal public order. The provision of public order to enable supply routes to open, evacuations to continue, and aid to be delivered, is essential and one that Russia has made as a condition for its future relations.
5. Negotiation of inclusive political arrangements with Afghanistan’s political and ethnic factions.

The UN mission in Afghanistan, including its human rights component, and the Al-Qaida Sanctions Committee’s Analytical Support and Sanctions Monitoring Team should be mandated with reporting monthly on the progress toward these five conditions. Their assessments should form the basis for any reconsideration of the Taliban’s status as a terrorist organization. And a negotiated political settlement must be a precondition to the release of the government’s foreign reserves, estimated to be $9.5 billion.

Before this, the humanitarian and development aid on which Afghanistan is almost completely reliant must be recalibrated to flow through international agencies. Models such as Hamas-run Gaza, Assad’s Syria, or Aristide’s Haiti, show that while far from effective, it is possible to provide urgent assistance outside government channels.

This is one of the reasons why the Taliban has sought to retain a strong UN presence across Afghanistan and why the UN must be given a more significant political mandate and resources. The World Bank-administered Afghan Reconstruction Trust Fund should remain the principal channel for international funds.

It is difficult in the short-term to see the US leading this collective effort, given its defensive and domestic-focused position. It could be a moment for the UK and EU to demonstrate their multilateral commitments and forge a coordinated conditions-based approach to a Taliban-administered Afghanistan at the UN.

Going beyond handwringing or gesture politics will be difficult and messy and, ultimately, Afghanistan’s future must be decided by Afghans. Until that day, however, this will save lives.

In conversation with Julien Harneis, UN Assistant Secretary-General 18 November 2024 — 2:30PM TO 3:30PM Anonymous (not verified) 11 November 2024 Chatham House and Online

In this discussion, Julien Harneis will give critical insights into the UN’s humanitarian response in Yemen and the importance of maintaining independent humanitarian assistance.

According to the United Nations, Yemen has faced the world’s worst humanitarian crisis in the last decade, with over 20 million people in need of assistance. Years of ongoing conflict have devastated infrastructure, displaced millions, and caused widespread food insecurity and health emergencies. Access to essential services remains a daily struggle, and the escalating economic collapse has left vulnerable communities facing critical shortages in food, water, and medical supplies.

However, humanitarian actors are continually facing challenges in delivering aid to Yemen due to security threats and supply chain barriers, highlighting the urgent need for coordinated and sustainable international assistance.

UN Assistant Secretary-General and Humanitarian Coordinator for Yemen, Julien Harneis, will provide an account of the humanitarian mission and evolving strategies in Yemen, the impact of regional conflicts in the delivery of aid and discuss other key questions including: