Alia's Gucci style... Kriti finds wisdom...Dia visits a forest...

Modi has launched India’s biggest-ever asset sale, a $29 billion privatization drive that would help prop up the economy.

The post India up for sale as PM Modi offers national icons to plug deficit appeared first on DealStreetAsia.

<strong>EXPECTATIONS</strong> The film <em>PM Narendra Modi</em> is set for release this Friday and the soundtrack has been unveiled too. Given the fact that the film is a biopic, one expects patriotic flavour in this music of <em>PM Narendra Modi</em> which has multiple composers and lyricists collaborating to bring together half a dozen songs. <img class="aligncenter size-full wp-image-968004" src="https://www.bollywoodhungama.com/wp-content/uploads/2019/04/PMNM.jpg" alt="" width="720" height="405" /> <strong>MUSIC</strong> Prasoon Joshi is the lyricist of the opening number <strong><em>'Saugandh Mujhe Iss Mitti Ki'</em></strong> that is composed by Shashi - Khushi and has Shashi Suman singing in a manner that is reminiscent of Sonu Nigam. He is joined by Sukhwinder Singh behind the mike and together they actually come up with a decent outing that reminds one of the kind of music that A.R. Rahman's <em>Lagaan</em> carried. <strong><em>'Namo Namo'</em></strong> has been a prominent slogan for last half a decade and that turns out to be the hook-line of the song. A rap number that is written and rendered by Parry G, this Hitesh Modak composed track is high on intensity and aims at being a power packed outing. Producer Sandip Ssingh too debuts as a singer with this theme song that has Lavaraj as the lyricist as well. Shankar-Ehsaan-Loy and Sameer's <strong><em>'Hindustani'</em></strong> was a huge hit when released back in time for Salman Khan and Sanjay Dutt's unreleased <em>Dus</em>. The song is presented in a new avtar with Parry G's rap kick-starting the proceedings and Sardaana writing added lyrics. This time around it is Shankar Mahadevan's son Siddharth Mahadevan who takes over the mantle and is joined by Shashi Suman as the singer. The overall impact is lacklustre though, as is the case with most of the recreations that are heard first. Shashi-Khushi and Sadaraa come together for <strong><em>'Fakeera'</em></strong> which turns out to be a rather dull outing. Very old fashioned and just not the kind of number that can be expected to make an impression amongst today's audiences, this Raja Hasan and Shashi Suman rendered track belongs to the quick-skip variety. The song which follows next turns out to be even duller, what with composer Hitesh Modak and lyricist Lavraj not really managing to entice any patriotic reactions. Based on Indian classical music, <strong><em>'Junoon'</em></strong> is sung by Javed Ali and though the singer does try, the ordinary tune and the arrangements that accompany it don't really help the cause. The soundtrack concludes with Suvarna Tiwari rendering <strong><em>'Ishwar Allah'</em></strong> which had featured in A.R. Rahman and Javed Akhtar's <em>1947 Earth</em>. Hitesh Modak recreates the song along with lyricist Lavraj and though the 'sur' is in synch with the mood of rest of the album, it doesn't quite entice you much to go for a repeat hearing. <strong>OVERALL</strong> Core situational and thematic. <strong>OUR PICK(S)</strong> <em>‘Saugandh Mujhe Iss Mitti Ki’</em>, <em>‘Namo Namo’</em>

Company: Jesseena Marine Services Private Limited
Experience: 4 to 7
location: Saudi Arabia
Ref: 24828815
Summary: Job Description : Vacancy for one of the Reputed Ministry of Defense -Military Hospital in Saudi Arabia. Criteria: - BSc / Post BSc Nursing from Govt. approved college through regular medium - 4 years experience....

Company: Jesseena Marine Services Private Limited
Experience: 3 to 5
location: Saudi Arabia
Ref: 24828613
Summary: Job Description : Vacancy for one of the Reputed Ministry of Defense -Military Hospital in Saudi Arabia. Criteria: - BSc / Post BSc Nursing from Govt. approved college through regular medium - minimum 3-5 years of ....

Company: Jesseena Marine Services Private Limited
Experience: 4 to 5
location: Saudi Arabia
Ref: 24828612
Summary: Job Description : Vacancy for one of the Reputed Ministry of Defense -Military Hospital in Saudi Arabia. Criteria: - BSc / Post BSc Nursing from Govt. approved college through regular medium - minimum 3-5 years of ....

Modi started his tenure as the 16th Prime Minister of India after his swearing-in on May 30, 2019.

Lewis Library - ML410.M9 G648 2018

Lewis Library - ML172.D47 2018

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Modi is likely to take feedback from the chief ministers of various states to discuss the next stage of the exit from the nationwide lockdown which was imposed on March 24.

1. This Red Dead Redemption II Mod Lets You Ride A Giant Cougar  Kotaku Australia
2. Red Dead Redemption 2 hog riding mod is even better than it sounds  GamesRadar+ AU
3. Ride tall, handsome hogs in this necessary RDR2 mod  PC Gamer
4. Red Dead Online: How to Enable Autopilot | Screen Rant  Screen Rant
5. This Red Dead Redemption 2 Theory Explains Dutch's Behavior | CBR  CBR - Comic Book Resources
6. View Full coverage on Google News

Listen to this glorious innertube attached to the exhaust mod. Honestly, this is so much more entertaining than the whistle tips.

modernmoon:

france,etretat by ZulfiyaG on Flickr.

Check out travel recommendations at Wanderfly!

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BOSTON - The U.S. Environmental Protection Agency (EPA) is proposing targeted modifications to the 2016 Small Municipal Separate Storm Sewer System (MS4) general permit for Massachusetts communities.

BOSTON - The U.S. Environmental Protection Agency (EPA) is proposing targeted modifications to the 2017 Small Municipal Separate Storm Sewer System (MS4) general permit for New Hampshire communities.

Fauci, 79, told CNN correspondent Jake Tapper that the contact was “low risk" — meaning he did not have direct contact with the sick staffer. A test Friday found Fauci did not have COVID-19, CNN reported.

Fauci, 79, told CNN correspondent Jake Tapper that the contact was “low risk" — meaning he did not have direct contact with the sick staffer. A test Friday found Fauci did not have COVID-19, CNN reported.

Tyra Banks probably isn’t smizing too much right now.

Apple India Website Puts Siri in Silent Mode

SuperSport United winger Aubrey Modiba says a conversation with club CEO Stanley Matthews convinced him to stay despite interest from Mamelodi Sundowns.

Members Event

Event participants

Richard Heald, CEO, UK India Business Council (UKIBC)
Manoj Ladwa, Communications Director, Narendra Modi for Prime Minister Campaign
Dr Gareth Price, Senior Research Fellow, Asia Programme, Chatham House

Chair: Adam Roberts, South Asia Bureau Chief, Delhi, The Economist

23 February 2015

Members Event

Event participants

Dr Mukulika Banerjee, Director, South Asia Centre, London School of Economics
Nandan Nilekani, Co-founder and Chairman, EkStep; Chairman, Unique Identification Authority of India (UIAI) (2009-14)
Dr Gareth Price, Senior Research Fellow, Asia Programme, Chatham House
Mihir Swarup Sharma, India Columnist, Bloomberg View; Senior Fellow, Observer Research Foundation, New Delhi
Chair: James Crabtree, Contributing Editor, Financial Times; Senior Visiting Fellow, Lee Kuan Yew School of Public Policy

Protease-activated receptor 2 (PAR-2) is activated by secreted proteases from immune cells or fungi. PAR-2 is normally expressed basolaterally in differentiated nasal ciliated cells. We hypothesized that epithelial remodeling during diseases characterized by cilial loss and squamous metaplasia may alter PAR-2 polarization. Here, using a fluorescent arrestin assay, we confirmed that the common fungal airway pathogen Aspergillus fumigatus activates heterologously-expressed PAR-2. Endogenous PAR-2 activation in submerged airway RPMI 2650 or NCI–H520 squamous cells increased intracellular calcium levels and granulocyte macrophage–colony-stimulating factor, tumor necrosis factor α, and interleukin (IL)-6 secretion. RPMI 2650 cells cultured at an air–liquid interface (ALI) responded to apically or basolaterally applied PAR-2 agonists. However, well-differentiated primary nasal epithelial ALIs responded only to basolateral PAR-2 stimulation, indicated by calcium elevation, increased cilia beat frequency, and increased fluid and cytokine secretion. We exposed primary cells to disease-related modifiers that alter epithelial morphology, including IL-13, cigarette smoke condensate, and retinoic acid deficiency, at concentrations and times that altered epithelial morphology without causing breakdown of the epithelial barrier to model early disease states. These altered primary cultures responded to both apical and basolateral PAR-2 stimulation. Imaging nasal polyps and control middle turbinate explants, we found that nasal polyps, but not turbinates, exhibit apical calcium responses to PAR-2 stimulation. However, isolated ciliated cells from both polyps and turbinates maintained basolateral PAR-2 polarization, suggesting that the calcium responses originated from nonciliated cells. Altered PAR-2 polarization in disease-remodeled epithelia may enhance apical responses and increase sensitivity to inhaled proteases.

β-1,3-d-Glucan is a ubiquitous glucose polymer produced by plants, bacteria, and most fungi. It has been used as a diagnostic tool in patients with invasive mycoses via a highly-sensitive reagent consisting of the blood coagulation system of horseshoe crab. However, no method is currently available for measuring β-1,6-glucan, another primary β-glucan structure of fungal polysaccharides. Herein, we describe the development of an economical and highly-sensitive and specific assay for β-1,6-glucan using a modified recombinant endo-β-1,6-glucanase having diminished glucan hydrolase activity. The purified β-1,6-glucanase derivative bound to the β-1,6-glucan pustulan with a KD of 16.4 nm. We validated the specificity of this β-1,6-glucan probe by demonstrating its ability to detect cell wall β-1,6-glucan from both yeast and hyphal forms of the opportunistic fungal pathogen Candida albicans, without any detectable binding to glucan lacking the long β-1,6-glucan branch. We developed a sandwich ELISA-like assay with a low limit of quantification for pustulan (1.5 pg/ml), and we successfully employed this assay in the quantification of extracellular β-1,6-glucan released by >250 patient-derived strains of different Candida species (including Candida auris) in culture supernatant in vitro. We also used this assay to measure β-1,6-glucan in vivo in the serum and in several organs in a mouse model of systemic candidiasis. Our work describes a reliable method for β-1,6-glucan detection, which may prove useful for the diagnosis of invasive fungal infections.

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.

On this Teachers’ Day, I fondly remember Fraulein Daphne Adams, my first German teacher who influenced my love for languages and who transitioned recently in Jamaica. Miss Adams was first and foremost an excellent, no-nonsense teacher of modern...

Each summer, Marcia Salmon would spend much time studying her son’s itinerary as he embarked on one of his tours to countries around the world. This year, Marcia does not have to deal with that bittersweet experience of watching her son, Kabaka...

New research shows that the rhythm of breathing directly impacts neural activity in a network of brain areas involved in smell, memory and emotions

The rhythm of breathing co-ordinates electrical activity across a network of brain regions associated with smell, memory, and emotions, and can enhance their functioning, according to a new study by researchers at Northwestern University. The findings, published in the Journal of Neuroscience, suggest that breathing does not merely supply oxygen to the brain and body, but may also organise the activity of populations of cells within multiple brain regions to help orchestrate complex behaviours.

Related: Your nose knows death is imminent | Mo Costandi

Related: A cooler way to evaluate brain surgery patients

Some businesses have been more successful than others finding ways with new business practices to maintain the same level of success they did pre-pandemic. 

Incarnate 2014, a course in arts and mission hosted by OM Italy, touches the lives of the students and local community.

A family in Turkey is impacted by the gospel through contacts with the Bible Correspondence Course.

The Hero Duet could be replaced by something that was showcased at the Auto Expo 2016 but could still be undergoing development.

About the new 1200cc model, Brixton says that it “shows the way of Brixton Motorcycles into even higher capacity classes and proves the development competence of our brand.”  

Three modern classic cruisers namely Royal Enfield Classic 350, Jawa and the Benelli Imperiale 400 present for a perfect rivalry. Here's which one of the three packs the most power!