Compounds according to Formula I and Formula II are potent inhibitors of Arginase I and II activity: where R1, R2, R3, R4, R5, R6, R7, R8, R9, D, M, X, and Y are defined as set forth in the specification. The invention also provides pharmaceutical compositions of the compounds and methods of their use for treating or preventing a disease or a condition associated with arginase activity.

The invention relates to a machine tool (1), comprising a plurality of fixed tool spindles (3) and such that can optionally be displaced from a retracted idle position to an extended working position and can be positioned at different positions in a frame-like rack (2), and a workpiece carrier (4) with at least one workpiece holder (5), with the workpiece (4) carrier being movable at least in several axes in a translational manner and preferably also in a rotational manner. In order to provide advantageous constructional conditions it is proposed that at least one of the tool spindles (3) is associated with a tool magazine (7) plus tool changer (8).

Intrapersonal communication systems and methods that provide an optical digital signal link between two or more local devices are disclosed. In some embodiments, the system includes a first signal converter disposed at a first end of the optical digital signal link and configured to convert between electrical digital signals from a first local device and optical digital signals from the optical digital signal link. The system can include an optical connector having a non-contact portion configured to couple optical digital signals between the first signal converter and the optical digital signal link across a gap. The system can include a second signal converter disposed at a second end of the optical digital signal link and configured to convert between electrical digital signals from the second local device and optical digital signals from the optical digital signal link.

According to one embodiment, a three-dimensional shape measuring apparatus includes at least an aperture plate that is provided with a plurality of confocal apertures which are two-dimensionally arranged to have a predetermined arrangement period, and an aperture plate displacement portion that displaces the aperture plate at a constant speed in a predetermined direction perpendicular to the optical axis direction. Further, the aperture plate is provided with a cover member which is moved integrally with the aperture plate and which includes a transparent body allowing the light beams from the light source to pass therethrough and to be irradiated to the plurality of confocal apertures, and protects the plurality of confocal apertures from dust. Further, an imaging optical system, by which each of reflected light beams is guided to a photo-detector, is designed in consideration of optical properties of the whole optical system including the transparent body of the cover member.

The present invention relates to a plasmon generator, in which a surface plasmon is excited by application of light. The plasmon generator extends along one direction. The plasmon generator includes a first end surface that is positioned on one end in the one direction and at which near-field light is generated along with the excitation of the plasmon; and a second cross section that is substantially parallel to the first end surface and is away from the first end surface. The first end surface has a polygonal shape that does not have a substantially acute inner angle. The second cross section has an upper part that has a shape substantially the same as or similar to that of the first end surface and a flare shaped lower part that is connected to the upper part and has a width that increases as it is far from the upper part.

A therapeutic compression apparatus having a primary wrap, a foot wrap and a stirrup is provided. The primary wrap encircles a first portion of a leg and applies compression thereto. The foot wrap encircles at least a portion of the foot and applies compression thereto. The foot wrap may be integrated with the stirrup, detachably connected or provided separately. The compression apparatus may be configured such that one or more bladders are provided therein. The compression apparatus may include a pressure gauge and pump for controlling an amount of pressure applied to the treatment site. A bladder assembly with a number of fluid bladder configurations is also provided for use within a compression apparatus. The bladder may be configured to provide a gradient pressure profile to the treatment site when filled.

The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

A paper coating or binding formulation comprises an aqueous polymer dispersion comprising a copolymer obtained by polymerization of an unsaturated monomer and a carbohydrate derived compound and a tetrasulfonate-based fluorescent whitening agent. The carbohydrate derived compound can be selected from the group consisting of dextrins, maltodextrins, and mixtures thereof. Methods of preparing a paper coating or binding formulation and improving the whitening properties of paper are also provided. Furthermore, paper including a copolymer obtained by polymerization of an unsaturated monomer and a carbohydrate derived compound and a tetrasulfonate-based fluorescent whitening agent is also disclosed.

An accommodating intraocular lens (AIOL) includes an optic adapted to produce a trapezoidal phase shift and a plurality of haptics. Each haptic extends from a haptic-optic junction to at least one transverse arm contacting a capsular bag of the eye, and each haptic has sufficient length and rigidity to stretch a capsular bag of the eye to contact ciliary muscles of the eye. The haptic-optic junctions vault the optic forward relative to the haptics and compression of the haptics by the ciliary muscles moves the anterior optic forward. A combined accommodative power produced by the motion of the anterior optic and the trapezoidal phase shift is at least 0.5 Diopters.

The presently disclosed subject matter provides compositions that selectively bind cyclooxygenase-2 and comprise a therapeutic and/or diagnostic moiety. Also provided are methods for using the disclosed compositions for diagnosing (i.e., by imaging) a target cell and/or treating a disorder associated with a cyclooxygenase-2 biological activity.

Porphyrin compounds are provided. The compounds may further comprise a fused polycyclic aromatic hydrocarbon or a fused heterocyclic aromatic. Fused polycyclic aromatic hydrocarbon s and fused heterocyclic aromatics may extend and broaden absorption, and modify the solubility, crystallinity, and film-forming properties of the porphyrin compounds. Additionally, devices comprising porphyrin compounds are also provided. The porphyrin compounds may be used in a donor/acceptor configuration with compounds, such as C60.

The present invention is directed to the use of the peptide compound Ac-Arg-Phe-Met-Trp-Met-Arg-NH2 as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Ac-Arg-Phe-Met-Trp-Met-Arg-NH2 optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.

The present invention is directed to the use of the peptide compound Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilizate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.

Plant viral vectors have great potential in rapid production of proteins, but no simple. Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures (VLPs or full-size mAb) is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of this technology for producing multiple-subunit protein complexes.

Disclosed is a drug effective in the treatment of fibromyalgia. Basically, the disclosed therapeutic agent was created on the basis of experiments showing improvement in symptoms when etanercept was administered to patients suffering from fibromyalgia. Etanercept is known as a therapeutic agent for rheumatoid arthritis, and the JFIQ score of patients not suffering from fibromyalgia improved considerably in the preferred embodiment. In other words, a therapeutic agent for fibromyalgia is disclosed that contains etanercept as an active ingredient in an effective amount.

The disk-shaped information recording medium having an outer diameter and an inner diameter comprises a substrate having a predetermined thickness, a first side that is one side of the substrate, a second side that is the other side of the substrate, a cylindrical portion forming a through hole formed at a center of the substrate, and a thin portion formed so as to surround an outer diameter of the cylindrical portion. The thin portion is thinner than the predetermined thickness and includes a non-inclined surface and an inclined surface formed on an outer diameter side of the non-inclined surface. The inclined surface is inclined at a predetermined angle to the non-inclined surface and is larger than the non-inclined surface in the thin portion.

There is provided a cartridge including a running portion which causes both end portions of a disc-shaped recording medium to run, and a pressing portion which presses one end portion of the disc-shaped recording medium to press the other end portion against the running portion. Static friction coefficients of a portion of the pressing portion coming in contact with the one end portion and a portion of the running portion coming in contact with the other end portion are different.

There is provided a disk cartridge including a case body in which a plurality of disk-shaped recording media are configured to be able to be received in an axial direction of a central shaft in parallel, and a first shell having a base surface section parallel to a recording surface of the disk-shaped recording medium and a second shell having a basal surface section parallel to the recording surface of the disk-shaped recording medium are coupled and separated through separation and connection in the axial direction, and a presser spring having a section to be attached, which is attached to the case body, and a pressing section configured to come in contact with an outer circumferential surface of the disk-shaped recording medium and to press the disk-shaped recording medium. The presser spring is formed of a resin material.

The disk-shaped information recording medium having an outer diameter and an inner diameter comprises a substrate having a predetermined thickness, a first side that is one side of the substrate, a second side that is the other side of the substrate, a cylindrical portion forming a through hole formed at a center of the substrate, and a thin portion formed so as to surround an outer diameter of the cylindrical portion. The thin portion is thinner than the predetermined thickness and includes a non-inclined surface and an inclined surface formed on an outer diameter side of the non-inclined surface. The inclined surface is inclined at an angle greater than or equal to 25 degrees and less than or equal to 35 degrees with respect to the non-inclined surface.

The invention concerns a harvested crop residue chopper and distribution arrangement for a combine (10) with a straw chopper (60) with a rotor (74) that can be brought into rotation about a horizontal axis (98) with chopper blades (76) fastened thereto that define an outer envelope (96), and with at least one impeller blower (82) arranged downstream of the straw chopper (60) with impeller blades (84) that can rotate about an axis of rotation (88) that extends vertically, in which the impeller blades (84) are provided with outer edges (94) that conform to the envelope (96) of the chopper knives (76) and follow it very closely and are not in contact with it.

A method for forming a nanocomposite material, the nanocomposite material formed thereby, and a battery made using the nanocomposite material. Metal oxide and graphene are placed in a solvent to form a suspension. The suspension is then applied to a current collector. The solvent is then evaporated to form a nanocomposite material. The nanocomposite material is then electrochemically cycled to form a nanocomposite material of at least one metal oxide in electrical communication with at least one graphene layer.

A composite material tape and a lithium secondary battery using the same are provided. The composite material tape includes an organic base and at least one inorganic element dispersed within the organic base. The composite material tapes of the present invention exhibit improved Insulative and heat-resistant characteristics.

A prescription paper has reproduction material placed on selected areas of the back side of the paper so that prescription information can be transferred directly onto the patient's records while the prescription writer is writing the prescription. The reproduction material can be a carbonized backing or any other suitable reproduction material. The front side of the prescription paper comprises at least two lines that are separated by a pre-selected distance to match the distance between adjacent lines on the medical record. The prescription writer can align the lines on the prescription paper to the lines on the medical record so that information can be neatly transferred to the space between the lines on the medical record.

A prescription paper has reproduction material placed on selected areas of the back side of the paper so that prescription information can be transferred directly onto the patient's records while the prescription writer is writing the prescription. The reproduction material can be a carbonized backing or any other suitable reproduction material. The front side of the prescription paper comprises at least two lines that are separated by a pre-selected distance to match the distance between adjacent lines on the medical record. The prescription writer can align the lines on the prescription paper to the lines on the medical record so that information can be neatly transferred to the space between the lines on the medical record.

The PB Reader solves the problem that the e-reader presents: the e-reader has a non-paper screen and printed documents need assembly, binding, and page turning via hands. This is an electronic, mechanical device that can quickly search, review and print documents and that has text-to-speech and remote control functionality. The unit is rectangular in shape similar as a traditional book, including a viewing window for reading and printing. The unit is fed by two paper-belt rollers, across which images and printed text are displayed. The two paper-belt rolls, which are held by two square axles that are driven by the stepping motor through multiple reduction gears. A pattern of round dots is printed on the bottom side of the paper belt, which can be decoded by a photoelectric sensor to take action of reeling pages. The signals control the stepper motor, allowing the reader to reel the page forward or backward, or jump directly to a specific position.The second component of this invention is the designated printer. Its body shape is rectangular. The said printer can print any text files and photos from a computer directly onto the blank paper belt in the PB Reader by means of sensing the code on the paper belt. This way, electronic files are transformed into physical paper files that are readable by the invention to ensure quick search, review and as well as safe storage.The invention also has a wireless remote control function, which will allow people who are disabled (or users who for whatever reasons do not have free use of their hands) to make use of the reader.

A clutch mechanism for a tape dispenser, for example, includes a first reel, a second reel, a biasing element, and a friction element. The first and second reels are rotatably disposed on first and second shafts. The biasing element is disposed between the second reel and second shaft such that the second reel is movable in a radial direction between first and second positions relative to the second shaft and the biasing element biases the second reel into the first position. The friction element extends around the first and second reels and arranged to generate a first normal force acting on the second reel when the second reel is in a first position, relative to the second shaft, and a second normal force acting on the second reel when the second reel is in a second position, relative to the second shaft.

In one embodiment, a method includes passing a signal through a noise whitening filter, passing the signal through a soft detector to calculate first soft information, passing the signal through the soft decoder to calculate second soft information based on the first soft information, and sending the second soft information to the soft detector, wherein the noise whitening filter is configured to process the signal according to the following transfer polynomial: W(D)=1−(p1D+ . . . p1Dλ), where p1 . . . pλ are noise whitening coefficients, D is delay corresponding to bit duration, and a transfer polynomial of the tape channel is F(D)=1+f1D+ . . . +fLDL, wherein L represents a memory length of the tape channel, and wherein λ represents a memory length of the noise whitening filter. Other methods, systems, and computer program products are described in more embodiments.

In one embodiment, a system includes a robotic accessor for transporting media between multiple storage slots and one or more data storage drives; a controller for controlling the robotic accessor; a memory in communication with and/or integrated with the controller for storing information about the media and the storage slots, the information including data corresponding to a physical distribution of the media in the storage slots; and logic integrated with and/or executable by the controller, the logic being adapted to: position the robotic accessor at a computed optimal position during an idle period of the robotic accessor, the computed optimal position being based at least in part on the physical distribution of the media in the storage slots.

A magnetic recording tape according to one embodiment includes at least about eight data bands, wherein each data band is defined between a pair of adjacent servo tracks, each pair of adjacent servo tracks defining only a single data band therebetween. One of the servo tracks has data encoded therein, the data including data for encryption. A magnetic recording tape according to another embodiment includes a plurality of servo tracks, each servo track comprising a series of magnetically defined bars. An average height of the bars is less than about 50 microns. About eight to about twenty six data bands are present on the tape. A tape supply cartridge according to various embodiments has a magnetic recording tape as described herein.

In accordance with one embodiment, a computer program product includes a computer readable storage medium having computer readable program code that is readable and/or executable by a processor to: receive a signal including precoded data read from a magnetic tape medium and pass the signal through a soft detector to calculator first soft information about each bit of the signal and to provide adaptive compensation for the precoded data, send the first soft information to a soft decoder, pass the signal through the soft decoder to calculate second soft information about each bit the signal, and send the second soft information to the soft detector, wherein the precoded data is passed through at least one precoder prior to being written to the magnetic tape medium via a precoder that applies 1/(1⊕D2) to bits of data, where D is delay corresponding to bit duration

A tape guide roller, for use with a tape drive that is configured to receive a length of tape, includes a roller body having an outer surface with one or more grooved areas and one or more non-grooved areas. The one or more grooved areas make up seventy-five percent or less of the outer surface, and the one or more non-grooved areas make up at least twenty-five percent of the outer surface. Furthermore, the one or more grooved areas are configured to affect traction between the roller body and the tape as the tape passes over the roller body.

A magnetic read sensor having an antiferromagnetic located embedded within a magnetic shield of the sensor so that the antiferromagnetic layer can pin the magnetization of the pinned layer without contributing to read gap thickness. The sensor is configured with a pinned layer having a free layer structure located within an active area of the sensor and a pinned layer that extends beyond the free layer and active area of the sensor. The antiferromagnetic layer can be located outside of the active and exchange coupled with the extended portion of the pinned layer.

The spacer is adapted for a rolling bearing comprising an inner ring, an outer ring and at least one row of contact rollers disposed between raceways provided on the rings. The spacer comprises opposite inner and outer portions, facing one another and a lateral portion extending transversally between the inner and outer portions and connected to said portions. The inner and outer portions delimit together with the lateral portion a pocket configured to receive a contact roller. The pocket is laterally open on the side opposite to the lateral portion.

There is provided a resin cage of a tapered roller bearing. The cage includes a small diameter annular portion, a large diameter annular portion, and a plurality of bar portions arranged at intervals in a circumferential direction to connect the annular portions. The bar portion has a pair of circumferentially-directed side surfaces, each having a roller guide surface, and an inner-side inner peripheral surface, a circumferential width of which is smaller on a side of the large diameter annular portion than on a side of the small diameter annular portion, and has a roller retaining region in which a radially outer side pocket width and a radially inner side pocket width between the opposed circumferentially-directed side surfaces of the adjacent bar portions are smaller than a diameter of the roller.

The present description relates to an olefin block copolymer preferably useful to form nonslip pads due to excellences in elasticity and heat resistance, and a sheet-shaped molded body comprising the olefin block copolymer The olefin block copolymer includes a plurality of blocks or segments, each of which includes an ethylene or propylene repeating unit and an α-olefin repeating unit at different weight fractions. The olefin block copolymer satisfies a defined relationship when a load of 5 to 10 kg is applied to a sheet-shaped molded body of the block copolymer for 12 hours or longer at a temperature of 60° C. or higher, and then removed.

A wedge-shaped vehicle barrier, including a top assembly pivotably coupled to a bottom assembly; a mechanism coupled to the top assembly and coupled to the bottom assembly, where the mechanism moves the top assembly between a first position that is substantially horizontal and a second position at a first angle; and one or more flexible slings coupled to a distal portion of the top assembly and a distal portion of the bottom assembly, where the one or more slings prevent the top assembly from rotating beyond a second angle when the top assembly is engaged by a vehicle, the second angle being greater than or equal to the first angle.

A system for occluding a physical anomaly. One embodiment comprises a shape memory material body wherein the shape memory material body fits within the physical anomaly occluding the physical anomaly. The shape memory material body has a primary shape for occluding the physical anomaly and a secondary shape for being positioned in the physical anomaly.

According to an embodiment of the present invention, a system optimizes an information processing environment, and comprises at least one processor. The system collects information pertaining to operational behavior of the information processing environment and including a plurality of parameters. A neural network structure is established to associate the parameters to a desired operational performance characteristic for the information processing environment. The neural network structure is trained with the collected information from the information processing environment to produce a model for the information processing environment. The model is optimized to determine values for the parameters and the information processing environment is adjusted based on the determined parameter values to attain the desired operational performance of the information processing environment. Embodiments of the present invention further include a method and computer program product for optimizing an information processing environment in substantially the same manner described above.

A method for making an elastomeric apertured web comprises providing a precursor web comprising a laminate which is subjected to incremental stretching to form an elastomeric precursor web. A forming apparatus is provided comprising a first member and a second member, wherein the first member comprises a mating member, and the second member comprises teeth which are joined to the second member. The elastomeric precursor web is moved through the forming apparatus, wherein apertures are formed in the elastomeric precursor web material as the teeth on the second member penetrate the mating member forming an elastomeric apertured web. The elastomeric apertured web exhibits a WVTR of at least about 1000 g/m2/day.

A safety feature prevents a two wheeled electric paper lift from raising a paper tray on uneven ground that includes a tilt switch positioned in parallel with an upper limit switch that controls the height in a vertical direction of the paper tray. When a tilt angle of the paper lift is greater than 5° the tilt switch will prevent the paper tray from being raised and thereby prevent the load on the paper tray from shifting or tipping over and causing injury to an operator.

An apparatus comprising a plurality of chambers for receiving an associated plurality of staples, each formed with a shape memory that allows the staple to adopt a straightened configuration, when placed in a stapler, and a deployed configuration for suturing when released from the stapler; and a sleeve moveable relative to the chambers between a first position, in which the staples are trapped by the sleeve within the chambers in the straightened configuration, and a second position, whereby the staples are freed to adopt the deployed configuration, wherein the sleeve is adapted to move between the first and second positions by rotating relative to the chambers.

The present invention relates to shaped bodies made of fiber-reinforced ceramic composites and comprising a core zone and at least one covering layer which has a coefficient of thermal expansion which is higher than that of the core zone. The covering layer is an SiC-rich covering layer and is divided into segments which are separated from the adjacent segments by gaps or bridging zones of a material which is different from the material of the segments. The invention also relates to a process for producing such shaped bodies by infiltration of an intermediate body with molten silicon and their use for friction disks, in vehicle construction or as protective plates.

A computerized system, method, and computer-readable media implementing a method for mass producing variable shaped printed products is presented. A set of cutlines defining a shape for the ordered item is associated with each ordered item. A ganging system selects a plurality of ordered items to be simultaneously produced. Individual cutter-ready outline files corresponding to the associated set of outlines for each of the items selected for production are rendered and inserted into a gang template to generate an aggregated cutlines gang file. The gang file and at least one sheet of substrate are submitted to a cutting system. The cutting system cuts the individual finished products from the substrate sheet(s).

A dome-shaped camera comprising: a camera body including a focus adjustment ring for manually performing focus adjustment; a base part which supports the camera body and includes a tilt mechanism which changes an angle of a tilt direction for supporting the camera body; a dome cover which covers the camera body; a mount device which mounts the dome cover on the base part so that the dome cover is rotatable about a center axis of the dome cover; and a power transmitting device which transmits a rotating force in a direction about the center axis added to the dome cover as a rotating force of a focus adjustment ring of the camera supported at any angle in the tilt direction via a power transmission member placed on a tilt axis.

A paper-sheet handling device relating to the present invention has a configuration such that a binder paper alignment unit for temporarily reserving a plurality of paper-sheets perforated at predetermined positions, a movement mechanism for binding the bundle of paper-sheets thus aligned owing to the above by means of a binding component, and a binder cassette for storing the binding components for being transferred thereto, wherein the movement mechanism is arranged on the downstream side of the binder paper alignment unit and the binder cassette and also, the binder paper alignment unit and the binder cassette are arranges radially on the upstream side to form an approximately V-shape by making the aforesaid movement mechanism to be a reference. It is possible depending on this configuration to concentrate the necessary constructional elements at the periphery of the movement mechanism, so that the arrangement of the component members in the horizontal direction of the device can be restricted and the aforesaid device can be miniaturized.

It, as shown in FIG. 11, is provided with a feed roller 31 that is movable, rotates the spiral coil 11 passing through punched holes 3a of the bundle of paper-sheets 3, and guides the spiral coil 11 to feed it toward a coil advance direction, a screw guide 49 at a movable and adjustable side that guides and conducts a forward end of the spiral coil 11 fed by the feed roller 31 toward the coil advance direction into the punched holes 3a thereof, and a control part that receives diameter-of-coil-setting information for setting a diameter of a coil of the spiral coil 11 and controls positions of the feed roller 31 and the screw guide 49 based on the diameter-of-coil-setting information. Such a configuration enables the feed roller 31 and the screw guide 49 to move to the guided positions of the spiral coil 11 indicated by the diameter-of-coil-setting information. Accordingly, it is possible to pass the spiral coils having the different diameters thereof through the holes of the bundle of paper-sheets stably.

A paper sheet binding die set comprises first and second dies, each having an opposed surface comprising a plurality of tooth portions. The first and second dies face each other such that the first die and the second die are capable of meshing with each other. Each tooth portion of the first die comprises a valley-bottom portion, and a peak-top portion. Each tooth portion of the second die comprises a valley-bottom portion, a peak-top portion, and an inclined-surface portion extending at an incline from the valley-bottom portion to the peak-top portion. The peak-top portion of each of the plurality of tooth portions of the first die has a length so as to cover the inclined-surface portion of the corresponding tooth portion of the second die upon meshing of the first and second dies. The first and second dies pressurize the plurality of stacked paper sheets to bind them together.

The present disclosure relates to methods and devices for securing cylindrical goods in containers during transportation. Some embodiments include void fillers configured to restrain motion of objects in freight containers. Some embodiments include methods of fabricating void fillers for use in freight containers. Some embodiments include methods of using void fillers to restrain object motion in freight containers. In some cases, a void filler is fabricated from a honeycomb-style cardboard materials. In some cases, a void filler is used to restrain an upright cylindrical item such as an upright paper roll in a freight container.

In a processing machine including a processor having a processing blade and a receiver having a reception member and in which a blade edge of the processing blade and a reception portion, of the reception member, engage with each other to process a paper sheet therebetween, the processing blade is one processing blade selected from a blade group and is attached to the processor so as to be changeable to another processing blade of the blade group, reception portions of kinds corresponding to a plurality of kinds of the processing blades of the blade group are formed on the reception member, and the processing blade attached to the processor is positioned so as to be in a position where the blade edge is engageable with the reception portion of the corresponding kind.