apa CBD News: Opening statement by Ms. Cristiana Pasca Palmer, Executive Secretary of the Convention on Biological Diversity, at the Asia-Pacific Regional Consultation Workshop on the Post-2020 Global Biodiversity Framework, Nagoya, Aichi Prefecture, Japan, 2 By www.cbd.int Published On :: Mon, 28 Jan 2019 00:00:00 GMT Full Article
apa CBD Notification SCBD/IMS/JMF/NS/ET/CP/88538 (2019-109): Date extension: Thematic Consultation on Transparent Implementation, Monitoring, Reporting and Review Mechanism, 20-22 February 2020 - Kunming, China and Thematic Consultation on Capacity Building a By www.cbd.int Published On :: Wed, 04 Dec 2019 00:00:00 GMT Full Article
apa CBD Notification SCBD/CPU/DC/KG/PD/PS/88522 (2019-110): Review of post-2020 Implementation Plan and Capacity-building Action Plan (Cartagena Protocol on Biosafety) By www.cbd.int Published On :: Thu, 05 Dec 2019 00:00:00 GMT Full Article
apa CBD Notification SCBD/SSSF/AS/CR/TM/88642 (2020-013): Regional Capacity-Building Workshop on Biodiversity and Health for the SEARO region By www.cbd.int Published On :: Fri, 24 Jan 2020 00:00:00 GMT Full Article
apa Capacity Theory with Local Rationality: The Strong Fekete-Szego Theorem on Curves By www.ams.org Published On :: Robert Rumely, University of Georgia - AMS, 2013, 437 pp., Hardcover, ISBN-13: 978-1-4704-0980-7, List: US$119, All AMS Members: US$95.20, SURV/193 This book is devoted to the proof of a deep theorem in arithmetic geometry, the Fekete-Szegö theorem with local rationality conditions. The... Full Article
apa Researchers present a microbial strain capable of massive succinic acid production By www.eurekalert.org Published On :: Wed, 06 May 2020 00:00:00 EDT (The Korea Advanced Institute of Science and Technology (KAIST)) A research team led by Distinguished Professor Sang-Yup Lee reported the production of a microbial strain capable of the massive production of succinic acid with the highest production efficiency to date. This strategy of integrating systems metabolic engineering with enzyme engineering will be useful for the production of industrially competitive bio-based chemicals. Full Article
apa COVID-19: Economic Implications for Japan and the United States By www8.gsb.columbia.edu Published On :: Fri, 01 May 2020 00:00:00 -0400 Exploring the economic implications of COVID-19 on Japan and the US. Full Article
apa POSTPONED: Africa, Japan and the UK: Emerging Partnerships Beyond Summits By feedproxy.google.com Published On :: Fri, 21 Feb 2020 13:00:02 +0000 Research Event 17 March 2020 - 9:30am to 1:15pm Chatham House | 10 St James's Square | London | SW1Y 4LE Agendapdf | 133.11 KB Event participants HE Nabil Ben Khedher, Ambassador of Tunisia to the United KingdomProfessor Naohiro Kitano, Visiting Fellow, Japan International Cooperation Agency Research Institute (JICA-RI); Professor, Waseda UniversityTaku Miyazaki, Deputy Director General, Japan External Trade Organisation (JETRO) LondonSerge Mouangue, Founder and Art Director, WAfricaNorio Suzuki, Senior Strategist, BBOXXHE Professor Mohammed Gana Yisa, Ambassador of the Federal Republic of Nigeria to Japan; Chairman, African Diplomatic Corps in Tokyo (ADC) TICAD CommitteeChairs:Dr Champa Patel, Director, Asia-Pacific Programme, Chatham HouseDr Alex Vines OBE, Managing Director, Ethics, Risk & Resilience; Director, Africa Programme Since Japan established its Tokyo International Conference on African Development (TICAD) in 1993, an increasing number of summits for African engagement have appeared across the Asia-Pacific region. TICAD VII, held on 28-30 August 2019 in Yokohama, sought to strengthen partnerships between Japan and Africa in three main areas: technical cooperation; business and women’s entrepreneurship; and next generation and people-to-people connectivity.The UK-Africa Investment Summit held in January 2020 highlighted similar themes, with an emphasis on investing to generate sustainable growth and create jobs. Common interests and goals among different African countries, Japan and the UK bring opportunities for trilateral cooperation.This event will examine how collaboration between African countries, Japan and the UK can help to more effectively achieve sustainable growth, business development and job creation.PLEASE NOTE THIS EVENT IS POSTPONED UNTIL FURTHER NOTICE. Department/project Africa Programme, Foreign Relations and Africa’s Agency in the International System, Inclusive Economic Growth, Governance and Technology Hanna Desta Programme Assistant, Africa Programme Email Full Article
apa N-glycosylation Site Analysis Reveals Sex-related Differences in Protein N-glycosylation in the Rice Brown Planthopper (Nilaparvata lugens) [Research] By feedproxy.google.com Published On :: 2020-03-01T00:05:26-08:00 Glycosylation is a common modification of proteins and critical for a wide range of biological processes. Differences in protein glycosylation between sexes have already been observed in humans, nematodes and trematodes, and have recently also been reported in the rice pest insect Nilaparvata lugens. Although protein N-glycosylation in insects is nowadays of high interest because of its potential for exploitation in pest control strategies, the functionality of differential N-glycosylation between sexes is yet unknown. In this study, therefore, the occurrence and role of sex-related protein N-glycosylation in insects were examined. A comprehensive investigation of the N-glycosylation sites from the adult stages of N. lugens was conducted, allowing a qualitative and quantitative comparison between sexes at the glycopeptide level. N-glycopeptide enrichment via lectin capturing using the high mannose/paucimannose-binding lectin Concanavalin A, or the Rhizoctonia solani agglutinin which interacts with complex N-glycans, resulted in the identification of over 1300 N-glycosylation sites derived from over 600 glycoproteins. Comparison of these N-glycopeptides revealed striking differences in protein N-glycosylation between sexes. Male- and female-specific N-glycosylation sites were identified, and some of these sex-specific N-glycosylation sites were shown to be derived from proteins with a putative role in insect reproduction. In addition, differential glycan composition between males and females was observed for proteins shared across sexes. Both lectin blotting experiments as well as transcript expression analyses with complete insects and insect tissues confirmed the observed differences in N-glycosylation of proteins between sexes. In conclusion, this study provides further evidence for protein N-glycosylation to be sex-related in insects. Furthermore, original data on N-glycosylation sites of N. lugens adults are presented, providing novel insights into planthopper's biology and information for future biological pest control strategies. Full Article
apa Australian public service's 'gap in capability' to deal with digital revolution By www.smh.com.au Published On :: Thu, 29 Oct 2015 00:19:02 GMT State of the Service report outlines the major hurdle to digital reform. Full Article
apa Japan-Russia Relations in the Abe-Putin Era By feedproxy.google.com Published On :: Mon, 24 Feb 2020 17:15:01 +0000 Research Event 16 April 2020 - 1:00pm to 2:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Alexander Bukh, Senior Lecturer, International Relations, Victoria University, Wellington, New Zealand; Author of These Islands Are Ours: The Social Construction of Territorial Disputes in Northeast Asia (Stanford University Press 2020)Chair: Mathieu Boulègue, Research Fellow, Russia and Eurasia Programme Japan and Russia are often referred to as 'distant neighbours'. In the early days of Prime Minister Shinzo Abe's second term in 2012, Japan sought to open a new era of bilateral relations with Russia. However, recent negotiations on the Kuril Islands/Northern Territories territorial dispute have stalled. Despite Abe’s extensive efforts to resolve the dispute, no concrete agreement has been reached so far. The speaker will provide an overview of the current state of Japan-Russia relations, including the prospect of resolving the territorial dispute during Prime Minister Abe's remaining days in office. Department/project Asia-Pacific Programme, Conflict, Peace and Stability, Geopolitics and Governance, Russia and Eurasia Programme, Russian Foreign Policy Lucy Ridout Programme Administrator, Asia-Pacific Programme +44 (0) 207 314 2761 Email Full Article
apa Low Dose IL-2 Combined with Rapamycin Led to an Expansion of CD4+CD25+FOXP3+ Tregs and Prolonged Human Islet-allograft Survival in Humanized Mice By diabetes.diabetesjournals.org Published On :: 2020-05-07T07:53:04-07:00 Islet transplantation is an emerging therapy for type 1 diabetes (T1D) and hypoglycaemic unawareness. However, a key challenge for islet transplantation is cellular rejection and the requirement for long-term immunosuppression. In this study we established a diabetic-humanized NOD-scidIL2Rnull(NSG) mouse model of T cell mediated human islet-allograft rejection and developed a therapeutic regimen of low-dose recombinant human interleukin2(IL-2) combined with low-dose rapamycin to prolong graft survival. NSG-mice that had received renal-subcapsular human islet-allografts and were transfused with 1x107 of human-spleen-mononuclear-cells (hSPMCs), reconstituted human CD45+ cells that were predominantly CD3+ T cells and rejected their grafts with a median survival time of 27 days. IL-2 alone (0.3x106 IU/m2 or 1x106 IU/m2), or rapamycin alone (0.5-1mg/kg) for 3 weeks did not prolong survival. However, the combination of rapamycin with IL-2 for 3 weeks significantly prolonged human islet-allograft survival. Graft survival was associated with expansion of CD4+CD25+FOXP3+ Tregs and enhanced TGF-β production by CD4+ T cells. CD8+ T cells showed reduced IFN- production and reduced expression of perforin-1. The combination of IL-2 and rapamycin has the potential to inhibit human islet-allograft rejection by expanding CD4+FOXP3+ Tregs in vivo and supressing effector cell function, and could be the basis of effective tolerance-based regimens. Full Article
apa Covid-19: Lack of capacity led to halting of community testing in March, admits deputy chief medical officer By feeds.bmj.com Published On :: Wednesday, May 6, 2020 - 12:25 Full Article
apa Japan-Russia Relations in the Abe-Putin Era By feedproxy.google.com Published On :: Mon, 24 Feb 2020 17:15:01 +0000 Research Event 16 April 2020 - 1:00pm to 2:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Alexander Bukh, Senior Lecturer, International Relations, Victoria University, Wellington, New Zealand; Author of These Islands Are Ours: The Social Construction of Territorial Disputes in Northeast Asia (Stanford University Press 2020)Chair: Mathieu Boulègue, Research Fellow, Russia and Eurasia Programme Japan and Russia are often referred to as 'distant neighbours'. In the early days of Prime Minister Shinzo Abe's second term in 2012, Japan sought to open a new era of bilateral relations with Russia. However, recent negotiations on the Kuril Islands/Northern Territories territorial dispute have stalled. Despite Abe’s extensive efforts to resolve the dispute, no concrete agreement has been reached so far. The speaker will provide an overview of the current state of Japan-Russia relations, including the prospect of resolving the territorial dispute during Prime Minister Abe's remaining days in office. Department/project Asia-Pacific Programme, Conflict, Peace and Stability, Geopolitics and Governance, Russia and Eurasia Programme, Russian Foreign Policy Lucy Ridout Programme Administrator, Asia-Pacific Programme +44 (0) 207 314 2761 Email Full Article
apa Mark Ricketts | A nation with a capacity for caring, but much more is needed By jamaica-gleaner.com Published On :: Sun, 22 Mar 2020 00:25:29 -0500 The global pandemic is real, with almost 8,000 deaths worldwide and nearly 200,000 persons having contracted the virus in 155 affected countries. What is particularly comforting for this country, amid pain and the not knowing, is the bedside and... Full Article
apa Insulin-Deficient Diabetic Condition Upregulates the Insulin-Secreting Capacity of Human Induced Pluripotent Stem Cell-Derived Pancreatic Endocrine Progenitor Cells After Implantation in Mice By diabetes.diabetesjournals.org Published On :: 2020-03-20T11:50:28-07:00 The host environment is a crucial factor for considering the transplant of stem cell–derived immature pancreatic cells in patients with type 1 diabetes. Here, we investigated the effect of insulin (INS)-deficient diabetes on the fate of immature pancreatic endocrine cell grafts and the underlying mechanisms. Human induced pluripotent stem cell–derived pancreatic endocrine progenitor cells (EPCs), which contained a high proportion of chromogranin A+ NK6 homeobox 1+ cells and very few INS+ cells, were used. When the EPCs were implanted under the kidney capsule in immunodeficient mice, INS-deficient diabetes accelerated increase in plasma human C-peptide, a marker of graft-derived INS secretion. The acceleration was suppressed by INS infusion but not affected by partial attenuation of hyperglycemia by dapagliflozin, an INS-independent glucose-lowering agent. Immunohistochemical analyses indicated that the grafts from diabetic mice contained more endocrine cells including proliferative INS-producing cells compared with that from nondiabetic mice, despite no difference in whole graft mass between the two groups. These data suggest that INS-deficient diabetes upregulates the INS-secreting capacity of EPC grafts by increasing the number of endocrine cells including INS-producing cells without changing the graft mass. These findings provide useful insights into postoperative diabetic care for cell therapy using stem cell–derived pancreatic cells. Full Article
apa Talk evidence - TIAs, aging in Japan and women in medicine By feeds.bmj.com Published On :: Wed, 23 Jan 2019 10:16:29 +0000 In this EBM round-up, Carl Heneghan, Helen Macdonald and Duncan Jarvies are back to give you an update Dual vs single therapy for prevention of TIA or minor stroke - how does the advice that dual work better translate in the UK? Carl explains why Japan can teach us to get active and, how GPs can use that information to "drop a decade" in... Full Article
apa Trade in Illegal Timber: The Response in Japan By feedproxy.google.com Published On :: Tue, 18 Nov 2014 10:28:10 +0000 25 November 2014 Japan's legality verification system, known as the goho-wood system, is not only voluntary but has serious design weaknesses which limit its ability to eliminate illegal products from Japan’s market. Read online English Japanese Dr Mari Momii, Independent Environmental Policy Analyst; Lecturer, Atomi University, Japan 20141124IllegalLoggingJapanMomii.jpg A worker walks near a log to be processed at the Okikura Lumber Mill facility, Tokyo, Japan. Photo by Getty Images. This paper is part of a broader Chatham House study which assesses illegal logging and the associated trade. The Japanese government has continued to engage on the issue of illegal logging and related trade, but its approach remains focused on ‘soft’, voluntary measures rather than establishing legally binding requirements. It has been actively promoting the country’s legality verification system, known as the goho-wood system, and this is helping to raise awareness of the issue of illegal logging in Japan. However, the system is not only voluntary but has serious design weaknesses which limit its ability to eliminate illegal products from Japan’s market.While the number of companies registered as goho-wood suppliers has increased, this may be occurring at the expense of sustainability certification, which is more demanding and expensive. The number of companies in Japan with FSC chain-of-custody certification remains low.Japan’s imports of timber-sector products at high risk of illegality are estimated to have declined significantly since the start of the century, though levelling off since 2010, while imports of high-risk paper-sector products are estimated to have gradually increased over this period. Levels of high-risk imports remain significantly above those of the other consumer countries reviewed. These are currently estimated to comprise 12 per cent and seven per cent of total timber- and paper-sector products respectively.It is recommended that the government develop further legislation to control imports of illegal products, including a requirement for risk assessment and mitigation as well as third-party monitoring. Such legislation would also help support the government’s policy to promote the domestic timber industry. Until such legislation is passed, Japanese industry should implement more robust risk assessment and mitigation procedures. Department/project Energy, Environment and Resources Programme, Improving Forest Governance and Tackling Illegal Logging and Deforestation Full Article
apa Methodology for Estimating Levels of Illegal Timber- and Paper-sector Imports: Estimates for China, France, Japan, the Netherlands, the UK, the US and Vietnam By feedproxy.google.com Published On :: Fri, 21 Nov 2014 10:50:40 +0000 25 November 2014 This paper accompanies a series of assessments on China, France, Japan, the Netherlands, the UK, the US and Vietnam, providing details on how the estimates of the level of illegality of imports of wood-based products into those countries were derived. Alison Hoare Senior Research Fellow, Energy, Environment and Resources Programme LinkedIn 20141124IllegalLoggingMethodologyHoare.jpg Photo by Getty Images. This paper accompanies a series of Chatham House assessments on China, France, Japan, the Netherlands, the UK, the US and Vietnam and provides details on how the estimates of the level of illegality of imports of wood-based products into those countries were derived. The assessments are part of a research project that monitored levels of illegal logging and related trade in selected consumer, producer and processing countries in order to evaluate the effectiveness of efforts to tackle this problem.The paper describes the methodology for estimating the levels of wood-based products at high risk of illegality that are being imported into consumer and processing countries. The methodology was developed in order to provide quantitative estimates of the scale of such imports and to assess how they have changed over time. The figures adopted for the assessments are based on the best available evidence; but, given the challenges of quantifying levels of illegal logging and the limited information available for some countries, they should not be regarded as definitive. Rather, they indicate the likely levels of illegality and, perhaps more important, how they may have changed over time. Related documents Research Paper Appendix: Methodology for Estimating Levels of Illegal Timber- and Paper-sector Imports: Estimates for China, France, Japan, the Netherlands, the UK, the US and Vietnampdf | 185.45 KB Annexe au document de recherche: Méthodologie d’estimation des niveaux d’importation de produits bois et papier illégaux: Estimations concernant la Chine, les États-Unis, la France, le Japon, les Pays-Bas, le Royaume-Uni et le Viêt Nampdf | 210 KB Department/project Energy, Environment and Resources Programme, Improving Forest Governance and Tackling Illegal Logging and Deforestation Full Article
apa Covid-19: Lack of capacity led to halting of community testing in March, admits deputy chief medical officer By feeds.bmj.com Published On :: Wednesday, May 6, 2020 - 12:25 Full Article
apa As Its Population Ages, Japan Quietly Turns to Immigration By www.migrationpolicy.org Published On :: Mon, 27 Mar 2017 15:35:24 -0400 One of the most rapidly aging societies in the world, Japan is looking to immigration to address increased labor shortages—albeit slowly and largely without public debate. This country profile offers a brief overview of Japan’s migration history and examines the current immigration system, in particular policies and programs to bring in foreign workers, particularly on a temporary basis. Full Article
apa Japan offers weekend's only top-level event as horse racing struggles to resume By www.upi.com Published On :: Fri, 08 May 2020 11:10:39 -0400 Coronavirus brings worldwide horse racing almost to a halt, with only one Grade 1 event on the weekend schedule, but rays of hope exist. Full Article
apa Characterization of Renal Glucose Reabsorption in Response to Dapagliflozin in Healthy Subjects and Subjects With Type 2 Diabetes By care.diabetesjournals.org Published On :: 2013-10-01 Ralph A. DeFronzoOct 1, 2013; 36:3169-3176Emerging Technologies and Therapeutics Full Article
apa Exploring the Potential of the SGLT2 Inhibitor Dapagliflozin in Type 1 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Pilot Study By care.diabetesjournals.org Published On :: 2015-03-01 Robert R. HenryMar 1, 2015; 38:412-419Evolving Tactics With Inhibition of Sodium-Glucose Cotransporters Full Article
apa Time Course of Normalization of Functional {beta}-Cell Capacity in the Diabetes Remission Clinical Trial After Weight Loss in Type 2 Diabetes By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To assess functional β-cell capacity in type 2 diabetes during 2 years of remission induced by dietary weight loss. RESEARCH DESIGN AND METHODS A Stepped Insulin Secretion Test with Arginine was used to quantify functional β-cell capacity by hyperglycemia and arginine stimulation. Thirty-nine of 57 participants initially achieved remission (HbA1c <6.5% [<48 mmol/mol] and fasting plasma glucose <7 mmol/L on no antidiabetic drug therapy) with a 16.4 ± 7.7 kg weight loss and were followed up with supportive advice on avoidance of weight regain. At 2 years, 20 participants remained in remission in the study. A nondiabetic control (NDC) group, matched for age, sex, and weight after weight loss with the intervention group, was studied once. RESULTS During remission, median (interquartile range) maximal rate of insulin secretion increased from 581 (480–811) pmol/min/m2 at baseline to 736 (542–998) pmol/min/m2 at 5 months, 942 (565–1,240) pmol/min/m2 at 12 months (P = 0.028 from baseline), and 936 (635–1,435) pmol/min/m2 at 24 months (P = 0.023 from baseline; n = 20 of 39 of those initially in remission). This was comparable to the NDC group (1,016 [857–1,507] pmol/min/m2) by 12 (P = 0.064) and 24 (P = 0.244) months. Median first-phase insulin response increased from baseline to 5 months (42 [4–67] to 107 [59–163] pmol/min/m2; P < 0.0001) and then remained stable at 12 and 24 months (110 [59–201] and 125 [65–166] pmol/min/m2, respectively; P < 0.0001 vs. baseline) but lower than that of the NDC group (250 [226–429] pmol/min/m2; P < 0.0001). CONCLUSIONS A gradual increase in assessed functional β-cell capacity occurred after weight loss, becoming similar to that of NDC group participants by 12 months. This result was unchanged at 2 years with continuing remission of type 2 diabetes. Full Article
apa Dapagliflozin Versus Placebo on Left Ventricular Remodeling in Patients With Diabetes and Heart Failure: The REFORM Trial By care.diabetesjournals.org Published On :: 2020-04-03T07:56:03-07:00 OBJECTIVETo determine the effects of dapagliflozin in patients with heart failure (HF) and type 2 diabetes mellitus (T2DM) on left ventricular (LV) remodeling using cardiac MRI.RESEARCH DESIGN AND METHODSWe randomized 56 patients with T2DM and HF with LV systolic dysfunction to dapagliflozin 10 mg daily or placebo for 1 year, on top of usual therapy. The primary end point was difference in LV end-systolic volume (LVESV) using cardiac MRI. Key secondary end points included other measures of LV remodeling and clinical and biochemical parameters.RESULTSIn our cohort, dapagliflozin had no effect on LVESV or any other parameter of LV remodeling. However, it reduced diastolic blood pressure and loop diuretic requirements while increasing hemoglobin, hematocrit, and ketone bodies. There was a trend toward lower weight.CONCLUSIONSWe were unable to determine with certainty whether dapagliflozin in patients with T2DM and HF had any effect on LV remodeling. Whether the benefits of dapagliflozin in HF are due to remodeling or other mechanisms remains unknown. Full Article
apa Efficacy and Safety of 1:1 Fixed-Ratio Combination of Insulin Glargine and Lixisenatide Versus Lixisenatide in Japanese Patients With Type 2 Diabetes Inadequately Controlled on Oral Antidiabetic Drugs: The LixiLan JP-O1 Randomized Clinical Trial By care.diabetesjournals.org Published On :: 2020-04-28T10:59:59-07:00 OBJECTIVETo assess the efficacy and safety of a 1:1 fixed-ratio combination of insulin glargine and lixisenatide (iGlarLixi) versus lixisenatide (Lixi) in insulin-naive Japanese patients with type 2 diabetes mellitus (T2DM) inadequately controlled on oral antidiabetic drugs (OADs).RESEARCH DESIGN AND METHODSIn this phase 3, open-label, multicenter trial, 321 patients with HbA1c≥7.5 to ≤10.0% (58–86 mmol/mol) and fasting plasma glucose (FPG) ≤13.8 mmol/L (250 mg/dL) were randomized 1:1 to iGlarLixi or Lixi for 52 weeks. The primary end point was change in HbA1c at week 26.RESULTSChange in HbA1c from baseline to week 26 was significantly greater with iGlarLixi (–1.58% [–17.3 mmol/mol]) than with Lixi (–0.51% [–5.6 mmol/mol]), confirming the superiority of iGlarLixi (least squares [LS] mean difference –1.07% [–11.7 mmol/mol], P < 0.0001). At week 26, significantly greater proportions of patients treated with iGlarLixi reached HbA1c <7% (53 mmol/mol) (65.2% vs. 19.4%; P < 0.0001), and FPG reductions were greater with iGlarLixi than Lixi (LS mean difference –2.29 mmol/L [–41.23 mg/dL], P < 0.0001). Incidence of documented symptomatic hypoglycemia (≤3.9 mmol/L [70 mg/dL]) was higher with iGlarLixi (13.0% vs. 2.5%) through week 26, with no severe hypoglycemic events in either group. Incidence of gastrointestinal events through week 52 was lower with iGlarLixi (36.0% vs. 50.0%), and rates of treatment-emergent adverse events were similar.CONCLUSIONSThis phase 3 study demonstrated superior glycemic control and fewer gastrointestinal adverse events with iGlarLixi than with Lixi, which may support it as a new treatment option for Japanese patients with T2DM that is inadequately controlled with OADs. Full Article
apa Japan’s Labor Migration Reforms: Breaking with the Past? By www.migrationpolicy.org Published On :: Thu, 20 Feb 2020 10:22:30 -0500 Japan is hoping to bring in as many as 350,000 medium-skilled foreign workers over five years to fill labor market gaps in its rapidly aging society. Yet does this system of Specified Skilled Workers represent an effort to secure a workforce without making long-term settlement possible? And considering its linkage to a Technical Intern Training Program much criticized for abusive practices, does this change represent real reform? This article examines these and other issues. Full Article
apa Okonomiyake - Japanese pizza with soy, honey and ginger sauce By www.abc.net.au Published On :: Mon, 16 Nov 2015 14:15:00 +0800 Referred to as a Japanese 'pizza', okonomiyaki is probably best described as a cabbage fritter. There are many versions that can include seafood, pork belly, kimchi or cheese, and either served with the sauce described or with Japanese mayonnaise. Delicious snack food, which can also be a meal. Full Article ABC Local southwestwa Lifestyle and Leisure:Recipes:All Australia:WA:Bunbury 6230
apa Japanese sweet ginger meatballs By www.abc.net.au Published On :: Thu, 15 Jun 2017 13:41:00 +1000 1 bunch of spring onions, finely chopped 250 g minced beef 250 g minced pork 20 g grated ginger 1 egg 2 tsps. roasted sesame oil 1 tbsp. cornflour, plus extra for dusting sunflower oil, for shallow frying 1 tbsp. white sesame seeds salt and ground white pepper For the sweet ginger sauce: 30 g grated ginger 3 tbsps. soy sauce 125 ml dashi stock or 1 tsp instant dashi powder mixed with water 2 tbsps. sugar 3 tbsps. mirin 3 tbsps. rice vinegar 1 tsp cornflour Full Article ABC Local widebay Lifestyle and Leisure:Recipes:All Australia:QLD:Bundaberg 4670
apa Efficacy and Safety of Dapagliflozin in the Elderly: Analysis From the DECLARE-TIMI 58 Study By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE Data regarding the effects of sodium–glucose cotransporter 2 inhibitors in the elderly (age ≥65 years) and very elderly (age ≥75 years) are limited. RESEARCH DESIGN AND METHODS The Dapagliflozin Effect on Cardiovascular Events (DECLARE)–TIMI 58 assessed cardiac and renal outcomes of dapagliflozin versus placebo in patients with type 2 diabetes. Efficacy and safety outcomes were studied within age subgroups for treatment effect and age-based treatment interaction. RESULTS Of the 17,160 patients, 9,253 were <65 years of age, 6,811 ≥65 to <75 years, and 1,096 ≥75 years. Dapagliflozin reduced the composite of cardiovascular death or hospitalization for heart failure consistently, with a hazard ratio (HR) of 0.88 (95% CI 0.72, 1.07), 0.77 (0.63, 0.94), and 0.94 (0.65, 1.36) in age-groups <65, ≥65 to <75, and ≥75 years, respectively (interaction P value 0.5277). Overall, dapagliflozin did not significantly decrease the rates of major adverse cardiovascular events, with HR 0.93 (95% CI 0.81, 1.08), 0.97 (0.83, 1.13), and 0.84 (0.61, 1.15) in age-groups <65, ≥65 to <75, and ≥75 years, respectively (interaction P value 0.7352). The relative risk reduction for the secondary prespecified cardiorenal composite outcome ranged from 18% to 28% in the different age-groups with no heterogeneity. Major hypoglycemia was less frequent with dapagliflozin versus placebo, with HR 0.97 (95% CI 0.58, 1.64), 0.50 (0.29, 0.84), and 0.68 (0.29, 1.57) in age-groups <65, ≥65 to <75, and ≥75 years, respectively (interaction P value 0.2107). Safety outcomes, including fractures, volume depletion, cancer, urinary tract infections, and amputations were balanced with dapagliflozin versus placebo, and acute kidney injury was reduced, all regardless of age. Genital infections that were serious or led to discontinuation of the study drug and diabetic ketoacidosis were uncommon, yet more frequent with dapagliflozin versus placebo, without heterogeneity (interaction P values 0.1058 and 0.8433, respectively). CONCLUSIONS The overall efficacy and safety of dapagliflozin are consistent regardless of age. Full Article
apa Association Between the Use of Antidepressants and the Risk of Type 2 Diabetes: A Large, Population-Based Cohort Study in Japan By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE This study aimed to reveal the associations between the risk of new-onset type 2 diabetes and the duration of antidepressant use and the antidepressant dose, and between antidepressant use after diabetes onset and clinical outcomes. RESEARCH DESIGN AND METHODS In this large-scale retrospective cohort study in Japan, new users of antidepressants (exposure group) and nonusers (nonexposure group), aged 20–79 years, were included between 1 April 2006 and 31 May 2015. Patients with a history of diabetes or receipt of antidiabetes treatment were excluded. Covariates were adjusted by using propensity score matching; the associations were analyzed between risk of new-onset type 2 diabetes and the duration of antidepressant use/dose of antidepressant in the exposure and nonexposure groups by using Cox proportional hazards models. Changes in glycated hemoglobin (HbA1c) level were examined in groups with continuous use, discontinuation, or a reduction in the dose of antidepressants. RESULTS Of 90,530 subjects, 45,265 were in both the exposure and the nonexposure group after propensity score matching; 5,225 patients (5.8%) developed diabetes. Antidepressant use was associated with the risk of diabetes onset in a time- and dose-dependent manner. The adjusted hazard ratio was 1.27 (95% CI 1.16–1.39) for short-term low-dose and 3.95 (95% CI 3.31–4.72) for long-term high-dose antidepressant use. HbA1c levels were lower in patients who discontinued or reduced the dose of antidepressants (F[2,49] = 8.17; P < 0.001). CONCLUSIONS Long-term antidepressant use increased the risk of type 2 diabetes onset in a time- and dose-dependent manner. Glucose tolerance improved when antidepressants were discontinued or the dose was reduced after diabetes onset. Full Article
apa How to create meaningful connections while apart | Priya Parker By feedproxy.google.com Published On :: Mon, 30 Mar 2020 15:39:05 +0000 Author Priya Parker shares tools for creating meaningful connections with friends, family and coworkers during the coronavirus pandemic -- and shows how we can take advantage of gatherings that are unique to this moment of social distancing. "We don't necessarily need to gather more," she says. "We need to gather better." (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and current affairs curator Whitney Pennington Rodgers. Recorded March 27, 2020) Full Article Higher Education
apa How Massachusetts Is Building Capacity of Educator-Preparation Programs By feedproxy.google.com Published On :: Thu, 18 Oct 2018 00:00:00 +0000 Research findings on the implementation of a new teacher candidate performance assessment in Massachusetts inform the development of additional supports for educator preparation programs. Full Article Massachusetts
apa Disputing Testamentary Capacity in the 21st Century. By www.catalog.slsa.sa.gov.au Published On :: Full Article
apa Stigma & Resilience Framework : (National strategic framework to address HIV stigma and build resilience capacity for people living with HIV) / written and edited by Brent Allan and Kirsten Machon. By www.catalog.slsa.sa.gov.au Published On :: "The HIV resilience framework will be of relevance to a wide range of people involved at all levels of the HIV response. We hope it provides encouragement for government decision makers and policy developers to pursue consistent and enabling policy and legislative environments and work cooperatively between jurisdictions and across departments to achieve best practice. Our consultation suggests that consistent legislation with the goal of supporting strong health outcomes, making disclosure safe, and eliminating stigmatising laws is crucial to creating environments in which people with HIV feel safe to access testing, treatment, and care. The HIV resilience framework also contains valuable insights for those who have responsibility for HIV health program management and service delivery, providing guidance to help ensure that programs, services, interventions or strategies supporting people living with HIV are developed and delivered in a way that is mindful of the interlinked twin goals of building personal resilience and eliminating stigma and discrimination." --President's message (page 6). Full Article
apa Ghosts of the tsunami : death and life in Japan's disaster zone / Richard Lloyd Parry. By www.catalog.slsa.sa.gov.au Published On :: Tohoku Earthquake and Tsunami, Japan, 2011. Full Article
apa In Denmark, Students Go Back to School, 6 Feet Apart By feedproxy.google.com Published On :: Mon, 20 Apr 2020 18:31:00 +0000 Photos by various photographers/Ritzau Scanpix via AP Last week, Denmark became the first European country to allow daycare and primary schools to reopen since the start of the coronavirus lockdown. The classroom setups included desks spaced six feet apart. (In Denmark, which uses the metric system, it’s actually 1.829 meters.) One teacher at the Korshoejskolen school […] Full Article From the Wires coronavirus COVID-19 Denmark Education Europe reopen schools
apa François-Charles-Joseph Bonaparte, King of Rome, as a boy. Engraving by W. Bromley, 1830, after Sir T. Lawrence. By feedproxy.google.com Published On :: Full Article
apa François-Charles-Joseph Bonaparte, King of Rome, as a boy. Engraving by W. Bromley, 1830, after Sir T. Lawrence. By feedproxy.google.com Published On :: London (3 Haymarket) : Published ... by W.B. Tiffin, June 21st 1830. Full Article
apa PHT Morning Skate: Reopening questions; Kapanen’s value By sports.yahoo.com Published On :: Wed, 06 May 2020 13:30:51 GMT Wednesday's collection of links. Full Article article Sports
apa Structure-activity relationships of the cannabinoids / editors, Rao S. Rapaka, Alexandros Makriyannis. By search.wellcomelibrary.org Published On :: Rockville, Maryland : National Institute on Drug Abuse, 1987. Full Article
apa High on the hill : the people of St Philip & St James Church, Old Noarlunga / City of Onkaparinga. By www.catalog.slsa.sa.gov.au Published On :: St. Philip and St. James Church (Noarlunga, S.A.) Full Article
apa High on the hill : the people of St Philip & St James Church, Old Noarlunga%cCity of Onkaparinga. By www.catalog.slsa.sa.gov.au Published On :: St. Philip and St. James Church (Noarlunga, S.A.) Full Article
apa Tapadh leibh airson nach do smoc sibh / design : Biman Mullick. By search.wellcomelibrary.org Published On :: London (33 Stillness Rd, SE23 1NG) : Cleanair, Campaign for a Smoke-free Environment, [198-?] Full Article
apa Tapadh leibh airson nach do smoc sibh / design: Biman Mullick. By search.wellcomelibrary.org Published On :: London (33 Stillness Road London SE23 1NG) : Cleanair Campaign for a Smoke-free Environment, [198-?] Full Article
apa Response of Neurons in the Lateral Intraparietal Area during a Combined Visual Discrimination Reaction Time Task By www.jneurosci.org Published On :: 2002-11-01 Jamie D. RoitmanNov 1, 2002; 22:9475-9489Behavioral Full Article
apa El Comité de Basilea finaliza sus principios sobre pruebas de tensión, analiza fórmulas para acabar con prácticas de arbitraje regulatorio, aprueba la lista anual de G-SIB y debate sobre el coeficiente de apalancamiento, los criptoacti By www.bis.org Published On :: 2018-09-20T14:00:00Z Spanish translation of press release - the Basel Committee on Banking Supervision is finalising stress-testing principles, reviews ways to stop regulatory arbitrage behaviour, agrees on annual G-SIB list, discusses leverage ratio, crypto-assets, market risk framework and implementation, 20 September 2018. Full Article