A chimeric protein containing neutrophil inhibitory factor and hirugen, the chimeric protein having an amino acid sequence that includes FPRPGSGG (SEQ ID NO:21) Also provided is a pharmaceutical composition comprising the chimeric protein, which can be used for treating or preventing cerebral injury and cerebral edema, or for inhibiting platelet aggregation.

A protein which is composed N-terminally of one or several C-terminal parts of the amino acid sequence of the mature tumor necrosis factor and C-terminally of one or several N-terminal parts of the amino acid sequence of the mature tumor necrosis factor, which activates epithelial ion channels and improves the lung function and which can be used for the manufacture of medicaments for the treatment of diseases associated with the lung function, such as oedemas.

The invention relates to indolesulfonyl halogenides which are useful for the protection of organic compounds comprising at least one guanidino moiety and/or at least one amino group. The invention further relates to a process for their preparation and their use as protecting reagents. The invention also relates to the process for the protecting reaction and to the protected compounds thereof.

Whether the growth hormone (GH)/Insulin-like growth factor 1(IGF-I) axis exerts cardioprotective effects remains controversial; and the underlying mechanism(s) for such actions are unclear. Here we tested the hypothesis that growth-hormone releasing hormone (GHRH) directly activates cellular reparative mechanisms within the injured heart, in a GH/IGF-I independent fashion. Following experimental myocardial infarction (MI), rats were randomly assigned to receive, during a 4 week period, either placebo (n=14), rat recombinant GH (rrGH, n=8) or JI-38 (n=8; 50 μg/Kg/day), a potent GHRH-agonist. JI-38 did not elevate serum levels of GH or IGF-I, but markedly attenuated the degree of cardiac functional decline and remodeling after injury. In contrast, GH administration markedly elevated body weight, heart weight, circulating GH and IGF-I, but did not offset the decline in cardiac structure and function. Whereas, both JI-38 and GH augmented levels of cardiac precursor cell proliferation, only JI-38 increased anti-apoptotic gene expression. The receptor for GHRH was detectable on myocytes supporting direct activation of cardiac signal transduction. Collectively, these findings demonstrate that within the heart GHRH-agonists can activate cardiac repair following MI, suggesting the existence of a potential signaling pathway based on GHRH in the heart. The phenotypic profile of the response to a potent GHRH agonist has therapeutic implications.

Plant viral vectors have great potential in rapid production of proteins, but no simple. Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures (VLPs or full-size mAb) is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of this technology for producing multiple-subunit protein complexes.

Compositions and methods for the treatment of asthma and inflammatory ocular disorders are disclosed.

The present invention relates to methods for producing a polypeptide having biological activity, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first polynucleotide encoding the polypeptide operably linked to a second polynucleotide encoding a variant signal peptide or a variant prepropeptide; and (b) isolating the secreted polypeptide having biological activity from the cultivation medium.

Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.

An insect-resistant protein exhibiting a sufficient resistance to insects; an insect-resistance gene encoding the insect-resistant protein; a recombinant vector containing the insect-resistance gene; a host cell and a plant cell having the recombinant vector transfected thereinto; a transformant transformed by the insect-resistance gene and a method for producing the same; a protein recovered thereby; and an insect-resistant agent comprising them as active ingredients. In accordance with the present invention, the insect-resistant protein is derived from a plant.

Disclosed are polypeptides, nucleic acids, and related compositions that render plants resistant to bacterial pathogens. Also disclosed are transgenic plants having the nucleic acids and resistant to bacterial pathogens.

IL4/IL13-binding proteins comprise binding domains, which inhibit IL4/IL13 binding to IL4Ralpaha and common gamma chain complexes (Type 1) and inhibit IL4 binding to IL4Ralpha and IL13Ralpha1 complexes (Type 2), and IL13 binding to IL13Ralpha1 and/or IL13Ralpha2, are useful in the treatment of cancer, inflammatory, and other pathological conditions, such as allergic or fibrotic conditions, especially pulmonary conditions.

The present invention relates to muscle repair promoters for local application that contain a colony-stimulating factor (CSF) as an active ingredient. The muscle repair promoters of the present invention exhibit their effect at low doses, particularly when they are administered intramuscularly.

The present invention provides variable mass labeling reagents, a set of the variable mass labeling reagents, and a multiplexed set of variable mass labeling reagents.

The disk-shaped information recording medium having an outer diameter and an inner diameter comprises a substrate having a predetermined thickness, a first side that is one side of the substrate, a second side that is the other side of the substrate, a cylindrical portion forming a through hole formed at a center of the substrate, and a thin portion formed so as to surround an outer diameter of the cylindrical portion. The thin portion is thinner than the predetermined thickness and includes a non-inclined surface and an inclined surface formed on an outer diameter side of the non-inclined surface. The inclined surface is inclined at a predetermined angle to the non-inclined surface and is larger than the non-inclined surface in the thin portion.

An apparatus for rotating disc is provided, the apparatus according to an exemplary embodiment is characterized in that an anti-slip torque that is applied to the upper face of the disc by using the clamp unit and the elastic member is stronger than a rotation torque that is generated by the turn table to inhibit slipping of the optical disc from the turn table.

A wobble determining apparatus is provided with: a calculating device for calculating (i) a first time required until reaching a number of revolutions of a motor which allows a predetermined linear velocity, and (ii) a second time required to move an optical head to a position which allows the predetermined linear velocity, on the basis of the number of revolutions of the motor and the position of the optical head; a judging device for judging whether to keep the optical head in accordance with the calculated first time and the calculated second time; and a controlling device for controlling a moving device not to move the optical head if it is judged to keep the optical head, and for controlling the moving device to move the optical head to the position which allows the predetermined linear velocity if it is judged not to keep the optical head.

A holding portion includes at least three pressing members which are operable to press an inner peripheral of a hole formed on the medium. The pressing members are movable between first positions where the pressing members do not come in contact with the inner peripheral and second positions where the pressing members come in contact with and press the inner peripheral. Each of the pressing members is adapted to interlockingly move with each other when moving toward the first positions and to press the inner peripheral independently from the other members when positioning the second positions.

A holding mechanism is operable to hold a top medium from a plurality of plate-shaped media accommodated in a stacker in a stacked manner. A transport arm supports the holding mechanism. When the lift mechanism lifts down the transport arm, one of a first elastic pressing force and a second elastic pressing force greater than the first elastic pressing force is selectively applied from the holding mechanism to an upper surface of the top medium.

The disk-shaped information recording medium having an outer diameter and an inner diameter comprises a substrate having a predetermined thickness, a first side that is one side of the substrate, a second side that is the other side of the substrate, a cylindrical portion forming a through hole formed at a center of the substrate, and a thin portion formed so as to surround an outer diameter of the cylindrical portion. The thin portion is thinner than the predetermined thickness and includes a non-inclined surface and an inclined surface formed on an outer diameter side of the non-inclined surface. The inclined surface is inclined at an angle greater than or equal to 25 degrees and less than or equal to 35 degrees with respect to the non-inclined surface.

Provided are apparatuses for grounding the objective lens driving unit of an optical pickup device. An optical pickup device includes an objective lens driving unit and a base that supports the objective lens driving unit, and wherein the objective lens driving unit includes a moving structure including an objective lens and a plurality of drive coils; a static structure comprising magnets corresponding to the plurality of drive coils, a yoke that supports the magnets, and a wire holder that has a plurality of wiring layers including a ground wiring layer; a plurality of suspension wires that connect the plurality of drive coils to the plurality of wiring layers; a supporting portion connected to the yoke and fixed to the wire holder; a projection extending from the supporting portion and disposed adjacent to the ground wiring layer; and conductive bonding material connects the ground wiring layer with the projection.

A medium processing device may include a head which reads or writes data to a recording medium; and a flexible cable which is connected with the head. The flexible cable may be formed in a multilayer structure including a data signal layer formed with a data signal pattern and disconnection detecting signal layers which cover a front face and a rear face of the data signal layer and are formed with a disconnection detecting signal pattern. The flexible cable may also include a terminal connecting part formed with a through hole into which a signal terminal of the head is inserted and a terminal covering part folded to cover the terminal connecting part and fixed to the terminal connecting part.

A harvesting system includes a self-propelled harvesting machine and a drivable collecting container equipped with a drive unit, which can be positioned relative to the harvesting machine and moved in parallel therewith. Crop is fed directly or indirectly to the collecting container during harvesting operation from the harvesting machine using a feed pipe equipped with an outlet chute. The collecting container is equipped with a device for loading it with crop in a uniform manner. The collecting container is moved in a constant position relative to the harvesting machine by way of a control device while the crop is being conveyed. The collecting container is preferably a filling device, by way of which uniform distribution of the crop in the collecting container (8) can be attained.

A biomass feed system includes a device to propel an airborne flow of the biomass along a trajectory within a collection device. At least one air flow port is disposed and operable in cooperation with at least one fan for discharging a flow of air for creating a blanket of pressurized air within the interior cavity beneath the trajectory for supporting and extending a distance of travel of the biomass within the collection device. The collection device can include an air flow outlet adjacent to a terminal end of the trajectory, to and through which the pressurized air will flow, in a manner for lifting and carrying at least some of the airborne biomass farther into the interior cavity. And, vanes or other elements can be provided to used to achieve better sideward distribution.

Method and apparatus are provided for mechanically processing an organ or organs taken out from slaughtered poultry in a processing device or processing line, which organ or organs form part of an organ package and wherein the organ or organs are separated from the organ package. The organ package is spatially oriented by the processing device without notably breaking tissue connections in the package, and in a preselected order so as to cause the harvesting of organs from the package to occur in a preselected sequence that depends on the location of the organ package in the processing device or processing line.

A poultry front half processing module is shown and described. The module includes a rotatable wing bracket for securely engaging the wings of the front half to allow more accurate processing and easier deboning and transfer operations.

The invention concerns an apparatus for processing meat, in particular fish, comprising a processing tool, an actuating unit associated with the processing tool for moving the processing tool out of a starting position into a processing position and vice versa, and a control device which is operatively connected to the processing tool or actuating unit for control of the processing tool, which is distinguished in that the actuating unit comprises a cylinder unit having two pressure cylinders which are arranged one behind the other and connected to each other, wherein the processing tool is arranged on one of the two pressure cylinders of the cylinder unit and the two pressure cylinders can be controlled independently of each other. Furthermore, the invention concerns a corresponding method.

Methods and systems for processing fish are provided which enable cutting of the fish and removal of the viscera without damage to either the viscera or the remaining fish product. The systems may include a gutting device to severe a gullet of the fish from the fish body and to gather and remove the viscera without significant damage to the viscera or the remaining fish product. Extractors for severing the connection between the gullet and the fish with one or more underlying cutting members are also provided to assist in removal of the viscera.

A method for processing poultry suspended by the feet from a conveyor hook is provided. The method and apparatus allow the quality of the poultry to be classified and graded in a simpler and more effective manner to realize higher yields or an extra added value. In one exemplary embodiment, a processing apparatus for a foot of the poultry is provided that includes a foot pad inspection apparatus.

The present invention relates to a device for processing carcasses of livestock such as cattle, pigs and sheep, comprising: at least two dressing tools for performing a dressing process on livestock carcasses, and a robot arm carrying the dressing tool. The invention also relates to a method for processing carcasses of livestock using such a device.

A processing apparatus for poultry is provided. In an exemplary embodiment, the apparatus includes one or more transfer units placed intermediate of, conveying poultry from, a first line to a subsequent second line, wherein both the first line and the second line are selected from the group including a slaughtering line, an evisceration line, a chilling line, a sorting line and a cutup line. Each transfer unit is embodied with a circulating support that includes material that is magnetically conductive and transfer devices are provided with at least one magnet so as to induce eddy currents in the circulating support that counteracts relative motion between the transfer devices and the circulating support.

Method and apparatus are provided for mechanically processing an organ or organs taken out from slaughtered poultry in a processing device or processing line, which organ or organs form part of an organ package and wherein said organ or organs are separated from the organ package. The organ package is spatially oriented by the processing device without notably breaking tissue connections in the package, and in a preselected order so as to cause harvesting of organs from the package to occur in a preselected sequence that depends on the location of the organ package in the processing device or processing line.

A slaughtered pig leg parts conveyor device is provided for conveying individual pig leg parts, wherein an individual pig leg part includes at least a portion of a pig leg and the pig foot. The conveyor device includes a track and one or more pig leg part carriers movable along said track, each carrier being adapted to carry an individual pig leg part. Each carrier has one pig foot retaining assembly adapted to engage on a single pig foot so as to retain the pig leg part in a position suspended from the carrier. The retaining assembly includes a pig foot aperture adapted to receive the pig foot.

A vacuum apparatus and method for recovering poultry breast sub-tenders or other trim products from poultry or meat carcass shells, or for recovering other materials. The apparatus has a cover which can be lowered on to a base to form a vacuum chamber. One or more vacuum hoses extend from the apparatus for suctioning the product into the vacuum chamber. A product container is removably positioned in the vacuum chamber such that the product suctioned into the vacuum chamber will fall into the product container by gravity.

The invention concerns a fish transporting apparatus for automatically feeding fish to a fish processing machine. The fish transporting apparatus can include a transport device with a bottom element for receiving the fish and lateral boundary elements for guiding the fish as well as a vibrating member for vibratory driving of the transport device, which is distinguished in that the bottom element is constructed as a grid plate with rectangular apertures. Furthermore, the invention concerns a device for aligning fish in a head/tail orientation with such a fish transporting apparatus.

A poultry processing device for removing skin from the meat of poultry is provided. The device can include a conveyor line for moving the poultry in their conveying path and one or more de-skinning devices in or adjacent to the conveying path for processing the passing poultry. Each of the de-skinning devices can include a rotatable gripper roll which is circumferentially provided with longitudinally extending teeth having radial ends facing away from a rotational axis of the roll and providing a frictional outer surface to the roll for catching engagement with the skin. Each of the de-skinning devices can further include pinch devices adjacent to the rotatable gripper roll to pinch or trap the skin between the gripper roll and the pinch devices.

A method for producing frozen oysters on the half shell, which comprises the steps of freezing live oysters in their shells, so that the oysters hinges will break open; subjecting the frozen oysters to a water treatment to promote disengagement of the oysters' flesh from one thin shell; and percussing the water treated oysters, so that at least one shell will be knocked off.

A conveying apparatus has a conveying path to supply a plurality of products for consumption having soft parts and intended for processing to a processing device. A conveying intermediate space has conveying surfaces that face one another and receive the products for consumption between them while applying pressure thereto. A first conveying surface comprises a flexible surface-deformable conveying cover and a row arrangement of pressure elements that are arranged next to one another in a row extending transverse to the conveying direction, each having a pressure-applying transverse profile extending transverse to the conveying direction, and are held to be displaceable in the height dimension direction of the conveying intermediate space against a restoring force such that each pressure element co-operates with the surface-deformable conveying cover during the passage of the products for consumption through the conveying path in order to form a variable conveyor cross-section.

A production method of an active material, and the active material are provided to realize an active material containing metal-containing particles and being capable of achieving satisfactory cycle performance and rate performance. The active material is produced by a method of polymerizing a mixture of a metal ion, a hydroxy acid, and a polyol to obtain a polymer, and a step of carbonizing the polymer. The active material used is one having a carbonaceous porous material, and metal particles and/or metal oxide particles supported in pores of the carbonaceous porous material, and particle diameter of the metal-containing particles are in the range of 10 to 300 nm.

Electrode protection in electrochemical cells, and more specifically, electrode protection in both aqueous and non-aqueous electrochemical cells, including rechargeable lithium batteries, are presented. In one embodiment, an electrochemical cell includes an anode comprising lithium and a multi-layered structure positioned between the anode and an electrolyte of the cell. A multi-layered structure can include at least a first single-ion conductive material layer, and at least a first polymeric layer positioned between the anode and the single-ion conductive material. The invention also can provide an electrode stabilization layer positioned within the electrode to control depletion and re-plating of electrode material upon charge and discharge of a battery. Advantageously, electrochemical cells comprising combinations of structures described herein are not only compatible with environments that are typically unsuitable for lithium, but the cells may be also capable of displaying long cycle life, high lithium cycling efficiency, and high energy density.

A system for producing energy that includes infusing porous carbon particles produced by pyrolysis of carbon-containing materials with an off-eutectic salt composition thus producing pore-free carbon particles, and reacting the carbon particles with oxygen in a fuel cell according to the reaction C+O2=CO2 to produce electrical energy.

A catalyst layer for a fuel cell membrane electrode assembly includes a plurality of agglomerates, adjacent ones of the plurality of agglomerates contacting with each other with pores provided between said adjacent ones of the plurality of agglomerates, each of the plurality of agglomerates being formed by packing a plurality of catalysts each consisting of noble metal fine particles supported on a fiber-like support material, adjacent ones of the plurality of catalysts contacting with each other with pores provided between said adjacent ones of the plurality of catalysts, and each of the plurality of catalysts contacting with a plurality of catalysts other than said each catalyst at a plurality of contact points. This allows providing a catalyst layer, a fuel cell membrane electrode assembly, and a fuel cell, each of which has compact size and excellent power generation performance, and a method for producing the same.

Disclosed are sets of ink components, and ink compositions, useful for printing markings, on security documents, that are relatively resistant to counterfeiting. Also disclosed are the security documents formed, a method of printing and a method of authenticating the printed material. The markings, formed of the ink compositions have a spectral response that deviates from a predicted spectral response when linearly additively combining spectral responses of components of the ink composition, so that it becomes difficult to reverse-engineer the ink composition from the markings. Use of plural different markings, with each marking being a microdot, increases difficulty in counterfeiting. By forming a template of spectral responses of the original pattern, spectral responses of a pattern on an unknown document can be compared to the spectral responses on the template for determining whether the unknown document is authentic. Formation of the markings is facilitated using an inkjet printer.

A promotional form is provided which includes a detachable element received within the surrounding margin of a base sheet, the base sheet being folded and sealed around one side of the detachable element to initially conceal a message, question or other indicia hidden until the detachable element is at least partially removed. The promotional form may include a plurality of detachable elements having correlated indicia printed on an exposed side and either on the concealed side of the element or in a portion of the opposing form section in registry with the detachable element. A game or educational piece may be inexpensively provided by correlating different indicia messages corresponding to respective detachable elements, so that in response to an initial query or instruction, a plurality of possible results may be revealed, leading in turn to an outcome revealed by removal of a further detachable element. Tampering with the form is revealed when multiple detachable elements corresponding to alternate results are removed, or the adhesive bonding the facing form sections is disturbed.

A printer, as an image forming apparatus, reverses the front and back sides of tab sheets that became no longer necessary and discharges when a reverse discharge is specified.

The invention provides the user a first insertion page position setting part that allows a user to designate insertion page positions that respectively indicate pages at which first tab sheets are to be inserted, and a second insertion page position setting part that allows the user to designate insertion page positions that respectively indicate pages at which second tab sheets are to be inserted, when a request for initiating the setting concerning the tab sheets is received. Further, the tab positions in the second tab sheets, which correspond to the insertion page positions designated in said second insertion page position setting part, are set up in accordance with the tab positions in the first tab sheets, which correspond to the insertion page positions designated in said first insertion page position setting part.

The Virtual Aggregation Processor enables end user devices to share a common wireless forward path of a multicast communication architecture in which the forward path delivered content is dynamically changed or modified based on a real-time, near-real-time, or delay-time basis via aggregated reverse path feedback from at least one of a plurality of end user devices. The Virtual Aggregation Processor periodically or continuously aggregates the feedback input received via the reverse path (having wired and/or wireless connectivity), modifies the forward path multi-media content, and delivers this dynamically modified multi-media content to the then connected population of end user devices via a wireless forward path multicast in a repetitive closed loop fashion.

A method for controlling within a printer driver the insertion of tab sheets into a print job. According to one embodiment, sheets of multiple levels are insertable. The printer driver provides at least input fields for entry and display of parameters for the definition of at least one tab sheet, and an interactive area for visualizing the hierarchical structure and the order of the at least one defined tab sheet corresponding to the level of the tab sheet in the print job. Depending on changes of a tab sheet defined by entered parameters, the visualization of the hierarchical structure and the order of the at least one defined tab sheet in the print job is updated in the interactive area.

Nanoparticles of a compound are produced by spraying a solution of the compound into a heated chamber. The resulting product comprises a free flowing mixture of nanoparticles of the compound.

A method is described for producing a character, pattern, symbol and/or image (8) on a substrate (2) by way of pigment particles (1) which are arranged thereon and lose their color effect under the action of a laser (23), wherein different pigment particles (1) with at least three different color effects are arranged on and/or in the substrate (2). The invention is distinguished by the following method steps: (a) production of a color chart (14), in which the individual color effect of individual pigment particles (1) or individual clusters of pigment particles is contained as a function of their spatial coordinate on and/or in the substrate (2); (b) spatially resolved irradiation, which changes the color effect of only individual pigment particles (1) or individual clusters of pigment particles, by way of a laser (23) at a single frequency on the basis of the color chart (14) in order to produce a resulting color effect. Furthermore, the present invention relates to substrates, in particular security documents, produced using a method of this type, and devices for carrying out methods of this type.

A gaming system used in a wager-based electronic gaming machine is described. The gaming system is configured to provide picture in a picture capabilities on the electronic gaming machine. In one embodiment, the gaming system can include a first gaming device and a second gaming device where the first gaming device controls the second gaming device. The first gaming device can be configured to receive data and/or communicate with an electronic gaming machine controller, a value input device and value output device. The second gaming device can be configured to receive touchscreen data from a touchscreen display and first video data from the first gaming device and second video data from the EGM controller. Under control of the first gaming device, the first video data and second video data can be output in various sizes and locations on the touchscreen display.