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Oceans may rise over a metre by 2100, warns scientists

About ten percent of the world's population, or 770 million people, today live on land less than five metres above the high tide line.




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Now, a mobile app predicts COVID-19 incidence days in advance

The predictive power of the App highlights the potential utility of real-time symptom tracking




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With 72 deals worth $3.7 bn, PE investments register growth in Oct: Report

Private equity investments witnessed a robust yearly growth in October with 72 PE deals garnering around USD 3.7 billion, even as merger and acquisition activity saw a downtrend, a report said on Thursday. According to Grant Thornton's monthly PE Dealtracker, private equity/venture capital transactions reported 22 per cent and 25 per cent increase in deal volumes and values, respectively as compared to October 2018. The rise in PE deal values was largely driven by the corporate tax rate cut, which has improved both investor sentiment and confidence. Last month, the average deal size stood at USD 52 million, up from USD 28 million recorded in September 2019. "There were 72 deals aggregating to USD 3.7 billion reported in October 2019. Upbeat PE/VC activity during the month offsets the shortfall in merger and acquisition (M&A) activity," Pankaj Chopda, Director, Grant Thornton India LLP said. "The key investments were primarily to pare debt, expand markets and capitalise on ...




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PE/VC deals up by 34% to $2.5 bn in Jan on increased credit investments

After a record-setting 2019, PE/VC investments in 2020 are off to a good start, said Vivek Soni




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PE/VC investments hit 24-month low of $1.7 bn, value falls by 39%

Uncertainty over the impact of Covid-19 is expected to act as a significant headwind to Indian PE/VC investments




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PE and VC investments at $5.1 billion in 1Q2020; a 12-quarter low: IVCA-EY

At $2.2 billion, large deals declined by over 70 per cent on a year-on-year basis in the same period




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[ASAP] Direct Identification of a-Bisabolol Enantiomers in an Essential Oil Using a Combined Ion Mobility–Mass Spectrometry/Quantum Chemistry Approach

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00982




en

[ASAP] Synthesis and Cytotoxicity Studies of Stilbene Long-Chain Fatty Acid Conjugates

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00027




en

[ASAP] Dysidealactams and Dysidealactones: Sesquiterpene Glycinyl-Lactams, Imides, and Lactones from a <italic toggle="yes">Dysidea</italic> sp. Marine Sponge Collected in Southern Australia

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00041




en

[ASAP] PTP1B-Inhibiting Branched-Chain Fatty Acid Dimers from <italic toggle="yes">Eremophila oppositifolia</italic> subsp. <italic toggle="yes">angustifolia</italic> Identified by High-Resolution PTP1B Inhibiti

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00070




en

[ASAP] Genomics–Metabolomics Profiling Disclosed Marine <italic toggle="yes">Vibrio spartinae</italic> 3.6 as a Producer of a New Branched Side Chain Prodigiosin

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01159




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[ASAP] Spongian Diterpenoids Derived from the Antarctic Sponge <italic toggle="yes">Dendrilla antarctica</italic> Are Potent Inhibitors of the <italic toggle="yes">Leishmania</italic> Parasite

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00025




en

[ASAP] 6-Deoxy- and 11-Hydroxytolypodiols: Meroterpenoids from the Cyanobacterium HT-58-2

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00844




en

[ASAP] Bioactive Polyhydroxanthones from <italic toggle="yes">Penicillium purpurogenum</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01071




en

[ASAP] Bioactive <italic toggle="yes">seco</italic>-Sativene Sesquiterpenoids from an <italic toggle="yes">Artemisia desertorum</italic> Endophytic Fungus, <italic toggle="yes">Cochliobolus sativ

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01148




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[ASAP] Irpexine, an Isoindolinone Alkaloid Produced by Coculture of Endophytic Fungi, <italic toggle="yes">Irpex lacteus</italic> and <italic toggle="yes">Phaeosphaeria oryzae</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00047




en

[ASAP] Diisonitrile-Mediated Reactive Oxygen Species Accumulation Leads to Bacterial Growth Inhibition

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00125




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[ASAP] Kalparinol, a Salvialane (Isodaucane) Sesquiterpenoid Derived from Native Australian <italic toggle="yes">Dysphania</italic> Species That Suggests a Putative Biogenetic Link to Zerumbone

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01039




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[ASAP] Unprecedented Quassinoids from <italic toggle="yes">Eurycoma longifolia</italic>: Biogenetic Evidence and Antifeedant Effects

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00244




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[ASAP] Talarolactone A, an Isocoumarin Derivative Fused with Dihydrothiophene with Selective Antimigratory Activity from the Endolichenic Fungus <italic toggle="yes">Talaromyces</italic> sp.

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00024




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[ASAP] Phenylpropanoid-Conjugated Triterpenoids from the Leaves of <italic toggle="yes">Actinidia arguta</italic> and Their Inhibitory Activity on a-Glucosidase

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00643




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[ASAP] Sesquiterpenoids from Cultures of the Basidiomycetes <italic toggle="yes">Irpex lacteus</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01177




en

[ASAP] Cyperane-Type and Related (Nor)Sesquiterpenoids from the Root Bark of <italic toggle="yes">Acanthopanax gracilistylus</italic> and Their Inhibitory Effects on Nitric Oxide Production

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00913




en

[ASAP] Antineoplastic Agents. 607. Emetine Auristatins

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00031




en

[ASAP] Psathyrins: Antibacterial Diterpenoids from <italic toggle="yes">Psathyrella candolleana</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00269




en

[ASAP] Production of Antitubercular Depsipeptides via Biosynthetic Engineering of Cinnamoyl Units

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00194




en

[ASAP] Isolation of Taste-Active Triterpenoids from <italic toggle="yes">Quercus robur</italic>: Sensory Assessment and Identification in Wines and Spirit

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00106




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[ASAP] Phaeosphaones: Tyrosinase Inhibitory Thiodiketopiperazines from an Endophytic <italic toggle="yes">Phaeosphaeria fuckelii</italic>

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00046




en

[ASAP] Licochalcone A Selectively Resensitizes ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Drugs

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01022




en

[ASAP] Total Synthesis of Isohericenone J via a Stille Coupling Reaction

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01251




en

[ASAP] Cytotoxic Monoterpenoid Indole Alkaloids from <italic toggle="yes">Tabernaemontana corymbosa</italic> as Potent Autophagy Inhibitors by the Attenuation of Lysosomal Acidification

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00856




en

[ASAP] Cucurbitane-Type Triterpenoids from the Vines of <italic toggle="yes">Momordica charantia</italic> and Their Anti-inflammatory Activities

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00592




en

[ASAP] Constituents of Two <italic toggle="yes">Dioscorea</italic> Species That Potentiate Antibiotic Activity against MRSA

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b01006




en

[ASAP] <italic toggle="yes">Streptomyces albogriseolus</italic> SY67903 Produces Eunicellin Diterpenoids Structurally Similar to Terpenes of the Gorgonian <italic toggle="yes">Muricella sibogae</italic>, the Bac

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00147




en

[ASAP] A Grand Challenge. 3. Unbiased Phenotypic Function of Metabolites from Australia Plants <italic toggle="yes">Gloriosa superba</italic> and <italic toggle="yes">Alangium villosum</italic> against Parkinson

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00880




en

[ASAP] Stoechanones A and B, Phytotoxic Copaane Sesquiterpenoids Isolated from <italic toggle="yes">Lavandula stoechas</italic> with Potential Herbicidal Activity against <italic toggle="yes">Amaranthus retroflexus<

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00182




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How tiny dependencies can topple the JavaScript Jenga tower

#486 — May 1, 2020

Unsubscribe  :  Read on the Web

JavaScript Weekly

???? I18n Ally: An All-in-One i18n Extension for VS Code — Got some internationalization work to do? I18n Ally gives you inline annotations, automated translations via Google Translate (which you can review), progress indication, etc. Supports React, Angular, Vue and other frameworks.

Anthony Fu

How a Few Lines of Code Broke Lots of Packages — Just under a week ago, people were reporting that create-react-app was broken. The culprit? A tiny change in a tiny dependency: is-promise. Luckily a fix was out very quickly and the creator of is-promise reflects on what happened here. Liran Tal also has some analysis of the situation.

Forbes Lindesay

Identify Front-End Issues Like JavaScript or Network Errors Fast — Datadog’s algorithmic alerts will proactively alert on any client-side issues such as JavaScript and network errors. Optimize the load time of your front-end resources, and detect any UI issues that affect critical user journeys. Try it free with Datadog Synthetics.

Datadog sponsor

Q: A JavaScript 'Quantum Circuit' Simulator — Bring quantum computing to your browser with this JavaScript simulation. If you were never quite sure what your JavaScript code was going to do, now you can formally explore the concept ????

Stewart Smith

Quick bytes:

???? Jobs

Find a Job Through Vettery — Vettery specializes in tech roles and is completely free for job seekers. Create a profile to get started.

Vettery

Senior Full-Stack Developer (Malmö/Sweden) — Every day is different from the next. Join our upbeat Team and work on exciting, major projects using a modern JavaScript stack.

Ortelius AB

???? Tutorials

A Guide to window.location — A breakdown that covers most of the methods and properties available on the DOM’s window.location object.

samantha ming

Implementing Dark Mode in React Apps Using styled-components

Blessing Krofegha

▶  Let's Build a Financial Dashboard App with React (Webinar On‑Demand) — Join TJ VanToll as he walks you through building a responsive Bootstrap-themed Stocks Portfolio app. Check it out today.

Progress KendoReact sponsor

Getting Started with NuxtJS — Learn how to create Vue.js-powered server-side rendered apps with NuxtJS including configuring an app and deploying it on Heroku.

Timi Omoyeni

▶  Learn Svelte: A 16-Part Course on Learning the Popular UI Framework — The course centers around building a chatbot, which is a nice change from the todos and other overused tutorial examples.

noah kaufman

10 Practical JavaScript Tricks — These kinds of lists are usually pretty run of the mill, but this one actually contains some lesser-known quick tips that you may not have seen before.

zander shirley

Moving TinyMCE to Modern JavaScript — The creators of TinyMCE (a popular WYSIWYG HTML editor) have been refactoring its rather legacy JavaScript (the first version came out 17 years ago!) to modern practices.

Joakim Lindkvist

7 JavaScript Design Patterns Every Developer Should Know — This is sort of like a (very) mini version of Addy Osmani’s 2017 book on JS design patterns (which is referenced at the end of the post).

deven rathore

▶  An Introduction to State Machines Using XStateXState is a neat way to work with state machines in JavaScript, Kyle is a neat teacher, and Egghead is a neat platform for unlocking these videos for us too.

Kyle Shevlin

Ride Down Into JavaScript Dependency Hell

AppSignal sponsor

A Collection of Challenging TypeScript Exercises“The goal: Let everyone play with many different TypeScript features and get an overview of TypeScript capabilities and principles.”

Marat Dulin

A Visual Guide to React Mental Models — Different people learn in different ways but good mental models are always valuable and can be helpful if you need to juggle all of the pieces involved in a framework like React.

Obed Parlapiano

Turning Vue Components Into Reusable npm Packages — Outlines how you can reuse Vue components across your projects by automating your process to bundle, test, document, and publish your components.

Sjoerd de voorhoede

???? Code & Tools

jExcel v4: A Vanilla JS Interactive Table / Spreadsheet Control — 4.0 adds support for tabs/workbooks, updating a remote data source with JSON, formula support in a sheet footer, and more. There are lots of demos and examples on the official homepage.

Paul Hodel

Will It CORS? — A handy online tool/wizard for establishing how your (potential) use case will (or won’t!) operate alongside CORS (Cross-Origin Resource Sharing).

HTTP Toolkit

Get Great Visual Feedback & Bug Reports, Even from Non-Technical Folk — Simply click a page element to pin visual feedback with screenshots & metadata. BugHerd = fast and easy bug tracking.

BugHerd sponsor

utfu: Replace Busted Characters From Legacy Text with UTF-8 — Useful when old content contains characters like “— in place of a single quote, and similar legacy text issues.

Daniel Sieradski

Middy 1.0: A Node Middleware Framework for AWS Lambda — Middy’s aim is to make writing serverless functions (hosted on AWS Lambda) easier by providing a familiar middleware abstraction to Node developers.

Luciano Mammino

useWorker() 3.0: A React Hook for Blocking-Free Background Tasks — Makes it easier to throw tasks off to a Web Worker in React.

Alessio Koci

webpack-blocks: Configure webpack using Functional Feature Blocks

Andy Wermke

JZZ: A MIDI Library for Node and the Browser — Send, receive and play MIDI messages from both Node and the browser on Linux, macOS and Windows.

Sema

MDX 1.6: Use JSX in Markdown Documents — This version introduces initial Vue support.

Compositor and Vercel

???? Upcoming Online Events

  • JavaScript Remote Conf 2020 (May 14-15) — Speakers lined up already include Raymond Camden, Christian Heilmann, and Aleksandra Sikora.
  • ESNEXT CONF 2020 (May 18-22) — From the Pika folks (of Snowpack fame). 12 speakers over 5 days so it's a gradual pace.
  • ForwardJS (May 26-29) — A real world event (ForwardJS Ottawa) that has now become a virtual event.
  • CascadiaJS 2020 (September 1-2) — This upcoming online conference is set to take place in September, and the CFP is open now through May 15.




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Long-term growth narrative has been set by Sitharaman: BofA's Kaku Nakhate

The government's decision of upholding power purchase agreements as well as the opening up of railways, city gas distribution, and electricity supply to the private sector, are welcome steps




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New tax structure will leave more cash in the hands of people: Revenue Secy

He said the Budget gives an option to individuals to migrate to a new regime by foregoing their existing exemptions and deductions for a lower tax rate




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Govt very transparent in setting new fiscal deficit target: FM Sitharaman

She further said that many people have been speculating that the fiscal deficit would cross 4%




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Govt not included AGR dues payment in Budget 2020-21: DEA Secretary

15 entities owe the government about Rs 1.47 trillion in past dues -- Rs 92,642 crore in unpaid licence fee and another Rs 55,054 crore in outstanding spectrum usage charges




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Budget 2020: Rs 2,500 cr not enough for tourism promotion, says industry

Tourism bodies say Indians spending Rs 9,000 cr abroad abroad due to poor domestic infra, which cannot be improved with this allocation




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LIC disinvestment: 100,000 employees stage walk-out across country

There are 13 unions in LIC, and employees and officers affiliated to 11 unions were on protest




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Wanted to keep Budget Speech shorter but ended up breaking own record: FM

In July presenting her maiden Budget, Sitharaman had spoken for 2 hours 17 minutes




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Economy fundamentals strong; markets show faith in Budget 2020: Sitharaman

FM says country's macroeconomic parameters are sound




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Open to tweaking Budget to address concerns of the industry, says FM

Finance ministry to come out with detailed rules on Vivad Se Vishwas Bill in a couple of days




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Odisha tables revenue surplus budget with total outgo pegged at Rs 1.5 trn

Budget estimates fiscal deficit to be at 3.4%, within permissible limit of FRBM target




en

Understanding Depression and Distress Among Medical Students

Interview with Laura Weiss Roberts, MD, MA, author of Understanding Depression and Distress Among Medical Students




en

Substituted Interests and Best Judgments: An Integrated Model of Surrogate Decision Making

Interview with Daniel P. Sulmasy, MD, PhD, author of Substituted Interests and Best Judgments: An Integrated Model of Surrogate Decision Making




en

Discussing Radiation Risks Associated With CT Scans With Patients

Interview with Mark Otto Baerlocher, MD, author of Discussing Radiation Risks Associated With CT Scans With Patients