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The Scouts acknowledged the necessity to "Be Prepared" over 100 years (!) ago; the industry should have, as well. Yet COVID-19 took businesses – more like the entire world – by surprise. Very few were prepared for the explosion of remote access, and the challenge of instantly shifting an entire organization to work from anywhere. Cato Networks shared its increase in remote access usage post

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UNWTO reveals stark predictions

We conducted a large-scale survey covering 58 countries and over 100,000 respondents between late March and early April 2020 to study beliefs and attitudes towards citizens’ and governments’ responses to the COVID-19 pandemic. Most respondents reacted strongly to the crisis: they report engaging in social distancing and hygiene behaviors, and believe that strong policy measures, such as shop closures and curfews, are necessary. They also believe that their government and their country’s citizens are not doing enough and underestimate the degree to which others in their country support strong behavioral and policy responses to the pandemic. The perception of a weak government and public response is associated with higher levels of worries and depression. Using both cross-country panel data and an event-study, we additionally show that strong government reactions correct misperceptions, and reduce worries and depression. Our findings highlight that policy-makers not only need to consider how their decisions affect the spread of COVID-19, but also how such choices influence the mental health of their population.

Leinster backs coach Felipe Contepomi believes that his former Argentina team-mate Agustín Pichot is the right man to develop rugby on a global scale.

The president must drop his opposition to 'globalism' in the interests of public health

Chinese companies producing faulty testing kits and masks are marring Beijing's attempts to assert leadership in the fight against the coronavirus.

A two-decade-long dry spell that has parched much of the western United States is turning into one of the deepest 'megadroughts' of the past 1,200 years.

The United States and other countries are failing to come together just when a cooperative international response is desperately needed.

Hundreds of tango lovers unite on Zoom for the Earth Virtual Milonga. Some dance as couples. Some dance with a pillow. At this party it's all good.

A book club for people who don't like book clubs, founded in 2012 in San Francisco and now boasting six chapters in L.A. County, has moved online.

We tend to look to the stars in troubled times. "Astro Poets," "You Were Born for This" and "Madame Clairevoyant's Guide to the Stars" teach us how.

YouTube and Tribeca Enterprises will launch the 10-day digital event We Are One: A Global Film Festival to benefit the World Health Organization and those affected by coronavirus.

GEORGE SOROS made a chilling warning about the state of global markets in 2012 that has fresh relevance today as world leaders grapple with the unprecedented challenge of rebuilding the post-coronavirus economy.

The global financial crisis has spawned a global protest movement campaigning against things like inequality, corporate greed, lack of jobs, etc. Although these protests have occurred for decades, they have typically been in the developing countries, or about the situation in developing countries. As such, many Western nations, who have strongly influenced the conditions in developing countries, have typically not paid much attention to such protests, no matter how large. However, this time, the global financial crisis has hit the ordinary citizens of Western nations quite hard, and inspired by the Arab Spring and protests in Spain, a global movement seems to have sprung up.

The global protests page had not been updated since the end of 2003, but has not included a brief overview of more recent protests such as the so-called Occupy Movement. The older content remains because it is interesting to note some of the parallels too, and it is perhaps important to note that these protests are unfortunately not new. Whether this time it can make a difference is too early to tell but a lot of people in wealthy countries this time are also participating.

Read full article: Public Protests Around the World

NASA’s Goddard Institute for Space Studies (GISS) monitors global surface temperatures on an ongoing basis. Their analysis shows temperatures around the globe in 2011 compared to the average global temperature from the mid-20th century. The comparison shows how Earth continues to experience warmer temperatures than several decades ago.

Global temperatures have warmed significantly since 1880, the beginning of what scientists call the “modern record.” At this time, the coverage provided by weather stations allowed for essentially global temperature data. As greenhouse gas emissions from energy production, industry and vehicles have increased, temperatures have climbed, most notably since the late 1970s. In this animation of temperature data from 1880-2011, reds indicate temperatures higher than the average during a baseline period of 1951-1980, while blues indicate lower temperatures than the baseline average.

Click on the image to see the video:

Read full article: Global Temperature Anomaly, 1880 - 2011

The latest data covering global arms sales shows that sale of arms in 2011 increased to around $85 billion, 84% of which went to developing countries. This was almost double the arms sales compared to 2010 which was the lowest since 2004.

One major factor for the increase was the US sales of arms to Saudi Arabia. Most other major arms sellers otherwise saw a decrease in sales and the trend in recent years had been declining sales.

The global financial crisis has affected many countries, and many developing countries started to see a decrease in purchases in the last few years. However, just 10 developing countries account for some 85% of all sales to developing countries in the period 2004 to 2011, which the data covers. Saudi Arabia tops that list followed by India and the United Arab Emirates. (As well as concerns about some of the regimes in the top buyers, some of this spending is also said to be due to modernizing efforts.)

Updated graphs and charts on arms sales data are provided here.

The arms trade is big business. The 5 permanent members of the UN Security Council (US, Russia, France, United Kingdom and China), together with Germany and Italy, account for approximately 85% of all arms sold between 2004 and 2011.

Some of the arms sold go to regimes where human rights violations will occur. Corruption often accompanies arms sales due to the large sums of money involved.

Read full article: The Arms Trade Is Big Business

A recent study found that coral reefs will face severe challenges even if average global warming temperature rise is restricted to 2 degrees Celsius. This is a rise that most countries are struggling to negotiate and meet. But reefs are very sensitive to temperature changes, experts fear the window of opportunity to prevent massive reef loss is very small.

Read full article: Nature and Animal Conservation

GEORGE SOROS made a chilling warning about the state of global markets in 2012 that has fresh relevance today as world leaders grapple with the unprecedented challenge of rebuilding the post-coronavirus economy.

Mitsubishi Electric Automation, Inc. Equal Opportunity Employer: Mitsubishi Electric Automation, Inc. ("MEAU") is committed to the employment and advancement of minorities, females, individuals with disabilities, and veterans. We are an equal opportunity employer and do not discriminate in hiri

Mitsubishi Electric Automation, Inc. Equal Opportunity Employer: Mitsubishi Electric Automation, Inc. ("MEAU") is committed to the employment and advancement of minorities, females, individuals with disabilities, and veterans. We are an equal opportunity employer and do not discriminate in hiring or

AS IT seems that old saying "Cometh the hour, cometh the man" has never been more apt, it's also entirely reasonable to say the world has been extremely poorly served by a raft of groups and organisations that should have been there to help - but that have failed lamentably.

THE CORONAVIRUS pandemic is forcing the political elite to finally acknowledge what the general public have known for some time; as a nation we have allowed ourselves to become far too dependent on importing essential goods and cheap labour from across the globe. The financial crisis of 2008 exposed as a myth the claim that globalisation would lead to ever greater prosperity for all. The current crisis has made it crystal clear that globalisation, as well as being bad news for our economy, puts lives at risk.

As the all-out effort for a vaccine accelerates, USA TODAY is rounding up some of the week's most notable developments.

Awards season is upon us once again and British stars are cleaning up in Hollywood. Take Away English reports.

A British firm claims it has been hired by a mysterious robotics company to find the perfect face for a new fleet of humanoid robots.

The Republican congressman chastised entertainment culture for being "divisive."

MRG is excited to release its highly comprehensive annual study IPTV Market Leader Report by Product and Region — Fall 2012.

MRG’s IPTV Market Leader Reports identify which IPTV systems and software companies are leading each of the six IPTV market segments: access systems, video headend systems, video-on-demand server software, set-top boxes, middleware, and content protection/digital rights management. The data is further segmented by geographic region as follows: North America, Latin America/Caribbean, Western Europe, Eastern Europe, Asia Pacific and the Middle East/Africa.

“IPTV is continuing its rapid growth worldwide but some of the more exciting opportunities are only just beginning in the Middle East/Africa and Latin America/Caribbean regions,” said Jose Alvear, Senior Research Analyst at MRG. “While the growth in the number of new IPTV service providers has been slowing down because telcos around the world have already deployed IPTV services for a number of years, there are still plenty of new opportunities available to vendors in emerging markets. In addition, vendors are now supplying multi-screen, content delivery and OTT services, as the global pay-TV industry continues to evolve into new screens and devices.”

Policymakers need to step up and do something useful — yesterday.

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China says it supports a World Health Organisation-led review into the global response to the coronavirus outbreak, but only "after the pandemic is over".

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Stay up to date with the latest news, views and analysis as the number of coronavirus cases in SA increases.

Research Event

Event participants

Michael Gasiorek, Professor of Economics, UKTPO Fellow, University of Sussex; Director, Interanalysis
Julia Magntorn Garrett, Research Officer, UKTPO, University of Sussex
Allie Renison, Head of Europe and Trade Policy at the Institute of Directors
Maximiliano Mendez-Parra, Senior Research Fellow, Overseas Development Institute
Chair: Professor Jim Rollo, Associate Fellow, Global Economy and Finance Department, Chatham House; Deputy Director, UK Trade Policy Observatory

15 March 2020

19 March 2020

Carbon monoxide (CO) remains the most common cause of human poisoning. The consequences of CO poisoning include cardiac dysfunction, brain injury, and death. CO causes toxicity by binding to hemoglobin and by inhibiting mitochondrial cytochrome c oxidase (CcO), thereby decreasing oxygen delivery and inhibiting oxidative phosphorylation. We have recently developed a CO antidote based on human neuroglobin (Ngb-H64Q-CCC). This molecule enhances clearance of CO from red blood cells in vitro and in vivo. Herein, we tested whether Ngb-H64Q-CCC can also scavenge CO from CcO and attenuate CO-induced inhibition of mitochondrial respiration. Heart tissue from mice exposed to 3% CO exhibited a 42 ± 19% reduction in tissue respiration rate and a 33 ± 38% reduction in CcO activity compared with unexposed mice. Intravenous infusion of Ngb-H64Q-CCC restored respiration rates to that of control mice correlating with higher electron transport chain CcO activity in Ngb-H64Q-CCC–treated compared with PBS-treated, CO-poisoned mice. Further, using a Clark-type oxygen electrode, we measured isolated rat liver mitochondrial respiration in the presence and absence of saturating solutions of CO (160 μm) and nitric oxide (100 μm). Both CO and NO inhibited respiration, and treatment with Ngb-H64Q-CCC (100 and 50 μm, respectively) significantly reversed this inhibition. These results suggest that Ngb-H64Q-CCC mitigates CO toxicity by scavenging CO from carboxyhemoglobin, improving systemic oxygen delivery and reversing the inhibitory effects of CO on mitochondria. We conclude that Ngb-H64Q-CCC or other CO scavengers demonstrate potential as antidotes that reverse the clinical and molecular effects of CO poisoning.

NAD+ is a central metabolite participating in core metabolic redox reactions. The prokaryotic NAD synthetase enzyme NadE catalyzes the last step of NAD+ biosynthesis, converting nicotinic acid adenine dinucleotide (NaAD) to NAD+. Some members of the NadE family use l-glutamine as a nitrogen donor and are named NadEGln. Previous gene neighborhood analysis has indicated that the bacterial nadE gene is frequently clustered with the gene encoding the regulatory signal transduction protein PII, suggesting a functional relationship between these proteins in response to the nutritional status and the carbon/nitrogen ratio of the bacterial cell. Here, using affinity chromatography, bioinformatics analyses, NAD synthetase activity, and biolayer interferometry assays, we show that PII and NadEGln physically interact in vitro, that this complex relieves NadEGln negative feedback inhibition by NAD+. This mechanism is conserved in distantly related bacteria. Of note, the PII protein allosteric effector and cellular nitrogen level indicator 2-oxoglutarate (2-OG) inhibited the formation of the PII-NadEGln complex within a physiological range. These results indicate an interplay between the levels of ATP, ADP, 2-OG, PII-sensed glutamine, and NAD+, representing a metabolic hub that may balance the levels of core nitrogen and carbon metabolites. Our findings support the notion that PII proteins act as a dissociable regulatory subunit of NadEGln, thereby enabling the control of NAD+ biosynthesis according to the nutritional status of the bacterial cell.

Chatham House is pleased to announce the speaker line-up for its second annual London Conference, at Lancaster House on 1-2 June 2015.