ag Systems and methods for zero voltage switching in power conversion systems By www.freepatentsonline.com Published On :: Tue, 02 Jun 2015 08:00:00 EDT System and method for regulating a power converter. A system for regulating a power converter includes a controller, a first switch, and a second switch. The controller is configured to generate a first switching signal and a second switching signal. The first switch is configured to receive the first switching signal, the first switch being coupled to an auxiliary winding of the power converter further including a primary winding and a secondary winding. The second switch is configured to receive the second switching signal and coupled to the primary winding of the power converter. The controller is further configured to, change, at a first time, the second switching signal to open the second switch, maintain, from the first time to a second time, the first switching signal to keep the first switch open, and change, at the second time, the first switching signal to close the first switch. Full Article
ag Glass for magnetic recording medium substrate and usage thereof By www.freepatentsonline.com Published On :: Tue, 14 Apr 2015 08:00:00 EDT An aspect of the present invention relates to glass for a magnetic recording medium substrate, which includes essential components in the form of SiO2, Li2O, Na2O, and one or more alkaline earth metal oxides selected from the group consisting of MgO, CaO, SrO, and BaO, wherein a molar ratio of a content of MgO to a combined content of MgO, CaO, SrO, and BaO (MgO/(MgO+CaO+SrO+BaO)) is equal to or greater than 0.80, and which has a Young's modulus of equal to or greater than 80 GPa, and a glass transition temperature of equal to or greater than 620° C. Full Article
ag Interfering near field transducer having a wide metal bar feature for energy assisted magnetic recording By www.freepatentsonline.com Published On :: Tue, 14 Apr 2015 08:00:00 EDT An apparatus for energy assisted magnetic recording of a storage disk include a plurality of dielectric waveguide cores configured to direct received incident light energy to a target, and a near field transducer (NFT) configured to focus light energy received from the plurality of waveguide cores and to transmit the focused light energy onto the storage disk surface to generate a heating spot on the storage disk. The NFT includes a plurality of propagating surface plasmon polariton (PSPP) elements that are energized by the light energy from the waveguide cores. Each of the PSPP elements has a plasmonic metal bar disposed above a single waveguide core in a longitudinal alignment. Each metal bar has a width at least twice the width of the heating spot generated on the storage disk. Full Article
ag Thermally assisted magnetic recording medium and magnetic recording and reproducing apparatus By www.freepatentsonline.com Published On :: Tue, 14 Apr 2015 08:00:00 EDT A thermally assisted magnetic recording medium (1) includes a substrate (101), an underlayer (3) that is formed above the substrate (101), and a magnetic layer (107) that is formed on the underlayer (3) and contains an alloy having an L10 structure as a main component. The underlayer (3) is formed by continuously laminating a first underlayer (104) having a BCC structure with a lattice constant that is 0.302 to 0.332 nm, a second underlayer (105) that has a NaCl structure including C, and a third underlayer (106) that is composed of MgO. Full Article
ag Thermally-assisted magnetic recording head having a plasmon generator By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT A return path section includes first and second yoke portions and first, second and third columnar portions. The first and second yoke portions and the first columnar portion are located on the same side in the direction of travel of the recording medium relative to a wave guide core. The second and third columnar portions are located on opposite sides of a plasmon generator and connected to a shield. The first yoke portion connects a main pole to the first columnar portion. The second yoke portion connects the first columnar portion to the second and third columnar portions. A coil is wound around the first columnar portion. Full Article
ag Magnetic recording head and disk device including the same By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT A recording head for recording information on a rotating recording medium of a storage device includes a main magnetic pole which generates a recording magnetic field in a direction perpendicular to a recording medium facing surface of the magnetic recording head, and a light generating element which is provided on a leading side of the main magnetic pole, and generates light for heating the recording layer of the recording medium. The main magnetic pole includes an end surface facing the light generating element that is inclined with respect to the direction perpendicular to the recording medium facing surface toward the light generating element. Full Article
ag Heat-dissipating stepped slider for a heat-assisted magnetic recording head By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT In a heat-assisted magnetic recording (HAMR) hard disk drive, a heat-dissipating head slider assembly is described in which the slider is stepped on the disk-opposing side and a HAMR laser module is mounted on the lower surface to assist with dissipation of heat from the laser. The lower surface is a surface of the main body of the slider and is composed primarily of a first material, and the slider may include a heat-dissipating plate that forms the higher stepped surface, where the plate is composed of a second material that has a higher thermal conductivity than the first material, such as silicon. Full Article
ag Heat assisted magnetic recording device with pre-heated write element By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT An apparatus includes a write element configured to apply a magnetic field to write data on a portion of a heat-assisted magnetic recording media in response to an energizing current. An energy source is configured to heat the portion of the media being magnetized by the write element. A preheat energizing current is applied to the write element during an interval before writing the data to the portion of the media. The preheat energizing current does not cause data to be written to the media and brings at least one of the write element and driver circuitry into thermal equilibrium prior to writing the data on the portion. Full Article
ag Data storage device adjusting laser input power to compensate for temperature variations By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT A data storage device is disclosed comprising a head actuated over a disk, wherein the head comprises a laser configured to heat the disk while writing data to the disk. A temperature is measured, and a first input power is generated based on a first function of the measured temperature, wherein the first function compensates for a temperature dependent output power of the laser. A second input power is generated based on a second function of the measured temperature, wherein the second function compensates for a temperature dependent coercivity of the disk. The first input power is combined with the second input power to generate a write power applied to the laser while writing data to the disk. Full Article
ag Thermally conductive features for a heat-assisted magnetic recording head By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT In a heat-assisted magnetic recording hard disk drive, one or more thermally conductive features are incorporated to assist with dissipation of heat from a laser module that comprises a laser and a submount. The submount may be coupled to the slider with solder covering a wider adhesive area for enhanced conduction of heat away from the laser module and to the slider, one or both of the submount and the laser may include a surface coating that increases the thermal radiation of the corresponding component, and/or one or both of the submount and the laser may include fins configured to transfer heat from the corresponding component. Further, a HAMR HGA may be configured such that the submount is coupled directly to the suspension flexure using a thermally conductive material, for conduction of heat away from the laser module and to the flexure. Full Article
ag Optical device, magnetic head, manufacturing method, and near-field light device By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT An near-field light device (100) is provided with: a first electrode layer (123) having a protruding portion (123a); a second electrode layer (121); and a light emitting layer (122), the protruding portion protrudes along a predetermined direction (Y axis direction) to be capable of extracting energy which is caused by emission of light at the light emitting layer, the predetermined direction intersects with a laminated direction (X axis direction) of the near-field light device, an edge surface of at least one portion of the projection portion is located at more outward side in the optical device than an edge surface of the second electrode layer is. Full Article
ag Information storage medium, reproducing method, and recording method By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A machine readable information storage medium, a reproducing method and apparatus which reproduces data from the storage medium, and a recording method and apparatus for recording data on the storage medium. The information storage medium includes a control area which stores within a data structure information usable by the recording or reproducing apparatus to record or reproduce the data on or from the storage medium. The information stored within the data structure includes a version corresponding to a specification. Full Article
ag Method of using a compression bandage By www.freepatentsonline.com Published On :: Tue, 07 Apr 2015 08:00:00 EDT A compression dressing and method of use is provided. The dressing is self-adherent, washable and reusable and provides a selected and generally constant pressure to the surface of an animal. Full Article
ag Bandage for facilitating transdermal respiration and healing By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT A bandage includes a reservoir filled with a perfluorochemical fluid, saturated with oxygen. Oxygen passes through a permeable membrane to the skin or wound to promote healing, and carbon dioxide travels from the skin or wound to the reservoir. Full Article
ag Device and method for control of hemorrhage By www.freepatentsonline.com Published On :: Tue, 12 May 2015 08:00:00 EDT A junctional and truncal tourniquet and a hip-girdling pelvic sling device for maintaining a desired amount of tension surrounding a person's hips and pelvis to securely support and stabilize a pelvis that has been fractured and for securing a pressure applying device to a person so that blood vessel-occluding pressure can be applied. Areas of mating types of fastener material such as mating hook-bearing fastener material and loop pile fastener material are arranged on the device to enable a strap to be secured at various effective lengths to provide a wide range of adjustability. The device may include inflatable bladders, stays, and a chin support and may be wrapped around a patient's neck as a cervical support collar, or around the torso to occlude blood vessels proximal to an injury on a limb. Full Article
ag Roughage By www.freepatentsonline.com Published On :: Tue, 18 Mar 2014 08:00:00 EDT The invention relates to dietary fiber for human and animal nutrition and more particularly to roughage consisting of a fiber formulation containing lignocellulose. Said formulation contains a fraction of a fibrous substance that is fermentable in the digestive tract and a fraction of a fibrous substance that is poorly or non-fermentable in the digestive tract. Full Article
ag Method for preparing a gelling and viscosifying agent for drilling mud and the product thereof By www.freepatentsonline.com Published On :: Tue, 25 Nov 2014 08:00:00 EST A method for preparing lignin graft copolymer comprising: reacting lignocellulosic materials with an acrylic compound by bulk condensation under nitrogen atmosphere in the presence of a non-oxidizing strong organic acid as catalyst; separating the reaction mixture to obtain a solid phase mainly containing lignocellulosic materials and a liquid phase containing lignin graft copolymer and unreacted acrylic compound; and removing solvent from the liquid phase to obtain the lignin graft copolymer. Full Article
ag Soil hydrophilization agent and methods for use By www.freepatentsonline.com Published On :: Tue, 25 Nov 2014 08:00:00 EST Disclosed are soil additives capable of hydrophilizing soil particles and/or increase available water capacity in soil. The soil additive are capable of increasing the available water content/capacity (AWC) in soils, the additive in one embodiment comprising a polymer composition having a hydrophilic portion and a hydrophobic portion, wherein the hydrophobic portion of the copolymer binds with the soil particle surface and the hydrophilic portion of the copolymer can bind with water. This results in the prevention, arrest or decelerated loss of water from the targeted area, for example the plant root zone, which allows for improved water usage efficiency by plants, grasses, vegetation, etc. Full Article
ag Polyester resin, electrostatic charge image developing toner, electrostatic charge image developer, toner cartridge, process cartridge, image forming apparatus, and image forming method By www.freepatentsonline.com Published On :: Tue, 17 Mar 2015 08:00:00 EDT A polyester resin is a polycondensate obtained by reacting a divalent alcohol, a divalent carboxylic acid, and a mono- or divalent rosin by the use of a zinc compound as a reaction catalyst. Full Article
ag Image-based patient-specific medical spinal surgery method and spinal prosthesis By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention relates to an image-based, patient-specific medical spinal surgery technique and to a spinal prosthesis used in the surgery, and particularly, to an image-based, patient-specific medical spinal surgery technique and to a spinal prosthesis which are intended to solve a problem of damage to a spine caused by installing a spinal prosthesis used in spinal surgery, by introducing an image of a patient to manufacture an insertable spinal prosthesis that is customized for a shape of a spine of an individual patient in a polymer-based material. Full Article
ag Clean generation of a fluoroaryl grignard reagent By www.freepatentsonline.com Published On :: Tue, 19 Jun 2001 08:00:00 EDT Fluoroaryl Grignard reagents are produced from a hydrocarbyl Grignard reagent and fluoroaromatic compounds via separate additions of different fluoroaromatic compounds, such that the conversion of hydrocarbyl Grignard reagent to the desired fluoroaryl Grignard reagent is essentially complete, and thus the reaction product is free or essentially free of agents that may negatively affect subsequent reactions. The fluoroaryl Grignard reagents may be further reacted with boron trihalides in order to obtain tris(fluoroaryl)boranes or tetrakis(fluoroaryl)borates. Full Article
ag Quick and sensitive method of quantifying mycolic acid to develop anti-microbial agents and a diagnostic kit thereof By www.freepatentsonline.com Published On :: Tue, 21 Dec 2004 08:00:00 EST The present invention relates to a rapid, sensitive, simple, and cost-effective spectrophotometric method of detecting and quantifying mycolic acid in a mycolic acid-fuschin dye complex with absorbance maxima ranging between 490-500 nm in the presence of various test compounds, for screening mycolic acid biosynthesis inhibitors useful as anti-microbial agents and a diagnostic kit thereof comprising basic fuschin dye in the concentration ranging between 0.1-1.0 gm/100 ml, phenol and 95% ethanol in the ratio ranging between 1:4 to 2:1 (v/v), and phenol and distilled water in the ratio ranging between 1:14 to 1:25. Full Article
ag Thermoplastic articles for packaging UV sensitive materials, processes for the articles production and use and novel UV absorbers By www.freepatentsonline.com Published On :: Tue, 05 Jan 2010 08:00:00 EST Thermoplastic composition and articles containing UV absorbers that protect the articles contents from harmful UV radiation are disclosed as well as methods for making the thermoplastic articles and methods for using the articles to contain and protect materials sensitive to UV radiation. The UV absorbers contain oxazolone and/or azine functional groups that absorb UV radiation and prevent its transmission into the article. Many of the compounds are novel compositions of matter. The generally clear thermoplastic articles of this disclosure are particularly useful for containing a variety of UV sensitive consumer products that would otherwise have to be packaged in opaque containers. Full Article
ag Universal linker compositions for the release or transfer of chemical agents from a polynucleotide By www.freepatentsonline.com Published On :: Tue, 29 Jun 2010 08:00:00 EDT A universal linker structure is provided, in which a functional group and activating leaving group are placed on a tether, allowing the placement of an electrophile at the end of any nucleic acid sequence. The electrophile on the tether can react with a second nucleic acid carrying a nucleophile when the two nucleic acids are hybridized near one another, resulting in release of the leaving group, and creation of a functional change. The linker can be designed to destabilize the ligation product without slowing the rate of reaction. This lowers product inhibition, and the target DNA or RNA can become a catalyst for isothermally generating multiple signals for detection. This enhanced signal is demonstrated in solution experiments and in solid supported assays. The universal linkers of the present invention are simple and inexpensive to prepare, and can be appended to any polynucleotide in automated steps on a standard DNA synthesizer. Full Article
ag Dehydroxyfluorination agent By www.freepatentsonline.com Published On :: Tue, 15 Nov 2011 08:00:00 EST There is provided a novel, useful dehydroxyfluorination agent containing sulfuryl fluoride (SO2F2) and an organic base that is free from a free hydroxyl group in the molecule. According to the present dehydroxyfluorination agent, it is not necessary to use perfluoroalkanesulfonyl fluoride, which is not preferable in large-scale use, and it is possible to advantageously produce optically-active fluoro derivatives, which are important intermediates of medicines, agricultural chemicals and optical materials, for example, 4-fluoroproline derivatives, 2'-deoxy-2'-fluorouridine derivatives, optically-active α-fluorocarboxylate derivatives, and monofluoromethyl derivatives, even in large scale. Full Article
ag Safety device for detecting electrode breakage By www.freepatentsonline.com Published On :: Tue, 18 Feb 2014 08:00:00 EST The invention relates to a safety device (1) for detecting electrode breakage in an electric arc furnace, wherein an electrode (6) is secured on an electrode support arm (4), and wherein a conduit is filled with a medium under a constant pressure and a pressure drop is produced at an electrode breakage, which is detected as an alarm signal. Here, the conduit (7a-d,3) is integrated in a protective component that is arranged beneath the electrode support arm (4) thereon, wherein in case of an electrode breakage, the conduit (7a-d,3) is damaged by a produce electric arc and the pressure drop takes place. Full Article
ag Furnace slag door and corresponding furnace By www.freepatentsonline.com Published On :: Tue, 24 Jun 2014 08:00:00 EDT The invention relates to a furnace slag door, comprising at least one panel which is moveable, in a mounted state of the slag door, from an opened position, in which the panel is remote from a corresponding slag discharge opening within the furnace wall to a closed position, in which the panel covers at least part of said slag discharge opening. The invention further comprises a corresponding furnace equipped with such slag door. The furnace is, in particular, an electric arc furnace (EAF) but may be as well of another type. Full Article
ag Low temperature melting furnace and metal sector using an external cooling passage By www.freepatentsonline.com Published On :: Tue, 01 Jul 2014 08:00:00 EDT A low temperature melting furnace using an external cooling passage includes a wall including a plurality of metal sectors, each metal sector including a cooling passage formed along a longitudinal direction thereof, and an extension tube provided outwardly from the wall and connected to the cooling passage. Full Article
ag Common field magnetic susceptors By www.freepatentsonline.com Published On :: Tue, 02 Sep 2014 08:00:00 EDT Thermoplastic pellitized materials are melted in gravity flow through coaxially oriented perforated cylindrical metal susceptors. The susceptors are equally energized by the interception of a common magnetic field formed by a high frequency powered inductor coil. Full Article
ag Graphite crucible for silicon electromagnetic induction heating and apparatus for silicon melting and refining using the graphite crucible By www.freepatentsonline.com Published On :: Tue, 03 Mar 2015 08:00:00 EST Disclosed herein are a graphite crucible for electromagnetic induction-based silicon melting and an apparatus for silicon melting/refining using the same, which performs a melting operation by a combination of indirect melting and direct melting. The crucible is formed of a graphite material and includes a cylindrical body having an open upper part through which a silicon raw material is charged into the crucible, and an outer wall surrounded by an induction coil, wherein a plurality of slits are vertically formed through the outer wall and an inner wall of the crucible such that an electromagnetic force created by an electric current flowing in the induction coil acts toward an inner center of the crucible to prevent a silicon melt from contacting the inner wall of the crucible. Full Article
ag Graphite crucible for electromagnetic induction melting silicon and apparatus for silicon melting and refining using the graphite crucible By www.freepatentsonline.com Published On :: Tue, 07 Apr 2015 08:00:00 EDT A graphite crucible for electromagnetic induction-based silicon melting and an apparatus for silicon melting/refining using the same, which performs a melting operation by a combination of indirect melting and direct melting. The crucible is formed of a graphite material and includes a cylindrical body having an open upper part through which a silicon raw material is charged into the crucible, and an outer wall surround by an induction coil, wherein a plurality of first slits are vertically formed through the outer wall and an inner wall of the crucible, and a plurality of second slits are vertically formed from an edge of the disc-shaped bottom of the crucible toward a center of the bottom. Full Article
ag Electromagnetic induction melting furnace to control an average nominal diameter of the TiB2 cluster of the Al-Ti-B alloy By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT An electromagnetic induction melting furnace to control an average nominal diameter of the TiB2 cluster of the Al—Ti—B alloy includes a main body containing the melted alloy; and a multi-layer coil disposed on the main body, wherein a frequency of the alternative current of each coil of the multi-layer coil is different, and the alloy is heated by inducing a magnetic field generated by the alternative currents. The selection of the frequency and the changeable magnetic field may reduce the cohesion force between the TiB2 grains of the Al—Ti—B alloy to control the average nominal diameter of the TiB2 cluster. Full Article
ag Electromagnetic induction melting furnace to control an average nominal diameter of the TiC cluster of the Al—Ti—C alloy By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT An electromagnetic induction melting furnace to control an average nominal diameter of the TiC cluster of the Al—Ti—C alloy includes a main body containing the melted alloy; and a multi-layer coil disposed on the main body, wherein a frequency of the alternative current of each coil of the multi-layer coil is different, and the alloy is heated by inducing a magnetic field generated by the alternative currents. The selection of the frequency and the changeable magnetic field may reduce the cohesion force between the TiC grains of the Al—Ti—C alloy to control the average nominal diameter of the TiC cluster. Full Article
ag Drive shaft coupling having sealed interior passage for pressurized fluid By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT A coupling for connecting a rotating tube cleaning shaft to a tube cleaning machine where high pressure fluid is pumped through the coupling, where the coupling is sealed to contain the high pressure fluid, and where a machine driven rotary flexible shaft passes through the coupling. Full Article
ag Power outage detection By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A network device receives notification configuration information that includes a time interval criteria and a selected geographical area for providing power outage notifications. The network device receives, during a particular time interval, a loss-of-power alarm from a network interface device (NID) associated with a customer premises. The loss-of-power alarm includes a particular NID identifier. The network device retrieves, from a database, customer configuration information that associates the particular NID identifier with a particular address and identifies a power outage in a particular region associated with the particular address. The identifying is based on receiving the loss-of-power alarm and determining if other loss-of-power alarms have been received from other NIDs in the same region and within the particular time interval. Full Article
ag Modeling defect management and product handling during the manufacturing process By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A method models a defect management routine. Both the modeling and a handling are executed within a manufacturing execution system. During an engineering phase: modeling the production process and creating a library of possible defect types which may occur; assigning the defect types to at least one defect group; creating a library of defect specifications; creating a library of defect type specification details; creating at least one runtime defect criteria that is used to link the defect type to a certain production volume; and creating a runtime defect measurement routine that monitors a corrective measure. During a runtime production phase evaluating the product produced; identifying the respective defect type out of the library of defect types; and using the identified defect type to determine a corrective measure, a runtime defect criteria identifying the resource causing the defect type, a production volume, and to run the respective runtime defect management routine. Full Article
ag Swarm management By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Systems, methods, and other embodiments associated with swarm management are described. One example system comprises a communication component configured to establish a communication link with at least one element, where the at least one element is part of a swarm. The example system also comprises a management component configured to manage performance of a task list by the swarm through the communication link. Full Article
ag Modular hangers for product storage and retrieval system By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A system for locating goods stored in a storage area includes a computer, radio frequency transceivers and modular hangers. Ordered goods are placed in storage units that each have addresses at a central filling center. The filled storage units are shipped to local storage areas where they are coupled to hook units to form modular hangers and stored on rails. The identifications of the goods and the electronic addresses for corresponding hangers are stored on a local computer database. When a user wants to pick up goods stored in the containers, the user inputs the identification or order information for the goods and the computer will cause the radio frequency transmitter to emit a data packet that includes a search address and illumination data. The hangers compare the search address to the electronic address. If there is a match, the hanger is illuminated so the ordered goods can be found. Full Article
ag Information processing apparatus, control method thereof and storage medium By www.freepatentsonline.com Published On :: Tue, 28 Jul 2015 08:00:00 EDT An information processing apparatus for performing recognition processing by a recognizer for a position and orientation of a work subject to undergo work by a working unit of a robot arm. The information processing apparatus including an obtaining unit adapted to obtain, for each of a plurality of positions and orientations of the work subject, a position and an orientation of the working unit in which the working unit can perform the work, and a restriction unit adapted to restrict a position and an orientation of the work subject used in the recognition processing by the recognizer to a position and an orientation of the work subject corresponding to the position and the orientation of the working unit that have been obtained by the obtaining unit. Full Article
ag Vitamin-targeted imaging agents By www.freepatentsonline.com Published On :: Tue, 16 Sep 2014 08:00:00 EDT The invention relates to compounds and methods for targeting radionuclide-based imaging agents to cells having receptors for a vitamin, or vitamin receptor binding derivative or analog thereof, by using such a vitamin as the targeting ligand for the imaging agent. The vitamin-based compounds can be used to target radionuclides to cells, such as a variety of tumor cell types, for use in diagnostic imaging of the targeted cells. Full Article
ag Rapid FRET-based diagnosis of bacterial pathogens By www.freepatentsonline.com Published On :: Tue, 07 Oct 2014 08:00:00 EDT Substrates for detecting microorganisms are provided, wherein the substrate comprises a set of molecular markers linked, optionally with linker molecules or moieties, to a di-, or tripeptide consisting of amino acids X1 and X2, or X1, X2 and X3, in which one of them, for example, X1, is a D-amino acid and the others, for example, X2 and X3, may be any D- or L-amino acid. The substrate preferably is used for the detection of Bacillus anthracis. Also provided are substrates for detecting Pseudomonas aeruginosa, wherein the substrate comprises a set of molecular markers linked, optionally with linker molecules or moieties to a tri-, tetra-, or pentapeptide consisting of glycine amino acids. The invention further comprises methods for detecting microorganisms, specifically B. anthracis and P. aeruginosa, with the substrates of the invention and use of the substrate(s) in such a method. Full Article
ag Methods and compositions for diagnostic and therapeutic targeting of COX-2 By www.freepatentsonline.com Published On :: Tue, 21 Oct 2014 08:00:00 EDT The presently disclosed subject matter provides compositions that selectively bind cyclooxygenase-2 and comprise a therapeutic and/or diagnostic moiety. Also provided are methods for using the disclosed compositions for diagnosing (i.e., by imaging) a target cell and/or treating a disorder associated with a cyclooxygenase-2 biological activity. Full Article
ag Cycloalkyl triamine pentacarboxylate as ligands for paramagnetic metal complexes By www.freepatentsonline.com Published On :: Tue, 04 Nov 2014 08:00:00 EST A cycloalkyl triamine pentacarboxylate compound coordinating to a metal ion to form a high stability metal complex in serum is provided. The metal complex of the present invention can be used as a contrast agent for magnetic resonance imaging (MRI). Full Article
ag Reagent system and method for modifying the luminescence of lanthanide(III) macrocyclic complexes By www.freepatentsonline.com Published On :: Tue, 23 Dec 2014 08:00:00 EST Disclosed is a spectrofluorimetrically detectable luminescent composition consisting essentially of at least one energy transfer acceptor lanthanide(III) complex having an emission spectrum maximum in the range from 300 to 2000 nanometers and a luminescence-enhancing amount of at least one energy transfer donor selected from the group consisting of a fluorophore, a lumiphore, an organic compound, a salt of an organic ion, a metal ion, a metal ion complex, or a combination thereof. Such energy transfer donor enhances the luminescence of at least one energy transfer acceptor lanthanide(III) complex, with the conditions that the emission spectrum of any energy transfer donor differs from that of its energy transfer acceptor lanthanide(III) complex; and such energy transfer donor can be dissolved to form a unitary solution in a solvent having an evaporation rate at least as great as that of water. Full Article
ag Tricarbonyl complexes with tridentate chelators for myocardium imaging By www.freepatentsonline.com Published On :: Tue, 27 Jan 2015 08:00:00 EST Chelators of the formulae (I), (II) and (III) and tricarbonyl complexes of radioisotopes of Tc and Re bound to them, for use in myocardial imaging. Full Article
ag Trifunctional reagent for conjugation to a biomolecule By www.freepatentsonline.com Published On :: Tue, 10 Feb 2015 08:00:00 EST A reagent for conjugation to a biomolecule, wherein the reagent is a single molecule with at least three functional parts and has schematic structure (I): a) wherein a trifunctional cross-linking moiety is coupled to b) an affinity ligand via a linker 1, said affinity ligand being capable of binding with another molecule having affinity for said ligand, to c) an effector agent, optionally via a linker 2, said effector agent exerting its effect on cells, tissues and/or humorous molecules in vivo or ex vivo, and to d) a biomolecule reactive moiety, optionally via a linker 3, said moiety being capable of forming a bond between the reagent and the biomolecule. Full Article
ag Bis-azo colorants for use as bluing agents By www.freepatentsonline.com Published On :: Tue, 24 Feb 2015 08:00:00 EST This invention relates to bis-azo colorants for use as bluing agents, laundry care compositions comprising bis-azo colorants that may serve as bluing agents, processes for making such bluing agents and laundry care compositions and methods of using the same. The bluing agents are generally comprised of at least two components: at least one chromophore component and at least one polymeric component. These bluing agents are advantageous in providing a whitening effect to fabrics, while not building up over time and causing undesirable blue discoloration to the treated fabrics. Full Article
ag Azo compounds reducing formation and toxicity of amyloid beta aggregation intermediates By www.freepatentsonline.com Published On :: Tue, 10 Mar 2015 08:00:00 EDT The present invention relates to compounds suitable as modulators of protein misfolding and/or protein aggregation. The compounds are particularly suitable as inhibitors of amyloid aggregate formation and/or modulators of amyloid surface properties, and/or as activators of degradation or reduction of amyloid aggregates. Full Article
ag GO-Gd-DTPA complex, preparation method thereof, and MRI contrast agent comprising the same By www.freepatentsonline.com Published On :: Tue, 24 Mar 2015 08:00:00 EDT Disclosed herein is a GO-Gd-DTPA (gadolinium-diethylenetriamine pentaacetic-graphene oxide) complex, which is formed by an ester bond of graphene oxide (GO) and gadopentetic acid (Gd-DTPA). Since the GO-Gd-DTPA can stably exist in the body because it has high stability in water, it is expected that it can be effectively used as an MRI contrast agent. Full Article
ag Quaternary data-storage materials and the preparation method thereof By www.freepatentsonline.com Published On :: Tue, 14 Apr 2015 08:00:00 EDT An organic compound has the following chemical structure: wherein R is different from R*; R and R* are independently hydrogen, halogen, nitro or methoxyl; and R1 is a C1-C6 alkyl or a phenyl group. A quaternary data storage device includes a bottom electrode, a top electrode, and the organic film layer sandwiched between the bottom electrode and the top electrode. Full Article