or

[ASAP] Discovery of a Silicon-Containing Pan-Genotype Hepatitis C Virus NS5A Inhibitor

By feedproxy.google.com
Published On :: Thu, 07 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00082


Full Article

or

[ASAP] Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core

By feedproxy.google.com
Published On :: Fri, 08 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00192


Full Article

or

[ASAP] Exploration of the Structural Space in 4(3<italic toggle="yes">H</italic>)-Quinazolinone Antibacterials

By feedproxy.google.com
Published On :: Fri, 08 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00153


Full Article

or

[ASAP] Drug Research Meets Network Science: Where Are We?

By feedproxy.google.com
Published On :: Fri, 08 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01989


Full Article

or

[ASAP] Discovery and Optimization of Glucose Uptake Inhibitors

By feedproxy.google.com
Published On :: Fri, 08 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02153


Full Article

or

[ASAP] Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin—Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme

By feedproxy.google.com
Published On :: Fri, 08 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00441


Full Article

or

[ASAP] Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma

By feedproxy.google.com
Published On :: Mon, 30 Mar 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00601


Full Article

or

[ASAP] Chimeric Peptidomimetics of SOCS 3 Able to Interact with JAK2 as Anti-inflammatory Compounds

By feedproxy.google.com
Published On :: Mon, 30 Mar 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00664


Full Article

or

[ASAP] Progress in the Field of Aldehyde Dehydrogenase Inhibitors: Novel Imidazo[1,2-<italic toggle="yes">a</italic>]pyridines against the 1A Family

By feedproxy.google.com
Published On :: Tue, 31 Mar 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00686


Full Article

or

[ASAP] Inhibitors of Hypoxia-Inducible Factors as Treatment for Cancer

By feedproxy.google.com
Published On :: Wed, 01 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00116


Full Article

or

[ASAP] Glycans Meet Sphingolipids: Structure-Based Design of Glycan Containing Analogues of a Sphingosine Kinase Inhibitor

By feedproxy.google.com
Published On :: Wed, 01 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00665


Full Article

or

[ASAP] Synthesis of Novel G Factor or Chloroquine-Artemisinin Hybrids and Conjugates with Potent Antiplasmodial Activity

By feedproxy.google.com
Published On :: Thu, 02 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00669


Full Article

or

[ASAP] Novel HIV-1 Protease Inhibitors with Morpholine as the P2 Ligand to Enhance Activity against DRV-Resistant Variants

By feedproxy.google.com
Published On :: Thu, 02 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00043


Full Article

or

[ASAP] Design, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence Time

By feedproxy.google.com
Published On :: Thu, 02 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00045


Full Article

or

[ASAP] Characterization of an Alginate Encapsulated LS180 Spheroid Model for Anti-colorectal Cancer Compound Screening

By feedproxy.google.com
Published On :: Fri, 03 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00076


Full Article

or

[ASAP] Structure Optimization of Gatastatin for the Development of ?-Tubulin-Specific Inhibitor

By feedproxy.google.com
Published On :: Mon, 06 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00526


Full Article

or

[ASAP] Chiral Analogues of PFI-1 as BET Inhibitors and Their Functional Role in Myeloid Malignancies

By feedproxy.google.com
Published On :: Tue, 07 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00625


Full Article

or

[ASAP] Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface

By feedproxy.google.com
Published On :: Tue, 07 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00111


Full Article

or

[ASAP] Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents

By feedproxy.google.com
Published On :: Wed, 08 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00639


Full Article

or

[ASAP] Exploring the Implication of DDX3X in DENV Infection: Discovery of the First-in-Class DDX3X Fluorescent Inhibitor

By feedproxy.google.com
Published On :: Thu, 09 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00681


Full Article

or

[ASAP] Discovery of BMS-986251: A Clinically Viable, Potent, and Selective ROR?t Inverse Agonist

By feedproxy.google.com
Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00063


Full Article

or

[ASAP] Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction

By feedproxy.google.com
Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00594


Full Article

or

[ASAP] New Dual CK2/HDAC1 Inhibitors with Nanomolar Inhibitory Activity against Both Enzymes

By feedproxy.google.com
Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00561


Full Article

or

[ASAP] Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents

By feedproxy.google.com
Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00129


Full Article

or

[ASAP] Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines

By feedproxy.google.com
Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00574


Full Article

or

[ASAP] Design and Synthesis of Tetrazole- and Pyridine-Containing Itraconazole Analogs as Potent Angiogenesis Inhibitors

By feedproxy.google.com
Published On :: Mon, 13 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00438


Full Article

or

[ASAP] Potential Cancer Treatment by Agonists of the Stimulator of Interferon Genes

By feedproxy.google.com
Published On :: Mon, 13 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00117


Full Article

or

[ASAP] Artemisinin Derivatives with Antimelanoma Activity Show Inhibitory Effect against Human DNA Topoisomerase 1

By feedproxy.google.com
Published On :: Tue, 14 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00131


Full Article

or

[ASAP] Discovery of a Potent Dual Inhibitor of Wild-Type and Mutant Respiratory Syncytial Virus Fusion Proteins

By feedproxy.google.com
Published On :: Wed, 15 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00008


Full Article

or

[ASAP] Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation

By feedproxy.google.com
Published On :: Wed, 15 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00661


Full Article

or

[ASAP] Characterization of Specific <italic toggle="yes">N</italic>-a-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library

By feedproxy.google.com
Published On :: Wed, 15 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00029


Full Article

or

[ASAP] Discovery of an Atropisomeric PI3Kß Selective Inhibitor through Optimization of the Hinge Binding Motif

By feedproxy.google.com
Published On :: Wed, 15 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00095


Full Article

or

[ASAP] Can Drug Repositioning Work as a Systematical Business Model?

By feedproxy.google.com
Published On :: Fri, 17 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00122


Full Article

or

[ASAP] Update to Our Reader, Reviewer, and Author Communities—April 2020

By feedproxy.google.com
Published On :: Wed, 22 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00206


Full Article

or

[ASAP] Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor

By feedproxy.google.com
Published On :: Mon, 27 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00155


Full Article

or

[ASAP] PROTAC Compounds Targeting a-Synuclein Protein for Treating Neurogenerative Disorders: Alzheimer’s and Parkinson’s Diseases

By feedproxy.google.com
Published On :: Tue, 28 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00192


Full Article

or

[ASAP] Development of Selective Steroid Inhibitors for the Glucose-6-phosphate Dehydrogenase from <italic toggle="yes">Trypanosoma cruzi</italic>

By feedproxy.google.com
Published On :: Wed, 29 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00106


Full Article

or

[ASAP] P2Y<sub>14</sub> Receptor Antagonists Reverse Chronic Neuropathic Pain in a Mouse Model

By feedproxy.google.com
Published On :: Thu, 30 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00115


Full Article

or

[ASAP] Discovery of RO7185876, a Highly Potent ?-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer’s Disease

By feedproxy.google.com
Published On :: Fri, 01 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00109


Full Article

or

[ASAP] Ultra-High-Throughput Acoustic Droplet Ejection-Open Port Interface-Mass Spectrometry for Parallel Medicinal Chemistry

By feedproxy.google.com
Published On :: Fri, 01 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00066


Full Article

or

[ASAP] Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors

By feedproxy.google.com
Published On :: Fri, 01 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00025


Full Article

or

[ASAP] Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase

By feedproxy.google.com
Published On :: Fri, 01 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00092


Full Article

or

[ASAP] Scaffold Repurposing of in-House Chemical Library toward the Identification of New Casein Kinase 1 d Inhibitors

By feedproxy.google.com
Published On :: Mon, 04 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00028


Full Article

or

[ASAP] Development of a Raltegravir-based Photoaffinity-Labeled Probe for Human Immunodeficiency Virus-1 Integrase Capture

By feedproxy.google.com
Published On :: Tue, 05 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00009


Full Article

or

[ASAP] Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793

By feedproxy.google.com
Published On :: Tue, 05 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00085


Full Article

or

[ASAP] Synthesis and Evaluation of <sup>11</sup>C- and <sup>18</sup>F-Labeled SOAT1 Inhibitors as Macrophage Foam Cell Imaging Agents

By feedproxy.google.com
Published On :: Wed, 06 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00127


Full Article

or

[ASAP] Ligand Design for Cereblon Based Immunomodulatory Therapy

By feedproxy.google.com
Published On :: Fri, 08 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00214


Full Article

or

Solar Trees Powering The Park Of South Florida

By latestsolarnews.com
Published On :: Sun, 23 Jul 2017 23:58:07 +0000

Joining South Florida’s lush, green canopy of real trees are a new crop of solar trees. These “trees” have blue trunks and bear no fruit, but supply clean energy to whoever needs it. If you’re at the beach and your phone starts to die, you can charge it right here using Solar Power. Here’s how …

The post Solar Trees Powering The Park Of South Florida appeared first on LatestSolarNews.


Full Article

or

Solar Powered Lights For The Yard

By latestsolarnews.com
Published On :: Wed, 26 Jul 2017 21:41:45 +0000

Reading about the various sofas reviews here and choosing amongst them to match your patio is not that difficult when compared to doing the entire electrical work of the patio. When you are lighting your patio the exact opposite thing you need to do is to be stumbling over electrical lines and attempting to put …

The post Solar Powered Lights For The Yard appeared first on LatestSolarNews.


Full Article

or

Sono Motors Introduces The SION Solar Powered Car

By latestsolarnews.com
Published On :: Sat, 23 Sep 2017 18:45:01 +0000

The fantasy of having the capacity to drive to work in a solar-powered car is at last turning into a reality. Sono Motors simply uncovered the SION solar-powered electric car gives you the ability to travel up to 18 miles utilizing only energy from the sun. Best of all, the SION isn’t only for the …

The post Sono Motors Introduces The SION Solar Powered Car appeared first on LatestSolarNews.


Full Article