Animal models of bacterial infection have been widely used to explore the in vivo activity of antibacterial drugs. These data are often submitted to the U.S. Food and Drug Administration to support human use in an investigational new drug application (IND). To better understand the range and scientific use of animal models in regulatory submissions, a database was created surveying recent pneumonia models submitted as part of IND application packages. The IND studies were compared to animal models of bacterial pneumonia published in the scientific literature over the same period of time. In this review, we analyze the key experimental design elements, such as animal species, immune status, pathogens selected, and route of administration, and study endpoints.

The MaMTH-DS assay detected inhibitors of mutant EGFR in non–small cell lung cancer cells.

As cancer researchers shutter their labs to comply with COVID-19–related work restrictions, some are turning their attention, resources, and technical know-how to the challenge of tackling the deadly coronavirus.

A collection of recently published news items.

A large international study found that the composition of the intestinal microbiome can predict clinical outcomes in patients undergoing allogenic hematopoietic-cell transplant (HCT) for blood cancers. The findings may help assess patients' transplantation-related mortality risk and aid in developing interventions to prevent or mitigate microbiome changes that affect HCT outcomes.

Chlorotoxin, a small peptide component of scorpion venom, may help pinpoint glioblastoma cells for destruction when engineered into a chimeric antigen receptor T-cell therapy. The concept has shown efficacy in mice, without off-target toxicity, and will soon be assessed in patients.

Human macrophages equipped with chimeric antigen receptor constructs infiltrate solid tumors, ingest malignant tissue, and stimulate adaptive immunity in mouse models. Several new biotech companies are racing to bring the technology into clinical trials.

Thermo Fisher Scientific announced plans in March to acquire Qiagen in a $11.5 billion deal that could bring morediagnostic offeringsand sample-preparation technologies to one of the world's leading manufacturers of scientific instruments, research services, and laboratory consumables.

As the COVID-19 pandemic worsens, the clinical cancer community is grappling with how to continue providing access to experimental but potentially lifesaving therapies while keeping immunocompromised patients safe. To that end, cancer centers are making changes to their clinical trial programs, while pharmaceutical companies are deciding how—or whether—trials should continue.

Antoni Ribas, MD, PhD, and Gillian Leng, MBChB, are featured.

In the plasmaMATCH trial, researchers performed circulating tumor DNA testing on patients with advanced breast cancer and matched those with ESR1, HER2, or AKT1 alterations to targeted therapies. Patients with HER2 and AKT1 mutations experienced response rates greater than 22% with durable benefit.

As COVID-19 continues to surge, cancer scientists engaged in basic research face unique challenges. At centers throughout the United States, investigators are confronting difficult decisions about which experiments to continue, while securing supplies and creating contingency plans for a complete shutdown.

Since 2018, the FDA has required that U.S. clinical trial results be reported to clinicaltrials.gov within a year of trial completion, but this mandate is often ignored. A recent study found that less than half of U.S. trials submitted results to the site by the deadline. Industry-led trials were the most likely to be reported on time.

In a draft guidance, the FDA urges researchers to take steps to increase enrollment of adults age 65 and older in clinical trials of investigational of cancer drugs. Noting that a drug's risk–benefit profile can vary significantly across age groups, the FDA recommends including older adults in early-phase studies and modifying trial designs and recruitment strategies to make it easier for them to participate.

Consistently, the field of genetic counseling has advocated that parents be advised to defer elective genetic testing of minors until adulthood to prevent a range of potential harms, including stigma, discrimination, and the loss of the child's ability to decide for him- or herself as an adult. However, consensus around the policy of "defer-when-possible" obscures the extent to which this norm is currently under siege. Increasingly, routine use of full or partial genome sequencing challenges our ability to control what is discovered in childhood or, when applied in a prenatal context, even before birth. The expansion of consumer-initiated genetic testing services challenges our ability to restrict what is available to minors. As the barriers to access crumble, medical professionals should proceed with caution, bearing in mind potential risks and continuing to assess the impact of genetic testing on this vulnerable population.

BACKGROUND AND PURPOSE:

Diffuse intrinsic pontine glioma is a lethal childhood brain cancer with dismal prognosis and MR imaging is the primary methodology used for diagnosis and monitoring. Our aim was to determine whether advanced diffusion, perfusion, and permeability MR imaging metrics predict survival and pseudoprogression in children with newly diagnosed diffuse intrinsic pontine glioma.

SUMMARY:

The remarkable temperature sensitivity of the brain is widely recognized and has been studied for its role in the potentiation of ischemic and other neurologic injuries. Pyrexia frequently complicates large-vessel acute ischemic stroke and develops commonly in critically ill neurologic patients; the profound sensitivity of the brain even to minor intraischemic temperature changes, together with the discovery of brain-to-systemic as well as intracerebral temperature gradients, has thus compelled the exploration of cerebral thermoregulation and uncovered its immutable dependence on cerebral blood flow. A lack of pragmatic and noninvasive tools for spatially and temporally resolved brain thermometry has historically restricted empiric study of cerebral temperature homeostasis; however, MR thermometry (MRT) leveraging temperature-sensitive nuclear magnetic resonance phenomena is well-suited to bridging this long-standing gap. This review aims to introduce the reader to the following: 1) fundamental aspects of cerebral thermoregulation, 2) the physical basis of noninvasive MRT, and 3) the physiologic interdependence of cerebral temperature, perfusion, metabolism, and viability.

Với sứ mệnh "mang thông tin thị trường bất động sản đến với mọi khách hàng" chúng tôi mong muốn cung cấp đến quý vị khán giả những thông tin dự án Hot nhất và đưa đến thông tin chính xác nhất, với nguồn thông tin tổng hợp từ những báo chính thống của Việt Nam về bất động sản cũng như từ các chủ đầu tư lớn tại Việt Nam.

Khu vực môi giới tốt nhất hiện nay: Quận 12, Quận 9, Quận 2, Quận Bình Chánh...

Loại BĐS môi giới chủ yếu: Bán căn hộ chung cư, bán biệt thự liền kề, bán đất, bán đất dự án

Danh sách các dự án BĐS đã môi giới thành công: Pier IX, Đông Tăng Long, Picity...

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Khi bắt đầu dự án, gia chủ đã trao đổi với kiến trúc sư rằng, với anh, mặt ngoài ngôi nhà là của người ta, còn bên trong mới là của mình. Hiểu được mong ước của gia chủ, kiến trúc sư đã thiết kế kiến trúc biệt thự phong cách New Mid-Century tối giản cả về hình khối, màu sắc nhưng vẫn toát lên sự tinh tế và hiện đại.

The constantly increasing number of new real estate projects which have been implemented in the Mekong Delta region has led to the rising land price and strong fluctuation in the local property market.

Honouring real estate developers who are relentless in their pursuit to be socially and environmentally responsible.

Buying a new house is a very big deal, and you want to make sure that your dream home doesn’t turn into a nightmare. It’s wise to check things out before you put in an offer.

Lots of people sell their current home at the same time as buying a new one, forming a property chain. Selling before you buy has risks, but it can also have great advantages.

Along with the recovery of market, property investment also rebounds with new trends. Here are three new trends of property investment that become more and more popular in 2015.

Regardless of age, all first-time real estate investors are prone to making the same mistakes. Here are some dos and don’ts for new investors.

गुजरात से तीन विशेष ट्रेनों की मदद से बृहस्पतिवार को भी 3674 श्रमिक तथा अन्य लोग आए। सूरत से आई तीसरी ट्रेन में छात्र-छात्रा तथा अन्य लोग भी शामिल रहे। चिकित्सीय परीक्षण और भोजन बाद इन्हें करीब 114 बसाें से गृह जनपद भेजा गया।

उत्तर प्रदेश के सरकारी राज्य विश्वविद्यालय, निजी विश्वविद्यालयों एवं महाविद्यालयों के लाखों छात्र-छात्राओं के लिए अच्छी खबर है। अब वे घर बैठे प्रदेश भर के विषय विशेषज्ञों का लाभ ले सकेंगे। शासन ने इसके लिए एक केंद्रीयकृत पोर्टल बनाने...