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Considering mutational meltdown as a potential SARS-CoV-2 treatment strategy




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Implementation of a statewide, multisite fetal tele-echocardiography program: evaluation of more than 1100 fetuses over 9 years




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Epidemiology of thrombosis in Canadian neonatal intensive care units




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Natural polyphenol assisted delivery of single-strand oligonucleotides by cationic polymers




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The impact of 2018 ASCO-CAP HER2 testing guidelines on breast cancer HER2 results. An audit of 2132 consecutive cases evaluated by immunohistochemistry and in situ hybridization




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Cost-effectiveness of <i>CYP2C19-</i>guided antiplatelet therapy in patients with acute coronary syndrome and percutaneous coronary intervention informed by real-world data




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Identification of gene modules associated with survival of diffuse large B-cell lymphoma treated with CHOP-based chemotherapy




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Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment




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Reconsidering marrow stem cell cycle status: insights into an actively cycling hematopoietic stem cell population




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Income Inequality and Homicide

Where financial disparities are greatest, the murder rate tends to be high




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Identification of type 2 diabetes loci in 433,540 East Asian individuals




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Ancient Andean cities boasted cosmopolitan residents




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Leucine-rich repeat containing 4 act as an autophagy inhibitor that restores sensitivity of glioblastoma to temozolomide




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Blood pressure control and complex health conditions in older adults: impact of recent hypertension management guidelines




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Blood pressure and nitric oxide synthesis capacity in physically active and inactive groups: the SABPA study




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Hypertension in rheumatic diseases: prevalence, awareness, treatment, and control rates according to current hypertension guidelines




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A metabolic labeling method detects m<sup>6</sup>A transcriptome-wide at single base resolution




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Structural basis for selectivity in a highly reducing type II polyketide synthase




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Why the Most Important Idea in Behavioral Decision Making Is a Fallacy

The popular idea that avoiding losses is a bigger motivator than achieving gains is not supported by the evidence




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Global Warming Linked to Higher Suicide Rates across North America

A 1 degree Celsius rise corresponded to a 1.4 percent increase in suicides




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Comparative efficacy of a hydroxyapatite and a fluoride toothpaste for prevention and remineralization of dental caries in children




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Clinical and radiographic evaluation of indirect pulp treatment of young permanent molars using photo-activated oral disinfection versus calcium hydroxide: a randomized controlled pilot trial




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Author Correction: Genetic circuit design automation for the gut resident species <i>Bacteroides thetaiotaomicron</i>




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Cellular thermal shift assay for the identification of drug–target interactions in the <i>Plasmodium falciparum</i> proteome




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Dermatophagoides pteronyssinus peptidase 1 (DERP1)

In vitro and rat studies suggest inhibiting the enzymatic activity of house dust mite (HDM) allergens could help treat allergic asthma.




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Globohexaosylceramide (globo-H); stage-specific embryonic antigen-3 (SSEA-3); SSEA-4

Mouse studies suggest chemically modified carbohydrate conjugates could be useful as antigens for the development of cancer vaccines.




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Epidermal growth factor receptor 1 (EGFR1; ErbB1; HER1); HER2 (EGFR2; ErbB2; neu); HER3 (EGFR3; ErbB3); VEGF

Tumor cell and mouse studies suggest tetravalent antibodies that target four different antigens could help treat cancers resistant to HER-targeted therapies.




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Estrogen receptor; LYN kinase (LYN); phosphoinositide 3-kinase (PI3K)

Studies in mice and human samples suggest inhibiting LYN could help treat estrogen receptor–positive breast cancers resistant to anti-estrogen therapy.




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Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling




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Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism




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Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation




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An in vitro Förster resonance energy transfer-based high-throughput screening assay identifies inhibitors of SUMOylation E2 Ubc9




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Sweet signals — gut–brain circuit for sugar identified




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Incidence of acute spinal cord injury in South Korea does not reflect a sizable number of traumatic spinal cord injuries




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A more accurate incidence of acute spinal cord injury in South Korea can be estimated by the national health insurance system




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Single-cell RNA sequencing reveals the heterogeneity of liver-resident immune cells in human




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Pomalidomide, dexamethasone, and daratumumab in relapsed refractory multiple myeloma after lenalidomide treatment




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Fixed orthodontic appliances: a practical guide




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Modeling shield immunity to reduce COVID-19 epidemic spread




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This Virus Is Tough, but History Provides Perspective: The 1968 Pandemic and the Vietnam War

Nathaniel L. Moir recounts the events of 1968: The war in Vietnam and extensive civil unrest in the United States — and yet another big problem that made life harder. In 1968, the H3N2 pandemic killed more individuals in the United States than the combined total number of American fatalities during both the Vietnam and Korean Wars.




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We’re In For A Rough Ride With Iran

In a dangerous world, every US use of military force should be backed up by a careful calculation of risks and a strategy to cope with the adversary’s response. Neither risk-balancing nor strategy is apparent in President Trump’s decision to kill Major General Qassem Soleimani, leader of the Quds Force of Iran’s Revolutionary Guard. With that killing — and Iran’s announcement it would exact a “harsh revenge” — there is a real danger the Middle East will slide even further into the fires of war.




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The Strategic Postures of China and India: A Visual Guide

Fueled by aggressive rhetoric from both capitals, Indian and Chinese ground forces engaged in a standoff between June and August 2017. The Doklam crisis, as it became known, stimulated introspection among officials and experts in both states about the future of their relationship. Politically, both strategic communities largely concluded that the peaceful resolution of border disputes is now less likely, forecasting more rivalry than cooperation. Militarily, Indian discussions on the strength of its military position against China in their disputed ground frontier areas have converged on the view that China holds the conventional and nuclear edge over India in this domain.

Based on our analysis of data on the location and capabilities of Indian and Chinese strategic forces and related military units, we conclude that this assessment of the balance of forces may be mistaken and a poor guide for Indian security and procurement policies. We recommend that instead of investing in new nuclear weapons platforms that our analysis suggests are not likely to be required to deter China, New Delhi should improve the survivability of its existing forces and fill the gap in global arms control leadership with an initiative on restraint and transparency.




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This Virus Is Tough, but History Provides Perspective: The 1968 Pandemic and the Vietnam War

Nathaniel L. Moir recounts the events of 1968: The war in Vietnam and extensive civil unrest in the United States — and yet another big problem that made life harder. In 1968, the H3N2 pandemic killed more individuals in the United States than the combined total number of American fatalities during both the Vietnam and Korean Wars.




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HPCA Hosts COP25 Side Event Focused on Reducing GHG Emissions through Carbon Pricing

As negotiators from around the world arrived in Madrid for the second week of the 25th UN Climate Change Conference (COP-25), the Harvard Project on Climate Agreements hosted an official COP side event on Dec. 9 focusing on the potential for reducing greenhouse-gas (GHG) emissions through the use of carbon pricing.




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How Do Past Presidents Rank in Foreign Policy?

How do presidents incorporate morality into decisions involving the national interest? Moral considerations explain why Truman, who authorized the use of nuclear weapons in Japan during World War II, later refused General MacArthur's request to use them in China during the Korean War. What is contextual intelligence, and how does it explain why Bush 41 is ranked first in foreign policy, but Bush 43 is found wanting? Is it possible for a president to lie in the service of the public interest? In this episode, Professor Joseph S. Nye considers these questions as he explores the role of morality in presidential decision-making from FDR to Trump.




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Oil Markets Provide a Glimpse of the Post-Pandemic Future

Henry Kissinger warns that many existing domestic and international institutions that have helped govern the past decades will not survive the Covid-19 crisis. He is surely correct.




ide

This Virus Is Tough, but History Provides Perspective: The 1968 Pandemic and the Vietnam War

Nathaniel L. Moir recounts the events of 1968: The war in Vietnam and extensive civil unrest in the United States — and yet another big problem that made life harder. In 1968, the H3N2 pandemic killed more individuals in the United States than the combined total number of American fatalities during both the Vietnam and Korean Wars.




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Genome-wide selection and genetic improvement during modern maize breeding




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Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease




ide

HPCA Hosts COP25 Side Event Focused on Reducing GHG Emissions through Carbon Pricing

As negotiators from around the world arrived in Madrid for the second week of the 25th UN Climate Change Conference (COP-25), the Harvard Project on Climate Agreements hosted an official COP side event on Dec. 9 focusing on the potential for reducing greenhouse-gas (GHG) emissions through the use of carbon pricing.