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Older adults are at an increased risk of lacking company and being socially isolated. Recent studies prove that a lack of social relationships is as strong a risk factor for mortality as are smoking, obesity, or a lack of physical activity. Enter Little Brothers.

Little Brothers is an effort dedicated to spreading awareness and relieving isolation and loneliness in elders, a problem that often goes unseen. Little Brothers is in 7 U.S. cities and 10 countries worldwide. Its mission is carried out by more than one nonprofit organization.

Little Brothers Friends of the Elderly San Francisco facilitates more than 4,000 friendly visits a year. Volunteers are matched with elders in San Francisco, and they form and build a relationship through home visits, outings, or common interests.

We recently met with Andrew Butler, the program manager at Little Brothers Friends of the Elderly San Francisco. He explained that many volunteers form a relationship with an elder, and their stereotypes about older people are quickly broken down.

"A lot of what we do is creating awareness. I think a lot of the information that we share through training or events really inspires people," said Butler. He also suggested that we speak with a member of Little Brothers Friends of the Elderly San Francisco, Andy Morgan, to get a proper feel for the organization.

Andy Morgan is a highly spiritual 86-year-old who loves to read. Originally from Transylvania, Andy came to San Francisco in 1962 and has worked a variety of jobs throughout his life.

However, he stresses that he has never defined himself by what he did for a living. Aside from books and his spirituality, Andy values personal relationships and enjoys company.

Our conversation with Andy revealed why Little Brothers' impact matters so much.

I wanted to ask if you have any main visitors.

Andy Morgan: Yeah! I have one main visitor come every week. Rain or shine, he comes and sees me. He brings me food from Trader Joe's, and he does my laundry.

Wow, that's a sweet deal. Would you share a particular visit that has stuck with you over the years?

There's nothing that stands out; every visit is enjoyable. What we usually do is grab a spiritual book, you know, all those books over there are on spirituality, and we read from it and then we discuss it. I've been on the spiritual path since the 1960s, so if he has any questions, I can try and clarify.

I was wondering what makes you happy.

What makes me happy? Knowing that my within-ness, that which makes me breathe and which makes me exist, is pure joy and pure love. When you do a lot of meditation, something opens up within you, and I just feel, practically all the time, this feeling of love and joy and peace.

Of course no one can maintain that 24/7, but I can always come back. If something goes wrong, I can just remind myself of my true nature.

That's beautiful. Thank you so much for opening your home to us.

My pleasure; it's been a joy having you guys. Could I just read you one very short poem? It says …

Be as a Flower

Truth is very simple
A flower does not try to be beautiful.
Its True Nature is Beauty.
Just by its Very Being.

In the same way, when you Awaken
To your true nature,
You will naturally exude Love,
Compassion, Beauty.
It is all you.
For it is your True Self.

(poem by Robert Adams)

TechSoup is proud to support our member, Little Brothers Friends of the Elderly San Francisco, in its mission to spread awareness about and help elders at risk of loneliness and isolation. There are incredible people like Andy all over the world who are at risk of being forgotten. But they should never be. TechSoup provides technology and services to Little Brothers staff members to help run their nonprofit so that they can focus on fighting the effects of elder isolation.

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The post How RDMA Became the Fuel for Fast Networks appeared first on The Official NVIDIA Blog.

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The post American Airlines Delivers the Goods, with Data Science Workstations appeared first on The Official NVIDIA Blog.

If you think flying commercial is stressful, consider the air cargo industry. Unlike passenger flights, which are often booked and paid for months in advance, cargo shipments are typically booked just 10 days before the planned departure. And customers don’t have to pay until they drop off their shipments. However, even when customers create a Read article >

The post American Airlines Delivers the Goods, with Data Science Workstations appeared first on The Official NVIDIA Blog.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

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In the lead-up to the Truth Matters conference in October, we will be focusing our attention on the sufficiency, authority, and clarity of Scripture. Of our previous blog series, none better embodies that emphasis than Frequently Abused Verses. The following entry from that series originally appeared on September 18, 2015. -ed.

In the quiet intimacy of the upper room, just hours before His arrest, Christ gave His disciples some final encouragement and instruction. He revealed again His unity with the Father, comforted His disciples with the promise of heaven, and told them about the Helper who would empower them for the work ahead (John 14:1-17). But as usual, the disciples failed to fully understand what He was saying.

Some of their confusion lives on in the church today. In particular, one of Christ’s statements in this passage has confounded and divided many believers, with some using the Lord’s promise as proof of the continuation of the apostolic gifts throughout the history of the church.

In John 14:12, Jesus promises His followers: “Truly, truly, I say to you, he who believes in Me, the works that I do, he will do also; and greater works than these he will do; because I go to the Father.”

In his book The Upper Room, John MacArthur explains why there is persistent confusion in the church today about the nature of Christ’s promise.

Christians over the centuries have wondered at the richness of such a promise. What does it mean? How could anyone do greater works than Jesus had done? He had healed people blind from birth, cast out the most powerful demons, and even raised Lazarus from the dead after four days in the grave. What could possibly be greater than those miracles? ^[1] John MacArthur, The Upper Room (The Woodlands, TX: Kress Biblical Resources, 2014) 93.

For charismatic authors who believe in the continuation of the apostolic gifts, the answer is simple. In his book Authentic Fire, Michael Brown explains it this way:

Jesus gave a universal promise in John 14:12 that implies that all believers can ask God to demonstrate His healing and miracle-working power through them, since the statement in John 14:12 is programmatic, as Jesus said: “Truly, truly, I say to you, whoever believes in me will also do the works that I do; and greater works than these will he do, because I am going to the Father.” How is this not universal in scope, given that the identical Greek phrase ho pisteuon eis eme, whoever believes in Me, is always universal in application in John? (See John 6:35; 7:38; 11:25; 12:44, 46.) And while we can debate exactly what Jesus intended by the “greater works,” it is difficult to escape from the conclusion that whoever believes in the Son will also perform miraculous signs, based on: 1) the immediate context (14:9-11, with the emphasis on miracles as the works done by Jesus); 2) the universality of the language used; and 3) the assurance which follows, guaranteeing the efficacy of prayer to the Father in Jesus’ name. . . .

This promise cannot be limited to the apostle based on the language of “whoever believes in Me,” nor can it [sic] limited to non-supernatural acts of service. The reverse is actually true. ^[2] Michael Brown, Authentic Fire (Lake Mary, FL: Excel Publishers, 2014) 188-189.

Writing for Charisma Magazine, charismatic author Larry Sparks makes the same assertion that Christ’s words to His disciples are “a powerful blanket statement” for all believers, throughout church history.

Whoever means whoever. This is beyond the 12 apostles and the 72 called-out ones in Luke 10. Whoever spans all generations. Whoever invites us, in the 21st century, to once again contend for an outpouring of supernatural power in our midst.^[3] http://www.charismamag.com/index.php/newsletters/spiritled-woman-e-magazine/23749-the-danger-of-celebrating-halloween

Bill Johnson, pastor of Bethel Church in Redding, California, (one of the most influential charismatic churches in the world) and instructor at the Bethel School of Supernatural Ministry, teaches a similar interpretation of the “greater works.” In his book When Heaven Invades Earth, he writes, “The miraculous is a large part of the plan of God for this world. And it is to come through the Church.” ^[4] Bill Johnson, When Heaven Invades Earth (Shippensburg, PA: Treasure House, 2003) 136. Johnson teaches that in His incarnation, Christ emptied Himself of all divine attributes, and in His humanity is the model for our lives.

Jesus became the model for all who would embrace the invitation to invade the impossible in His name. He performed miracles, wonders, and signs, as a man in right relationship to God . . . not as God. If He performed miracles because He was God, then they would be unattainable for us. But if He did them as a man, I am responsible to pursue His lifestyle. ^[5] When Heaven Invades Earth, 29.

Through that lens of Christ’s humanity, Johnson understands John 14:12 as a challenge to surpass His miraculous works.

Jesus’ prophecy of us doing greater works than He did has stirred the Church to look for some abstract meaning to this very simple statement. Many theologians seek to honor the works of Jesus as unattainable, which is religion, fathered by unbelief. It does not impress God to ignore what He promised under the guise of honoring the work of Jesus on the earth. Jesus’ statement is not that hard to understand. Greater means “greater.” And the works he referred to are signs and wonders. It will not be a disservice to Him to have a generation obey Him, and go beyond His own high-water mark. He showed us what one person could do who has the Spirit without measure. What could millions do? That was His point, and it became His prophecy. ^[6] When Heaven Invades Earth, 185.

We could go on and on with examples of that kind of teaching from charismatic sources, but you get the point. For those arguing for the continuation of the apostolic gifts, John 14:12 is a battleground text.

But was it really meant to be a promise of miraculous power to every believer? The testimony of church history suggests it was not, as many generations of saints have come and gone without any evidence of apostolic power. And while charismatics will argue that there is evidence of miracles today, it’s always anecdotal, rarely documented or objectively substantiated, and often comes from the far-flung corners of the globe.

Even by that flawed standard, the Spirit’s supposed miraculous work today is significantly different than His ministry through the apostles in the first-century church. Far from healing the crippled, curing the ravages of disease, and raising the dead, it seems the focus of the Holy Spirit’s healing ministry today is limited to rheumatoid arthritis, nagging back pain, and other subjective ailments. No longer is His work dramatic, obvious, and undeniable—today it’s mysterious, indiscriminate, and surprisingly absent when and where it’s most needed.

There is no arguing against the fact that Christ bestowed His supernatural power to His disciples (Acts 5:12-16). But there is no reason to characterize their miracles as “greater” than Christ’s, either in magnitude or degree. Furthermore, there is scant evidence that His promise of power extends to the subsequent generations of the church. In other words, not only have we not seen the charismatic interpretation validated by nearly 19 centuries of Christian history, it can’t even be validated by the miraculous works of the twelve apostles! (For further exegetical explanation of the limits of Christ’s promise in John 14:12, I recommend this article from Matt Waymeyer.)

So if Christ wasn’t promising miraculous power that exceeded His own, what did He mean by “greater works?” As John MacArthur explains, Jesus was indicating that the disciples works would be greater not in power, but in extent.

The key to understanding this promise is in the last phrase of verse 12: “because I go to the Father.” When Jesus went to the Father, He sent the Holy Spirit. The Spirit’s power completely transformed the disciples from a group of fearful, timid individuals into a cohesive force that reached the world with the gospel. The impact of their preaching exceeded even the impact of Jesus’ public teaching ministry during His lifetime. Jesus never preached outside a 175-mile radius extending from His birthplace. Within His lifetime, Europe never received word of the gospel. But under the ministry of the disciples the good news began to spread, and it’s still spreading today. Their works were greater than His, not in power, but in scope. Through the indwelling Holy Spirit, each one of those disciples had access to power in dimensions they did not previously have, even with the physical presence of Christ.

The disciples undoubtedly thought that without Christ they would be reduced to nothing. He was the source of their strength; how could they have power without Him? His promise was meant to ease those fears. If they felt secure in His presence, they would be even more secure, more powerful, able to do more, if He returned to the Father and sent the Holy Spirit. ^[7] The Upper Room, 93-94.

Christ did not hand-pick His disciples merely to perform signs and wonders in His name. They were chosen to extend the good news of His sacrificial, atoning death beyond the reaches of Israel and Palestine, to the far reaches of the globe. They were preaching the completed work of Christ on behalf of sinners, spawning spiritual revival throughout the known world. In that sense, their work was greater than Christ’s, as they bore witness to the truth of His life and death, and saw firsthand the transforming work of the Holy Spirit.

As John MacArthur explains, the work of the gospel is the greatest ministry work of all.

After all, the greatest miracle God can perform is salvation. Every time we introduce someone to faith in Jesus Christ, we are observers of the new birth; we are supporting the most important spiritual work in the world. How exciting it is to be involved in what God is doing spiritually and to do things greater than even Jesus saw in His day. ^[8] The Upper Room, 94.

The teaching of the Roman Catholic Church stands in stark opposition to the biblical gospel. Rather than salvation by grace through faith, they preach a false gospel of works.

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The Bcl-2 (B cell lymphoma 2)-related protein Nr-13 plays a major role in the regulation of cell death in developing avian B cells. With over 65% sequence similarity to the chicken Nr-13, herpesvirus of turkeys (HVT) vNr-13, encoded by the HVT079 and HVT096 genes, is the first known alphaherpesvirus-encoded Bcl-2 homolog. HVT-infected cells were reported to be relatively more resistant to serum starvation, suggested that vNr-13 could be involved in protecting the cells. Here, we describe CRISPR/Cas9-based editing of exon 1 of the HVT079 and HVT096 genes from the HVT genome to generate the mutant HVT-vNr-13 to gain insights into its functional roles. Overall, wild-type HVT and HVT-vNr-13 showed similar growth kinetics; however, at early time points, HVT-vNr-13 showed 1.3- to 1.7-fold-lower growth of cell-associated virus and 3- to 6.2-fold-lower growth of cell-free virus. In transfected cells, HVT vNr-13 showed a mainly diffuse cytoplasmic distribution with faint nuclear staining. Further, vNr-13 localized to the mitochondria and endoplasmic reticulum (ER) and disrupted mitochondrial network morphology in the transfected cells. In the wild-type HVT-infected cells, vNr-13 expression appeared to be directly involved in the disruption of the mitochondrial network, as the mitochondrial network morphology was substantially restored in the HVT-vNr-13-infected cells. IncuCyte S3 real-time apoptosis monitoring demonstrated that vNr-13 is unequivocally involved in the apoptosis inhibition, and it is associated with an increase of PFU, especially under serum-free conditions in the later stages of the viral replication cycle. Furthermore, HVT blocks apoptosis in infected cells but activates apoptosis in noninfected bystander cells.

IMPORTANCE B cell lymphoma 2 (Bcl-2) family proteins play important roles in regulating apoptosis during homeostasis, tissue development, and infectious diseases. Several viruses encode homologs of cellular Bcl-2-proteins (vBcl-2) to inhibit apoptosis, which enable them to replicate and persist in the infected cells and to evade/modulate the immune response of the host. Herpesvirus of turkeys (HVT) is a nonpathogenic alphaherpesvirus of turkeys and chickens that is widely used as a live vaccine against Marek’s disease and as recombinant vaccine viral vectors for protecting against multiple avian diseases. Identical copies of the HVT genes HVT079 and HVT096 encode the Bcl-2 homolog vNr-13. While previous studies have identified the potential ability of vNr-13 in inhibiting apoptosis induced by serum deprivation, there have been no detailed investigations on the functions of vNr-13. Using CRISPR/Cas9-based ablation of the vNr-13 gene, we demonstrated the roles of HVT vNr-13 in early stages of the viral replication cycle, mitochondrial morphology disruption, and apoptosis inhibition in later stages of viral replication.

Transportation infrastructure owners manage an array of different asset types such as bridges, road pavements, earthworks and drainage. Currently, most organization management procedures are siloed by asset type; however, there are important interactions between these asset groups that need to be managed in a cross-asset way. Although these interactions are known, there is little or no quantification of these interactions. For the first time, this paper quantifies that 74% of Highways England's earthwork failures are a result of drainage-related problems, either the lack of drainage infrastructure or the poor performance of it. The analysis undertaken is an important first step not only in moving towards more connected asset management planning for earthworks and drainage, but to also provide guidance for other owners of earthwork infrastructure assets to improve their strategic asset management procedures.

Thematic collection: This article is part of the Ground-related risk to transportation infrastructure collection available at https://www.lyellcollection.org/cc/Ground-related-risk-to-transportation-infrastructure