Source: Dr. Joseph Pantginis 11/04/2024

H.C. Wainwright & Co. analysts Dr. Joseph Pantginis, Dr. Lander Egaña Gorroño, Dr. Joshua Korsen, Dr. Matthew Keller, and Dr. Sara Nik, in a research report published on November 4, 2024, maintained their Buy rating on Lexicon Pharmaceuticals Inc. (LXRX:NASDAQ) with a price target of US$6.00. The report follows Lexicon's presentation of preclinical data for LX9851, its ACSL5 inhibitor for obesity, at ObesityWeek 2024.

The analysts highlighted key findings from the presentations, stating, "LX9851 promotes reduction of fat mass without affecting lean body mass" and "LX9851 improves and sustains GLP-1 RA-mediated weight loss, even after semaglutide discontinuation." They added that "Mechanistic studies suggest that LX9851-mediated ACSL5 inhibition activates the ileal brake."

Regarding the drug's potential, they noted, "LX9851 is a first-in-class, oral small molecule ACSL5 inhibitor designed to enhance and maintain weight loss promoted by incretin mimetics (GLP-1 receptor agonists), and offer improved treatment alternatives for obesity and related metabolic disorders."

The report also addressed recent developments with sotagliflozin, detailing the AdCom voting results and potential scenarios for FDA action. The analysts stated, "Although we anticipate favorable feedback from the agency regarding eGFR ≥60 to <90 range, our bet is that a confirmatory trial may be required to validate sota's efficacy in this subpopulation and obtain approval."

H.C. Wainwright & Co.'s valuation methodology is based on a clinical net present value (NPV) model. The analysts explained, "Our valuation is based on our clinical net present value (NPV) model, which allows us to flex multiple assumptions affecting a drug's profile. We currently value Lexicon solely on sotagliflozin sales in the U.S. for HF (INPEFA), HCM, and LX9211 for DPNP."

They added, "We believe significant upside potential exists, based on: (1) attaining higher market penetration for HF, and HCM; and (2) adding the earlier stage assets."

In conclusion, H.C. Wainwright & Co.'s maintenance of their Buy rating and US$6 price target reflects confidence in Lexicon's pipeline potential, particularly with LX9851 and sotagliflozin. The share price at the time of the report of US$1.22 represents a potential return of approximately 392% to the analysts' target price, highlighting the significant upside potential if the company's development programs prove successful.

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Disclosures for H.C. Wainwright & Co., Lexicon Pharmaceuticals Inc., November 4, 2024

This material is confidential and intended for use by Institutional Accounts as defined in FINRA Rule 4512(c). It may also be privileged or otherwise protected by work product immunity or other legal rules. If you have received it by mistake, please let us know by e-mail reply to unsubscribe@hcwresearch.com and delete it from your system; you may not copy this message or disclose its contents to anyone. The integrity and security of this message cannot be guaranteed on the Internet. H.C. WAINWRIGHT & CO, LLC RATING SYSTEM: H.C. Wainwright employs a three tier rating system for evaluating both the potential return and risk associated with owning common equity shares of rated firms. The expected return of any given equity is measured on a RELATIVE basis of other companies in the same sector. The price objective is calculated to estimate the potential movements in price that a given equity could reach provided certain targets are met over a defined time horizon. Price objectives are subject to external factors including industry events and market volatility.

H.C. Wainwright & Co, LLC (the “Firm”) is a member of FINRA and SIPC and a registered U.S. Broker-Dealer. I, Joseph Pantginis, Ph.D., Lander Egaña Gorroño, Ph.D., Joshua Korsen, Ph.D., Matthew Keller, Ph.D. and Sara Nik, Ph.D. , certify that 1) all of the views expressed in this report accurately reflect my personal views about any and all subject securities or issuers discussed; and 2) no part of my compensation was, is, or will be directly or indirectly related to the specific recommendation or views expressed in this research report; and 3) neither myself nor any members of my household is an officer, director or advisory board member of these companies. None of the research analysts or the research analyst’s household has a financial interest in the securities of Lexicon Pharmaceuticals, Inc. (including, without limitation, any option, right, warrant, future, long or short position). As of September 30, 2024 neither the Firm nor its affiliates beneficially own 1% or more of any class of common equity securities of Lexicon Pharmaceuticals, Inc..

Neither the research analyst nor the Firm knows or has reason to know of any other material conflict of interest at the time of publication of this research report. The research analyst principally responsible for preparation of the report does not receive compensation that is based upon any specific investment banking services or transaction but is compensated based on factors including total revenue and profitability of the Firm, a substantial portion of which is derived from investment banking services. The firm or its affiliates received compensation from Lexicon Pharmaceuticals, Inc. for non-investment banking services in the previous 12 months. The Firm or its affiliates did not receive compensation from Lexicon Pharmaceuticals, Inc. for investment banking services within twelve months before, but will seek compensation from the companies mentioned in this report for investment banking services within three months following publication of the research report. The Firm does not make a market in Lexicon Pharmaceuticals, Inc. as of the date of this research report.

The securities of the company discussed in this report may be unsuitable for investors depending on their specific investment objectives and financial position. Past performance is no guarantee of future results. This report is offered for informational purposes only, and does not constitute an offer or solicitation to buy or sell any securities discussed herein in any jurisdiction where such would be prohibited. This research report is not intended to provide tax advice or to be used to provide tax advice to any person. Electronic versions of H.C. Wainwright & Co., LLC research reports are made available to all clients simultaneously. No part of this report may be reproduced in any form without the expressed permission of H.C. Wainwright & Co., LLC. Additional information available upon request. H.C. Wainwright & Co., LLC does not provide individually tailored investment advice in research reports. This research report is not intended to provide personal investment advice and it does not take into account the specific investment objectives, financial situation and the particular needs of any specific person. Investors should seek financial advice regarding the appropriateness of investing in financial instruments and implementing investment strategies discussed or recommended in this research report. H.C. Wainwright & Co., LLC’s and its affiliates’ salespeople, traders, and other professionals may provide oral or written market commentary or trading strategies that reflect opinions that are contrary to the opinions expressed in this research report. H.C. Wainwright & Co., LLC and its affiliates, officers, directors, and employees, excluding its analysts, will from time to time have long or short positions in, act as principal in, and buy or sell, the securities or derivatives (including options and warrants) thereof of covered companies referred to in this research report. The information contained herein is based on sources which we believe to be reliable but is not guaranteed by us as being accurate and does not purport to be a complete statement or summary of the available data on the company, industry or security discussed in the report. All opinions and estimates included in this report constitute the analyst’s judgment as of the date of this report and are subject to change without notice. Securities and other financial instruments discussed in this research report: may lose value; are not insured by the Federal Deposit Insurance Corporation; and are subject to investment risks, including possible loss of the principal amount invested.

( Companies Mentioned: LXRX:NASDAQ, )

The logo of National Oceanic and Atmospheric Administration is seen at the Nation Hurricane Center in Miami on Aug. 29, 2019. President Biden has nominated Rick Spinrad to head NOAA.; Credit: Eva Marie Uzcategui/Getty Images

President Biden is nominating Rick Spinrad to lead the National Oceanic and Atmospheric Administration, the government's premier agency on climate science which oversees the National Weather Service.

Prior to his current role as a professor of oceanography at Oregon State University, Spinrad served as NOAA's top scientist under President Obama and the U.S. representative to the United Nations' Intergovernmental Oceanographic Commission.

The nomination comes at a difficult moment in NOAA's history. The agency has been without an official, Senate-confirmed leader since former President Donald Trump took office in January 2017, after his two nominees to lead the agency failed to garner enough support to win a full vote before the Senate.

If Spinrad manages to win over the Senate, he will have to contend with a challenge beyond the agency's already-rigorous scientific mandate: restoring public confidence in a traditionally apolitical agency marred by political scandal.

In September 2019, then-President Trump wrongly said Alabama was in the projected path of Hurricane Dorian. He continued to reassert the claim for several days, including during an Oval Office briefing on the storm — in which he displayed what appeared to be an official National Weather Service map in which the storm's projected path was extended to Alabama by someone using a black marker.

After a National Weather Service office in Birmingham put out a tweet correctly stating that Alabama would not feel the effects of the storm, NOAA published an unsigned defense of the president's claims and rebuking its professional staff who posted the message.

Dan Sobien, then-president of the National Weather Service Employees Organization, said at the time that "the hard working employees of the NWS had nothing to do with the utterly disgusting and disingenuous tweet sent out by NOAA management."

If confirmed, Spinrad will lead a 12,000-person agency charged with a diverse portfolio that spans daily weather forecasts, climate monitoring, fisheries management and coastal restoration.

In a statement, the Environmental Defense Fund's Eric Schwaab applauded Spinrad's nomination, saying that NOAA's workers "couldn't ask for a better leader to restore scientific integrity and honor the agency's mission."

Biden, whose administration has made climate action a central focus, has proposed the largest budget in NOAA's history — $6.9 billion, a $1.5 billion increase over the 2021 budget allocated by Congress. It remains to be seen whether Congress will agree to the increase.

This content is from Southern California Public Radio. View the original story at SCPR.org.

As search and rescue efforts at the site of the Surfside, Fla., condo collapse stretch into day nine, officials have said that the number of confirmed fatalities has risen to 20, while the number of people unaccounted for has dropped from 145 to 128.

Miami-Dade County Mayor Daniella Levine Cava told reporters Friday that one of the two fatalities recovered overnight was the 7-year-old daughter of a firefighter for the city of Miami.

"It goes without saying that every night since this last Wednesday has been immensely difficult for everybody, particularly the families that have been impacted," Levine Cava said. "But last night was truly different and more difficult for our first responders. These men and women are paying an enormous human toll each every day, and I ask that all of you please keep all of them in your thoughts and prayers."

"They truly represent the very best in all of us, and we need to be there for them as they are here for us," she said.

The number of people who have been accounted for has grown to 188, officials also confirmed Friday. In many cases, detectives followed leads regarding individuals who were unaccounted for but then reached them and discovered they were safe.

They even discovered additional family members who were safe and who could have been in the building, and added them to the tally of accounted for individuals.

Officials have not yet released the names of all of the dead and missing people, and asked Friday that the privacy of the families be respected.

This content is from Southern California Public Radio. View the original story at SCPR.org.

The Akshaya Patra Foundation reduced the process time taken from planning the menu to delivery to schools by using mobility solution and automation.

The Challenge is part of Small Steps to Health and Wealth�, a national Cooperative Extension program developed to motivate Americans to take action to simultaneously improve their health and personal finances. SSHW was built around a framework of 25 research-based behavior change strategies. The Challenge was originally developed in a �paper and pencil� format with printed worksheets and is now available online.

Children learn their habits, attitudes and beliefs from their parents and other caregivers, and that includes their willingness to try new and healthy foods. The American Dietetic Association and Catawba County Women, Infants, and Children (WIC) encourages adults to be good role models and teach children how to appreciate nutrition and enjoy healthful eating.

What if the August 23 earth tremors had been closer or stronger? Would you know what to do? Here are some tips from Catawba County Emergency Services.

The information was developed and compiled by the Children's Agenda Planning Committee, appointed by the Catawba County Board of Commissioners. The committee's vision is to ensure a safe community where all children are engaged, enriched and equipped to reach their full potential.

County employees in the first Leadership Academy recently helped families in transition through a Family Care Center project.

Synopsis of Catawba County Board of Commissioners meeting of December 16, 2013.

Police officers are perhaps the most visible faces of the law, and one of the few groups authorized to use force when dealing with the public. But despite the pivotal role that officers play in preventing and controlling crime, and in promoting justice, the science base is often inadequate regarding the value, fairness, and legitimacy of police practices and policies.

High schools that successfully engage students in learning have many things in common.

Many U.S. farmers who grow genetically engineered (GE) crops are realizing substantial economic and environmental benefits -- such as lower production costs, fewer pest problems, reduced use of pesticides, and better yields -- compared with conventional crops, says a new report from the National Research Council.

On average, Americans die sooner and experience higher rates of disease and injury than people in other high-income countries, says a new report from the National Research Council and Institute of Medicine.

Ovarian cancer should not be categorized as a single disease, but rather as a constellation of different cancers involving the ovary, yet questions remain on how and where various ovarian cancers arise, says a new congressionally mandated report from the National Academies of Sciences, Engineering, and Medicine.

An extensive study by the National Academies of Sciences, Engineering, and Medicine has found that new technologies in genetic engineering and conventional breeding are blurring the once clear distinctions between these two crop-improvement approaches.

Although there is widespread perception among the public and medical professionals that food allergy prevalence is on the rise, no study in the U.S. has been conducted with sufficient sample size and in various populations to determine the true prevalence of food allergies, and most studies likely overestimate the proportion of the population with this condition, says a new report from the National Academies of Sciences, Engineering, and Medicine.

The National Academies Committee on Genetically Engineered Crops - Past Experiences and Future Prospects authored an almost 600-page landmark report, released in May 2016. It was perhaps the most comprehensive analysis of genetically engineered crops to date.

The U.S. Department of Energy should place a higher priority on developing an accurate and actionable inventory of agency-owned or managed properties that can be leased or sold for energy development, says a new report from the National Academies of Sciences, Engineering, and Medicine.

Improved understanding of the coupled natural-human coastal system will help promote resilience of coastal communities and ecosystems under rapidly changing environmental conditions and support informed decision-making, says a new report from the National Academies of Sciences, Engineering, and Medicine.

The Gulf Research Program (GRP) of the National Academies of Sciences, Engineering, and Medicine is collaborating with the Sea Grant Oil Spill Science Outreach Program to convene a series of workshops aimed at improving community preparedness for future oil spills.

The Gulf Research Program of the National Academies of Sciences, Engineering, and Medicine today announced the recipients of its 2018 Science Policy Fellowships.

The Gulf Research Program of the National Academies of Sciences, Engineering, and Medicine today announced the recipients of its 2018 Early-Career Research Fellowships.

The Gulf Research Program (GRP) of the National Academies of Sciences, Engineering, and Medicine is now accepting applications for its Early-Career Research Fellowships and Science Policy Fellowships for 2019.

Renewed interest in exploration of the moon has the potential to benefit lunar science greatly and could evolve into a program facilitated by partnerships between commercial companies and NASA’s Science Mission Directorate (SMD), say companion reports by the National Academies of Sciences, Engineering, and Medicine.

The National Academies today released Criteria for Selecting the Leading Health Indicators for Healthy People 2030, the first of two reports that will help inform the development of Healthy People 2030 (HP2030).

The Gulf Research Program of the National Academies of Sciences, Engineering, and Medicine announced today the recipients of its 2019 Early-Career Research Fellowships.

In light of the present situation in the U.S., we believe that it is essential to explore a wide range of options for treating the increasing numbers of very ill patients with COVID-19 respiratory illness.

The Gulf Research Program of the National Academies of Sciences, Engineering, and Medicine today announced the 20 recipients of its 2020 Early-Career Research Fellowships.

Each year, more than 1.7 million adults in the United States develop sepsis, and 270,000 people die as a result. It’s a dangerous medical complication that occurs when an existing infection — such as pneumonia, a bladder infection, or a skin infection — triggers an extreme reaction throughout the body that can rapidly lead to tissue damage, organ failure, and even death.

Many high school seniors are rethinking their plans after they graduate because of the COVID-19 pandemic. Students are hesitant to commit to colleges if it means e-learning instead of the traditional classroom and on-campus experience.

Learning experiences in computing that are designed with attention to K-12 students’ interests, identities, and backgrounds may attract underrepresented groups to computing better than learning experiences that mimic current professional computing practices and culture do, says a new report from the National Academies of Sciences, Engineering, and Medicine.

The COVID-19 pandemic has presented a relatively rare situation in which the entire globe is grappling with the same crisis at the same time, albeit with widely varying approaches, resource levels, and political structures.

The U.S. surgeon general has released a public advisory calling misinformation a “serious threat to public health.” The National Academies have been addressing misinformation in health and science on multiple fronts and are taking steps to help cultivate a fact- and evidence-based information environment.

The COVID-19 pandemic and more frequent wildfires have highlighted the need for respiratory protection for the public and all types of workers, including essential and gig economy workers. A new report recommends frameworks to ensure both groups receive timely access to appropriate respiratory protective devices and guidance on their effective use.

The leaders of the national science academies of the United States, Ukraine, Poland, Denmark, Germany, the United Kingdom, and ALLEA have developed an action plan for the international science community to build a strong science, innovation, research, and training system in Ukraine.

The COVID-19 pandemic, wildfires, and other hazards have highlighted major gaps in the nation’s system for ensuring timely access to respirators and masks for the public and for many workers. A recent report and two webinars examined ways to fill these gaps.

The radio frequency spectrum is a natural resource that underpins all wireless activity. A new report assesses the likelihood of harmful interference from operating a radio network near GPS frequency bands, and considers approaches for evaluating concerns.

As the U.N. Climate Change Conference (COP27) approaches, a new report recommends steps to improve the accuracy and usability of greenhouse gas emissions information for decision-makers, including creating a global information clearinghouse.

To reduce racial disparities in the U.S. criminal justice system, policymakers at all levels should explore ways to decrease police stops and searches, jail detention, prison admission, and long sentences through coordinated policy reforms.

A new report identifies research and possible action steps that governments, nongovernmental and philanthropic organizations, universities, and the private sector can take to operationalize the United Nations Sustainable Development Goals.

Research funded by NIH that uses nonhuman primates is critical to the nation’s ability to respond adequately to public health emergencies and carry out high-impact biomedical research, but gaps in the systems that support research using these animal models are undermining national health emergency readiness.

ESET researchers discovered Arid Viper espionage campaigns spreading trojanized apps to Android users in Egypt and Palestine

What if your favorite dating, social media or gaming app revealed your exact coordinates to someone you’d rather keep at a distance?

Demystifying CVE-2024-7262 and CVE-2024-7263

CosmicBeetle, after improving its own ransomware, tries its luck as a RansomHub affiliate

Keep your cool, arm yourself with the right knowledge, and other tips for staying unshaken by fraudsters’ scare tactics

The world needs more cybersecurity professionals – here are three great ways to give you an ‘in’ to the ever-growing and rewarding security industry

ESET research dives deep into a series of attacks that leveraged bespoke toolsets to compromise air-gapped systems belonging to governmental and diplomatic entities