Homicide is the third leading cause of mortality in general population youth aged 15 to 29 years. Groups at greatest risk for early violent death (racial/ethnic minorities, males, poor persons, and urban youth) are overrepresented in the juvenile justice system.

We examined rates of and risk factors for firearm homicide and other causes of death in delinquents 16 years after detention. Our study analyzes gender differences; compares Hispanics, African Americans, and non-Hispanic whites; and includes a representative sample of delinquents. (Read the full article)

Total serum bilirubin levels ≥30 mg/dL have been labeled as "hazardous." Levels this high are rare, occurring in 3 to 10 per 100 000 births. Few studies have examined etiologies and long-term outcomes in these infants.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a major identifiable cause, but is under-assessed. Chronic, bilirubin-induced neurotoxicity is rare and only occurred in the setting of additional risk factors (prematurity, G6PD deficiency, sepsis) and at levels far above recommended exchange transfusion thresholds. (Read the full article)

Cancer continues to be the leading disease-related cause of death among children and adolescents in the United States. More information is needed about recent trends.

This study provides recent, robust data supporting the increasing incidence of pediatric thyroid cancer and rising overall cancer rates among African American children and adolescents and is the first study to describe increasing rates of pediatric renal carcinoma. (Read the full article)

Germ cell tumors in children are heterogeneous and rare neoplasms that occur in various locations, such as gonads, the central nervous system, and the pelvis. The incidence rate has been increasing in some countries.

Population-based analyses of germ cell tumors in children are rare. This population-based study describes the incidence rates, trends, and survival of germ cell tumors in German children from 1987 to 2011. (Read the full article)

Micronutrient deficiencies, including deficiencies of vitamin B-12 and folate, are common worldwide and may be a contributing factor to the estimated 165 million stunted children.

Routine supplementation of vitamin B-12 improved linear and ponderal growth in subgroups of young Indian children. We provide evidence that vitamin B-12 deficiency is a contributor to poor growth in low- and middle-income countries. (Read the full article)

Neonatal arterial ischemic stroke is associated with later cerebral palsy and cognitive impairment. Many studies on neonatal ischemic stroke are limited by modest sample sizes, and prospective studies that include outcomes assessments are scarce.

Results from this prospective, nationwide, population-based study provide information on the epidemiology, associated clinical variables, clinical manifestation, vascular distribution, and treatment of neonatal arterial ischemic stroke. The study also provides outcomes regarding motor function and cognition. (Read the full article)

More than a quarter of child deaths in the United Kingdom are estimated to have identifiable failures in care. Although children account for 40% of the family practice workload, little is known about iatrogenic harm to children in this setting.

This is the first analysis of nationally collected pediatric safety incident reports from family practice. To mitigate harm to children, priority areas requiring improvement include medication provision, referral of unwell children, provision of evidence-based treatment, and adequate diagnosis and assessment. (Read the full article)

Suboptimal brain development and increased risk of cognitive deficits are well documented in very low birth weight children. Supplementation with docosahexaenoic acid and arachidonic acid has been associated with positive cognitive effects.

This follow-up study of a randomized controlled trial of supplementation with docosahexaenoic acid and arachidonic acid to very low birth weight infants is the first report on both cognition and brain macrostructure measured with MRI. No cognitive or neuroanatomical effects were detected at 8 years. (Read the full article)

Street youth demonstrate elevated mortality compared with the general adolescent and young adult population. Suicide is a leading cause of death among street youth. Many street youth have experienced childhood maltreatment, including abuse and neglect.

In this prospective cohort of street youth, self-reported attempted suicide and history of childhood maltreatment were common. Individuals who experienced childhood physical abuse, emotional abuse, or emotional neglect were at highest risk of attempting suicide. (Read the full article)

Embryonal tumors occur almost exclusively in children. The group is heterogeneous and includes relatively common pediatric tumors as well as rare tumors. The incidence rate for hepatoblastoma has been increasing in some countries.

This population-based study is the first comprehensive study on embryonal tumors in German children. Incidence rates, trends, and survival for 1991 through 2012 are presented. A statistically significant increasing trend for hepatoblastoma was detected for the first time in Europe. (Read the full article)

De novo mutations of the sodium channel gene SCN1A are the major cause of Dravet syndrome, an infantile-onset epileptic encephalopathy. The incidence of this genetic disorder in the United States is unclear.

Dravet syndrome due to SCN1A mutation is twice as common in the United States as previously thought. Genetic testing should be considered in children with ≥2 prolonged febrile seizures by 1 year of age. (Read the full article)

Pediatric autoimmune hepatitis is an uncommon condition; children and youth can present with a diverse and insidious clinical course and biochemical features. Response to treatment is generally good, and transplantation is rarely needed.

This population-based study adds knowledge regarding the incidence of pediatric autoimmune hepatitis in Canada, as well as a description of diagnostic and therapeutic approaches among centers. Long-term outcomes are also described. (Read the full article)

It was far too easy to accidentally start an app subscription if you own an iPhone with Touch ID. Apple just solved the problem with a pop-up.

Peroxidases are a group of heterogeneous family of enzyme that plays diverse biological functions. Ascorbate peroxidase is a redox enzyme that is reduced by trypanothione, which plays a central role in the redox defence system of Leishmania. In view of developing new and novel therapeutics, we have performed in silico studies in order to search for ligand library and identification of new drug candidates and its physiological role against promastigotes and intracellular amastigotes of Leishmania donovani. Our results demonstrated that the selected inhibitor ZINC96021026 has significant anti-leishmanial effect and effectively killed both free and intracellular forms of the parasite. ZINC96021026 was found to be identical to ML-240, a selective inhibitor of Valosin-containing protein (VCP) or p97, a member of AAA-ATPase protein family which was derived from the scaffold of DBeQ, targeting the D2-ATPase domain of the enzyme. ZINC96021026 (ML-240) thus have broad range of cellular functions, thought to be derived from its ability to unfold proteins or disassemble protein complexes besides inhibiting the ascorbate peroxidase activity. ML-240 may inhibits the parasite's ascorbate peroxidase leading to extensive apoptosis and inducing generation of reactive oxygen species. Taken together, our results demonstrated that ML-240 could be an attractive therapeutic option for treatment against leishmaniasis.

In number 10 in our countdown, I tried to offer a few thoughts to funders as they embraced new agendas and looked to avoid repeating yesterday's missteps.

Russell B. Toomey
Oct 1, 2018; 142:e20174218-e20174218
ARTICLES

A man renews his decision to follow Christ after chatting with a volunteer during an OM flash mob in a busy area of Santiago.

A Sussex County Judge has found a Millsboro man guilty of murder. On November 17, 2016, a passerby discovered Darrin Gibbs of Millsboro lying face down on Monroe Street with a gunshot wound to the back of his head. Witness testimony, ballistics evidence, and video surveillance ultimately identified one of Gibbs’ associates, A.J. McMullen, as […]

India has decided to not to join RCEP trade deal as it did not address the key concerns. It is being told that the decision has been taken for farmers and smaller entreprenuers. Congress was trying to corner BJP on this but now the news is out from Thailand

India has decided to not to join RCEP trade deal as it did not address the key concerns. It is being told that the decision has been taken for farmers and smaller entreprenuers. Congress was trying to corner BJP on this but now the news is out from Thailand

A 35-year old Indian woman, who was five months pregnant, was founded murdered in her apartment and her husband was found dead in an apparent suicide in the Hudson River near here, authorities said.

The death of a Dubai-based Indian industrialist, who died after falling from a high-rise building last week, was a case of suicide over financial problems, police confirmed after an investigation,...

They had started their journey on foot from Maharashtra hoping to reach Madhya Pradesh, but it was their bodies that reached their home districts of Shahdol and Umaria by special trains on Saturday...

Punjab cabinet ministers today walked out of a meeting with bureaucrats to decide a new excise policy, sources said. Finance Minister Manpreet Badal had an argument with Chief Secretary Karan Avatar...

Delaware residents should ask pesticide contractors for their state pesticide business license information before hiring them, state agricultural officials advise. "Spring and summer are a busy season for pesticide applicators, as many people get their lawns spruced up," said Dave Pyne, pesticides administrator for the Department of Agriculture. "We want homeowners to know that all pesticide applicators in Delaware should be licensed and certified, which ensures everyone is working by approved standards."

Delaware growers are the first on the East Coast able to take advantage of a new online tool that helps protect sensitive crops from pesticides that may drift due to wind or weather. Delaware is the newest participant in the DriftWatch program, which allows growers of certain crops or commercial beekeepers to alert pesticide applicators of sensitive areas before they spray.

In the scam, the homeowner is told that they must leave their house for a period of twelve hours while the individual sprays crops in the nearby vicinity. There are some indicators that these visits are a scam in an attempt to get the homeowner to leave their house unattended. There are currently no agricultural pesticide spraying practices in Delaware that would require one to leave their home.

DOVER, Del. – The Delaware Department of Agriculture is urging all pesticide applicators that plan to use dicamba this growing season to check the U.S. Environmental Protection Agency’s (EPA) online Bulletins Live! Two system on a monthly basis before spraying. This new online system allows agriculture and other pesticide users to easily determine where pesticide […]

Executive Order creates commission focused on reentry reform, and new office at DOC to oversee implementation WILMINGTON, Del. – Governor John Carney on Tuesday signed Executive Order #27, which focuses on improving reentry procedures for incarcerated individuals in Delaware. The Executive Order creates a commission focused on reentry reform, policies, and procedures, with a goal […]

A public meeting will be held at p.m. Thursday, Dec. 20 at McCullough Middle School, 20 Chase Avenue, New Castle, DE 19720 to discuss Croda’s Nov. 25 accidental ethylene oxide release, with the meeting organized by the Department of Natural Resources and Environmental Control (DNREC) and facilitated by the Delaware Emergency Management Agency (DEMA)

Road mishaps cost India 3-5% of its gross domestic product every year. India amounts to one percent of the vehicles across the world, yet it contributes almost 6% of the road fatalities on the road.

140 people died while 600 accidents were recorded on Indian roads amid the nationwide lockdown. Many of them were migrant labourers returning home

The Covid-19 pandemic has dealt a severe blow to the already grounded and insolvent Jet Airways. About 40 people who were a part of Jet’s asset preservation team were let go earlier this week.

Life insurance claims to the extent of basic sum assured if policyholder dies due to infection by the corona virus is admissible.

The therapy involves taking antibodies from the blood of a person who has recovered from COVID-19 and transfusing those antibodies into an active coronavirus patient to help kickstart the immune system.