cl Soccer: Bundesliga return includes Dortmund on May 16, Bayern Munich, May 17 By www.upi.com Published On :: Thu, 07 May 2020 11:22:58 -0400 The German Bundesliga released its full soccer schedule Thursday after German officials announced that the league is allowed to resume games after they were suspended due to the coronavirus pandemic. Full Article
cl Weekend live sports include UFC 249, 14 baseball games in Asia By www.upi.com Published On :: Fri, 08 May 2020 03:00:10 -0400 UFC 249 will be sandwiched between 14 live baseball broadcasts out of South Korea and Taiwan this weekend for American sports fans to watch as they wait for major sports leagues to return. Full Article
cl International Classification of Diseases, 10th Revision, Coding for Diabetes By clinical.diabetesjournals.org Published On :: 2017-10-01 Joy DuganOct 1, 2017; 35:232-238Practical Pointers Full Article
cl A Review of the Pathophysiology, Classification, and Treatment of Foot Ulcers in Diabetic Patients By clinical.diabetesjournals.org Published On :: 2009-03-01 Warren ClaytonMar 1, 2009; 27:52-58Features Full Article
cl Clinical Outcomes in Patients With Isolated or Combined Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State: A Retrospective, Hospital-Based Cohort Study By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE Many patients with hyperglycemic crises present with combined features of diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). The implications of concomitant acidosis and hyperosmolality are not well known. We investigated hospital outcomes in patients with isolated or combined hyperglycemic crises. RESEARCH DESIGN AND METHODS We analyzed admissions data listing DKA or HHS at two academic hospitals. We determined 1) the frequency distributions of HHS, DKA, and combined DKA-HHS (DKA criteria plus elevated effective osmolality); 2) the relationship of markers of severity of illness and clinical comorbidities with 30-day all-cause mortality; and 3) the relationship of hospital complications associated with insulin therapy (hypoglycemia and hypokalemia) with mortality. RESULTS There were 1,211 patients who had a first admission with confirmed hyperglycemic crises criteria, 465 (38%) who had isolated DKA, 421 (35%) who had isolated HHS, and 325 (27%) who had combined features of DKA-HHS. After adjustment for age, sex, BMI, race, and Charlson Comorbidity Index score, subjects with combined DKA-HHS had higher in-hospital mortality compared with subjects with isolated hyperglycemic crises (adjusted odds ratio [aOR] 2.7; 95% CI 1.4, 4.9; P = 0.0019). In all groups, hypoglycemia (<40 mg/dL) during treatment was associated with a 4.8-fold increase in mortality (aOR 4.8; 95% CI 1.4, 16.8). Hypokalemia ≤3.5 mEq/L was frequent (55%). Severe hypokalemia (≤2.5 mEq/L) was associated with increased inpatient mortality (aOR 4.9; 95% CI 1.3, 18.8; P = 0.02). CONCLUSIONS Combined DKA-HHS is associated with higher mortality compared with isolated DKA or HHS. Severe hypokalemia and severe hypoglycemia are associated with higher hospital mortality in patients with hyperglycemic crises. Full Article
cl Watch: Utah man reunited with class ring 38 years after it was lost in Germany By www.upi.com Published On :: Thu, 07 May 2020 15:42:56 -0400 A Utah man who lost his high school class ring in Germany in 1982 was reunited with the ring thanks to a man who found it on a beach in the United States. Full Article
cl Evidence-Informed Clinical Practice Recommendations for Treatment of Type 1 Diabetes Complicated by Problematic Hypoglycemia By care.diabetesjournals.org Published On :: 2015-06-01 Pratik ChoudharyJun 1, 2015; 38:1016-1029Type 1 Diabetes at a Crossroads Full Article
cl Lipid and Inflammatory Cardiovascular Risk Worsens Over 3 Years in Youth With Type 2 Diabetes: The TODAY clinical trial By care.diabetesjournals.org Published On :: 2013-06-01 TODAY Study GroupJun 1, 2013; 36:1758-1764TODAY Study Full Article
cl Day and Night Home Closed-Loop Insulin Delivery in Adults With Type 1 Diabetes: Three-Center Randomized Crossover Study By care.diabetesjournals.org Published On :: 2014-07-01 Lalantha LeelarathnaJul 1, 2014; 37:1931-1937Emerging Technologies and Therapeutics Full Article
cl Feasibility of Outpatient Fully Integrated Closed-Loop Control: First studies of wearable artificial pancreas By care.diabetesjournals.org Published On :: 2013-07-01 Boris P. KovatchevJul 1, 2013; 36:1851-1858Diabetes Care Symposium Full Article
cl Overnight Closed-Loop Insulin Delivery in Young People With Type 1 Diabetes: A Free-Living, Randomized Clinical Trial By care.diabetesjournals.org Published On :: 2014-05-01 Roman HovorkaMay 1, 2014; 37:1204-1211Advances in Artificial Pancreas Development Full Article
cl Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range By care.diabetesjournals.org Published On :: 2019-08-01 Tadej BattelinoAug 1, 2019; 42:1593-1603International Consensus Report Full Article
cl Rapid Rise in Hypertension and Nephropathy in Youth With Type 2 Diabetes: The TODAY clinical trial By care.diabetesjournals.org Published On :: 2013-06-01 TODAY Study GroupJun 1, 2013; 36:1735-1741TODAY Study Full Article
cl Standardizing Clinically Meaningful Outcome Measures Beyond HbA1c for Type 1 Diabetes: A Consensus Report of the American Association of Clinical Endocrinologists, the American Association of Diabetes Educators, the American Diabetes Association, the Endo By care.diabetesjournals.org Published On :: 2017-12-01 Gina AgiostratidouDec 1, 2017; 40:1622-1630Continuous Glucose Monitoring and Risk of Hypoglycemia Full Article
cl Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010 By care.diabetesjournals.org Published On :: 2012-07-01 Franca B. BartonJul 1, 2012; 35:1436-1445Diabetes Care Symposium Full Article
cl Undiagnosed NIDDM: Clinical and Public Health Issues By care.diabetesjournals.org Published On :: 1993-04-01 Maureen I HarrisApr 1, 1993; 16:642-652Kelly West Lecture 1992 Full Article
cl Evaluating Clinical Accuracy of Systems for Self-Monitoring of Blood Glucose By care.diabetesjournals.org Published On :: 1987-09-01 William L ClarkeSep 1, 1987; 10:622-628Technical Article Full Article
cl Current State of Type 1 Diabetes Treatment in the U.S.: Updated Data From the T1D Exchange Clinic Registry By care.diabetesjournals.org Published On :: 2015-06-01 Kellee M. MillerJun 1, 2015; 38:971-978Type 1 Diabetes at a Crossroads Full Article
cl Bank of England: British economy could decline 14 percent By www.upi.com Published On :: Thu, 07 May 2020 07:29:45 -0400 A Bank of England report said Thursday the British economy could fall as much as 14 percent this year, which would be its worst showing in more than 300 years. Full Article
cl South Korea sees new cluster of COVID-19 cases tied to nightclubs By www.upi.com Published On :: Fri, 08 May 2020 07:16:30 -0400 Just days after South Korea loosened its social distancing guidelines, a new COVID-19 cluster of infections has sprung up in the capital city of Seoul tied to several nightclubs. Full Article
cl U.S. Navy ships, trailed by Russia, visit Barents Sea above Arctic Circle By www.upi.com Published On :: Mon, 04 May 2020 13:35:28 -0400 U.S. Navy ships on Monday entered the Barents Sea between Norway and Russia, for the first time since the 1980s, "to assert freedom of navigation and demonstrate seamless integration among allies," the U.S. Navy said. Full Article
cl PIONEER 1: Randomized Clinical Trial of the Efficacy and Safety of Oral Semaglutide Monotherapy in Comparison With Placebo in Patients With Type 2 Diabetes By care.diabetesjournals.org Published On :: 2019-09-01 Vanita R. ArodaSep 1, 2019; 42:1724-1732Emerging Therapies: Drugs and Regimens Full Article
cl Disclosures: Standards of Medical Care in Diabetes--2020 By care.diabetesjournals.org Published On :: 2020-01-01 Jan 1, 2020; 43:S205-S206Disclosures Full Article
cl The Pathophysiology of Hyperglycemia in Older Adults: Clinical Considerations By care.diabetesjournals.org Published On :: 2017-04-01 Pearl G. LeeApr 1, 2017; 40:444-452Emerging Science and Concepts for Management of Diabetes and Aging Full Article
cl Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range By care.diabetesjournals.org Published On :: 2019-08-01 Tadej BattelinoAug 1, 2019; 42:1593-1603International Consensus Report Full Article
cl Redefining Hypoglycemia in Clinical Trials: Validation of Definitions Recently Adopted by the American Diabetes Association/European Association for the Study of Diabetes By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE To determine if the International Hypoglycaemia Study Group (IHSG) level 2 low glucose definition can identify clinically relevant hypoglycemia in clinical trials and offer value as an end point for future trials. RESEARCH DESIGN AND METHODS A post hoc analysis was performed of the SWITCH (SWITCH 1: n = 501, type 1 diabetes; SWITCH 2: n = 721, type 2 diabetes) and DEVOTE (n = 7,637, type 2 diabetes) trials utilizing the IHSG low glucose definitions. Patients in all trials were randomized to either insulin degludec or insulin glargine 100 units/mL. In the main analysis, the following definitions were compared: 1) American Diabetes Association (ADA) 2005 (plasma glucose [PG] confirmed ≤3.9 mmol/L with symptoms); and 2) IHSG level 2 (PG confirmed <3.0 mmol/L, independent of symptoms). RESULTS In SWITCH 2, the estimated rate ratios of hypoglycemic events indicated increasing differences between treatments with decreasing PG levels until 3.0 mmol/L, following which no additional treatment differences were observed. Similar results were observed for the SWITCH 1 trial. In SWITCH 2, the IHSG level 2 definition produced a rate ratio that was lower than the ADA 2005 definition. CONCLUSIONS The IHSG level 2 definition was validated in a series of clinical trials, demonstrating its ability to discriminate between basal insulins. This definition is therefore recommended to be uniformly adopted by regulatory bodies and used in future clinical trials. Full Article
cl Vasodilatory Actions of Glucagon-Like Peptide 1 Are Preserved in Skeletal and Cardiac Muscle Microvasculature but Not in Conduit Artery in Obese Humans With Vascular Insulin Resistance By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE Obesity is associated with microvascular insulin resistance, which is characterized by impaired insulin-mediated microvascular recruitment. Glucagon-like peptide 1 (GLP-1) recruits skeletal and cardiac muscle microvasculature, and this action is preserved in insulin-resistant rodents. We aimed to examine whether GLP-1 recruits microvasculature and improves the action of insulin in obese humans. RESEARCH DESIGN AND METHODS Fifteen obese adults received intravenous infusion of either saline or GLP-1 (1.2 pmol/kg/min) for 150 min with or without a euglycemic insulin clamp (1 mU/kg/min) superimposed over the last 120 min. Skeletal and cardiac muscle microvascular blood volume (MBV), flow velocity and blood flow, brachial artery diameter and blood flow, and pulse wave velocity (PWV) were determined. RESULTS Insulin failed to change MBV or flow in either skeletal or cardiac muscle, confirming the presence of microvascular insulin resistance. GLP-1 infusion alone increased MBV by ~30% and ~40% in skeletal and cardiac muscle, respectively, with no change in flow velocity, leading to a significant increase in microvascular blood flow in both skeletal and cardiac muscle. Superimposition of insulin to GLP-1 infusion did not further increase MBV or flow in either skeletal or cardiac muscle but raised the steady-state glucose infusion rate by ~20%. Insulin, GLP-1, and GLP-1 + insulin infusion did not alter brachial artery diameter and blood flow or PWV. The vasodilatory actions of GLP-1 are preserved in both skeletal and cardiac muscle microvasculature, which may contribute to improving metabolic insulin responses and cardiovascular outcomes. CONCLUSIONS In obese humans with microvascular insulin resistance, GLP-1’s vasodilatory actions are preserved in both skeletal and cardiac muscle microvasculature, which may contribute to improving metabolic insulin responses and cardiovascular outcomes. Full Article
cl A Multinational, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Efficacy of Cyclical Topical Wound Oxygen (TWO2) Therapy in the Treatment of Chronic Diabetic Foot Ulcers: The TWO2 Study By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE Topical oxygen has been used for the treatment of chronic wounds for more than 50 years. Its effectiveness remains disputed due to the limited number of robust high-quality investigations. The aim of this study was to assess the efficacy of multimodality cyclical pressure Topical Wound Oxygen (TWO2) home care therapy in healing refractory diabetic foot ulcers (DFUs) that had failed to heal with standard of care (SOC) alone. RESEARCH DESIGN AND METHODS Patients with diabetes and chronic DFUs were randomized (double-blind) to either active TWO2 therapy or sham control therapy—both in addition to optimal SOC. The primary outcome was the percentage of ulcers in each group achieving 100% healing at 12 weeks. A group sequential design was used for the study with three predetermined analyses and hard stopping rules once 73, 146, and ultimately 220 patients completed the 12-week treatment phase. RESULTS At the first analysis point, the active TWO2 arm was found to be superior to the sham arm, with a closure rate of 41.7% compared with 13.5%. This difference in outcome produced an odds ratio (OR) of 4.57 (97.8% CI 1.19, 17.57), P = 0.010. After adjustment for University of Texas Classification (UTC) ulcer grade, the OR increased to 6.00 (97.8% CI 1.44, 24.93), P = 0.004. Cox proportional hazards modeling, also after adjustment for UTC grade, demonstrated >4.5 times the likelihood to heal DFUs over 12 weeks compared with the sham arm with a hazard ratio of 4.66 (97.8% CI 1.36, 15.98), P = 0.004. At 12 months postenrollment, 56% of active arm ulcers were closed compared with 27% of the sham arm ulcers (P = 0.013). CONCLUSIONS This sham-controlled, double-blind randomized controlled trial demonstrates that, at both 12 weeks and 12 months, adjunctive cyclical pressurized TWO2 therapy was superior in healing chronic DFUs compared with optimal SOC alone. Full Article
cl Time Course of Normalization of Functional {beta}-Cell Capacity in the Diabetes Remission Clinical Trial After Weight Loss in Type 2 Diabetes By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To assess functional β-cell capacity in type 2 diabetes during 2 years of remission induced by dietary weight loss. RESEARCH DESIGN AND METHODS A Stepped Insulin Secretion Test with Arginine was used to quantify functional β-cell capacity by hyperglycemia and arginine stimulation. Thirty-nine of 57 participants initially achieved remission (HbA1c <6.5% [<48 mmol/mol] and fasting plasma glucose <7 mmol/L on no antidiabetic drug therapy) with a 16.4 ± 7.7 kg weight loss and were followed up with supportive advice on avoidance of weight regain. At 2 years, 20 participants remained in remission in the study. A nondiabetic control (NDC) group, matched for age, sex, and weight after weight loss with the intervention group, was studied once. RESULTS During remission, median (interquartile range) maximal rate of insulin secretion increased from 581 (480–811) pmol/min/m2 at baseline to 736 (542–998) pmol/min/m2 at 5 months, 942 (565–1,240) pmol/min/m2 at 12 months (P = 0.028 from baseline), and 936 (635–1,435) pmol/min/m2 at 24 months (P = 0.023 from baseline; n = 20 of 39 of those initially in remission). This was comparable to the NDC group (1,016 [857–1,507] pmol/min/m2) by 12 (P = 0.064) and 24 (P = 0.244) months. Median first-phase insulin response increased from baseline to 5 months (42 [4–67] to 107 [59–163] pmol/min/m2; P < 0.0001) and then remained stable at 12 and 24 months (110 [59–201] and 125 [65–166] pmol/min/m2, respectively; P < 0.0001 vs. baseline) but lower than that of the NDC group (250 [226–429] pmol/min/m2; P < 0.0001). CONCLUSIONS A gradual increase in assessed functional β-cell capacity occurred after weight loss, becoming similar to that of NDC group participants by 12 months. This result was unchanged at 2 years with continuing remission of type 2 diabetes. Full Article
cl “Cubicle Activism”: Companies Face Growing Demands from Workers to Cut Ties with ICE and Others in Immigration Arena By www.migrationpolicy.org Published On :: Tue, 29 Oct 2019 16:24:30 -0400 From online petitions to organized walkouts, corporate America is facing increasing employee activism over its business involvement with agencies implementing the federal government's immigration policies. This "cubicle activism," seen at companies ranging from Amazon and Google to Bank of America and Wayfair, has garnered mixed success to date, forcing divestiture from private prison contractors but fewer results in other contexts, as this article explores. Full Article
cl HHS releases video tutorial for searching list of excluded individuals/entities By www.ada.org Published On :: Thu, 09 Jan 2020 10:12:00 -0600 The Department of Health and Human Services released Nov. 25 a five-minute video explaining how to search its list of excluded individuals and entities, called LEIE. Full Article
cl Texas A&M dental school opens new clinic, education building By www.ada.org Published On :: Tue, 21 Jan 2020 10:14:00 -0600 Texas A&M College of Dentistry announced Jan. 17 it opened it’s a new 160,000-square-foot, nine-story clinic, which enables the dental school to increase underserved patients’ access to care. Full Article
cl ADA House rescinds The Dentist’s Prayer, amends recognition of religious diversity policy to be more inclusive By www.ada.org Published On :: Mon, 27 Jan 2020 10:37:00 -0600 In an effort to advance the Association’s diversity and inclusion efforts, the ADA House of Delegates voted at its meeting in September to rescind the policy titled “The Dentist’s Prayer,” used by some state and local dental societies during their meetings, and amend its policy on recognition of religious diversity. Full Article
cl Study clubs ‘enhance the level of care provided’ By www.ada.org Published On :: Wed, 29 Jan 2020 12:01:00 -0600 The Duluth Dental Forum in northeastern Minnesota celebrated its 75th anniversary in late 2019, stating that it was the second-oldest study club of its kind in the United States. Full Article
cl CDC reminds clinicians to use standard precautions, recommends isolating patients with coronavirus symptoms By www.ada.org Published On :: Fri, 07 Feb 2020 13:41:00 -0600 In light of the “emerging, rapidly evolving” outbreak of the novel coronavirus 2019-nCoV, the Centers for Disease Control and Prevention is reminding clinicians to use standard precautions consistently and advising they isolate patients who show signs and symptoms of the virus. Full Article
cl Phishing email claims to be from ADA president By www.ada.org Published On :: Mon, 02 Mar 2020 17:04:00 -0600 At least one American Dental Association member has reported receiving a phishing email appearing to come from an address containing ADA President Chad P. Gehani's name and including a link to "view member's details." Full Article
cl ADA seeks clarification from HHS regarding chief dental officer By www.ada.org Published On :: Fri, 06 Mar 2020 14:50:00 -0600 The American Dental Association is applauding the U.S. Department of Health and Human Services’ decision to appoint a chief dental officer at the Centers for Medicare & Medicaid but would like to confirm the position is exclusive to CMS. Full Article
cl Study: Evidence does not support classifying fluoride as cognitive neurodevelopmental hazard By www.ada.org Published On :: Tue, 10 Mar 2020 09:53:00 -0500 The National Academies of Sciences, Engineering, and Medicine announced March 5 that it does not find that the National Toxicology Program adequately supported its conclusion that fluoride is “presumed” to be a cognitive neurodevelopmental hazard to humans. Full Article
cl Connecticut Foundation for Dental Outreach postpones Mission of Mercy dental clinic amid coronavirus concerns By www.ada.org Published On :: Tue, 10 Mar 2020 15:36:00 -0500 The Connecticut Foundation for Dental Outreach has postponed the Connecticut Mission of Mercy Free Dental Clinic scheduled for March 20-21 in Danbury, Connecticut, "out of abundant caution" amid the coronavirus disease outbreak. Full Article
cl ADA to Congress: Include dentists, patients in coronavirus legislation By www.ada.org Published On :: Fri, 13 Mar 2020 12:44:00 -0500 The American Dental Association is urging Congress to include oral health care providers and their patients in any legislation proposed to confront the coronavirus disease outbreak. Full Article
cl ADA asks Treasury Department, Small Business Administration to clarify intent of interim rule By www.ada.org Published On :: Sun, 05 Apr 2020 11:09:00 -0500 The Association continues to wait for clear guidance from the U.S. Department of Treasury and Small Business Administration on the best way to help dentists considering applying for Paycheck Protection Program 7(a) loans and Economic Injury Disaster Loans. Full Article
cl New clinical dental licensure examination to launch in June By www.ada.org Published On :: Mon, 06 Apr 2020 08:46:00 -0500 The Dental Licensure Objective Structured Clinical Examination, or DLOSCE, is expected to launch in June, the Joint Commission on National Dental Examinations announced April 2. Full Article
cl Chicago Dental Society donates thousands of supplies to dental school clinic, health care facilities By www.ada.org Published On :: Thu, 16 Apr 2020 10:49:00 -0500 The Chicago Dental Society and its members donated thousands of personal protective equipment to front-line health care workers in response to the COVID-19 pandemic. Full Article
cl ADA, others ask lawmakers to include nonprofits in COVID-19 legislation By www.ada.org Published On :: Thu, 23 Apr 2020 10:52:00 -0500 As Congress works on the next coronavirus-related relief package, the ADA and 37 other health care organizations are asking lawmakers to support nonprofit groups in those efforts. Full Article
cl ADA asks FCC to include dentists in COVID-19 Telehealth Program By www.ada.org Published On :: Mon, 27 Apr 2020 15:17:00 -0500 The ADA is asking the Federal Communications Commission to extend the agency’s COVID-19 Telehealth Program to include dental practices regardless of the practice’s size, location or for-profit status. Full Article
cl ADASRI manuscript wins 2020 William J. Gies Award in clinical research By www.ada.org Published On :: Mon, 04 May 2020 13:19:00 -0500 A manuscript authored by the American Dental Association Science & Research Institute and Council on Scientific Affairs won the 2020 William J. Gies Award in clinical research from the American and International Associations for Dental Research. Full Article
cl PracticeUpdate Clinical Dentistry Channel unveiled to keep dentists current By www.ada.org Published On :: Mon, 04 May 2020 16:03:00 -0500 The ADA announced May 1 the creation and launch of the PracticeUpdate Clinical Dentistry Channel, which delivers free evidence-based clinical content in general dentistry and specialty topics curated by a world-renowned editorial and advisory board. Full Article
cl UCLA dental school researchers create nanoparticle that could improve bone defect treatment By www.ada.org Published On :: Tue, 05 May 2020 10:25:00 -0500 A team of researchers at the University of California, Los Angeles School of Dentistry has developed a nanoparticle that could improve treatment for bone defects. Full Article
cl ADA tip sheet includes CDC guidance on identifying counterfeit N95 masks By www.ada.org Published On :: Thu, 07 May 2020 15:25:00 -0500 The American Dental Association has created a tip sheet with guidance from the National Institute for Occupational Safety and Health group at the Centers for Disease Control and Prevention to help health care professionals avoid buying or using counterfeit N95 respirators, which are often simply referred to as masks. Full Article
cl Dow, Total part of group that raised $1B to clean plastic in ocean By www.upi.com Published On :: Wed, 16 Jan 2019 08:18:54 -0500 Some 30 companies including Dow, Total and other big makers of plastic raised $1 billion to contribute to cleaner ocean waters. Full Article
