cl The UK's Decision to Leave the EU: What Next for UK Energy and Climate? By feedproxy.google.com Published On :: Wed, 29 Jun 2016 12:00:01 +0000 Invitation Only Research Event 12 July 2016 - 3:00pm to 6:30pm Chatham House, London In May 2016, Chatham House published a research paper that assessed the options for the UK’s climate and energy policy in the event of a British vote to leave the EU. It determined that:The UK’s energy market is deeply integrated with that of its European neighbours and that it would be neither possible nor desirable to ‘unplug’ the UK from Europe’s energy networks. A degree of continued adherence to EU market regulations, energy efficiency standards of appliances, environmental and governance rules would be inevitable. The EU’s collective negotiation on international climate issues has given the UK greater political weight than any member state has alone.The EU’s coordinated approach in engaging with major fossil fuel producers such as Russia and countries in the Middle East has helped support price stability and security of supply, including through infrastructure investment to make existing pipeline systems more efficient and improve storage and capacity. In light of the decision to leave, Chatham House is hosting a roundtable to reassess the options for a future UK-EU energy and climate change partnership. The meeting will bring together those experienced on UK and EU policy in both climate change and energy and explore the short and medium-term climate and energy policy considerations. Attendance at this event is by invitation only. Department/project Energy, Environment and Resources Programme Owen Grafham Manager, Energy, Environment and Resources Programme +44 (0)20 7957 5708 Email Full Article
cl Security and Climate Change: Are we Living in 'The Age of Consequences'? By feedproxy.google.com Published On :: Fri, 11 Nov 2016 14:23:00 +0000 Research Event 1 December 2016 - 7:00pm to 9:00pm Chatham House, London Event participants Brigadier General Stephen A. Cheney, CEO, American Security Project; Member, Foreign Affairs Policy Board, US Department of StateMajor General Munir Muniruzzaman, President and CEO, Bangladesh Institute of Peace and Security Studies; Former Military Advisor to the President of Bangladesh Rear Admiral Neil Morisetti, Director of Strategy, UK Department of Science, Technology, Engineering and Public Policy; University College London; Former UK Government Climate and Energy Security EnvoyDr Patricia Lewis, Research Director, International Security, Chatham HouseChair: Rt Hon Sir Oliver Letwin MP, Former UK Cabinet Office Minister The US Department of Defense regards climate change as an ‘accelerant of instability and conflict’. A former head of the US Pacific Command described it as the most significant long-term security threat in his region. US federal agencies have recently been mandated to fully consider the impacts of climate change in the development of national security policy. This step-change in the US approach reflects the Pentagon’s conclusion that climate impacts are a ‘threat multiplier’ for security concerns – not just for the future – but which pose ‘an immediate risk to national security’.A new documentary from the US, The Age of Consequences, explores the links between climate change and security, including in current events in Syria, Egypt, the Sahel and Bangladesh. Our high-level panel will reflect on key sections from the documentary, which will be screened during the event, and explore whether security strategists, militaries and policy-makers in nations other than the US are fully cognisant of the risks posed by a changing climate, and whether they are ready to anticipate and respond to its potentially destabilizing effects.The panel discussion will be followed by a Q&A.THIS EVENT IS NOW FULL AND REGISTRATION HAS CLOSED. Department/project Energy, Environment and Resources Programme Full Article
cl The Climate vs. Donald Trump By feedproxy.google.com Published On :: Fri, 18 Nov 2016 11:49:29 +0000 19 November 2016 Rob Bailey Former Research Director, Energy, Environment and Resources @ClimateRob All countries stand to lose if the US backslides on climate change, most of all the US. 2016-11-19-COP22.jpg Outside the COP22 Climate Change Conference in Marrakech. Photo by Getty Images. On 7 November, as governments reconvened in Marrakech for the first major round of climate talks since the momentous Paris summit, they had the wind in their sails. The sense of momentum that had built in the run-up to Paris had continued, with recent global deals to phase out HFCs (potent greenhouse gases used in refrigeration and air conditioning) and tackle emissions from aviation. However, by the morning of 9 November the mood changed to one of unease and trepidation, as news of Donald Trump’s US election victory sunk in. Only days after entering into force, the Paris Agreement was faced with the possibility of the world’s second largest emitter, and a key dealmaker and architect of the regime, withdrawing.Although details of Trump’s positions on climate and energy policy are scarce, his statements on the campaign trail appear to signal a marked departure from the Obama administration’s approach. The president-elect has said he would ‘cancel’ the Paris Agreement and ‘rescind’ the Climate Action Plan which underpins US action to reduce emissions. On the basis of these statements, it is hard to view the election result as anything other than a major setback for the climate. The new international climate regime now faces a very early and very big test.Paris’s first testThe response from governments has been swift. Statement after statement emphasized a clear and consistent message: countries remain committed to the Paris Agreement and to delivering their emissions reductions. While there is hope that the US will remain a part, the message was that the process will continue regardless. Importantly, there have as yet been no indications that recusant parties to the agreement might use a US withdrawal as cover to do the same.This display of unity is arguably Marrakech’s defining success. Progress in talks to flesh out the so-called ‘rulebook’ for how the Paris Agreement will operate come 2020 was modest in some areas and disappointing in others; on finance, the perennial tensions between developed and developing countries were as clear as ever. But when the time came to uphold the nascent regime in the face of a threat, powerful international norms on climate action meant there were no divisions.Two important questionsThe prospect of US disengagement from the international regime, whether de jure or de facto, raises two important questions: one for the US and another for the rest of the world.For the international community, the question is one of leadership. In the run-up to Paris, the US and China together set expectations for a global agreement, signalling their intent through a series of joint announcements that set the bar for ambition and carried other countries with them. Progressive countries hoped this partnership would re-emerge in 2018, when talks begin on closing the gap between national emission reduction plans and what is needed to achieve the Paris goal of containing warming ‘well below’ 2°C. A wholesale step change in ambition is required if the 2°C goal is to remain within reach, requiring intense climate diplomacy of the kind witnessed before Paris. Will China be prepared to unilaterally set the pace and raise ambition first? Will a new partner come forward, or new coalition emerge, to fill the vacuum left by the US and work alongside China to provide leadership?The US faces a question of national interest. With the rest of the world apparently united on climate change, what costs might the US incur were it to withdraw from the global regime? To fly in the face of strong international norms on climate action would certainly erode American soft power and concede global status to China, which continues to signal its ambition to decarbonize. And with the US expected to take a more protectionist approach to trade, it is possible that other countries, frustrated at US free-riding on the emissions reductions of others, might impose tariffs on American imports to adjust for the lower emissions costs of US exporters. Nor will American prosperity be served by the US economy remaining shackled to fossil fuels while the rest of the world’s economy transitions away from them. All countries stand to lose if the US backslides on climate change, most of all the US.To comment on this article, please contact Chatham House Feedback Full Article
cl The Impacts of the Demand for Woody Biomass for Power and Heat on Climate and Forests By feedproxy.google.com Published On :: Mon, 30 Jan 2017 10:52:15 +0000 23 February 2017 Although most renewable energy policy frameworks treat biomass as carbon-neutral at the point of combustion, biomass emits more carbon per unit of energy than most fossil fuels. Download PDF Duncan Brack Associate Fellow, Energy, Environment and Resources Programme @DuncanBrack Google Scholar 2017-02-15-woody-biomass-climate-forests-brack.jpg Fuel composed of wood chips to be used for the UEM (Usine d’Electricité de Metz) biomass plant in Metz, eastern France. Photo: Getty Images. SummaryThe use of wood for electricity generation and heat in modern (non-traditional) technologies has grown rapidly in recent years, and has the potential to continue to do so.The EU has been, and remains, the main global source of demand, as a result of its targets for renewable energy. This demand is largely met by its own forest resources and supplemented by imports from the US, Canada and Russia.Countries outside the EU, including the US, China, Japan and South Korea, have the potential to increase the use of biomass (including agricultural residues as well as wood), but so far this has not taken place at scale, partly because of the falling costs of competing renewables such as solar PV and wind. However, the role of biomass as a system balancer, and its supposed ability, in combination with carbon capture and storage technology, to generate negative emissions, seem likely to keep it in contention in the future.Although most renewable energy policy frameworks treat biomass as though it is carbon-neutral at the point of combustion, in reality this cannot be assumed, as biomass emits more carbon per unit of energy than most fossil fuels. Only residues that would otherwise have been burnt as waste or would have been left in the forest and decayed rapidly can be considered to be carbon-neutral over the short to medium term.One reason for the perception of biomass as carbon-neutral is the fact that, under IPCC greenhouse gas accounting rules, its associated emissions are recorded in the land use rather than the energy sector. However, the different ways in which land use emissions are accounted for means that a proportion of the emissions from biomass may never be accounted for.In principle, sustainability criteria can ensure that only biomass with the lowest impact on the climate are used; the current criteria in use in some EU member states and under development in the EU, however, do not achieve this as they do not account for changes in forest carbon stock.Also see Woody Biomass for Power and Heat: Impacts on the Global Climate, which assesses the impact of the use of biomass for energy on greenhouse gas emissions, how these are accounted for under international climate accounting rules, and analyses the sustainability criteria currently in use and under development to minimise negative impacts. Department/project Energy, Environment and Resources Programme, The Environmental Impact of the Use of Biomass for Power and Heat Full Article
cl Inner Circle gives thanks for Jacob Miller on his birthday - Singer would have caused ‘problem’ at King’s House, says former bandmate By jamaica-gleaner.com Published On :: Mon, 04 May 2020 00:19:16 -0500 Long before the existence of the Internet and going viral was a thing, reggae singer Jacob Miller, back in the ‘70s, coined a term that went viral – under heavy manners. Ian Lewis of Inner Circle band, the Bad Boys of Reggae, recalled that his... Full Article
cl Inner Circle to create song from winning poem - Close to 100 entries for Circle of Light contest By jamaica-gleaner.com Published On :: Tue, 05 May 2020 00:07:04 -0500 IT IS said that every cloud has a silver lining, and that could still hold true, even in the midst of a terrifying global pandemic. Despite COVID-19, the cycle of life continues, and out of it has sprung forth an inspiring poetry competition,... Full Article
cl A very fascinating internet site along with great articles! By investing.96.lt Published On :: Thu, 17 Mar 2016 22:29:34 UTC This is one of the very most exciting internet sites I have actually ever observed. It is very exciting considering that of its one-of-a-kind subject matter and also amazing short articles. Full Article Entertainment
cl Dryer Vent Cleaning Will County 312-848-4146 By investing.96.lt Published On :: Sat, 21 Jan 2017 04:25:25 UTC Dryer Vent Cleaning Will County 312-848-4146 - Dryer Vent Cleaning Will County IL: Dryer Vent Wizard provides residential and commercial dryer vent service. The Dryer Vent Installation experts can make your clothes dryer safer and greener by improving dryer performance to extend dryer life. Visit: http://www.willcountyil.dryerventcleaningnow. Full Article Entertainment
cl Danielia Mclean A powerhouse in business By jamaica-gleaner.com Published On :: Mon, 09 Mar 2020 00:16:06 -0500 M arketing guru and smashing entrepreneur Danielia McLean is known to the business and communication worlds as a powerhouse fiercely working to clutch success. Finding a novel business idea can be difficult; pursuing it, successfully, even more so... Full Article
cl Reasons for optimism for each MLB club By mlb.mlb.com Published On :: Sun, 17 Feb 2019 21:02:04 EDT On this opening week of Spring Training, all 30 Major League teams have one thing in common: optimism. Here's an optimism cheat sheet for each of them. Full Article
cl Reasons for optimism for each MLB club By mlb.mlb.com Published On :: Sun, 17 Feb 2019 21:02:04 EDT On this opening week of Spring Training, all 30 Major League teams have one thing in common: optimism. Here's an optimism cheat sheet for each of them. Full Article
cl Pitch clocks nothing new to younger players By mlb.mlb.com Published On :: Tue, 19 Feb 2019 18:02:13 EDT Pitch clocks are set to make their Spring Training debuts this week, and it will be in games featuring hordes of players for whom playing on a timer is nothing new. Full Article
cl Reasons for optimism for each MLB club By mlb.mlb.com Published On :: Sun, 17 Feb 2019 21:02:04 EDT On this opening week of Spring Training, all 30 Major League teams have one thing in common: optimism. Here's an optimism cheat sheet for each of them. Full Article
cl Airbnb laying off 1,900 employees due to travel decline By jamaica-gleaner.com Published On :: Wed, 06 May 2020 14:14:35 -0500 Airbnb says it is laying off 25% of its workforce as it confronts a steep decline in global travel due to the new coronavirus pandemic. It’s a serious setback for the 12-year-old home-sharing company, which just a few months ago was... Full Article
cl TV network fights closure with court petition By jamaica-gleaner.com Published On :: Fri, 08 May 2020 00:19:25 -0500 MANILA (AP): The Philippines’ largest TV and radio network, which was shutdown this week by a government regulator, asked the Supreme Court on Thursday to allow it to return to the air amid an uproar over its closure. ABS-CBN Corp said in its... Full Article
cl Deepening the pool - Western Jamaican swim clubs seek government development and new pool in region to foster training By jamaica-gleaner.com Published On :: Wed, 06 May 2020 23:18:02 -0500 Western Bureau: A number of swimming officials in western Jamaica say that the region’s struggles with underdevelopment will continue even if the COVID-19 pandemic is brought under control. They say this is because they still lack proper pools to... Full Article
cl Female athletes need more recognition – Clayton By jamaica-gleaner.com Published On :: Fri, 08 May 2020 00:23:08 -0500 National 400m hurdles champion Rushell Clayton is concerned about what she says are inequalities between men and women in track and field. Clayton was speaking at a Women in Sports Conference in Kingston recently and discussed issues of inequality... Full Article
cl Michelle Sinclair GP - surgery buildings are not up to scratch By feeds.bmj.com Published On :: Fri, 13 Feb 2015 16:17:25 +0000 Michelle Sinclar, a GP in Hampshire who is concerned that GP premises aren't fit for purpose and limit her ability to provide fully rounded patient care. BMJ Voices is a collection of readers’ experiences of working in the NHS. For this, The BMJ is seeking short audio submissions from UK listeners. These submissions will be published on... Full Article
cl Biomarkers - miracle or marketing? By feeds.bmj.com Published On :: Tue, 18 Jul 2017 16:20:32 +0000 The BMJ has been campaigning for an end to “too much medicine” - the pernicious effect of marketing on the range of tests and treatments that doctors offer patients - tests and treatments which are motivated by the financial reward to the system, than the health of the individual. A new analysis on BMJ.com takes a look at what’s happening in the... Full Article
cl Exercise in old age - "we need kendo classes in Huddersfield" By feeds.bmj.com Published On :: Wed, 18 Oct 2017 16:24:10 +0000 There's a crisis in old age care - not just in the UK, around the world, as population demographics shift, and the proportion of older people increase - there's a worry about who's going to look after them, and how much is it going to cost? However, a new analysis on bmj.com says this picture need not be so gloomy - they say that encouraging... Full Article
cl UK children are drinking less and the importance of a publicly provided NHS By feeds.bmj.com Published On :: Fri, 28 Sep 2018 18:36:43 +0000 Brits have a reputation as Europe’s boozers - and for good reason, with alcohol consumption higher than much of the rest of the continent. That reputation is extended to our young people too - but is it still deserved? Joanna Inchley, senior research fellow at the University of St Andrews, explains new research on decreasing drinking -... Full Article
cl Vinay Prasad - there is overdiagnosis in clinical trials By feeds.bmj.com Published On :: Wed, 03 Oct 2018 17:11:07 +0000 We want clinical trials to be thorough - but Vinay Prasad, assistant professor of medicine at Oregon Health Science University, argues that the problem of overdiagnosis may be as prevalent, in the way we measure disease in our research, as our practice. In this podcast he joins us to discuss the problem, and why he thinks what qualifies as... Full Article
cl Talk Evidence - Z drugs, subclinical hypothyroidism and Drazen's dozen By feeds.bmj.com Published On :: Tue, 25 Jun 2019 16:58:44 +0000 This week on the podcast, (2.02) a listener asks, when we suggest something to stop, should we suggest an alternative instead? (8.24) Helen tells us to stop putting people on treatment for subclinical hypothyroidism, but what does that mean for people who are already receiving thyroxine? (20.55) Carl has a black box warning about z drugs, and... Full Article
cl Climate change will make universal health coverage precarious By feeds.bmj.com Published On :: Tue, 24 Sep 2019 14:26:52 +0000 The BMJ in partnership with The Harvard Global Health Institute has launched a collection of articles exploring how to achieve effective universal health coverage (UHC). The collection highlights the importance of quality in UHC, potential finance models, how best to incentivise stakeholders, and some of the barriers to true UHC. One of those... Full Article
cl How Blockchain could improve clinical trial transparency By feeds.bmj.com Published On :: Sat, 12 Oct 2019 13:06:50 +0000 Blockchain is the digital technology that underpins cryptocurrencies such as bitcoin, and has been proposed as the digital panacea of our times. But Leeza Osipenko, from the London School of Economics, has thought about how it could actually be used in clinical trials, and what else would need to change in our regulatory environment to make that... Full Article
cl Talk Evidence - digital clubbing, osteoarthritis & sustainable EBM By feeds.bmj.com Published On :: Mon, 16 Dec 2019 19:36:54 +0000 We’re back for the December Talk Evidence, and this month we’re being very digital Firstly,(1.20) Helen tells us about arthritic fingers - should we be using prednisolone for treatment when people have painful osteoarthritis of the hand Then (13.30) Carl gets us all to check our fingers for clubbing, and we find out how useful it is as a test... Full Article
cl From dance class to social prescription - starting and evaluating an idea By feeds.bmj.com Published On :: Tue, 07 Jan 2020 10:47:03 +0000 If you read the Christmas BMJ in the last few weeks, you might have noticed a lot around art and health - the way in which engagement in arts can help in prevention and treatment, but can also affect those more nebulous things which really matter to patients - loneliness, self expression, being connected to the wider community. That obviously... Full Article
cl Cycling - Does the health benefit outweigh the accident risk (in the UK) By feeds.bmj.com Published On :: Thu, 12 Mar 2020 16:22:11 +0000 We all know we should be doing more exercise, and one way to do that is by active commuting - journeying to work on foot or by bike. One thing preventing people from taking up cycling is the fear of being involved in road traffic accidents, and that the risk isn't worth the benefit of the extra exercise. It’s even more confusing when air... Full Article
cl Wellbeing – advice from a military medic to frontline clinicians By feeds.bmj.com Published On :: Wed, 22 Apr 2020 11:53:26 +0000 There is no doubt that anxiety levels that clinicians are feeling during this pandemic are high. One military medic believes the current situation is comparable to his experience when posted during British campaigns in Afghanistan and Iraq. Cormac Doyle offers advice on how to deal with high-stress conditions, both in a work and at home, as... Full Article
cl Talk evidence covid-19 update: natural history of covid, include patients in guidelines By feeds.bmj.com Published On :: Sat, 09 May 2020 09:13:00 +0000 For the next few months Talk Evidence is going to focus on the new corona virus pandemic. There is an enormous amount of uncertainty about the disease, what the symptoms are, fatality rate, treatment options, things we shouldn't be doing. We're going to try to get away from the headlines and talk about what we need to know - to hopefully give you... Full Article
cl Fuel selection in human skeletal muscle in insulin resistance: a reexamination By diabetes.diabetesjournals.org Published On :: 2000-05-01 DE KelleyMay 1, 2000; 49:677-683Articles Full Article
cl 5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle By diabetes.diabetesjournals.org Published On :: 1999-08-01 EJ Kurth-KraczekAug 1, 1999; 48:1667-1671Articles Full Article
cl Moving GLUT4: The Biogenesis and Trafficking of GLUT4 Storage Vesicles By diabetes.diabetesjournals.org Published On :: 1997-11-01 Shane ReaNov 1, 1997; 46:1667-1677Perspectives in Diabetes Full Article
cl Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents By diabetes.diabetesjournals.org Published On :: 1999-08-01 G PerseghinAug 1, 1999; 48:1600-1606Articles Full Article
cl Evidence for 5'AMP-Activated Protein Kinase Mediation of the Effect of Muscle Contraction on Glucose Transport By diabetes.diabetesjournals.org Published On :: 1998-08-01 Tatsuya HayashiAug 1, 1998; 47:1369-1373Rapid Publications Full Article
cl Estimation of Insulin Secretion Rates from C-Peptide Levels: Comparison of Individual and Standard Kinetic Parameters for C-Peptide Clearance By diabetes.diabetesjournals.org Published On :: 1992-03-01 Eve Van CauterMar 1, 1992; 41:368-377Original Article Full Article
cl Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action By diabetes.diabetesjournals.org Published On :: 1997-06-01 D A PanJun 1, 1997; 46:983-988Original Article Full Article
cl Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications By diabetes.diabetesjournals.org Published On :: 1995-08-01 Roger H UngerAug 1, 1995; 44:863-870Perspectives in Diabetes Full Article
cl Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and I{kappa}B-{alpha} By diabetes.diabetesjournals.org Published On :: 2002-07-01 Samar I. ItaniJul 1, 2002; 51:2005-2011Rapid Publications Full Article
cl Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study By diabetes.diabetesjournals.org Published On :: 2002-04-01 Andreas FestaApr 1, 2002; 51:1131-1137Complications Full Article
cl The Triumvirate: {beta}-Cell, Muscle, Liver: A Collusion Responsible for NIDDM By diabetes.diabetesjournals.org Published On :: 1988-06-01 Ralph A DeFronzoJun 1, 1988; 37:667-687Lilly Lecture 1987 Full Article
cl Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes By diabetes.diabetesjournals.org Published On :: 2002-10-01 David E. KelleyOct 1, 2002; 51:2944-2950Metabolism and Signal Transduction Full Article
cl Classification and Diagnosis of Diabetes Mellitus and Other Categories of Glucose Intolerance By diabetes.diabetesjournals.org Published On :: 1979-12-01 National Diabetes Data GroupDec 1, 1979; 28:1039-1057Articles Full Article
cl Clinical and Molecular Prevalence of Lipodystrophy in an Unascertained Large Clinical Care Cohort By diabetes.diabetesjournals.org Published On :: 2020-01-20T12:00:26-08:00 Lipodystrophies are a group of disorders characterized by absence or loss of adipose tissue and abnormal fat distribution, commonly accompanied by metabolic dysregulation. Although considered rare disorders, their prevalence in the general population is not well understood. We aimed to evaluate the clinical and genetic prevalence of lipodystrophy disorders in a large clinical care cohort. We interrogated the electronic health record (EHR) information of >1.3 million adults from the Geisinger Health System for lipodystrophy diagnostic codes. We estimate a clinical prevalence of disease of 1 in 20,000 individuals. We performed genetic analyses in individuals with available genomic data to identify variants associated with inherited lipodystrophies and examined their EHR for comorbidities associated with lipodystrophy. We identified 16 individuals carrying the p.R482Q pathogenic variant in LMNA associated with Dunnigan familial partial lipodystrophy. Four had a clinical diagnosis of lipodystrophy, whereas the remaining had no documented clinical diagnosis despite having accompanying metabolic abnormalities. We observed a lipodystrophy-associated variant carrier frequency of 1 in 3,082 individuals in our cohort with substantial burden of metabolic dysregulation. We estimate a genetic prevalence of disease of ~1 in 7,000 in the general population. Partial lipodystrophy is an underdiagnosed condition. and its prevalence, as defined molecularly, is higher than previously reported. Genetically guided stratification of patients with common metabolic disorders, like diabetes and dyslipidemia, is an important step toward precision medicine. Full Article
cl Too close for comfort - St Mary families in cramped homes have eyes on virus By jamaica-gleaner.com Published On :: Fri, 08 May 2020 00:26:06 -0500 Sandra Ferguson resides with her children and grandchildren in a concrete dwelling that is sectioned into four living quarters in the Fort George Road area of Annotto Bay. With 10 of them sharing kitchen and bathroom facilities, Ferguson said... Full Article
cl World Bank predicts sharpest decline of remittances to Caribbean By jamaica-gleaner.com Published On :: Thu, 23 Apr 2020 15:26:53 -0500 WASHINGTON, CMC – The World Bank has predicted the sharpest decline of remittances to Latin America and the Caribbean, saying that global remittances on a whole are projected to fall by about 20 percent in 2020 due to the economic crisis... Full Article
cl Reasons for optimism for each MLB club By mlb.mlb.com Published On :: Sun, 17 Feb 2019 21:02:04 EDT On this opening week of Spring Training, all 30 Major League teams have one thing in common: optimism. Here's an optimism cheat sheet for each of them. Full Article
cl Why can’t vehicle registration be renewed online? By jamaica-gleaner.com Published On :: Tue, 05 May 2020 00:10:48 -0500 THE EDITOR, Madam: I arrived at the Constant Spring tax office at 6:05 a.m. on Monday, May 4 to renew my vehicle registration. At that hour, there were already 30 persons ahead of me. Persons related horror stories of spending up to five hours in... Full Article
cl Mitochondrial Proton Leak Regulated by Cyclophilin D Elevates Insulin Secretion in Islets at Nonstimulatory Glucose Levels By diabetes.diabetesjournals.org Published On :: 2020-01-20T12:00:25-08:00 Fasting hyperinsulinemia precedes the development of type 2 diabetes. However, it is unclear whether fasting insulin hypersecretion is a primary driver of insulin resistance or a consequence of the progressive increase in fasting glycemia induced by insulin resistance in the prediabetic state. Herein, we have discovered a mechanism that specifically regulates non–glucose-stimulated insulin secretion (NGSIS) in pancreatic islets that is activated by nonesterified free fatty acids, the major fuel used by β-cells during fasting. We show that the mitochondrial permeability transition pore regulator cyclophilin D (CypD) promotes NGSIS, but not glucose-stimulated insulin secretion, by increasing mitochondrial proton leak. Islets from prediabetic obese mice show significantly higher CypD-dependent proton leak and NGSIS compared with lean mice. Proton leak–mediated NGSIS is conserved in human islets and is stimulated by exposure to nonesterified free fatty acids at concentrations observed in obese subjects. Mechanistically, proton leak activates islet NGSIS independently of mitochondrial ATP synthesis but ultimately requires closure of the KATP channel. In summary, we have described a novel nonesterified free fatty acid–stimulated pathway that selectively drives pancreatic islet NGSIS, which may be therapeutically exploited as an alternative way to halt fasting hyperinsulinemia and the progression of type 2 diabetes. Full Article
cl Perivascular Adipose Tissue Controls Insulin-Stimulated Perfusion, Mitochondrial Protein Expression, and Glucose Uptake in Muscle Through Adipomuscular Arterioles By diabetes.diabetesjournals.org Published On :: 2020-03-20T11:50:28-07:00 Insulin-mediated microvascular recruitment (IMVR) regulates delivery of insulin and glucose to insulin-sensitive tissues. We have previously proposed that perivascular adipose tissue (PVAT) controls vascular function through outside-to-inside communication and through vessel-to-vessel, or "vasocrine," signaling. However, direct experimental evidence supporting a role of local PVAT in regulating IMVR and insulin sensitivity in vivo is lacking. Here, we studied muscles with and without PVAT in mice using combined contrast-enhanced ultrasonography and intravital microscopy to measure IMVR and gracilis artery diameter at baseline and during the hyperinsulinemic-euglycemic clamp. We show, using microsurgical removal of PVAT from the muscle microcirculation, that local PVAT depots regulate insulin-stimulated muscle perfusion and glucose uptake in vivo. We discovered direct microvascular connections between PVAT and the distal muscle microcirculation, or adipomuscular arterioles, the removal of which abolished IMVR. Local removal of intramuscular PVAT altered protein clusters in the connected muscle, including upregulation of a cluster featuring Hsp90ab1 and Hsp70 and downregulation of a cluster of mitochondrial protein components of complexes III, IV, and V. These data highlight the importance of PVAT in vascular and metabolic physiology and are likely relevant for obesity and diabetes. Full Article
