opera CBD Communiqué: The Ministers of Foreign Affairs of the Group of 77 and China support the adoption of the Multi-Year Plan of Action on South-South Cooperation on Biodiversity for Development at the tenth meeting of the Conference of the Parties to th By www.cbd.int Published On :: Fri, 01 Oct 2010 00:00:00 GMT Full Article
opera CBD Press Release: The Group of 77 and China propose a Multi-Year Plan of Action for South-South Cooperation on Biodiversity for Development for adoption at the tenth meeting of the Conference of the Parties. By www.cbd.int Published On :: Wed, 20 Oct 2010 00:00:00 GMT Full Article
opera CBD Press Release: World development cooperation family adopts biodiversity as a major tool for human development and poverty alleviation. By www.cbd.int Published On :: Fri, 29 Oct 2010 00:00:00 GMT Full Article
opera CBD Communiqué: Translating the Aichi Biodiversity Targets into National Realities: Japan Biodiversity Fund Fully Operational. By www.cbd.int Published On :: Mon, 04 Apr 2011 00:00:00 GMT Full Article
opera CBD Communiqué: Republic of Korea a Leader for South-South Cooperation on Biodiversity for Development By www.cbd.int Published On :: Tue, 24 May 2011 00:00:00 GMT Full Article
opera CBD Press Release: Intergovernmental forum for biodiversity for food and agriculture and the Convention on Biological Diversity strengthen cooperation for achievement of biodiversity targets By www.cbd.int Published On :: Mon, 18 Jul 2011 00:00:00 GMT Full Article
opera CBD Communiqué: Modus operandi agreed by Rio conventions By www.cbd.int Published On :: Tue, 20 Sep 2011 00:00:00 GMT Full Article
opera CBD Communiqué: Cooperating for nature: South Africa as a regional hub for South-South cooperation on biodiversity for development By www.cbd.int Published On :: Thu, 29 Sep 2011 00:00:00 GMT Full Article
opera CBD News: Message by Ahmed Djoghlaf, CBD Executive Secretary, on the occasion of the United Nations Day for South-South Cooperation, 19 December 2011 By www.cbd.int Published On :: Fri, 16 Dec 2011 00:00:00 GMT Full Article
opera CBD News: After several years of international negotiations, the final operational design of the Intergovernmental Platform on Biodiversity and Ecosystem Services (IPBES) has been agreed. By www.unep.org Published On :: Mon, 23 Apr 2012 00:00:00 GMT Full Article
opera CBD News: Message of the CBD Executive Secretary, Braulio Ferreira de Souza Dias, on the occasion of World Water Day, "Water Cooperation", 22 March 2013 By www.cbd.int Published On :: Thu, 21 Mar 2013 00:00:00 GMT Full Article
opera CBD News: Message of the CBD Executive Secretary, Mr. Braulio F. de Souza Dias, on the occasion of the United Nations Day for South-South Cooperation, 12 September 2013 By www.cbd.int Published On :: Wed, 11 Sep 2013 00:00:00 GMT Full Article
opera CBD News: Governments have established firm foundations for the operation of the Nagoya Protocol on Access and Benefit-sharing of Genetic Resources, contributing to the momentum towards entry into force and setting the agenda for the first meeting of its By www.cbd.int Published On :: Fri, 28 Feb 2014 00:00:00 GMT Full Article
opera CBD News: Parties to the Convention on Biological Diversity (CBD) wrapped up a weeklong meeting on implementation with recommendations on, among others, resource mobilization, technical and scientific cooperation, poverty eradication and sustainable devel By www.cbd.int Published On :: Fri, 20 Jun 2014 00:00:00 GMT Full Article
opera CBD News: The Republic of Korea and the Secretariat of the Convention on Biological Diversity (CBD), with the purpose of promoting technical and scientific co-operation and to support achievement of the goals and targets of the Convention, have today sign By www.cbd.int Published On :: Tue, 19 May 2015 00:00:00 GMT Full Article
opera CBD News: To support the mobilisation and alignment of technical and financial resources for priority capacity-building needs, IPBES is developing a prototype Matchmaking Facility. This Facility aims to promote and facilitate dialogue and cooperation amon By us8.campaign-archive1.com Published On :: Mon, 20 Jul 2015 00:00:00 GMT Full Article
opera CBD News: Over the years, South-South cooperation has emerged as a powerful tool for enhancing international cooperation for achieving sustainable development. In fact, since 2008, developing countries have exported more to one another than to developed c By www.cbd.int Published On :: Fri, 11 Sep 2015 00:00:00 GMT Full Article
opera CBD News: This year's World Day to Combat Desertification shows the importance of being inclusive as we cooperate to restore and rehabilitate degraded land. It also points to the convergence of international action and landmark agreements recently ado By www.cbd.int Published On :: Fri, 17 Jun 2016 00:00:00 GMT Full Article
opera CBD News: I am honoured to address this fifth Global Biodiversity Summit of Cities, as we also celebrate 10 years of very productive cooperation with ICLEI-Local Governments for Sustainability as a valued partner. By www.cbd.int Published On :: Sat, 10 Dec 2016 00:00:00 GMT Full Article
opera CBD News: The focus of work this week "towards an enhanced regional cooperation to restore Mediterranean landscapes: improving ecosystem resilience for the benefit of people and the environment.", directly supports the Strategic Plan for Biodive By www.cbd.int Published On :: Fri, 24 Mar 2017 00:00:00 GMT Full Article
opera CBD News: A Memorandum of Cooperation (MoC) geared towards enhancing cooperation between the Secretariats of the Convention on Biological Diversity (CBD) and the FAO International Treaty on Plant Genetic Resources for Food and Agriculture was signed today By www.cbd.int Published On :: Mon, 09 Jul 2018 00:00:00 GMT Full Article
opera CBD News: In the "Beijing Call for Biodiversity Conservation and Climate Change", French President Emmanuel Macron and Chinese President Xi Jinping on 6 November reaffirmed their commitments to enhance international cooperation on climate change By www.diplomatie.gouv.fr Published On :: Thu, 07 Nov 2019 00:00:00 GMT Full Article
opera CBD Notification SCBD/IMS/JMF/ET/CPa/88555 (2020-001): Invitation to provide additional views and suggestions regarding the draft proposals to strengthen technical and scientific cooperation in support of the post-2020 Global Biodiversity Framework By www.cbd.int Published On :: Fri, 03 Jan 2020 00:00:00 GMT Full Article
opera CBD Notification SCBD/IMS/JMF/ET/CPa/88555 (2020-010): Reminder and Extension of Deadline: Invitation to provide additional views and suggestions regarding the draft proposals to strengthen technical and scientific cooperation in support of the post-2020 By www.cbd.int Published On :: Wed, 22 Jan 2020 00:00:00 GMT Full Article
opera A Toeplitz-type operator on Hardy spaces in the unit ball By www.ams.org Published On :: Wed, 08 Apr 2020 11:21 EDT Jordi Pau and Antti Perälä Trans. Amer. Math. Soc. 373 (2020), 3031-3062. Abstract, references and article information Full Article
opera A note on the consistency operator By www.ams.org Published On :: Thu, 02 Apr 2020 13:59 EDT James Walsh Proc. Amer. Math. Soc. 148 (2020), 2645-2654. Abstract, references and article information Full Article
opera Refined scales of decaying rates of operator semigroups on Hilbert spaces: Typical behavior By www.ams.org Published On :: Thu, 02 Apr 2020 13:59 EDT Moacir Aloisio, Silas L. Carvalho and César R. de Oliveira Proc. Amer. Math. Soc. 148 (2020), 2509-2523. Abstract, references and article information Full Article
opera Nuclear composition operators on Bloch spaces By www.ams.org Published On :: Thu, 02 Apr 2020 13:59 EDT Tonie Fares and Pascal Lefèvre Proc. Amer. Math. Soc. 148 (2020), 2487-2496. Abstract, references and article information Full Article
opera Complex symmetry and cyclicity of composition operators on ????²(ℂ₊) By www.ams.org Published On :: Thu, 02 Apr 2020 13:59 EDT S. Waleed Noor and Osmar R. Severiano Proc. Amer. Math. Soc. 148 (2020), 2469-2476. Abstract, references and article information Full Article
opera On Kalton’s theorem for regular compact operators and Grothendieck property for positive projective tensor products By www.ams.org Published On :: Thu, 02 Apr 2020 13:59 EDT Qingying Bu Proc. Amer. Math. Soc. 148 (2020), 2459-2467. Abstract, references and article information Full Article
opera Spectra of Symmetrized Shuffling Operators By www.ams.org Published On :: Victor Reiner, University of Minnesota, Franco Saliola, Universite du Quebec a Montreal, and Volkmar Welker, Philipps-Universitaet Marburg - AMS, 2014, 109 pp., Softcover, ISBN-13: 978-0-8218-9095-0, List: US$76, All AMS Members: US$60.80, MEMO/228/1072 For a finite real reflection group (W) and a (W)-orbit (mathcal{O}) of flats in its reflection arrangement--or equivalently a conjugacy class of... Full Article
opera Global and Local Regularity of Fourier Integral Operators on Weighted and Unweighted Spaces By www.ams.org Published On :: David Dos Santos Ferreira, Universite Paris 13, and Wolfgang Staubach, Uppsala University - AMS, 2013, 65 pp., Softcover, ISBN-13: 978-0-8218-9119-3, List: US$63, All AMS Members: US$50.40, MEMO/229/1074 The authors investigate the global continuity on (L^p) spaces with (pin [1,infty]) of Fourier integral operators with smooth and rough amplitudes... Full Article
opera Operator-Valued Measures, Dilations, and the Theory of Frames By www.ams.org Published On :: Deguang Han, University of Central Florida, David R. Larson, Texas A&M University, Bei Liu, Tianjin University of Technology, and Rui Liu, Nankai University - AMS, 2013, 84 pp., Softcover, ISBN-13: 978-0-8218-9172-8, List: US$65, All AMS Members: US$52, MEMO/229/1075 The authors develop elements of a general dilation theory for operator-valued measures. Hilbert space operator-valued measures are closely related to... Full Article
opera ER stress increases store-operated Ca2+ entry (SOCE) and augments basal insulin secretion in pancreatic beta cells [Molecular Bases of Disease] By www.jbc.org Published On :: 2020-04-24T06:08:45-07:00 Type 2 diabetes mellitus (T2DM) is characterized by impaired glucose-stimulated insulin secretion and increased peripheral insulin resistance. Unremitting endoplasmic reticulum (ER) stress can lead to beta-cell apoptosis and has been linked to type 2 diabetes. Although many studies have attempted to link ER stress and T2DM, the specific effects of ER stress on beta-cell function remain incompletely understood. To determine the interrelationship between ER stress and beta-cell function, here we treated insulin-secreting INS-1(832/13) cells or isolated mouse islets with the ER stress–inducer tunicamycin (TM). TM induced ER stress as expected, as evidenced by activation of the unfolded protein response. Beta cells treated with TM also exhibited concomitant alterations in their electrical activity and cytosolic free Ca2+ oscillations. As ER stress is known to reduce ER Ca2+ levels, we tested the hypothesis that the observed increase in Ca2+ oscillations occurred because of reduced ER Ca2+ levels and, in turn, increased store-operated Ca2+ entry. TM-induced cytosolic Ca2+ and membrane electrical oscillations were acutely inhibited by YM58483, which blocks store-operated Ca2+ channels. Significantly, TM-treated cells secreted increased insulin under conditions normally associated with only minimal release, e.g. 5 mm glucose, and YM58483 blocked this secretion. Taken together, these results support a critical role for ER Ca2+ depletion–activated Ca2+ current in mediating Ca2+-induced insulin secretion in response to ER stress. Full Article
opera Savannah College of Art and Design (Hong Kong) to discontinue operation By www.info.gov.hk Published On :: Fri, 13 Mar 2020 20:04:52 Full Article
opera Which operations can restart first? New guide could help hospitals decide By www.eurekalert.org Published On :: Fri, 08 May 2020 00:00:00 EDT (Michigan Medicine - University of Michigan) Now, as hospitals across the country start to return to doing non-emergency operations that keep their beds full and their books balanced, they need to think carefully about what resources each of those procedures will need as the pandemic continues. A new guide could help them prioritize and plan. Created by poring over seven years' worth of data from 17 common operations in dozens of hospitals, it's available for free for any hospital to use. Full Article
opera Cultivating cooperation through kinship By www.eurekalert.org Published On :: Thu, 30 Apr 2020 00:00:00 EDT (University of Chicago Press Journals) Extensive cooperation among biologically unrelated individuals is uniquely human. It would be surprising if this uniqueness were not related to other uniquely human characteristics, yet current theories of human cooperation tend to ignore the human aspects of human behavior. This paper presents a theory of cooperation that draws on social, cultural, and psychological aspects of human uniqueness for which current theories have little or no explanation. Full Article
opera The Future of EU–US Cooperation in Space Traffic Management and Space Situational Awareness By feedproxy.google.com Published On :: Mon, 19 Aug 2019 10:09:54 +0000 29 August 2019 As more space activities develop, there is an increasing requirement for comprehensive space situational awareness (SSA). This paper provides an overview of the current landscape in SSA and space traffic management as well as possible scenarios for EU–US cooperation in this area. Read online Download PDF Alexandra Stickings Research Fellow for Space Policy and Security, RUSI 2019-08-19-SpaceTrafficManagement.jpg Deployment of the NanoRacks-Remove Debris Satellite from the International Space Station. Photo: Getty Images. SummarySpace situational awareness (SSA) and space traffic management (STM) are essential for sustainable near-Earth orbit. International cooperation in SSA and STM is vital with the growing number of satellite operators and the increasingly complex space environment.The various definitions of SSA and STM are ambiguous. Understanding the activities that fall under each term can better assist in finding areas for cooperation and collaboration.SSA has historically been a military activity, leading to an incomplete public catalogue of its use and barriers to sharing information with other states and the commercial sector. The rise in private space actors has increased the number of commercial STM providers and, with plans in the US to move responsibility for STM to civilian control, there will likely be more opportunities for international collaboration, particularly through the EU Space Surveillance and Tracking (SST) programme.Individual EU member states possess developed STM capabilities, but overall these are still some way behind those of allies such as the US. Further investment in STM infrastructure and programmes is required for the EU and individual European states to be an essential partner to the US and add value to the global effort.There are worldwide challenges, both political and technical, to providing STM coverage, which may lead to a lack of collaboration and gaps in understanding of activities in orbit. Existing sensors have limitations in terms of the size of objects that can be detected and the precision with which their movements can be predicted. These capability gaps represent opportunities for the EU to contribute.The EU can build on its tradition of support for openness and civil society by creating a system that fosters an environment of cooperation and collaboration involving industry, commercial STM providers and the wider international community.Although collaboration in STM is vital, the EU should also aim to tackle issues within the wider definition of SSA including space weather, intelligence and the security of ground stations.The EU is well placed to become a global leader in SSA and STM. However, it needs to take into consideration the current political and technical landscape when making decisions regarding investment in capabilities and the pursuit of international partnerships. Department/project International Security Programme, Cyber and Space Full Article
opera EU–US Cooperation on Tackling Disinformation By feedproxy.google.com Published On :: Tue, 17 Sep 2019 15:23:58 +0000 3 October 2019 Disinformation, as the latest iteration of propaganda suitable for a digitally interconnected world, shows no signs of abating. This paper provides a holistic overview of the current state of play and outlines how EU and US cooperation can mitigate disinformation in the future. Read online Download PDF Sophia Ignatidou Academy Associate, International Security Programme @SophiaIgnatidou LinkedIn 2019-09-19-FakeNews.jpg A congressional staff member displays print outs of social media posts during a hearing before the House Select Intelligence Committee 1 November 2017 in Washington, DC. Photo: Getty Images. EU and US cooperation on tackling disinformation needs to be grounded in an international human rights framework in order to bridge the differences of both parties and include other countries facing this challenge.The disinformation debate needs to be reformulated to cover systemic issues rather than merely technical or security concerns. A lag in regulatory development has led to systemic vulnerabilities. In this context, policymakers need to push for more evidence-based analysis, which is only attainable if technology companies engage in honest debate and allow meaningful access to data – as determined by government appointed researchers rather than the companies themselves – taking into account and respecting users’ privacy.Data governance needs to be the focus of attempts to tackle disinformation. Data’s implications for information, market and power asymmetries, feed into and exacerbate the problem.Policymakers should focus on regulating the distribution of online content rather than the subject matter itself, which may have implications for freedom of speech.Disinformation is mainly the result of inefficient gatekeeping of highly extractive digital companies. The old gatekeepers, journalists and their respective regulators, need to be actively engaged in devising the new regulatory framework.Legacy media need to urgently consider the issue of ‘strategic silence’ and avoid being co-opted by political actors aiming to manipulate the accelerated, reactive news cycle by engaging in divisive ‘clickbait’ rhetoric verging on disinformation and propaganda. When strategic silence is not an option, contextual analysis is fundamental. The EU delegation should assist the coordination of EU–US efforts to tackle disinformation by drawing on the work and expertise at the G7 Rapid Response Mechanism (RRM), the Transatlantic Commission on Election Integrity (TCEI), the European Centre of Excellence for Countering Hybrid Threats (Hybrid CoE), the High-level Panel on Digital Cooperation, and work with the International Telecommunication Union (ITU) to foster a long-term interdisciplinary forum to harness technological innovation to protect and support democracy from threats such as disinformation.The EU and US must avoid rushed regulation that may condone enhanced surveillance or vilify journalism that scrutinizes those in power in the name of security. Department/project International Security Programme, Internet Governance Full Article
opera Synergy in North Africa: Furthering Cooperation By feedproxy.google.com Published On :: Mon, 20 Jan 2020 15:57:54 +0000 21 January 2020 Discussions of North African integration have evoked ideas of a shared identity and a common destiny in the region. However, recent attempts to build regional blocs in North Africa have been unsuccessful. This paper examines the benefits of a ‘synergistic’ approach to North African cooperation. Read online Download PDF in English Download PDF in Arabic Dr Mohammed Masbah Associate Fellow, Middle East and North Africa Programme @MasbahMohammed LinkedIn Google Scholar Mohamed El Dahshan Associate Fellow, Middle East and North Africa Programme @eldahshan LinkedIn Google Scholar 2020-01-21-Market.jpg A Tunisian vendor poses as he sells white truffles at a market in the town of Ben Guerdane, 40km west of the Libyan border, in February 2016. Photo: Getty Images. SummaryNorth African integration is not a new idea. However, countries in the region have so far struggled to form a cohesive bloc with deep political, economic and social ties. Political instability has effectively deprioritized North African integration. A focus on thematic (political, economic and security) ‘synergies’ may provide a better framework for cooperation than seeking opportunities for all-encompassing ‘deep’ and ‘comprehensive’ integration.Governments of North Africa dedicate considerable resources to domestic security. Much of their efforts are conducted at the national-level and directed towards threats from terrorists, insurgents and militias. Improved security cooperation would achieve better outcomes and economies of scale, including efforts to tackle human trafficking.A new generation of jihadis has emerged in North Africa since 2011. Nearly 27 per cent of the 30,000 fighters who travelled to Syria are from the Maghreb. While government counterterrorism operations have been effective, countries have failed to address the root causes of radicalization.Border economies have suffered as a consequence of a security focus on terrorism and smuggling, which has rendered many previously accepted cross-border trade activities illegal. States have struggled to provide alternative livelihoods for those who have lost this source of income. Border forces tend to lack the right combination of capacity, training and equipment to secure borders and often resort to heavy-handed tactics.New thinking is required to develop a more human-centric and proactive approach to migration issues in the region, which continues to witness huge flows of migrants. The migration policy of Morocco, introduced through legislation in 2014, could be a model for North Africa.The countries of North Africa have varying economic profiles, ranging from economically diverse Morocco to oil-and-gas-dependant Libya. However, they all face similar challenges including unemployment (particularly among the young), poor public-service delivery, low FDI levels, an oversized public sector, ineffective tax collection, and high informality.Fostering entrepreneurship and the development of small and medium-sized enterprises (SMEs) are priorities for North African countries, particularly regarding job creation. Regulatory cooperation – such as harmonizing SME definitions, legislation and support institutions – across North Africa is an obvious area where further integration would encourage the development of start-ups and small businesses.With the advent of the fourth industrial revolution, North African governments must address their technological gaps and work to improve public–private cooperation. In some sectors, such as the fintech industry, North African countries can build upon nascent synergies that have developed organically, such as those of start-up incubators and angel investors that work across the region.Renewables, particularly solar energy production, are a promising development for North Africa. While regional initiatives, such as Desertec, have stalled due to political differences between countries, the sector has witnessed exponential growth in Tunisia, Egypt and Morocco, where the involvement of the private sector has proved successful. Department/project Middle East and North Africa Programme, North Africa Dialogues Full Article
opera Can fluorescence-guided surgery help identify all lesions in unknown locations or is the integrated use of a roadmap created by preoperative imaging mandatory? A blinded study in prostate cancer patients. By jnm.snmjournals.org Published On :: 2019-11-11T12:55:20-08:00 Rationale: Lymphatic tracers can help visualize the lymphatic drainage patterns and sentinel nodes of individual prostate cancer patients. To determine the role of nuclear medicine, in particular the positional guidance of a SPECT/CT-based 3D imaging roadmap, in this process we studied to which extend fluorescence-guidance underestimated the number of target lesions. Methods: SPECT/CT imaging was performed after intraprostatic tracer administration of either ICG-99mTc-nanocolloid (hybrid tracer group) or 99mTc-nanocolloid to create a roadmap that depicted all sentinel nodes (SNs). Patients who received 99mTc-nanocolloid were injected with "free" ICG immediately prior to surgery ("free" ICG group). Before unblinding, fluorescence-guidance was used for intraoperative SN identification. This was followed by extended pelvic lymph node dissection (ePLND). Following unblinding of the SPECT/CT images, the number of missed SN’s were recorded and their resection was pursued when the anatomy allowed. Results: Preoperative SPECT/CT revealed no differences in the SN identification rate between ICG-99mTc-nanocolloid and 99mTc-nanocolloid. However, fluorescence-guidance only allowed intraoperative removal of all SNs in 40% of patients in the hybrid tracer group and in 20% of patients in the "free" ICG group. Overall, 75.9% of the intraoperatively resected SNs in the hybrid tracer group and 51.8% of the SNs in the "free" ICG group were removed solely under fluorescence-guidance. During ePLND 22 additional SNs were resected (7 in the hybrid tracer group and 15 in the "free" ICG group). After unblinding 18 remaining SNs were identified (6 in the hybrid group and 12 in the "free" ICG group). In the "free" ICG group, ex vivo evaluation of the excised specimens revealed that 14 SNs removed under ePLND or after unblinding contained radioactivity but no fluorescence. Conclusion: The preoperative imaging roadmap provided by SPECT/CT enhanced the detection of prostate SNs in more ectopic locations in 17 of the 25 patients and the hybrid tracer ICG-99mTc-nanocolloid was shown to outperform "free" ICG. Overall, fluorescence-guided pelvic nodal surgery underestimated the number of SNs in 60-80% of patients. Full Article
opera Label-free Visualization of Early Cancer Hepatic Micrometastasis and Intraoperative Image-guided Surgery by Photoacoustic Imaging By jnm.snmjournals.org Published On :: 2019-12-05T10:37:41-08:00 Objectives: The detection of cancer micrometastasis for early diagnosis and treatment poses a great challenge for conventional imaging techniques. The aim of study is to evaluate the performance of photoacoustic imaging (PAI) in detecting hepatic micrometastases from melanoma in a very early stage and perform tumor resection by intraoperative photoacoustic image-guidance. Methods: In vivo studies were performed by following protocols approved by the Ethical Committee for Animal Research at Xiamen University. First, a B16 melanoma hepatic metastasis mouse model (n = 10) was established to study the development of micrometastases in vivo. Next, the hepatic metastasis mice models were imaged by scalable PAI instrument, ultrasound, 9.4 T high-resolution magnetic resonance imaging (MRI), positron emission tomography/computed tomography (PET/CT), and bioluminescence imaging. Photoacoustic images acquired with optical wavelengths spanning from 680 to 850 nm were spectrally unmixed by using a linear least-squares method to differentiate various components. Differences in the signal-to-background ratios among different modalities were determined with the two-tailed paired t test. The diagnosis results were assessed with histologic examinations. Excised liver samples from patients diagnosed with hepatic cancer were also examined to identify tumor boundary. In vivo metastatic melanoma removal in surgery was precisely guided by the portable PAI system. Results: PAI achieved as small as ~400 µm hepatic melanoma detection at a depth up to 7 mm in vivo, which could early detect small melanoma compared with ultrasound and MRI in mouse models. The signal ratio of tumor-to-liver acquired with PAI in micrometastases at 8 days (4.2 ± 0.2, n = 6) and 14 days (9.2 ± 0.4, n = 5) were significantly higher than those obtained with PET/CT (1.8 ± 0.1, n = 5 and 4.5 ± 0.2, n = 5, P <0.001 for both). Functional PAI provided dynamic oxygen saturation changes during tumor growth. The limit of detection was measured to be approximately 219 cells per microliter in vitro. We successfully performed intraoperative photoacoustic image-guided surgery in vivo using the rapid portable PAI system. Conclusion: Our findings offer a rapid and effective tool to noninvasively detect micrometastases and guide intraoperative resection as a complementary clinical imaging application. Full Article
opera Intraoperative 68Gallium-PSMA Cerenkov Luminescence Imaging for surgical margins in radical prostatectomy - a feasibility study By jnm.snmjournals.org Published On :: 2020-02-14T14:01:21-08:00 Objective: To assess the feasibility and accuracy of Cerenkov Luminescence Imaging (CLI) for assessment of surgical margins intraoperatively during radical prostatectomy (RPE). Methods: A single centre feasibility study included 10 patients with high-risk primary prostate cancer (PC). 68Ga-PSMA PET/CT scans were performed followed by RPE and intraoperative CLI of the excised prostate. In addition to imaging the intact prostate, in the first two patients the prostate gland was incised and imaged with CLI to visualise the primary tumour. We compared the tumour margin status on CLI to postoperative histopathology. Measured CLI intensities were determined as tumour to background ratio (TBR). Results: Tumour cells were successfully detected on the incised prostate CLI images as confirmed by histopathology. 3 of 10 men had histopathological positive surgical margins (PSMs), and 2 of 3 PSMs were accurately detected on CLI. Overall, 25 (72%) out of 35 regions of interest (ROIs) proved to visualize a tumour signal according to standard histopathology. The median tumour radiance in these areas was 11301 photons/s/cm2/sr (range 3328 - 25428 photons/s/cm2/sr) and median TBR was 4.2 (range 2.1 – 11.6). False positive signals were seen mainly at the prostate base with PC cells overlaid by benign tissue. PSMA-immunohistochemistry (PSMA-IHC) revealed strong PSMA staining of benign gland tissue, which impacts measured activities. Conclusion: This feasibility showed that 68Ga-PSMA CLI is a new intraoperative imaging technique capable of imaging the entire specimen’s surface to detect PC tissue at the resection margin. Further optimisation of the CLI protocol, or the use of lower-energetic imaging tracers such as 18F-PSMA, are required to reduce false positives. A larger study will be performed to assess diagnostic performance. Full Article
opera Mobilizing Multinational Military Operations in Africa: Quick Fixes or Sustainable Solutions? By feedproxy.google.com Published On :: Wed, 16 Oct 2019 09:55:01 +0000 Research Event 25 October 2019 - 9:30am to 11:15am Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Professor Tony Chafer, University of PortsmouthProfessor Gordon Cumming, Cardiff UniversityDr Roel van der Velde, Cardiff UniversityAhmed Soliman, Research Fellow, Horn of Africa, Chatham HouseDr Elisa Lopez Lucia, Université Libre de Bruxelles; University of PortsmouthChair: Janet Adama Mohammed, West Africa Programme Director, Conciliation Resources Peacekeeping missions which have sought to address evolving forms of conflict and instability on the African continent – led by the United Nations, African Union and European Union – have frequently been overstretched.Across regions including the Sahel, the Horn and West Africa, the issues of violent extremism and criminality – often set against a backdrop of collapsing or severely weakened central states – have led to the mobilisation of a diverse set of new collective responses.These include notable African-led efforts such as AMISOM in Somalia or more recently the G5 Sahel, where France have played a pivotal role in initiating new and more ad hoc approaches to coalition-building.As existing multinational missions in Africa continue to evolve on the ground and while new collective opportunities increasingly present themselves, it is critical for policymakers to understand how far such efforts reflect meaningful long-term solutions to the challenges of conflict and insecurity.At this roundtable event, participants will reflect on how such missions become mobilised and legitimised, the extent to which they can be defined as ‘new’, and whether they represent a truly sustainable means to tackle the issue of conflict in Africa.This roundtable is held in partnership with Cardiff University and the University of Portsmouth and is supported by the Leverhulme Trust. Department/project Africa Programme, West Africa, African Peace and Security, Horn of Africa Fergus Kell Projects Assistant, Africa Programme + 44 (0) 20 7314 3671 Email Full Article
opera The Hurdles to Developing a COVID-19 Vaccine: Why International Cooperation is Needed By feedproxy.google.com Published On :: Thu, 23 Apr 2020 09:26:36 +0000 23 April 2020 Professor David Salisbury CB Associate Fellow, Global Health Programme LinkedIn Dr Champa Patel Director, Asia-Pacific Programme @patel_champa While the world pins its hopes on vaccines to prevent COVID-19, there are scientific, regulatory and market hurdles to overcome. Furthermore, with geopolitical tensions and nationalistic approaches, there is a high risk that the most vulnerable will not get the life-saving interventions they need. 2020-04-23-Covid-Vaccine.jpg A biologist works on the virus inactivation process in Belo Horizonte, Brazil on 24 March 2020. The Brazilian Ministry of Health convened The Technological Vaccine Center to conduct research on COVID-19 in order to diagnose, test and develop a vaccine. Photo: Getty Images. On 10 January 2020, Chinese scientists released the sequence of the COVID-19 genome on the internet. This provided the starting gun for scientists around the world to start developing vaccines or therapies. With at least 80 different vaccines in development, many governments are pinning their hopes on a quick solution. However, there are many hurdles to overcome. Vaccine developmentFirstly, vaccine development is normally a very long process to ensure vaccines are safe and effective before they are used. Safety is not a given: a recent dengue vaccine caused heightened disease in vaccinated children when they later were exposed to dengue, while Respiratory Syncytial Virus vaccine caused the same problem. Nor is effectiveness a given. Candidate vaccines that use novel techniques where minute fragments of the viruses’ genetic code are either injected directly into humans or incorporated into a vaccine (as is being pursued, or could be pursued for COVID-19) have higher risks of failure simply because they haven’t worked before. For some vaccines, we know what levels of immunity post-vaccination are likely to be protective. This is not the case for coronavirus. Clinical trials will have to be done for efficacy. This is not optional – regulators will need to know extensive testing has taken place before licencing any vaccine. Even if animal tests are done in parallel with early human tests, the remainder of the process is still lengthy. There is also great interest in the use of passive immunization, whereby antibodies to SARS-CoV-2 (collected from people who have recovered from infection or laboratory-created) are given to people who are currently ill. Antivirals may prove to be a quicker route than vaccine development, as the testing requirements would be shorter, manufacturing may be easier and only ill people would need to be treated, as opposed to all at-risk individuals being vaccinated.Vaccine manufacturingDevelopers, especially small biotechs, will have to make partnerships with large vaccine manufacturers in order to bring products to market. One notorious bottleneck in vaccine development is getting from proof-of-principle to commercial development: about 95 per cent of vaccines fail at this step. Another bottleneck is at the end of production. The final stages of vaccine production involve detailed testing to ensure that the vaccine meets the necessary criteria and there are always constraints on access to the technologies necessary to finalize the product. Only large vaccine manufacturers have these capacities. There is a graveyard of failed vaccine candidates that have not managed to pass through this development and manufacturing process.Another consideration is adverse or unintended consequences. Highly specialized scientists may have to defer their work on other new vaccines to work on COVID-19 products and production of existing products may have to be set aside, raising the possibility of shortages of other essential vaccines. Cost is another challenge. Vaccines for industrialized markets can be very lucrative for pharmaceutical companies, but many countries have price caps on vaccines. Important lessons have been learned from the 2009 H1N1 flu pandemic when industrialized countries took all the vaccines first. Supplies were made available to lower-income countries at a lower price but this was much later in the evolution of the pandemic. For the recent Ebola outbreaks, vaccines were made available at low or no cost. Geopolitics may also play a role. Should countries that manufacture a vaccine share it widely with other countries or prioritize their own populations first? It has been reported that President Trump attempted to purchase CureVac, a German company with a candidate vaccine. There are certainly precedents for countries prioritizing their own populations. With H1N1 flu in 2009, the Australian Government required a vaccine company to meet the needs of the Australian population first. Vaccine distributionGlobal leadership and a coordinated and coherent response will be needed to ensure that any vaccine is distributed equitably. There have been recent calls for a G20 on health, but existing global bodies such as the Coalition for Epidemic Preparedness Innovations (CEPI) and GAVI are working on vaccines and worldwide access to them. Any new bodies should seek to boost funding for these entities so they can ensure products reach the most disadvantaged. While countries that cannot afford vaccines may be priced out of markets, access for poor, vulnerable or marginalized peoples, whether in developed or developing countries, is of concern. Developing countries are at particular risk from the impacts of COVID-19. People living in conflict-affected and fragile states – whether they are refugees or asylum seekers, internally displaced or stateless, or in detention facilities – are at especially high risk of devastating impacts. Mature economies will also face challenges. Equitable access to COVID-19 vaccine will be challenging where inequalities and unequal access to essential services have been compromised within some political systems. The need for global leadership There is an urgent need for international coordination on COVID-19 vaccines. While the WHO provides technical support and UNICEF acts as a procurement agency, responding to coronavirus needs clarity of global leadership that arches over national interests and is capable of mobilizing resources at a time when economies are facing painful recessions. We see vaccines as a salvation but remain ill-equipped to accelerate their development.While everyone hopes for rapid availability of safe, effective and affordable vaccines that will be produced in sufficient quantities to meet everyone’s needs, realistically, we face huge hurdles. Full Article
opera Problem Notes for SAS®9 - 65856: The process of updating a lookup table in SAS Business Rules Manager (running in UNIX operating environments) does not work properly By feedproxy.google.com Published On :: Mon, 27 Apr 2020 13:37:52 EST Under UNIX, the process of updating a lookup table in SAS Business Rules Manager does not work properly. The problem occurs when you perform these steps: Open a lookup table. Cl Full Article BRLSTBNDL+SAS+Business+Rules+Manager
opera ER stress increases store-operated Ca2+ entry (SOCE) and augments basal insulin secretion in pancreatic beta cells [Molecular Bases of Disease] By feedproxy.google.com Published On :: 2020-04-24T06:08:45-07:00 Type 2 diabetes mellitus (T2DM) is characterized by impaired glucose-stimulated insulin secretion and increased peripheral insulin resistance. Unremitting endoplasmic reticulum (ER) stress can lead to beta-cell apoptosis and has been linked to type 2 diabetes. Although many studies have attempted to link ER stress and T2DM, the specific effects of ER stress on beta-cell function remain incompletely understood. To determine the interrelationship between ER stress and beta-cell function, here we treated insulin-secreting INS-1(832/13) cells or isolated mouse islets with the ER stress–inducer tunicamycin (TM). TM induced ER stress as expected, as evidenced by activation of the unfolded protein response. Beta cells treated with TM also exhibited concomitant alterations in their electrical activity and cytosolic free Ca2+ oscillations. As ER stress is known to reduce ER Ca2+ levels, we tested the hypothesis that the observed increase in Ca2+ oscillations occurred because of reduced ER Ca2+ levels and, in turn, increased store-operated Ca2+ entry. TM-induced cytosolic Ca2+ and membrane electrical oscillations were acutely inhibited by YM58483, which blocks store-operated Ca2+ channels. Significantly, TM-treated cells secreted increased insulin under conditions normally associated with only minimal release, e.g. 5 mm glucose, and YM58483 blocked this secretion. Taken together, these results support a critical role for ER Ca2+ depletion–activated Ca2+ current in mediating Ca2+-induced insulin secretion in response to ER stress. Full Article
opera More changes announced to court operations By jamaica-gleaner.com Published On :: Fri, 08 May 2020 13:19:10 -0500 Additional changes have been made to the operations of the island's courts in light of COVID-19. Changes below: Criminal Cases All hearings in the Home Circuit Court Division of the Gun Court, the High Court Division of the Gun Court, the... Full Article
opera Colin Steer | Cooperation, creativity and challenges in education amid COVID-19 By jamaica-gleaner.com Published On :: Sun, 12 Apr 2020 00:10:43 -0500 Public reaction to the initial threat of the coronavirus (COVID-19) was predictably mixed. While international news of the contagion across continents helped people to appreciate that this was not restricted to a particular region, not many people... Full Article
opera Caymanas Track operations resume tomorrow By jamaica-gleaner.com Published On :: Thu, 07 May 2020 20:09:44 -0500 Supreme Ventures Racing and Entertainment Limited, operators of Caymanas Track, has announced the re-opening of the main track, effective tomorrow. The company said in a press release on Thursday evening that the track will be opened for two days... Full Article