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Joe Biden to hold first high-dollar fundraiser, featuring Gov. Gavin Newsom

Joe Biden, the presumptive Democratic presidential nominee, will hold his first high-dollar fundraiser, featuring California Gov. Gavin Newsom.




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Gavin Newsom endorses Joe Biden for president during high-dollar fundraiser

Gavin Newsom endorses Joe Biden for president




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4th family member charged in murder of Family Dollar security guard who asked customer to wear mask

Brya Bishop was arrested days before her 25th birthday and charged with three felonies.




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Review: Was Andy Warhol a saint or scourge, genius or dolt? A new biography befits a great life

Blake Gopnik's definitive 'Warhol' gathers up all the receipts on the blank icon who stormed the barricades of art, only to serve it up to commerce.




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Celebrate Star Wars Day with new Barbie dolls and a Baby Yoda board game

Mattel and Hasbro are saluting Star Wars Day by offering four limited-edition Barbies and a Baby Yoda version of the Monopoly board game.




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Four years after Prince's death, superfan Maya Rudolph remembers him as 'a perfect musician'

On Tuesday, actor and comedian Maya Rudolph will host "Let's Go Crazy: The Grammy Salute to Prince," a primetime CBS TV special recorded in January.




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'American Idol' stays safe with remote episode and Katy Perry as hand sanitizer

For the first time ever, "American Idol" put on a quarantined show with judges and contestants appearing from their homes in more than 20 locations.




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Varvel: How a kid from Castleton went from playing with dolls to a YouTube sensation

Taking the road less traveled has made all the difference

      




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Família de Aldir Blanc desmente Regina Duarte e diz que recebeu condolências de assessor

Em entrevista à CNN Brasil, secretária Especial da Cultura diz que optou por mandar mensagens privadas às famílias, em vez de fazer homenagens públicas.




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Why new IU AD Scott Dolson is 'perfect person for that job' — from those that know him

"I know he is going to do a great job of continuing to move Indiana athletics in the right direction," Steve Alford said of Scott Dolson.

       




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Podolski beats Ronaldo to award

Germany's Lukas Podolski is named young player of the World Cup as Cristiano Ronaldo's antics for Portugal cost him the prize.



  • World Cup 2006

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‘After eight years on drugs, I run a million-dollar firm again'

The US designer who rebuilt his life after destroying it through cocaine and crystal meth addiction.




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‘A Short Hike’: A pleasant break from the winter doldrums

'A Short Hike" is a good example of how a familiar video game form can be made into something more quiet and unhurried.




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‘Final Fantasy VII Remake’: True to its 1990s teen-idol roots

"Final Fantasy VII Remake" is a beautiful-looking game with a juvenile mindset that’s fun to pass through but hard for non-teenagers to be riveted by.




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NFL Week 4 betting tips: Target the Dolphins, Browns

Getting a jump on early lines can give bettors added value in their wagering. Here are three teams to focus on for Week 4.




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NFL Week 4 ATS picks: The Patriots are no sure thing against the Dolphins

New England has a negative point differential heading into Week 4 for the first time since 2008.




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‘American Idol’ and ‘The Voice’ winners describe what happens after the show — including a gig on ‘A Capitol Fourth’

Laine Hardy and Maelyn Jarmon may have won different shows, but their experiences are very similar.




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In quarantine, Thomas Dolby's kids turn dad's hit "Europa..." into "Corona..."

A couple of days ago, Thomas Dolby posted this video to Twitter and YouTube of a track called "Corona and the Pirate Twins," a spoof of his 1982 hit, "Europa and the Pirate Twins." The song is credited to Dolby Kids. Thomas included the following note:

"This is what my mischievous offspring have been getting up to during the Lockdown."

Here is the original video for "Europa..."

Bonus track:

And here is Thomas Dolby doing a touching home solo version of his achingly beautiful "Screen Kiss" from 1984's Flat Earth. He did it as a tribute to Matthew Seligman, the celebrated bassist who recently died of COVID-19. Seligman played bass on Dolby's recordings, including Flat Earth, and also played for Bowie, Robyn Hitchcock, Peter Murphy, and countless others. He was also a member of the Soft Boys.

Image: YouTube Read the rest




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BREAKING: 43-Yr-Old Father Of 9, Dollar Store Sec Guard, Shot DEAD While Allegedly Trying To Enforce MI Gov Whitmer’s Face Covering Exec Order

The following article, BREAKING: 43-Yr-Old Father Of 9, Dollar Store Sec Guard, Shot DEAD While Allegedly Trying To Enforce MI Gov Whitmer’s Face Covering Exec Order, was first published on 100PercentFedUp.com.

Will the mainstream media report about the senseless death of a 43-year-old father of nine, who would have been alive today if it were not for VP wannabe, Gretchen Whitmer's executive order that forced him to respond to a customer not wearing a face mask? 

Continue reading: BREAKING: 43-Yr-Old Father Of 9, Dollar Store Sec Guard, Shot DEAD While Allegedly Trying To Enforce MI Gov Whitmer’s Face Covering Exec Order ...




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Review article: The 100 billion dollar brain: central intelligence machinery in the UK and the US

12 March 2015 , Volume 91, Number 2

Richard J. Aldrich




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CBD Notification SCBD/IMS/JMF/NVW/86292 (2019-117): Follow-up invitation to participate in and/or contribute to the piloting and further development of a methodology for the voluntary peer review of national biodiversity strategies and action plans




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A Novel Approach to Adolescents With Type 1 Diabetes: The Team Clinic Model

Jennifer K. Raymond
Feb 1, 2015; 28:68-71
Care Innovations




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Radiation Dosimetry in 177Lu-PSMA-617 Therapy Using a Single Post-treatment SPECT/CT: A Novel Methodology to Generate Time- and Tissue-specific Dose Factors

Calculation of radiation dosimetry in targeted nuclear medicine therapies is traditionally resource-intensive requiring multiple post-therapy SPECT acquisitions. An alternative approach is to take advantage of existing pharmacokinetic data from these smaller cohorts to enable dose computation from a single post-treatment scan in a manner that may be applied to a much broader patient population. Methods: In this work, a technical description for simplified dose estimation is presented and applied to assessment of 177Lu-PSMA-617 therapy (Prostate-Specific Membrane Antigen) for metastatic prostate cancer. By normalizing existing time-activity curves to a single measurement time, it is possible to calculate a mean and range of time-integrated activity values which relate to radiation absorbed dose. To assist with accurate pharmacokinetic modelling of the training cohort, a method for contour-guided image registration was developed. Results: Tissue-specific dose conversion factors for common post-treatment imaging times are reported along with a characterization of added uncertainty in comparison to a traditional serial imaging protocol. Single time point dose factors for tumor were determined to be 11.0, 12.1, 13.6, and 15.2 Gy per MBq/mL at image times of 24, 48, 72, and 96 hours, respectively. For normal tissues, parotid gland factors were 6.7, 9.4, 13.3, and 19.3 Gy per MBq/mL and kidneys were 7.1, 10.3, 15.0, and 22.0 Gy per MBq/mL at those times. Tumor dose estimates were most accurate using delayed scanning at times beyond 72 hours. Dose to healthy tissues is best characterized by scanning patients in the first two days of treatment owing to the larger degree of tracer clearance in this early phase. Conclusion: The work demonstrates a means for efficient dose estimation in 177Lu-PSMA-617 therapy. By providing methods to simplify and potentially automate radiation dosimetry we hope to accelerate the understanding of radiobiology and development of dose-response models in this unique therapeutic context.




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Talk Evidence - Tramadol, medical harm, and alexa

Welcome back to Talk Evidence - where Helen Macdonald and Carl Heneghan take you through what's happening in the world of Evidence. This month we'll be discussing tramadol being prescripted postoperatively, and a new EBM verdict says that should change(1.36). How much preventable harm does healthcare causes (11.20. A canadian project to help...




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Methodology for Estimating Levels of Illegal Timber- and Paper-sector Imports: Estimates for China, France, Japan, the Netherlands, the UK, the US and Vietnam

25 November 2014

This paper accompanies a series of assessments on China, France, Japan, the Netherlands, the UK, the US and Vietnam, providing details on how the estimates of the level of illegality of imports of wood-based products into those countries were derived.

Alison Hoare

Senior Research Fellow, Energy, Environment and Resources Programme

This paper accompanies a series of Chatham House assessments on China, France, Japan, the Netherlands, the UK, the US and Vietnam and provides details on how the estimates of the level of illegality of imports of wood-based products into those countries were derived. The assessments are part of a research project that monitored levels of illegal logging and related trade in selected consumer, producer and processing countries in order to evaluate the effectiveness of efforts to tackle this problem.

The paper describes the methodology for estimating the levels of wood-based products at high risk of illegality that are being imported into consumer and processing countries. The methodology was developed in order to provide quantitative estimates of the scale of such imports and to assess how they have changed over time. The figures adopted for the assessments are based on the best available evidence; but, given the challenges of quantifying levels of illegal logging and the limited information available for some countries, they should not be regarded as definitive. Rather, they indicate the likely levels of illegality and, perhaps more important, how they may have changed over time.




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Infectious diseases in children and adolescents in China: analysis of national surveillance data from 2008 to 2017




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Association between maternal and paternal mental illness and risk of injuries in children and adolescents: nationwide register based cohort study in Sweden




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Excess BMI Accelerates Islet Autoimmunity in Older Children and Adolescents

OBJECTIVE

Sustained excess BMI increases the risk of type 1 diabetes (T1D) in autoantibody-positive relatives without diabetes of patients. We tested whether elevated BMI also accelerates the progression of islet autoimmunity before T1D diagnosis.

RESEARCH DESIGN AND METHODS

We studied 706 single autoantibody–positive pediatric TrialNet participants (ages 1.6–18.6 years at baseline). Cumulative excess BMI (ceBMI) was calculated for each participant based on longitudinally accumulated BMI ≥85th age- and sex-adjusted percentile. Recursive partitioning analysis and multivariable modeling defined the age cut point differentiating the risk for progression to multiple positive autoantibodies.

RESULTS

At baseline, 175 children (25%) had a BMI ≥85th percentile. ceBMI range was –9.2 to 15.6 kg/m2 (median –1.91), with ceBMI ≥0 kg/m2 corresponding to persistently elevated BMI ≥85th percentile. Younger age increased the progression to multiple autoantibodies, with age cutoff of 9 years defined by recursive partitioning analysis. Although ceBMI was not significantly associated with progression from single to multiple autoantibodies overall, there was an interaction with ceBMI ≥0 kg/m2, age, and HLA (P = 0.009). Among children ≥9 years old without HLA DR3-DQ2 and DR4-DQ8, ceBMI ≥0 kg/m2 increased the rate of progression from single to multiple positive autoantibodies (hazard ratio 7.32, P = 0.004) and conferred a risk similar to that in those with T1D-associated HLA haplotypes. In participants <9 years old, the effect of ceBMI on progression to multiple autoantibodies was not significant regardless of HLA type.

CONCLUSIONS

These data support that elevated BMI may exacerbate islet autoimmunity prior to clinical T1D, particularly in children with lower risk based on age and HLA. Interventions to maintain normal BMI may prevent or delay the progression of islet autoimmunity.




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Depressive Symptoms in Children and Adolescents With Type 1 Diabetes: Association with diabetes-specific characteristics

Korey K. Hood
Jun 1, 2006; 29:1389-1389
BR Epidemiology/Health Services/Psychosocial Research




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2017 American Academy of Pediatrics Clinical Practice Guideline: Impact on Prevalence of Arterial Hypertension in Children and Adolescents With Type 1 Diabetes

OBJECTIVE

In 2017, the American Academy of Pediatrics introduced a new guideline (2017 Clinical Practice Guideline of the American Academy of Pediatrics [AAP 2017]) to diagnose arterial hypertension (HTN) in children that included revised, lower normative blood pressure (BP) values and cut points for diagnosing high BP in adolescents. We studied the impact of the new AAP 2017 guideline on prevalence of HTN in children with type 1 diabetes mellitus (T1DM).

RESEARCH DESIGN AND METHODS

Up to September 2018, 1.4 million office BP measurements in 79,849 children and adolescents (aged 5–20 years) with T1DM have been documented in the DPV (Diabetes Prospective Follow-up) registry. BP values of the most recent year were aggregated, and BP values of 74,677 patients without antihypertensive medication were analyzed (median age 16 years and diabetes duration 5.3 years and 52.8% boys). BP values were classified according to AAP 2017 and the references of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) (2011) and the Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents (fourth report) (2004).

RESULTS

Of the patients, 44.1%, 29.5%, and 26.5% were hypertensive according to AAP 2017, KiGGS, and fourth report, respectively. Differences in prevalence of HTN were strongly age dependent: <10 years, AAP 2017 31.4%, KiGGS 30.7%, fourth report 19.6%; 10 to <15 years, AAP 2017 30.9%, KiGGS 31.2%, fourth report 22.4%; and ≥15 years, AAP 2017 53.2%, KiGGS 28.4%, fourth report 30.0%. Among teenagers ≥15 years, 59.1% of boys but only 46.3% of girls were classified as hypertensive by AAP 2017 but only 21.1%/26% of boys and 36.7%/34.4% of girls by KiGGS/fourth report, respectively.

CONCLUSIONS

Classification of BP as hypertension depends strongly on the normative data used. Use of AAP 2017 results in a significant increase in HTN in teenagers ≥15 years with T1DM, particularly in boys. AAP 2017 enhances the awareness of elevated BP in children, particularly in patients with increased risk for cardiovascular disease.




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Adolescent Obesity and Early-Onset Type 2 Diabetes

OBJECTIVE

Type 2 diabetes (T2D) is increasingly diagnosed at younger ages. We investigated the association of adolescent obesity with incident T2D at early adulthood.

RESEARCH DESIGN AND METHODS

A nationwide, population-based study evaluated 1,462,362 adolescents (59% men, mean age 17.4 years) during 1996–2016. Data were linked to the Israeli National Diabetes Registry. Weight and height were measured at study entry. Cox proportional models were applied.

RESULTS

During 15,810,751 person-years, 2,177 people (69% men) developed T2D (mean age at diagnosis 27 years). There was an interaction among BMI, sex, and incident T2D (Pinteraction = 0.023). In a model adjusted for sociodemographic variables, the hazard ratios for diabetes diagnosis were 1.7 (95% CI 1.4–2.0), 2.8 (2.3–3.5), 5.8 (4.9–6.9), 13.4 (11.5–15.7), and 25.8 (21.0–31.6) among men in the 50th–74th percentile, 75th–84th percentile, overweight, mild obesity, and severe obesity groups, respectively, and 2.2 (1.6–2.9), 3.4 (2.5–4.6), 10.6 (8.3–13.6), 21.1 (16.0–27.8), and 44.7 (32.4–61.5), respectively, in women. An inverse graded relationship was observed between baseline BMI and mean age of T2D diagnosis: 27.8 and 25.9 years among men and women with severe obesity, respectively, and 29.5 and 28.5 years among low-normal BMI (5th–49th percentile; reference), respectively. The projected fractions of adult-onset T2D that were attributed to high BMI (≥85th percentile) at adolescence were 56.9% (53.8–59.9%) and 61.1% (56.8–65.2%) in men and women, respectively.

CONCLUSIONS

Severe obesity significantly increases the risk for incidence of T2D in early adulthood in both sexes. The rise in adolescent severe obesity is likely to increase diabetes incidence in young adults in coming decades.




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Silverbeet Dolmas

This recipe featured on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, shared by Jad Choucair of Mankoushe.




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Health Care Transition in Adolescents and Young Adults With Diabetes

Michael E. Bowen
Jun 1, 2010; 28:99-106
Feature Articles




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North Carolina Awards $12 Million Dollar Grant to Improve Literacy Instruction

A $12.2 million dollar grant from the state Department of Public Instruction will go to a program based at North Carolina State University to provide additional training literacy training to teachers in 16 high-needs districts across the state.




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Engaging men who use violence : invitational narrative approaches / Professor Sarah Wendt, Dr Kate Seymour, Fiona Buchanan, Chris Dolman, Dr Natalie Greenland.

"This study contributes to the limited evidence available on how invitational narrative approaches are used in the domestic and family violence field. It focused on invitational narrative ways of engaging and working with men who perpetrate domestic and family violence. Focusing on the processes and skills of practice embedded in invitational narrative ideas enabled the examination of different ways of engaging men that have the potential to lead to sustained change. Accordingly, the main aim of this study was to explore invitational narrative ways of working in order to build an understanding of the processes and skills that engage men and enable behavioural and attitudinal change." --Executive summary (page 6).




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Good reasons for bad feelings : insights from the frontier of evolutionary psychiatry / Randolph M. Nesse.

Mental illness -- Genetic aspects.




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A description of the arteries of the human body. Reduced to tables / by Adolphus Murray ; Translated from the original by Archd. Scott.

Edinburgh : And Bell and Bradfute, and E. Balfour, 1801.




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Die accessorischen Geschlechtsdrusen der Wirbeltiere, mit besonderer Berucksichtigung des Menschen / von Rudolf Disselhorst.

Wiesbaden : J.F. Bergmann, 1897.




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Die Anwendung der Galvanokaustik im Innern des Kehlkopfes und Schlundkopfes : nebst einer kurzen Anleitung zur Laryngoskopie und Rhinoskopie / von Rudolph Voltolini.

Wien : W. Braumuller, 1867.




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Die Behandlung der Tuberculosen Wirbelentzundung nebst Pathologischen Erfahrungen auf Grund von 700 Fallen / von Julius Dollinger.

Stuttgart : Enke, 1896.




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Die Geburt bei engem Becken : Bericht aus der Klinik Chrobak uber den Zeitraum 1878-1895 / von Heinrich Ludwig und Rudolf Savor.

Wien : A. Holder, 1897.




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Die mechanische Bedeutung ser Schienbeinform : mit besonderer Berücksichtigung der Platyknemie ... / von Hugo Hieronymus Hirsch ; mit einem Vorwort von Rudolf Virchow.

Berlin : J. Springer, 1895.




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Die Methoden der Milchuntersuchung : für Aerzte, Chemiker und Hygieniker / zusammengestellt von Paul Sommerfeld ; mit einem Vorwort von Adolf Baginsky.

Berlin : A. Hirschwald, 1896.




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Die neuesten und nützlichsten praktischen Wahrheiten und Erfahrungen für Ärzte und Wundärzte / von Adolf Friedrich Löffler.

Erfurt : Keyser, 1803.




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Die Postmortale Temperatursteigerung / von Adolf Valentin.

Leipzig : J.B. Hirschfeld, 1869.




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Die Schwerhörigkeit durch Starrheit der Paukenfenster / von Rudolf Panse.

Jena : Fischer, 1897.




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Dissertatio solemnis medica exhibens brevem systematicam morborum in gravidis expositionem ... / auctor Franc. Adolphus Jacobi.

Bonnae : Typis Joan. Frid. Abshoven, 1790.




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Dm menstruationens Betndning ... / af Adolph Hannover.

Kjobenhavn : Reitzelg Forlag, 1851.




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Drei anatomisch - physiologische Abhandlungen uber das Auge / von Adolph Hannover.

[Germany] : [publisher not identified], 1845.




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Einfuhrung in das Studium der medicin : (medicinische Encyklopadie und Methodologie) / Vorlesungen gehalten an der Universitat zu Berlin von Jul. Pagel.

Berlin : Urban & Schwarzenberg, 1899.