de India could save 91,000 crore rupees on import bill through biofuel blending: Hardeep Singh Puri By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:04:01 +0530 Full Article
de Photocatalytic 1,3-Oxyheteroarylation of Aryl Cyclopropanes with Azine N-oxides By pubs.rsc.org Published On :: Chem. Sci., 2024, Accepted ManuscriptDOI: 10.1039/D4SC06723A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Doyoung Kim, Hyewon Ju, Wooseok Lee, Sungwoo HongCyclopropanes, valuable C3 building blocks in organic synthesis, possess high strain energy and inherent stability. We present an efficient, environmentally benign 1,3-oxyheteroarylation of aryl cyclopropanes using azine N-oxides as bifunctional...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
de Guest modulating the photoactivity of a titanium-oxide cage By pubs.rsc.org Published On :: Chem. Sci., 2024, Advance ArticleDOI: 10.1039/D4SC04983G, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Dexin Wang, Yanshu Liu, Guanyun Zhang, Menghui Chu, Fangfang Gao, Guanjie Chen, Guo Wang, Chen-Ho Tung, Yifeng WangTi-oxide salicylate clusters with novel biloculate cages and exchangeable guests are reported. The guests influence the physiochemical properties and photocatalytic CO2/epoxide cycloaddition activities of the complexes.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
de Gaining the Molecular Design Principles for Efficient Diarylethene Photoacid and Photohydride Generators Based on Photochemical Reaction Mechanism By pubs.rsc.org Published On :: Chem. Sci., 2024, Accepted ManuscriptDOI: 10.1039/D4SC06202G, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yifan Su, Dexin Zheng, Lingfeng Ge, Le Yu, David Lee Phillips, Jiani Ma, Yu FangAbstract: Photoacid generators (PAGs) and photohydride generators (PHGs) are specific photolabile protecting groups that release acid and hydride, respectively. Over the past decade, great efforts have been devoted to developing...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
de Synthesis of highly condensed phospholes by Lewis acid-assisted dehydrogenative Mallory reaction under visible light irradiation By pubs.rsc.org Published On :: Chem. Sci., 2024, Accepted ManuscriptDOI: 10.1039/D4SC05657D, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ikki Kamiyoshi, Yuki Kojima, Shibo Xu, Kosuke Yasui, Yuji Nishii, Koji HiranoA photo-promoted oxidative cyclization, that is, Mallory reaction of 2,3-diarylbenzophopholes has been developed. With an assistance of Bi(OTf)3 Lewis acid, the reaction proceeds smoothly under visible light irradiation even without...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
de Goalpara Sainik school gave countless cadets to country: Assam Guv By www.newkerala.com Published On :: Wed, 13 Nov 2024 16:00:02 +0530 Full Article
de $19 mn Loss & Damage funding pledged by Sweden at COP29, bringing total pledged funding to $720 mn By www.newkerala.com Published On :: Wed, 13 Nov 2024 16:12:02 +0530 Full Article
de Vistara's last flight from Odisha takes off for Delhi ahead of merger with Air India By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:06:02 +0530 Full Article
de Assam: Army celebrates 'National Education Day' with students in Tinsukia By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:08:01 +0530 Full Article
de UP: Devotees celebrate 'Tulsi Vivah' at Balua Ghat in Prayagraj, marking sacred union of Lord Vishnu, Vrinda By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:10:02 +0530 Full Article
de Defence Space Agency hosts first ever space exercise 'Antariksha Abhyas - 2024' in Delhi By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:14:02 +0530 Full Article
de Rajnath Singh stresses on adaptive defence to cope with Age of Grey Zone, hybrid warfare By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:20:02 +0530 Full Article
de Akashteer: Transforming India's air defence with cutting-edge technology By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:26:02 +0530 Full Article
de DRDO conducts maiden flight test of Long-Range Land Attack Cruise Missile (LRLACM) By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:44:02 +0530 Full Article
de All cases related to loan fraud at Perumbavoor Urban Cooperative Society to be handed over to Crime Branch By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:46:46 +0530 Police say 29 cases have been registered. Probe by district joint registrar of Cooperative department finds 26 persons, mostly members of previous director boards, accountable for irregularities to the tune of ₹33.33 crore Full Article Kerala
de HC modifies the status quo order on maintaining constructions for Tent City in two islands of Lakshadweep By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:14:08 +0530 Full Article Kochi
de No gaps in management of biodegradable waste, Kerala tells NGT By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:23:47 +0530 Full Article Kerala
de French lower house rejects massively amended 2025 budget By www.thehindu.com Published On :: Wed, 13 Nov 2024 09:53:03 +0530 Prime Minister Michel Barnier's minority government now has a largely free hand in submitting a cleaned-up text to the Senate upper house Full Article World
de COP29: India, other developing countries demand fair climate finance commitments By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:33:21 +0530 India, LMDCs advocate for equitable climate finance at COP29, pushing for transparency, fairness, and flexibility in financial commitments Full Article Environment
de 5.3 magnitude earthquake jolts parts of Pakistan By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:40:21 +0530 No casualties have been reported so far for the earthquake that had its epicentre around the Hindukush mountain range Full Article World
de France’s bullfighters see red over bill to ban under-16s By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:10:52 +0530 Although public opinion favours outlawing bullfighting in France, a bid to ban the practice failed in 2022 Full Article World
de Indonesia and Australia hold joint military drills after signing a new defense agreement By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:32:15 +0530 The Indonesian and Australian militaries are holding joint combat drills off Indonesia’s main island of Java with about 2,000 troops training in air, maritime, amphibious and land operations Full Article World
de In vitro identification of oridonin hybrids as potential anti-TNBC agents inducing cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3674-3694DOI: 10.1039/D4MD00580E, Research ArticleJinhua Ning, Nini Zhan, Zhanpan Wu, Yuzhe Li, Die Zhang, Yadian Shi, Yingxun Zhou, Chuan-Huizi Chen, Wenbin JinOridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin in human plasma.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
de Furoxan–piplartine hybrids as effective NO donors and ROS inducers in PC3 cancer cells: design, synthesis, and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3778-3794DOI: 10.1039/D4MD00281D, Research ArticleCarolyne Brustolin Braga, Julio Cesar Milan, Matheus Andrade Meirelles, Bruno Zavan, Guilherme Álvaro Ferreira-Silva, Ester Siqueira Caixeta, Marisa Ionta, Ronaldo A. PilliA novel hybrid integrating piplartine with a furoxan moiety exhibited a sub-micromolar IC50 and extraordinary selectivity for PC3 cells, which was associated with its capacity to release NO, generate ROS, induce DNA damage, and trigger apoptosis.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
de Pyridinyl 4-(2-oxoalkylimidazolidin-1-yl)benzenesulfonates and their hydrochloride salts as novel water soluble antimitotic prodrugs bioactivated by cytochrome P450 1A1 in breast cancer cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3728-3745DOI: 10.1039/D4MD00476K, Research ArticleVincent Ouellette, Chahrazed Bouzriba, Atziri Corin Chavez Alvarez, Quentin Bruxelles, Geneviève Hamel-Côté, Sébastien FortinNew water soluble antimitotic CYP1A1-activated prodrugs named PYRAIB-SOs and their hydrochlorides targeting breast cancers.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
de Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3800-3816DOI: 10.1039/D4MD00585F, Research ArticleMarwa Abdel-Motaal, Dalal Ali Aldakhili, Ayman B. Farag, Ayman Abo Elmaaty, Marwa Sharaky, Nadia A. Mohamed, Saad Shaaban, Abdullah Yahya Abdullah Alzahrani, Ahmed A. Al-KarmalawyNovel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
de Asymmetric imidazole-4,5-dicarboxamide derivatives as SARS-CoV-2 main protease inhibitors: design, synthesis and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3880-3888DOI: 10.1039/D4MD00414K, Research ArticlePhuong Nguyen Hoai Huynh, Phatcharin Khamplong, Minh-Hoang Phan, Thanh-Phuc Nguyen, Phuong Ngoc Lan Vu, Quang-Vinh Tang, Phumin Chamsodsai, Supaphorn Seetaha, Truong Lam Tuong, Thien Y. Vu, Duc-Duy Vo, Kiattawee Choowongkomon, Cam-Van T. VoNovel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
de Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3746-3758DOI: 10.1039/D4MD00122B, Research Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shadid U. Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong LiWe designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
de Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3862-3879DOI: 10.1039/D4MD00313F, Research ArticleDaniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro AccettaThis study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
de Hydrophobic CPP/HDO conjugates: a new frontier in oligonucleotide-warheaded PROTAC delivery By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3695-3703DOI: 10.1039/D4MD00546E, Research ArticleMiyako Naganuma, Nobumichi Ohoka, Motoharu Hirano, Daishi Watanabe, Genichiro Tsuji, Takao Inoue, Yosuke DemizuA novel hydrophobic cell-penetrating peptide (CPP) and heteroduplex oligonucleotide (HDO)-conjugated PROTAC, CPP/HDO-PROTAC, was designed to enhance its intracellular delivery and degradation efficiency.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
de Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3912-3912DOI: 10.1039/D4MD90040E, Correction Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex JosephThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
de Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00610K, Research Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina MarzanoIn this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
de Advances in Detecting Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Using Molecular Receptors and Nanostructured Assemblies By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00661E, Review ArticleAvijit Kumar DasThe detection and quantification of non-steroidal anti-inflammatory drugs (NSAIDs) are crucial due to their widespread use and potential impact on human health and the environment. This review provides a comprehensive...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
de Supreme Court stays order for CBI probe into sexual assault of minor in Chennai By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:07:47 +0530 Calls for a list of five to seven direct recruit IPS officers, including three women, who hail from other States but are now serving in Tamil Nadu cadre Full Article Tamil Nadu
de IIT Madras to conduct two-day summit on extended reality By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:19:23 +0530 The aim is to develop academic partnership programmes to boost research in XR or extended reality Full Article Chennai
de T.N. govt. to take a call on verifying criminal antecedents before appointing schoolteachers By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:15:58 +0530 It also assures Madras High Court of putting in place an effective complaint redressal mechanism in the interest of school students Full Article Tamil Nadu
de IIT-M students develop robot for O.P. Jindal university’s Constitution Museum By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:44:27 +0530 It is trained to respond to questions from visitors in Hindi and English, IIT-M professor says Full Article Tamil Nadu
de Leaders of various parties condemn attack on govt. doctor By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:08:06 +0530 Full Article Tamil Nadu
de Delhi AQI drops to 361 in ‘very poor’ category as smog engulfs national capital By www.thehindu.com Published On :: Wed, 13 Nov 2024 09:14:04 +0530 Delhi recorded its first dense fog of the season on Wednesday as visibility dropped to 0 metres at 8 a.m. Full Article Delhi
de Delhi airport sees seven flight diversions owing to bad weather By www.thehindu.com Published On :: Wed, 13 Nov 2024 11:39:37 +0530 The IMD reported that very dense fog began forming at around 5.30 a.m., resulting in a thick haze over various parts of Delhi Full Article Delhi
de Delhi High Court upholds ban on two-wheelers on Expressways By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:18:26 +0530 Two-wheelers, three-wheelers, and other slow-moving vehicles, such as tractors, are prohibited as per the Gazette Notifications dated June 14, 2018, and January 15, 2021 Full Article Delhi
de Delhi’s air quality turns ‘severe’ for first time this season: CPCB By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:52:21 +0530 According to Central Pollution Control Board data, Delhi’s air quality reaches ‘severe’ levels with AQI of 418 Full Article Delhi
de U.S. oil industry urges Trump to ditch Biden climate policies By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:27:45 +0530 Full Article Business
de Arvinder Singh Sahney is new chairman of Indian Oil By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:43:29 +0530 Full Article Business
de Developed nations need to triple their contribution to make climate finance credible: Avinash Persaud By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:16:07 +0530 Currently, developed nations are expected to pay $100 billion a year but they haven’t stuck to agreed targets, and this system ends next year. Full Article Business
de Vodafone Idea narrows Q2 loss to ₹7,176 crore By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:56:55 +0530 Full Article Business
de SKDRDP provides desks and benches worth ₹2.75 crore to 507 government primary schools in four districts of Karnataka By www.thehindu.com Published On :: Wed, 13 Nov 2024 12:49:14 +0530 Rajya Sabha MP Veerendra Heggade urges parents to get their wards admitted to government schools as they now have better facilities Full Article Mangaluru
de Free and fair inquiry sought into death of snakebite victim in Srikakulam district By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:10:47 +0530 Son of the victim alleges that local medical and health officials misleading higher-ups regarding the incident Full Article Andhra Pradesh
de Incessant rains cause landslides on Tirumala ghat road By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:56:12 +0530 Full Article Andhra Pradesh
de Andhra Pradesh Budget reflects aspirations of all sections of people, say legislators By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:10:11 +0530 It has given impetus to the developmental goals outlined in the NDA’s election manifesto, say MLAs on the first day of discussion Full Article Andhra Pradesh
