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Photocatalytic 1,3-Oxyheteroarylation of Aryl Cyclopropanes with Azine N-oxides
Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC06723A, Edge Article
DOI: 10.1039/D4SC06723A, Edge Article
Open Access
This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Doyoung Kim, Hyewon Ju, Wooseok Lee, Sungwoo Hong
Cyclopropanes, valuable C3 building blocks in organic synthesis, possess high strain energy and inherent stability. We present an efficient, environmentally benign 1,3-oxyheteroarylation of aryl cyclopropanes using azine N-oxides as bifunctional...
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Cyclopropanes, valuable C3 building blocks in organic synthesis, possess high strain energy and inherent stability. We present an efficient, environmentally benign 1,3-oxyheteroarylation of aryl cyclopropanes using azine N-oxides as bifunctional...
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de
Guest modulating the photoactivity of a titanium-oxide cage
Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC04983G, Edge Article
DOI: 10.1039/D4SC04983G, Edge Article
Open Access
This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Dexin Wang, Yanshu Liu, Guanyun Zhang, Menghui Chu, Fangfang Gao, Guanjie Chen, Guo Wang, Chen-Ho Tung, Yifeng Wang
Ti-oxide salicylate clusters with novel biloculate cages and exchangeable guests are reported. The guests influence the physiochemical properties and photocatalytic CO2/epoxide cycloaddition activities of the complexes.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
Ti-oxide salicylate clusters with novel biloculate cages and exchangeable guests are reported. The guests influence the physiochemical properties and photocatalytic CO2/epoxide cycloaddition activities of the complexes.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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de
Gaining the Molecular Design Principles for Efficient Diarylethene Photoacid and Photohydride Generators Based on Photochemical Reaction Mechanism
Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC06202G, Edge Article
DOI: 10.1039/D4SC06202G, Edge Article
Open Access
This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Yifan Su, Dexin Zheng, Lingfeng Ge, Le Yu, David Lee Phillips, Jiani Ma, Yu Fang
Abstract: Photoacid generators (PAGs) and photohydride generators (PHGs) are specific photolabile protecting groups that release acid and hydride, respectively. Over the past decade, great efforts have been devoted to developing...
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Abstract: Photoacid generators (PAGs) and photohydride generators (PHGs) are specific photolabile protecting groups that release acid and hydride, respectively. Over the past decade, great efforts have been devoted to developing...
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de
Synthesis of highly condensed phospholes by Lewis acid-assisted dehydrogenative Mallory reaction under visible light irradiation
Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05657D, Edge Article
DOI: 10.1039/D4SC05657D, Edge Article
Open Access
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ikki Kamiyoshi, Yuki Kojima, Shibo Xu, Kosuke Yasui, Yuji Nishii, Koji Hirano
A photo-promoted oxidative cyclization, that is, Mallory reaction of 2,3-diarylbenzophopholes has been developed. With an assistance of Bi(OTf)3 Lewis acid, the reaction proceeds smoothly under visible light irradiation even without...
The content of this RSS Feed (c) The Royal Society of Chemistry
A photo-promoted oxidative cyclization, that is, Mallory reaction of 2,3-diarylbenzophopholes has been developed. With an assistance of Bi(OTf)3 Lewis acid, the reaction proceeds smoothly under visible light irradiation even without...
The content of this RSS Feed (c) The Royal Society of Chemistry
de
$19 mn Loss & Damage funding pledged by Sweden at COP29, bringing total pledged funding to $720 mn
de
Vistara's last flight from Odisha takes off for Delhi ahead of merger with Air India
de
UP: Devotees celebrate 'Tulsi Vivah' at Balua Ghat in Prayagraj, marking sacred union of Lord Vishnu, Vrinda
de
Defence Space Agency hosts first ever space exercise 'Antariksha Abhyas - 2024' in Delhi
de
Rajnath Singh stresses on adaptive defence to cope with Age of Grey Zone, hybrid warfare
de
All cases related to loan fraud at Perumbavoor Urban Cooperative Society to be handed over to Crime Branch
Police say 29 cases have been registered. Probe by district joint registrar of Cooperative department finds 26 persons, mostly members of previous director boards, accountable for irregularities to the tune of ₹33.33 crore
de
HC modifies the status quo order on maintaining constructions for Tent City in two islands of Lakshadweep
de
French lower house rejects massively amended 2025 budget
Prime Minister Michel Barnier's minority government now has a largely free hand in submitting a cleaned-up text to the Senate upper house
de
COP29: India, other developing countries demand fair climate finance commitments
India, LMDCs advocate for equitable climate finance at COP29, pushing for transparency, fairness, and flexibility in financial commitments
de
5.3 magnitude earthquake jolts parts of Pakistan
No casualties have been reported so far for the earthquake that had its epicentre around the Hindukush mountain range
de
France’s bullfighters see red over bill to ban under-16s
Although public opinion favours outlawing bullfighting in France, a bid to ban the practice failed in 2022
de
Indonesia and Australia hold joint military drills after signing a new defense agreement
The Indonesian and Australian militaries are holding joint combat drills off Indonesia’s main island of Java with about 2,000 troops training in air, maritime, amphibious and land operations
de
In vitro identification of oridonin hybrids as potential anti-TNBC agents inducing cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP
RSC Med. Chem., 2024, 15,3674-3694
DOI: 10.1039/D4MD00580E, Research Article
DOI: 10.1039/D4MD00580E, Research Article
Jinhua Ning, Nini Zhan, Zhanpan Wu, Yuzhe Li, Die Zhang, Yadian Shi, Yingxun Zhou, Chuan-Huizi Chen, Wenbin Jin
Oridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin in human plasma.
The content of this RSS Feed (c) The Royal Society of Chemistry
Oridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin in human plasma.
The content of this RSS Feed (c) The Royal Society of Chemistry
de
Furoxan–piplartine hybrids as effective NO donors and ROS inducers in PC3 cancer cells: design, synthesis, and biological evaluation
RSC Med. Chem., 2024, 15,3778-3794
DOI: 10.1039/D4MD00281D, Research Article
DOI: 10.1039/D4MD00281D, Research Article
Carolyne Brustolin Braga, Julio Cesar Milan, Matheus Andrade Meirelles, Bruno Zavan, Guilherme Álvaro Ferreira-Silva, Ester Siqueira Caixeta, Marisa Ionta, Ronaldo A. Pilli
A novel hybrid integrating piplartine with a furoxan moiety exhibited a sub-micromolar IC50 and extraordinary selectivity for PC3 cells, which was associated with its capacity to release NO, generate ROS, induce DNA damage, and trigger apoptosis.
The content of this RSS Feed (c) The Royal Society of Chemistry
A novel hybrid integrating piplartine with a furoxan moiety exhibited a sub-micromolar IC50 and extraordinary selectivity for PC3 cells, which was associated with its capacity to release NO, generate ROS, induce DNA damage, and trigger apoptosis.
The content of this RSS Feed (c) The Royal Society of Chemistry
de
Pyridinyl 4-(2-oxoalkylimidazolidin-1-yl)benzenesulfonates and their hydrochloride salts as novel water soluble antimitotic prodrugs bioactivated by cytochrome P450 1A1 in breast cancer cells
RSC Med. Chem., 2024, 15,3728-3745
DOI: 10.1039/D4MD00476K, Research Article
DOI: 10.1039/D4MD00476K, Research Article
Vincent Ouellette, Chahrazed Bouzriba, Atziri Corin Chavez Alvarez, Quentin Bruxelles, Geneviève Hamel-Côté, Sébastien Fortin
New water soluble antimitotic CYP1A1-activated prodrugs named PYRAIB-SOs and their hydrochlorides targeting breast cancers.
The content of this RSS Feed (c) The Royal Society of Chemistry
New water soluble antimitotic CYP1A1-activated prodrugs named PYRAIB-SOs and their hydrochlorides targeting breast cancers.
The content of this RSS Feed (c) The Royal Society of Chemistry
de
Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators
RSC Med. Chem., 2024, 15,3800-3816
DOI: 10.1039/D4MD00585F, Research Article
DOI: 10.1039/D4MD00585F, Research Article
Marwa Abdel-Motaal, Dalal Ali Aldakhili, Ayman B. Farag, Ayman Abo Elmaaty, Marwa Sharaky, Nadia A. Mohamed, Saad Shaaban, Abdullah Yahya Abdullah Alzahrani, Ahmed A. Al-Karmalawy
Novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators.
The content of this RSS Feed (c) The Royal Society of Chemistry
Novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators.
The content of this RSS Feed (c) The Royal Society of Chemistry
de
Asymmetric imidazole-4,5-dicarboxamide derivatives as SARS-CoV-2 main protease inhibitors: design, synthesis and biological evaluation
RSC Med. Chem., 2024, 15,3880-3888
DOI: 10.1039/D4MD00414K, Research Article
DOI: 10.1039/D4MD00414K, Research Article
Phuong Nguyen Hoai Huynh, Phatcharin Khamplong, Minh-Hoang Phan, Thanh-Phuc Nguyen, Phuong Ngoc Lan Vu, Quang-Vinh Tang, Phumin Chamsodsai, Supaphorn Seetaha, Truong Lam Tuong, Thien Y. Vu, Duc-Duy Vo, Kiattawee Choowongkomon, Cam-Van T. Vo
Novel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.
The content of this RSS Feed (c) The Royal Society of Chemistry
Novel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.
The content of this RSS Feed (c) The Royal Society of Chemistry
de
Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling
RSC Med. Chem., 2024, 15,3746-3758
DOI: 10.1039/D4MD00122B, Research Article
DOI: 10.1039/D4MD00122B, Research Article
Open Access
This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Shadid U. Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong Li
We designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.
The content of this RSS Feed (c) The Royal Society of Chemistry
We designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.
The content of this RSS Feed (c) The Royal Society of Chemistry
de
Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors
RSC Med. Chem., 2024, 15,3862-3879
DOI: 10.1039/D4MD00313F, Research Article
DOI: 10.1039/D4MD00313F, Research Article
Daniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro Accetta
This study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.
The content of this RSS Feed (c) The Royal Society of Chemistry
This study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.
The content of this RSS Feed (c) The Royal Society of Chemistry
de
Hydrophobic CPP/HDO conjugates: a new frontier in oligonucleotide-warheaded PROTAC delivery
RSC Med. Chem., 2024, 15,3695-3703
DOI: 10.1039/D4MD00546E, Research Article
DOI: 10.1039/D4MD00546E, Research Article
Miyako Naganuma, Nobumichi Ohoka, Motoharu Hirano, Daishi Watanabe, Genichiro Tsuji, Takao Inoue, Yosuke Demizu
A novel hydrophobic cell-penetrating peptide (CPP) and heteroduplex oligonucleotide (HDO)-conjugated PROTAC, CPP/HDO-PROTAC, was designed to enhance its intracellular delivery and degradation efficiency.
The content of this RSS Feed (c) The Royal Society of Chemistry
A novel hydrophobic cell-penetrating peptide (CPP) and heteroduplex oligonucleotide (HDO)-conjugated PROTAC, CPP/HDO-PROTAC, was designed to enhance its intracellular delivery and degradation efficiency.
The content of this RSS Feed (c) The Royal Society of Chemistry
de
Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy
RSC Med. Chem., 2024, 15,3912-3912
DOI: 10.1039/D4MD90040E, Correction
DOI: 10.1039/D4MD90040E, Correction
Open Access
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex Joseph
The content of this RSS Feed (c) The Royal Society of Chemistry
The content of this RSS Feed (c) The Royal Society of Chemistry
de
Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands
RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00610K, Research Article
DOI: 10.1039/D4MD00610K, Research Article
Open Access
This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina Marzano
In this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....
The content of this RSS Feed (c) The Royal Society of Chemistry
In this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....
The content of this RSS Feed (c) The Royal Society of Chemistry
de
Advances in Detecting Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Using Molecular Receptors and Nanostructured Assemblies
RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00661E, Review Article
DOI: 10.1039/D4MD00661E, Review Article
Avijit Kumar Das
The detection and quantification of non-steroidal anti-inflammatory drugs (NSAIDs) are crucial due to their widespread use and potential impact on human health and the environment. This review provides a comprehensive...
The content of this RSS Feed (c) The Royal Society of Chemistry
The detection and quantification of non-steroidal anti-inflammatory drugs (NSAIDs) are crucial due to their widespread use and potential impact on human health and the environment. This review provides a comprehensive...
The content of this RSS Feed (c) The Royal Society of Chemistry
de
Supreme Court stays order for CBI probe into sexual assault of minor in Chennai
Calls for a list of five to seven direct recruit IPS officers, including three women, who hail from other States but are now serving in Tamil Nadu cadre
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IIT Madras to conduct two-day summit on extended reality
The aim is to develop academic partnership programmes to boost research in XR or extended reality
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T.N. govt. to take a call on verifying criminal antecedents before appointing schoolteachers
It also assures Madras High Court of putting in place an effective complaint redressal mechanism in the interest of school students
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IIT-M students develop robot for O.P. Jindal university’s Constitution Museum
It is trained to respond to questions from visitors in Hindi and English, IIT-M professor says
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Delhi AQI drops to 361 in ‘very poor’ category as smog engulfs national capital
Delhi recorded its first dense fog of the season on Wednesday as visibility dropped to 0 metres at 8 a.m.
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Delhi airport sees seven flight diversions owing to bad weather
The IMD reported that very dense fog began forming at around 5.30 a.m., resulting in a thick haze over various parts of Delhi
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Delhi High Court upholds ban on two-wheelers on Expressways
Two-wheelers, three-wheelers, and other slow-moving vehicles, such as tractors, are prohibited as per the Gazette Notifications dated June 14, 2018, and January 15, 2021
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Delhi’s air quality turns ‘severe’ for first time this season: CPCB
According to Central Pollution Control Board data, Delhi’s air quality reaches ‘severe’ levels with AQI of 418
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Developed nations need to triple their contribution to make climate finance credible: Avinash Persaud
Currently, developed nations are expected to pay $100 billion a year but they haven’t stuck to agreed targets, and this system ends next year.
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SKDRDP provides desks and benches worth ₹2.75 crore to 507 government primary schools in four districts of Karnataka
Rajya Sabha MP Veerendra Heggade urges parents to get their wards admitted to government schools as they now have better facilities
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Free and fair inquiry sought into death of snakebite victim in Srikakulam district
Son of the victim alleges that local medical and health officials misleading higher-ups regarding the incident
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Andhra Pradesh Budget reflects aspirations of all sections of people, say legislators
It has given impetus to the developmental goals outlined in the NDA’s election manifesto, say MLAs on the first day of discussion