This retro style is making a comeback for a reason.

Brian Zingg
Apr 15, 2020; 40:3250-3267
Systems/Circuits

Jozsef Csicsvari
Jan 1, 1999; 19:274-287
Articles

MN Shadlen
Feb 15, 1996; 16:1486-1510
Articles

A Bragin
Jan 1, 1995; 15:47-60
Articles

EndeavourOS is a rolling release Arch Linux-based distribution with some handy new features that improve the user experience. This latest version comes with graphical install options and preconfigured desktop environments. Several new in-house utilities improve package management and error reporting. There are lots of installation tips with the Calamares installer, which has a new look and feel.

Does your customer relationship management strategy have what it takes to reach Generation Y? It's estimated that by 2021, an additional $394 billion in revenue could be gained from artificial intelligence adoption in CRM activities in the U.S. As companies grow and technology evolves at a faster-than-ever pace, collecting, storing and providing data is becoming a bigger and bigger task.

Edge conditions and the change they drive are fascinating. Some people use the word "margin" because it's at the margin that things change. A situation exists more or less in equilibrium with the rest of its environment until in one way or another the stresses become so great that change happens. We have lots of metaphors, like "tipping point" and "the straw that broke the camel's back."

Op-ed by Agustín Carstens published in the Financial Times on 29 March 2020.

Revealing the organization and function of neural circuits is greatly facilitated by viral tools that spread transsynaptically. Adeno-associated virus (AAV) exhibits anterograde transneuronal transport, however, the synaptic specificity of this spread and its broad application within a diverse set of circuits remains to be explored. Here, using anatomic, functional, and molecular approaches, we provide evidence for the preferential transport of AAV1 to postsynaptically connected neurons and reveal its spread is strongly dependent on synaptic transmitter release. In addition to glutamatergic pathways, AAV1 also spreads through GABAergic synapses to both excitatory and inhibitory cell types. We observed little or no transport, however, through neuromodulatory projections (e.g., serotonergic, cholinergic, and noradrenergic). In addition, we found that AAV1 can be transported through long-distance descending projections from various brain regions to effectively transduce spinal cord neurons. Combined with newly designed intersectional and sparse labeling strategies, AAV1 can be applied within a wide variety of pathways to categorize neurons according to their input sources, morphology, and molecular identities. These properties make AAV1 a promising anterograde transsynaptic tool for establishing a comprehensive cell-atlas of the brain, although its capacity for retrograde transport currently limits its use to unidirectional circuits.

SIGNIFICANCE STATEMENT The discovery of anterograde transneuronal spread of AAV1 generates great promise for its application as a unique tool for manipulating input-defined cell populations and mapping their outputs. However, several outstanding questions remain for anterograde transsynaptic approaches in the field: (1) whether AAV1 spreads exclusively or specifically to synaptically connected neurons, and (2) how broad its application could be in various types of neural circuits in the brain. This study provides several lines of evidence in terms of anatomy, functional innervation, and underlying mechanisms, to strongly support that AAV1 anterograde transneuronal spread is highly synapse specific. In addition, several potentially important applications of transsynaptic AAV1 in probing neural circuits are described.

Nicotine addiction, through smoking, is the principal cause of preventable mortality worldwide. Human genome-wide association studies have linked polymorphisms in the CHRNA5-CHRNA3-CHRNB4 gene cluster, coding for the α5, α3, and β4 nicotinic acetylcholine receptor (nAChR) subunits, to nicotine addiction. β4*nAChRs have been implicated in nicotine withdrawal, aversion, and reinforcement. Here we show that β4*nAChRs also are involved in non-nicotine-mediated responses that may predispose to addiction-related behaviors. β4 knock-out (KO) male mice show increased novelty-induced locomotor activity, lower baseline anxiety, and motivational deficits in operant conditioning for palatable food rewards and in reward-based Go/No-go tasks. To further explore reward deficits we used intracranial self-administration (ICSA) by directly injecting nicotine into the ventral tegmental area (VTA) in mice. We found that, at low nicotine doses, β4KO self-administer less than wild-type (WT) mice. Conversely, at high nicotine doses, this was reversed and β4KO self-administered more than WT mice, whereas β4-overexpressing mice avoided nicotine injections. Viral expression of β4 subunits in medial habenula (MHb), interpeduncular nucleus (IPN), and VTA of β4KO mice revealed dose- and region-dependent differences: β4*nAChRs in the VTA potentiated nicotine-mediated rewarding effects at all doses, whereas β4*nAChRs in the MHb-IPN pathway, limited VTA-ICSA at high nicotine doses. Together, our findings indicate that the lack of functional β4*nAChRs result in deficits in reward sensitivity including increased ICSA at high doses of nicotine that is restored by re-expression of β4*nAChRs in the MHb-IPN. These data indicate that β4 is a critical modulator of reward-related behaviors.

SIGNIFICANCE STATEMENT Human genetic studies have provided strong evidence for a relationship between variants in the CHRNA5-CHRNA3-CHRNB4 gene cluster and nicotine addiction. Yet, little is known about the role of β4 nicotinic acetylcholine receptor (nAChR) subunit encoded by this cluster. We investigated the implication of β4*nAChRs in anxiety-, food reward- and nicotine reward-related behaviors. Deletion of the β4 subunit gene resulted in an addiction-related phenotype characterized by low anxiety, high novelty-induced response, lack of sensitivity to palatable food rewards and increased intracranial nicotine self-administration at high doses. Lentiviral vector-induced re-expression of the β4 subunit into either the MHb or IPN restored a "stop" signal on nicotine self-administration. These results suggest that β4*nAChRs provide a promising novel drug target for smoking cessation.

For visually guided navigation, the use of environmental cues is essential. Particularly, detecting local boundaries that impose limits to locomotion and estimating their location is crucial. In a series of three fMRI experiments, we investigated whether there is a neural coding of navigational distance in the human visual cortex (both female and male). We used virtual reality software to systematically manipulate the distance from a viewer perspective to different types of a boundary. Using a multivoxel pattern classification employing a linear support vector machine, we found that the occipital place area (OPA) is sensitive to the navigational distance restricted by the transparent glass wall. Further, the OPA was sensitive to a non-crossable boundary only, suggesting an importance of the functional constraint of a boundary. Together, we propose the OPA as a perceptual source of external environmental features relevant for navigation.

SIGNIFICANCE STATEMENT One of major goals in cognitive neuroscience has been to understand the nature of visual scene representation in human ventral visual cortex. An aspect of scene perception that has been overlooked despite its ecological importance is the analysis of space for navigation. One of critical computation necessary for navigation is coding of distance to environmental boundaries that impose limit on navigator's movements. This paper reports the first empirical evidence for coding of navigational distance in the human visual cortex and its striking sensitivity to functional constraint of environmental boundaries. Such finding links the paper to previous neurological and behavioral works that emphasized the distance to boundaries as a crucial geometric property for reorientation behavior of children and other animal species.

MECP2 gain-of-function and loss-of-function in genetically engineered monkeys recapitulates typical phenotypes in patients with autism, yet where MECP2 mutation affects the monkey brain and whether/how it relates to autism pathology remain unknown. Here we report a combination of gene–circuit–behavior analyses including MECP2 coexpression network, locomotive and cognitive behaviors, and EEG and fMRI findings in 5 MECP2 overexpressed monkeys (Macaca fascicularis; 3 females) and 20 wild-type monkeys (Macaca fascicularis; 11 females). Whole-genome expression analysis revealed MECP2 coexpressed genes significantly enriched in GABA-related signaling pathways, whereby reduced β-synchronization within fronto-parieto-occipital networks was associated with abnormal locomotive behaviors. Meanwhile, MECP2-induced hyperconnectivity in prefrontal and cingulate networks accounted for regressive deficits in reversal learning tasks. Furthermore, we stratified a cohort of 49 patients with autism and 72 healthy controls of 1112 subjects using functional connectivity patterns, and identified dysconnectivity profiles similar to those in monkeys. By establishing a circuit-based construct link between genetically defined models and stratified patients, these results pave new avenues to deconstruct clinical heterogeneity and advance accurate diagnosis in psychiatric disorders.

SIGNIFICANCE STATEMENT Autism spectrum disorder (ASD) is a complex disorder with co-occurring symptoms caused by multiple genetic variations and brain circuit abnormalities. To dissect the gene–circuit–behavior causal chain underlying ASD, animal models are established by manipulating causative genes such as MECP2. However, it is unknown whether such models have captured any circuit-level pathology in ASD patients, as demonstrated by human brain imaging studies. Here, we use transgenic macaques to examine the causal effect of MECP2 overexpression on gene coexpression, brain circuits, and behaviors. For the first time, we demonstrate that the circuit abnormalities linked to MECP2 and autism-like traits in the monkeys can be mapped to a homogeneous ASD subgroup, thereby offering a new strategy to deconstruct clinical heterogeneity in ASD.

Behavior can be guided by neuronal activity in visual, auditory, or somatosensory cerebral cortex, depending on task requirements. In contrast to this flexible access of cortical signals, several observations suggest that behaviors depend more on neurons in later areas of visual cortex than those in earlier areas, although neurons in earlier areas would provide more reliable signals for many tasks. We recorded from neurons in different levels of visual cortex of 2 male rhesus monkeys while the animals did a visual discrimination task and examined trial-to-trial correlations between neuronal and behavioral responses. These correlations became stronger in primary visual cortex as neuronal signals in that area became more reliable relative to the other areas. The results suggest that the mechanisms that read signals from cortex might access any cortical area depending on the relative value of those signals for the task at hand.

SIGNIFICANCE STATEMENT Information is encoded by the action potentials of neurons in various cortical areas in a hierarchical manner such that increasingly complex stimulus features are encoded in successive stages. The brain must extract information from the response of appropriate neurons to drive optimal behavior. A widely held view of this decoding process is that the brain relies on the output of later cortical areas to make decisions, although neurons in earlier areas can provide more reliable signals. We examined correlations between perceptual decisions and the responses of neurons in different levels of monkey visual cortex. The results suggest that the brain may access signals in any cortical area depending on the relative value of those signals for the task at hand.

Total food losses have been estimated at 1.3 billion tons per year, which represents roughly one-third of the world food production for human consumption. The economic value of food losses and waste amounts to $680 billion in industrialized countries and $310 billion in developing countries. In total, food loss and waste amount to one trillion dollars globally. Lost and wasted food [...]

All over the world local varieties of fruit, vegetables and grain are grown. Many are seemingly forgotten or are underutilized despite having outstanding nutritional or taste qualities. Some have good commercial potential and could be an excellent cash crop for a smallscale or family farmers, aimed at the local, regional or international market. Here are six traditional crops and six facts [...]

In the year 2000, the UN Member States set the eight Millennium Development Goals. One of the most ambitious was to eradicate extreme poverty and hunger. As part of this goal, the United Nations General Assembly set a target to halve the proportion of people who suffer from hunger by 2015.  But have you ever wondered how hunger is measured in [...]

Feeding the world’s growing population, which is expected to go beyond 9 billion by 2050, is one of the world’s biggest challenges. Some of the highest rates of population growth are predicted to occur in areas that are highly dependent on the agriculture sector (i.e. crops, livestock, forests and fisheries). Sustainable agricultural growth is one of the most effective means [...]

Pulses have been consumed for at least 10 000 years and are among the most extensively used foods in the world. They provide protein and fibre, and are a great source of vitamins and minerals, such as iron, zinc and magnesium. You probably already eat more pulses than you realize but can you put your finger on these facts on pulses? [...]

Maize, rice and wheat are fundamental to world food security. We must safeguard production in the world’s grain belts and rice bowls, and increase yields in countries where production has to substantially improve as populations grow. Climate change adds new pressures on cereals, including rising temperatures and a higher incidence of pests, diseases, droughts and floods. FAO’s model of ecosystem-based agriculture, [...]

The oceans have it all: from microscopic life to the largest animal that has ever lived on Earth, from the colourless to the shimmering, from the frozen to the boiling and from the sunlit to the mysterious dark of the deepest parts of the planet. Oceans are an essential component of the Earth's ecosystem -- a source of biodiversity, food, and [...]

FAO plays an important and unique role as a neutral forum, offering unbiased, high-quality information across all areas related to food, agriculture and sustainable natural resources management. With over 500 new publications a year, FAO provides robust technical knowledge and global statistics. By broadly disseminating timely, accurate and compelling information, FAO informs the work of practitioners, researchers and policy-makers, while raising [...]

With the health of our oceans at stake, illegal, unreported and unregulated (IUU) fishing has quickly become a monumental problem. The term “IUU fishing” is used for any fishing activities that operate outside of the law. There are many types of IUU fishing, for example, fishing without license or authorization, not accurately reporting the fish caught, fishing in prohibited areas [...]

Where would you find the world’s largest recreation center and the most natural supermarket? Forests wouldn’t have been your first answer, would it? That’s the thing about forests. They keep secrets.

Here's what you need to know to preserve your copy of history

The British Navy knew it couldn't completely disguise a ship to protect it from attack during WWI. So they turned to 'Dazzle Painting'

The snails are an invasive crop pest that are known to eat more than just coffee rust

A new simulation points to a previously untold chapter in Titan’s history

A collection of 14 restored wooden statues, including a two-ton William IV, will be shown at the Box Museum in England

The cats also cross the road an average of 4.5 times in six days, putting themselves in danger

The findings further refute the outdated notion that humans' capacity for complex artistic expression evolved exclusively in Europe

A new theory suggests the hot, harsh planet’s interior could have contained volatiles like water

Matilda McCrear was just 2 when she was captured and brought to Alabama on the "Clotilda"

The impact that created Pluto’s 'heart' may have rippled through its ocean and damaged its rear

This is the story behind the breads you might be baking in lockdown

Mary Pearson, who was briefly engaged to the writer's brother, may be the real-life counterpart of Lydia Bennet from "Pride and Prejudice"

A new analysis of ancient ostrich eggs at the British Museum underscores the interconnectedness of the ancient world

Pompeii Archaeological Park Director Massimo Osanna narrates stunning drone footage of preserved daily life in the ancient city