rat As COVID-19 Slows Human Mobility, Can the Global Compact for Migration Meet the Test for a Changed Era? By www.migrationpolicy.org Published On :: Mon, 27 Apr 2020 16:05:08 -0400 The coronavirus pandemic dramatically reshaped how human mobility is managed just as the Global Compact for Safe, Orderly, and Regular Migration was beginning to move from paper to implementation. As governments face pressing public-health, economic, and other concerns in responding to COVID-19, this MPI Europe commentary explores whether the first comprehensive global agreement on migration can adjust to a changed reality. Full Article
rat “Cubicle Activism”: Companies Face Growing Demands from Workers to Cut Ties with ICE and Others in Immigration Arena By www.migrationpolicy.org Published On :: Tue, 29 Oct 2019 16:24:30 -0400 From online petitions to organized walkouts, corporate America is facing increasing employee activism over its business involvement with agencies implementing the federal government's immigration policies. This "cubicle activism," seen at companies ranging from Amazon and Google to Bank of America and Wayfair, has garnered mixed success to date, forcing divestiture from private prison contractors but fewer results in other contexts, as this article explores. Full Article
rat Will Supreme Court Ruling on DACA Finally Force Congress to Break the Ice on Immigration Reform? By www.migrationpolicy.org Published On :: Tue, 19 Nov 2019 12:36:19 -0500 The fate of the Deferred Action for Childhood Arrivals (DACA) program has ping ponged between all three branches of government. But with the Supreme Court poised to decide DACA's future in spring 2020, Congress may finally be forced to act to resolve the status of DREAMers after nearly two decades of considering various DREAM Act bills. Could this break the long stalemate Congress has had on passing substantive immigration legislation, and pave the way for other actions? Full Article
rat Interlocking Set of Trump Administration Policies at the U.S.-Mexico Border Bars Virtually All from Asylum By www.migrationpolicy.org Published On :: Wed, 26 Feb 2020 17:23:32 -0500 Through a set of interlocking policies, the Trump administration has walled off the asylum system at the U.S.-Mexico border, guaranteeing that only a miniscule few can successfully gain protection. While the Migrant Protection Protocols, more commonly known as Remain in Mexico, have been a key part of throttling asylum applications, two newer, far less visible programs hold the potential to complete the job, as this article explores. Full Article
rat Promising Strategies for Reintegration of Migrants Returning to Mexico and Central America By www.migrationpolicy.org Published On :: Thu, 17 Jan 2019 18:03:26 -0500 This MPI webinar focuses on reception and reintegration services for returning migrants, along with the heightened pressure policymakers in Mexico and Central America are facing to design systems and programs that support both returnees and the communities in which they settle. Authors of a year-long study of reception and reintegration services in Mexico and the Northern Triangle discuss the findings of their fieldwork. Full Article
rat On the Move in a War Zone: Mixed Migration Flows to and through Yemen By www.migrationpolicy.org Published On :: Wed, 06 Feb 2019 10:01:12 -0500 War and impending famine in Yemen have captured significant attention. Yet often overlooked is the country’s role as the epicenter of one of the world’s busiest mixed migration routes, linking Africa, Asia, and Europe. This article examines the migration pathways to and through the country, push and pull factors, and the impact of civil war on human movement. Full Article
rat Explainer: Illegal Immigration in the United States By www.migrationpolicy.org Published On :: Wed, 13 Feb 2019 16:12:18 -0500 How has the size of the unauthorized population in the United States changed over time? How is illegal immigration changing, and where do unauthorized immigrants come from? This explainer answers basic questions about illegal immigration, the changing patterns from Mexico, and more. Full Article
rat A New Migration Policy for A New Era: A Conversation with Mexico's Interior Secretary Olga Sánchez Cordero By www.migrationpolicy.org Published On :: Thu, 28 Feb 2019 14:38:21 -0500 On her first official trip to Washington, DC, Secretary of the Interior Olga Sánchez Cordero offered a public address on Mexico’s new approach to migration policy at MPI. Her remarks and the event discussion were mostly conducted in Spanish, and this recording is of the simultaneous English interpretation. Full Article
rat Una nueva política migratoria para una nueva era: Una conversación con la Secretaria de Gobernación Olga Sánchez Cordero By www.migrationpolicy.org Published On :: Thu, 28 Feb 2019 18:28:45 -0500 Durante su primera visita oficial a Washington, DC, la Secretaria de Gobierno Olga Sánchez Cordero presento un discurso público sobre la nueva política migratoria de México en el Instituto de Políticas Migratorias. Full Article
rat Policy Options for Responding to Changing Migration Flows at the Southwest Border By www.migrationpolicy.org Published On :: Wed, 03 Apr 2019 13:27:37 -0400 Testimony of Andrew Selee, President of MPI, before Senate Committee on Homeland Security and Governmental Affairs on April 4, 2019 regarding response to changing migration flows at the Southwest border. Full Article
rat Is U.S.-Mexico Cooperation on Migration Possible? By www.migrationpolicy.org Published On :: Wed, 17 Apr 2019 12:36:02 -0400 Over recent months, the number of Central American migrants apprehended at the U.S.-Mexico border has surged, presenting a critical challenge in the relationship between the two neighboring countries. Experts from a Study Group on U.S.-Mexico Migration convened by El Colegio de México and MPI discuss current trends, policies, and politics surrounding migration from the Northern Triangle of Central America and the U.S.-Mexico relationship, ways to improve U.S. and Mexican asylum systems, possible new approaches to labor migration, ways to address smuggling networks, and modernize border management. Full Article
rat Beyond Walls and Tariffs: Responding to Migration Challenges at the U.S.-Mexico Border By www.migrationpolicy.org Published On :: Tue, 18 Jun 2019 10:17:39 -0400 This event organized by the Migration Policy Institute and American Enterprise Institute features a conversation on U.S.-Mexico border conditions, as well as policy responses and regional cooperation on illegal immigration. Full Article
rat Beyond Walls and Tariffs: Responding to Migration Challenges at the U.S.-Mexico Border By www.migrationpolicy.org Published On :: Tue, 09 Jul 2019 18:16:08 -0400 This event features a smart conversation by a range of experts on U.S.-Mexico border conditions, looking at policy responses by both countries and regional cooperation. Full Article
rat Strategic Solutions for the United States and Mexico to Manage the Migration Crisis By www.migrationpolicy.org Published On :: Wed, 17 Jul 2019 09:07:25 -0400 Amid surging migration from Central America, the United States and Mexico in June 2019 agreed to a series of enforcement measures. Yet these near-term efforts will be difficult to maintain given chronic institutional weaknesses and poorly thought-out policy structures in both countries. This commentary, by the presidents of MPI and El Colegio de México, offers a set of long-term, collaborative solutions to dissuade illegal migration while ensuring fairness to those seeking protection. Full Article
rat Soluciones estratégicas para afrontar la crisis migratoria en Estados Unidos y México By www.migrationpolicy.org Published On :: Wed, 17 Jul 2019 17:27:19 -0400 Dado el incremento de los flujos migratorios provenientes de Centroamérica, el pasado mes de junio de 2019, los Estados Unidos y México acordaron tomar una serie de medidas para reducir los flujos irregulares. Sin embargo, será muy difícil mantener estos esfuerzos de corto plazo, debido a una debilidad institucional crónica y a estructuras de política pública poco planificadas en ambos países. Este comentario ofrece cinco recomendaciones a ambos países considerando soluciones de mediano y largo plazo para disuadir la migración irregular y, al mismo tiempo, garantizar que aquellos que busquen protección tengan un proceso justo. Full Article
rat ADA CERP collaboration focuses on dentistry’s role in interprofessional education By www.ada.org Published On :: Thu, 09 Jan 2020 12:06:00 -0600 The ADA’s Continuing Education Recognition Program, or ADA CERP, announced in December that it is collaborating with Joint Accreditation for Interprofessional Continuing Education, in an effort to offer dentists more opportunities to participate in interprofessional education. Full Article
rat American College of Dentists celebrates centennial anniversary By www.ada.org Published On :: Tue, 14 Jan 2020 10:05:00 -0600 As the American College of Dentists celebrates its 100th anniversary, its leaders are ready to continue their mission of advancing excellence, ethics, professionalism and leadership in dentistry. Full Article
rat Former executive director of FDI World Dental Federation dies By www.ada.org Published On :: Tue, 11 Feb 2020 07:37:00 -0600 Dr. Per Äke Zillen, executive director of the FDI World Dental Federation from 1989-2001, died Jan. 19 following a battle with cancer. Full Article
rat Indian Health Service, ADA collaborate on Give Kids A Smile for first time By www.ada.org Published On :: Wed, 19 Feb 2020 13:10:00 -0600 It was a Give Kids A Smile event not only for the children of the Mississippi Band of Choctaw Indians but also no fewer than 117 Indian Health Service dental programs across 24 states that were participating in GKAS with the events alone estimated to involve 14,000 American Indian/Alaska Native children. Full Article
rat March JADA finds past incarceration associated with oral health issues By www.ada.org Published On :: Mon, 24 Feb 2020 09:00:00 -0600 Formerly incarcerated people in the U.S. have worse oral health outcomes than those who have never been in prison, according to a study published in the March issue of The Journal of the American Dental Association. Full Article
rat American Institute of Dental Public Health mentors next generation of service-oriented dentists By www.ada.org Published On :: Tue, 25 Feb 2020 13:26:00 -0600 Dr. David P. Cappelli, Ph.D., acknowledges that as providers, we don’t often understand difficulties that some patients face to receive needed dental care. Full Article
rat ADA Accelerator Series seeks to speed up dentists’ success By www.ada.org Published On :: Wed, 04 Mar 2020 15:43:00 -0600 The Association is launching in March a new online, on-demand program specifically designed to provide information — from parental leave to financial support — that is tailored to the early-career dentist’s unique work-life balance needs. Full Article
rat Howard dental school celebrates GKAS By www.ada.org Published On :: Mon, 09 Mar 2020 09:56:00 -0500 The Howard University College of Dentistry treated 35 students from Washington’s Raymond Elementary School at a Feb. 7 Give Kids A Smile event. Full Article
rat DEA Call Center suspends phone operations By www.ada.org Published On :: Mon, 23 Mar 2020 12:54:00 -0500 Springfield, Virginia — The Drug Enforcement Administration announced that effective March 23, the DEA Call Center has temporarily suspended phone operations due to COVID-19 pandemic. Full Article
rat ADA asks Treasury Department, Small Business Administration to clarify intent of interim rule By www.ada.org Published On :: Sun, 05 Apr 2020 11:09:00 -0500 The Association continues to wait for clear guidance from the U.S. Department of Treasury and Small Business Administration on the best way to help dentists considering applying for Paycheck Protection Program 7(a) loans and Economic Injury Disaster Loans. Full Article
rat Small Business Administration: Dentists can apply for both economic injury disaster and paycheck protection program loans By www.ada.org Published On :: Mon, 06 Apr 2020 13:28:00 -0500 Dentists can apply for both Economic Injury Disaster Loans and Paycheck Protection Program 7(a) loans, the Small Business Administration told the American Dental Association on April 6. Full Article
rat Webinar on Small Business Administration loans available online By www.ada.org Published On :: Fri, 10 Apr 2020 10:26:00 -0500 The ADA webinar, Small Business Administration Loans: Understanding the Options for Dentist Owners, is available online. Full Article
rat New ADA course to answer army of questions about coding accurately By www.ada.org Published On :: Fri, 10 Apr 2020 12:12:00 -0500 As the source of dental procedure codes, the ADA has created a new online training course to ensure that dentists and their team members confidently understand CDT codes and how to use them correctly. Full Article
rat ADA asks Congress to increase funding, extend dates for Small Business Administration loans By www.ada.org Published On :: Mon, 13 Apr 2020 14:08:00 -0500 The ADA is urging Congress to continue supporting small businesses during the COVID-19 pandemic by increasing funding and streamlining the application process for Small Business Administration loans. Full Article
rat Amalgam separator deadline remains intact By www.ada.org Published On :: Fri, 17 Apr 2020 10:04:00 -0500 The deadline for dental offices to install amalgam separators remains intact but the Environmental Protection Agency announced March 26 that it will be initiating “a new temporary enforcement discretion policy” during the COVID-19 pandemic. Full Article
rat ADA FDC Annual Meeting postpones registration By www.ada.org Published On :: Tue, 21 Apr 2020 16:19:00 -0500 The American Dental Association and Florida Dental Association have postponed registration for the ADA FDC Annual Meeting from April 22 to early summer, in light of the COVID-19 pandemic. Full Article
rat ADA streams webinar April 27 on respiratory protection By www.ada.org Published On :: Thu, 23 Apr 2020 14:40:00 -0500 A recorded webinar will stream April 27 outlining the Association’s interim recommendation for personal protective equipment in dental settings as some states consider loosening social distancing mandates. Full Article
rat Major corporations, cities buying into Texas' green energy boom By www.upi.com Published On :: Mon, 28 Jan 2019 09:50:51 -0500 The U.S. wind industry is in a scramble to get a batch of turbine farms running in the next two years, before the federal government phases out a key tax credit. Full Article
rat Arthritis drug shows promise against respiratory distress caused by COVID-19 By www.upi.com Published On :: Thu, 07 May 2020 19:18:36 -0400 Anakinra, a drug developed to treat rheumatoid arthritis might help patients who have developed acute respiratory distress syndrome caused by COVID-19, a small study published by The Lancet Rheumatology has found. Full Article
rat 15-minute COVID-19 test proves accurate at confirming infection By www.upi.com Published On :: Fri, 08 May 2020 17:19:00 -0400 A new, point-of-care testing kit for COVID-19 that can deliver results in 15 minutes accurately diagnoses people more than 80 percent of time, an analysis has found. Full Article
rat Exploring the Potential of Two-Generation Strategies in Refugee Integration By www.migrationpolicy.org Published On :: Fri, 14 Dec 2018 11:45:21 -0500 On this webinar, MPI researchers and Utah and Colorado refugee coordinators explore promising practices to better serve refugee families, including education services for refugee youth, innovative efforts to secure better jobs for adult refugees, and other services designed to aid integration over time. They also discuss the potential for implementing and supporting two-generation approaches to refugee integration at a time when the system’s funding and capacity are in peril. Full Article
rat Sustainable Reintegration: Strategies to Support Migrants Returning to Mexico and Central America By www.migrationpolicy.org Published On :: Tue, 15 Jan 2019 11:23:40 -0500 Reception and reintegration programs for deported and other returning migrants represent a long-term investment for migrant-origin and destination countries, holding the potential to reduce re-migration and permit communities of origin to benefit from the skills migrants learn abroad. This report offers recommendations to make reintegration programs more effective in Mexico and Central America. Full Article
rat Breaking New Ground: Ten Ideas to Revamp Integration Policy in Europe By www.migrationpolicy.org Published On :: Wed, 23 Jan 2019 10:00:37 -0500 To address the intersecting challenges facing European societies—from population aging and labor-market change, to immigration and political upheaval—governments need to hone new strategies for helping both newcomers and long-term residents succeed amid diversity. This report explores some of the most promising approaches, drawing on input from policymakers, the private sector, civil society, and others. Full Article
rat Exploring New Legal Migration Pathways: Lessons from Pilot Projects By www.migrationpolicy.org Published On :: Thu, 14 Feb 2019 10:26:36 -0500 As European countries launch ambitious new legal migration partnerships with several origin and transit countries in Africa, this report takes stock of the long and mixed history of such projects. To make the most of their potential to encourage skills development and fill pressing labor gaps, policymakers will need to think carefully about the partners and sectors they choose, among other key considerations. Full Article
rat Trends in Uninsured Rates Before and After Medicaid Expansion in Counties Within and Outside of the Diabetes Belt By care.diabetesjournals.org Published On :: 2020-01-27T16:03:28-08:00 OBJECTIVETo examine trends in uninsured rates between 2012 and 2016 among low-income adults aged <65 years and to determine whether the Patient Protection and Affordable Care Act (ACA), which expanded Medicaid, impacted insurance coverage in the Diabetes Belt, a region across 15 southern and eastern states in which residents have high rates of diabetes.RESEARCH DESIGN AND METHODSData for 3,129 U.S. counties, obtained from the Small Area Health Insurance Estimates and Area Health Resources Files, were used to analyze trends in uninsured rates among populations with a household income ≤138% of the federal poverty level. Multivariable analysis adjusted for the percentage of county populations aged 50–64 years, the percentage of women, Distressed Communities Index value, and rurality.RESULTSIn 2012, 39% of the population in the Diabetes Belt and 34% in non-Belt counties were uninsured (P < 0.001). In 2016 in states where Medicaid was expanded, uninsured rates declined rapidly to 13% in Diabetes Belt counties and to 15% in non-Belt counties. Adjusting for county demographic and economic factors, Medicaid expansion helped reduce uninsured rates by 12.3% in Diabetes Belt counties and by 4.9% in non-Belt counties. In 2016, uninsured rates were 15% higher for both Diabetes Belt and non-Belt counties in the nonexpansion states than in the expansion states.CONCLUSIONSACA-driven Medicaid expansion was more significantly associated with reduced uninsured rates in Diabetes Belt than in non-Belt counties. Initial disparities in uninsured rates between Diabetes Belt and non-Belt counties have not existed since 2014 among expansion states. Future studies should examine whether and how Medicaid expansion may have contributed to an increase in the use of health services in order to prevent and treat diabetes in the Diabetes Belt. Full Article
rat Performance of High-Sensitivity Cardiac Troponin Assays To Reflect Comorbidity Burden and Improve Mortality Risk Stratification in Older Adults With Diabetes By care.diabetesjournals.org Published On :: 2020-03-11T14:49:52-07:00 OBJECTIVEIncorporation of comorbidity burden to inform diabetes management in older adults remains challenging. High-sensitivity cardiac troponins are objective, quantifiable biomarkers that may improve risk monitoring in older adults. We assessed the associations of elevations in high-sensitivity cardiac troponin I (hs-cTnI) and T (hs-cTnT) with comorbidities and improvements in mortality risk stratification.RESEARCH DESIGN AND METHODSWe used logistic regression to examine associations of comorbidities with elevations in either troponin (≥85th percentile) among 1,835 participants in the Atherosclerosis Risk in Communities (ARIC) Study with diabetes (ages 67–89 years, 43% male, 31% black) at visit 5 (2011–2013). We used Cox models to compare associations of high cardiac troponins with mortality across comorbidity levels.RESULTSElevations in either troponin (≥9.4 ng/L for hs-cTnI, ≥25 ng/L for hs-cTnT) were associated with prevalent coronary heart disease, heart failure, chronic kidney disease, pulmonary disease, hypoglycemia, hypertension, dementia, and frailty. Over a median follow-up of 6.2 years (418 deaths), both high hs-cTnI and high hs-cTnT further stratified mortality risk beyond comorbidity levels; those with a high hs-cTnI or hs-cTnT and high comorbidity were at highest mortality risk. Even among those with low comorbidity, a high hs-cTnI (hazard ratio [HR] 3.0 [95% CI 1.7, 5.4]) or hs-cTnT (HR 3.3 [95% CI 1.8, 6.2]) was associated with elevated mortality. CONCLUSIONS Many comorbidities were reflected by both hs-cTnI and hs-cTnT; elevations in either of the troponins were associated with higher mortality risk beyond comorbidity burden. High-sensitivity cardiac troponins may identify older adults at high mortality risk and be useful in guiding clinical care of older adults with diabetes. Full Article
rat Sleep Duration Patterns in Early to Middle Adulthood and Subsequent Risk of Type 2 Diabetes in Women By care.diabetesjournals.org Published On :: 2020-03-24T15:44:44-07:00 OBJECTIVETo identify sleep duration trajectories from early to middle adulthood and their associations with incident type 2 diabetes.RESEARCH DESIGN AND METHODSUsing a group-based modeling approach, we identified sleep duration trajectories based on sleep duration in ages 20–25, 26–35, 36–45, and 46+ years, which were retrospectively assessed in 2009 among 60,068 women from the Nurses’ Health Study II (median age 54.9 years) who were free of diabetes, cardiovascular disease, and cancer. We investigated the prospective associations between sleep duration trajectories and diabetes risk (2009–2017) using multivariable Cox proportional hazards models.RESULTSWe documented 1,797 incident diabetes cases over a median follow-up of 7.8 years (442,437 person-years). Six sleep duration trajectories were identified: persistent 5-, 6-, 7-, or 8-h sleep duration and increased or decreased sleep duration. After multivariable adjustment for diabetes risk factors, compared with the persistent 7-h sleep duration group, the hazard ratio was 1.43 (95% CI 1.10, 1.84) for the 5-h group, 1.17 (1.04, 1.33) for the 6-h group, 0.96 (0.84, 1.10) for the 8-h group, 1.33 (1.09, 1.61) for the increased sleep duration group, and 1.32 (1.10, 1.59) for the decreased sleep duration group. Additional adjustment for time-updated comorbidities and BMI attenuated these associations, although a significantly higher risk remained in the decreased sleep duration group (1.24 [1.03, 1.50]).CONCLUSIONSPersistent short sleep duration or changes in sleep duration from early to middle adulthood were associated with higher risk of type 2 diabetes in later life. These associations were weaker after obesity and metabolic comorbidities were accounted for. Full Article
rat Erratum. Randomized Controlled Trial of Mobile Closed-Loop Control. Diabetes Care 2020;43:607-615 By care.diabetesjournals.org Published On :: 2020-04-03T07:56:03-07:00 Full Article
rat Erratum. Predicting 10-Year Risk of End-Organ Complications of Type 2 Diabetes With and Without Metabolic Surgery: A Machine Learning Approach. Diabetes Care 2020;43:852-859 By care.diabetesjournals.org Published On :: 2020-04-15T14:26:52-07:00 Full Article
rat Commercially Available Insulin Products Demonstrate Stability Throughout the Cold Supply Chain Across the U.S. By care.diabetesjournals.org Published On :: 2020-04-27T16:36:14-07:00 OBJECTIVEA recent publication questioned the integrity of insulin purchased from U.S. retail pharmacies. We sought to independently validate the method used, isotope dilution solid-phase extraction (SPE) liquid chromatography mass spectrometry (LC-MS), and expand analysis to two U.S. Pharmacopeia (USP) methods (high-performance LC with ultraviolet detection and LC-MS).RESEARCH DESIGN AND METHODSEach method was used to evaluate nine insulin formulations, purchased at four pharmacies, within five geographic locations in the U.S.RESULTSAll human and analog insulins measured by the USP methods (n = 174) contained the expected quantity of active insulin (100 ± 5 units/mL). When using isotope dilution SPE-LC-MS, units-per-milliliter values were well below product labeling due to unequal recovery of the internal standard compared with target insulin.CONCLUSIONSInsulin purchased from U.S. pharmacies is consistent with product labeling. Full Article
rat Metabolic Factors, Lifestyle Habits, and Possible Polyneuropathy in Early Type 2 Diabetes: A Nationwide Study of 5,249 Patients in the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) Cohort By care.diabetesjournals.org Published On :: 2020-04-28T09:53:07-07:00 OBJECTIVETo investigate the association of metabolic and lifestyle factors with possible diabetic polyneuropathy (DPN) and neuropathic pain in patients with early type 2 diabetes.RESEARCH DESIGN AND METHODSWe thoroughly characterized 6,726 patients with recently diagnosed diabetes. After a median of 2.8 years, we sent a detailed questionnaire on neuropathy, including the Michigan Neuropathy Screening Instrument questionnaire (MNSIq), to identify possible DPN (score ≥4) and the Douleur Neuropathique en 4 Questions (DN4) questionnaire for possible associated neuropathic pain (MNSIq ≥4 + pain in both feet + DN4 score ≥3).RESULTSAmong 5,249 patients with data on both DPN and pain, 17.9% (n = 938) had possible DPN, including 7.4% (n = 386) with possible neuropathic pain. In regression analyses, central obesity (waist circumference, waist-to-hip ratio, and waist-to-height ratio) was markedly associated with DPN. Other important metabolic factors associated with DPN included hypertriglyceridemia ≥1.7 mmol/L, adjusted prevalence ratio (aPR) 1.36 (95% CI 1.17; 1.59); decreased HDL cholesterol <1.0/1.2 mmol/L (male/female), aPR 1.35 (95% CI 1.12; 1.62); hs-CRP ≥3.0 mg/L, aPR 1.66 (95% CI 1.42; 1.94); C-peptide ≥1,550 pmol/L, aPR 1.72 (95% CI 1.43; 2.07); HbA1c ≥78 mmol/mol, aPR 1.42 (95% CI 1.06; 1.88); and antihypertensive drug use, aPR 1.34 (95% CI 1.16; 1.55). Smoking, aPR 1.50 (95% CI 1.24; 1.81), and lack of physical activity (0 vs. ≥3 days/week), aPR 1.61 (95% CI 1.39; 1.85), were also associated with DPN. Smoking, high alcohol intake, and failure to increase activity after diabetes diagnosis associated with neuropathic pain.CONCLUSIONSPossible DPN was associated with metabolic syndrome factors, insulin resistance, inflammation, and modifiable lifestyle habits in early type 2 diabetes. Full Article
rat Efficacy and Safety of 1:1 Fixed-Ratio Combination of Insulin Glargine and Lixisenatide Versus Lixisenatide in Japanese Patients With Type 2 Diabetes Inadequately Controlled on Oral Antidiabetic Drugs: The LixiLan JP-O1 Randomized Clinical Trial By care.diabetesjournals.org Published On :: 2020-04-28T10:59:59-07:00 OBJECTIVETo assess the efficacy and safety of a 1:1 fixed-ratio combination of insulin glargine and lixisenatide (iGlarLixi) versus lixisenatide (Lixi) in insulin-naive Japanese patients with type 2 diabetes mellitus (T2DM) inadequately controlled on oral antidiabetic drugs (OADs).RESEARCH DESIGN AND METHODSIn this phase 3, open-label, multicenter trial, 321 patients with HbA1c≥7.5 to ≤10.0% (58–86 mmol/mol) and fasting plasma glucose (FPG) ≤13.8 mmol/L (250 mg/dL) were randomized 1:1 to iGlarLixi or Lixi for 52 weeks. The primary end point was change in HbA1c at week 26.RESULTSChange in HbA1c from baseline to week 26 was significantly greater with iGlarLixi (–1.58% [–17.3 mmol/mol]) than with Lixi (–0.51% [–5.6 mmol/mol]), confirming the superiority of iGlarLixi (least squares [LS] mean difference –1.07% [–11.7 mmol/mol], P < 0.0001). At week 26, significantly greater proportions of patients treated with iGlarLixi reached HbA1c <7% (53 mmol/mol) (65.2% vs. 19.4%; P < 0.0001), and FPG reductions were greater with iGlarLixi than Lixi (LS mean difference –2.29 mmol/L [–41.23 mg/dL], P < 0.0001). Incidence of documented symptomatic hypoglycemia (≤3.9 mmol/L [70 mg/dL]) was higher with iGlarLixi (13.0% vs. 2.5%) through week 26, with no severe hypoglycemic events in either group. Incidence of gastrointestinal events through week 52 was lower with iGlarLixi (36.0% vs. 50.0%), and rates of treatment-emergent adverse events were similar.CONCLUSIONSThis phase 3 study demonstrated superior glycemic control and fewer gastrointestinal adverse events with iGlarLixi than with Lixi, which may support it as a new treatment option for Japanese patients with T2DM that is inadequately controlled with OADs. Full Article
rat Acrylamide Exposure and Oxidative DNA Damage, Lipid Peroxidation, and Fasting Plasma Glucose Alteration: Association and Mediation Analyses in Chinese Urban Adults By care.diabetesjournals.org Published On :: 2020-04-28T14:58:19-07:00 OBJECTIVEAcrylamide exposure from daily-consumed food has raised global concern. We aimed to assess the exposure-response relationships of internal acrylamide exposure with oxidative DNA damage, lipid peroxidation, and fasting plasma glucose (FPG) alteration and investigate the mediating role of oxidative DNA damage and lipid peroxidation in the association of internal acrylamide exposure with FPG.RESEARCH DESIGN AND METHODSFPG and urinary biomarkers of oxidative DNA damage (8-hydroxy-deoxyguanosine [8-OHdG]), lipid peroxidation (8-iso-prostaglandin-F2α [8-iso-PGF2α]), and acrylamide exposure (N-acetyl-S-[2-carbamoylethyl]-l-cysteine [AAMA], N-acetyl-S-[2-carbamoyl-2-hydroxyethyl]-l-cysteine [GAMA]) were measured for 3,270 general adults from the Wuhan-Zhuhai cohort. The associations of urinary acrylamide metabolites with 8-OHdG, 8-iso-PGF2α, and FPG were assessed by linear mixed models. The mediating roles of 8-OHdG and 8-iso-PGF2α were evaluated by mediation analysis.RESULTSWe found significant linear positive dose-response relationships of urinary acrylamide metabolites with 8-OHdG, 8-iso-PGF2α, and FPG (except GAMA with FPG) and 8-iso-PGF2α with FPG. Each 1-unit increase in log-transformed level of AAMA, AAMA + GAMA (UAAM), or 8-iso-PGF2α was associated with a 0.17, 0.15, or 0.23 mmol/L increase in FPG, respectively (P and/or P trend < 0.05). Each 1% increase in AAMA, GAMA, or UAAM was associated with a 0.19%, 0.27%, or 0.22% increase in 8-OHdG, respectively, and a 0.40%, 0.48%, or 0.44% increase in 8-iso-PGF2α, respectively (P and P trend < 0.05). Increased 8-iso-PGF2α rather than 8-OHdG significantly mediated 64.29% and 76.92% of the AAMA- and UAAM-associated FPG increases, respectively.CONCLUSIONSExposure of the general adult population to acrylamide was associated with FPG elevation, oxidative DNA damage, and lipid peroxidation, which in turn partly mediated acrylamide-associated FPG elevation. Full Article
rat Cardiovascular Risk Reduction With Liraglutide: An Exploratory Mediation Analysis of the LEADER Trial By care.diabetesjournals.org Published On :: 2020-05-04T10:48:32-07:00 OBJECTIVEThe LEADER trial (ClinicalTrials.gov reg. no. NCT01179048) demonstrated a reduced risk of cardiovascular (CV) events for patients with type 2 diabetes who received the glucagon-like peptide 1 receptor agonist liraglutide versus placebo. The mechanisms behind this CV benefit remain unclear. We aimed to identify potential mediators for the CV benefit observed with liraglutide in the LEADER trial.RESEARCH DESIGN AND METHODSWe performed exploratory analyses to identify potential mediators of the effect of liraglutide on major adverse CV events (MACE; composite of CV death, nonfatal myocardial infarction, or nonfatal stroke) from the following candidates: glycated hemoglobin (HbA1c), body weight, urinary albumin-to-creatinine ratio (UACR), confirmed hypoglycemia, sulfonylurea use, insulin use, systolic blood pressure, and LDL cholesterol. These candidates were selected as CV risk factors on which liraglutide had an effect in LEADER such that a reduction in CV risk might result. We used two methods based on a Cox proportional hazards model and the new Vansteelandt method designed to use all available information from the mediator and to control for confounding factors.RESULTSAnalyses using the Cox methods and Vansteelandt method indicated potential mediation by HbA1c (up to 41% and 83% mediation, respectively) and UACR (up to 29% and 33% mediation, respectively) on the effect of liraglutide on MACE. Mediation effects were small for other candidates.CONCLUSIONSThese analyses identify HbA1c and, to a lesser extent, UACR as potential mediators of the CV effects of liraglutide. Whether either is a marker of an unmeasured factor or a true mediator remains a key question that invites further investigation. Full Article
rat Is U.S.-Mexico Cooperation on Migration Possible? By www.migrationpolicy.org Published On :: Mon, 08 Apr 2019 09:48:29 -0400 As the numbers of Central American migrants crossing into Mexico and the United States rises—putting migration front and center in the U.S.-Mexico relationship again—this event examines the opportunities for cooperation between the two countries, along with ways to improve U.S. and Mexican asylum systems, create new approaches to labor migration, address smuggling networks, and modernize border management. Full Article