With the northeast monsoon over southern China being generally weaker than normal for most of the time in March, the month was much warmer than usual, the Hong Kong Observatory said today.

The monthly mean temperature was 21.3 degrees Celsius, 2.2 degrees above normal and the mean minimum temperature was 19.7 degrees Celsius, 2.5 degrees above average. Both were the joint second highest on record for March.

The monthly mean maximum temperature was 23.8 degrees Celsius, 2.4 degrees above normal and the fifth highest on record for the month.

The month was also drier than usual with a total rainfall of 41.3mm, about half of the normal figure.

The accumulated rainfall recorded in the first three months of the year was 135.9mm, about 16% below average.

Acidosis is a key driver for many diseases, including cancer, sepsis, and stroke. The spatiotemporal dynamics of dysregulated pH across disease remains elusive and current diagnostic strategies do not provide localization of pH alterations. We sought to explore if PET imaging using hydrophobic cyclic peptides that partition into the cellular membrane at low extracellular pH (denoted as "pHLIC") can permit accurate in vivo visualization of acidosis. Methods: Acid-sensitive cyclic peptide c[E4W5C] pHLIC was conjugated to bifunctional maleimide-NO2A and radiolabeled with copper-64 (t1/2 = 12.7 h). C57BL/6J mice were administered LPS (15 mg/kg) or saline (vehicle) and serially imaged with [⁶⁴Cu]Cu-c[E4W5C] over 24 h. Ex vivo autoradiography was performed on resected brain slices and subsequently stained with cresyl violet to enable high-resolution spatial analysis of tracer accumulation. A non- pH-sensitive cell-penetrating control peptide (c[R4W5C]) was used to confirm specificity of [⁶⁴Cu]Cu-c[E4W5C]. CD11b (macrophage/microglia) and TMEM119 (microglia) immunostaining was performed to correlate extent of neuroinflammation with [⁶⁴Cu]Cu-c[E4W5C] PET signal. Results: [⁶⁴Cu]Cu-c[E4W5C] radiochemical yield and purity was >95% and >99% respectively, with molar activity >0.925 MBq/nmol. Significantly increased [⁶⁴Cu]Cu-c[E4W5C] uptake was observed in LPS-treated mice (vs. vehicle) within peripheral tissues including blood, lungs, liver, and small intestines (P < 0.001-0.05). Additionally, there was significantly increased [⁶⁴Cu]Cu-c[E4W5C] uptake in the brains of LPS-treated animals. Autoradiography confirmed increased uptake in the cerebellum, cortex, hippocampus, striatum, and hypothalamus of LPS-treated mice (vs. vehicle). Immunohistochemical (IHC) analysis revealed microglial/macrophage infiltrate, suggesting activation in brain regions containing increased tracer uptake. [⁶⁴Cu]Cu-c[R4W5C] demonstrated significantly reduced uptake in the brain and periphery of LPS mice compared to the acid-mediated [⁶⁴Cu]Cu-c[E4W5C] tracer. Conclusion: Here, we demonstrate that a pH-sensitive PET tracer specifically detects acidosis in regions associated with sepsis-driven pro-inflammatory responses. This study suggests that [⁶⁴Cu]Cu-pHLIC is a valuable tool to noninvasively assess acidosis associated with both central and peripheral innate immune activation.

Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 20 minutes long and presents 5-6 recently published articles from ADA journals.

Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting.

This month we review articles on:

1. Association of body mass index, fitness, and mortality in patients with diabetes
2. Cognitive deficits and traditional diabetic complications in the severely obese
3. Late Relapse of Diabetes after Bariatric Surgery
4. Hypoglycemia in Type 1 Diabetes and Subsequent Cognitive Deficits
5. Nutrient Induced Beta Cell Stress
6. Topical Oxygen Therapy in the Treatment of Diabetic Foot Ulcers

For more information about each of ADA’s science and medical journals, please visit www.diabetesjournals.org.

Presented by:

Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health

John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Abington Jefferson Health

This is a special issue focusing on Covid-19 and Diabetes:

1. Characteristics of and Important Lessons From
   the Coronavirus Disease 2019 (COVID-19) Outbreak in China
2. Clinical course and risk factors for mortality
3. Diabetes and Hypertension: Are ACE’s, ARBs and NSAIDs OK to Use?

Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 20 minutes long and presents 5-6 recently published articles from ADA journals.

Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting.

For more information about each of ADA’s science and medical journals, please visit www.diabetesjournals.org.

Presented by:

Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health

John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Abington Jefferson Health

The ADA Council on Dental Practice is encouraging dentists to acknowledge the dedication and contributions of their dental assistants during Dental Assistants Recognition Week.

Formerly incarcerated people in the U.S. have worse oral health outcomes than those who have never been in prison, according to a study published in the March issue of The Journal of the American Dental Association.

The Health Resources and Services Administration is hosting a virtual job fair March 4 from 6:45-10:15 p.m. ET. In addition, HRSA’s National Health Service Corps Loan Repayment Program is now accepting applications for 2020 through April 23.

The deadline for submission of abstracts for the FDI World Dental Congress is March 25.

Dr. Martin Nweeia began researching narwhals in 2000. He came to the conclusion that the prevailing research available about the narwhal’s tooth — such as Charles Darwin’s belief that the narwhal’s tooth was a secondary sexual characteristic like an antler or a horn — was only part of the story.

ADA Practice Transitions, a service offered by the ADA focused on helping dentists make the process of joining or leaving a practice successful, is offering a free three-month trial.

On March 20, the ADA will release an on-demand webinar offering answers to frequently asked questions about infection control protocol and procedures related to COVID-19.

The ADA is presenting two free webinars March 27, aiming to help dentists financially weather the economic downturn during the COVID-19 outbreak and illustrate how ADA advocacy has helped turn the tide.

Dr. Michael Glick, professor in oral diagnostic sciences at the University at Buffalo School of Dental Medicine, is stepping down as editor of The Journal of the American Dental Association effective March 31.

The March 2020 issue of College & Research Libraries is now freely available online. Visit the C&RL website for complete contents from 1939 to the present and followC&RL on Facebook and Twitter for updates and discussion. Note: The November 2013 issue was the final print issue of College & Research Libraries. The journal began an online-only publication model in [...]

Thousands of teachers marched in Annapolis on Monday evening, pushing for higher pay and more resources for their students.

Stuttgart : Enke, 1899.

Paris : G. Steinheil, 1892.

Londres : Paris, 1840.

[Rome?]

Marcus Sorensen is using his connections in Sweden to stay ready in case the NHL season resumes.

Official counts of COVID-19 deaths have been criticized for potentially including people who did not die of COVID-19 but merely died with COVID-19. I address that critique by fitting a generalized additive model to weekly counts of all registered deaths in England and Wales during the 2010s. The model produces baseline rates of death registrations expected in the absence of the COVID-19 pandemic, and comparing those baselines to recent counts of registered deaths exposes the emergence of excess deaths late in March 2020. Among adults aged 45+, about 38,700 excess deaths were registered in the 5 weeks comprising 21 March through 24 April (612 $pm$ 416 from 21$-$27 March, 5675 $pm$ 439 from 28 March through 3 April, then 9183 $pm$ 468, 12,712 $pm$ 589, and 10,511 $pm$ 567 in April's next 3 weeks). Both the Office for National Statistics's respective count of 26,891 death certificates which mention COVID-19, and the Department of Health and Social Care's hospital-focused count of 21,222 deaths, are appreciably less, implying that their counting methods have underestimated rather than overestimated the pandemic's true death toll. If underreporting rates have held steady, about 45,900 direct and indirect COVID-19 deaths might have been registered by April's end but not yet publicly reported in full.

Klemm (Family)

French translation of the BIS press release about the BIS Quarterly Review, March 2018

French translation of "Frequently asked questions on market risk capital requirements" by the Basel Committee, March 2018.

French translation of the BIS press release about the BIS Quarterly Review, September 2018

French translation of the BIS press release about the BIS Quarterly Review, March 2019

Spanish translation of the speech by Mr Agustín Carstens, General Manager of the BIS, on the occasion of the Bank's Annual General Meeting, Basel, 30 June 2019.

Spanish translation of the BIS press release on the presentation of the Annual Economic Report 2019, 30 June 2019.

To view more press releases, please visit http://www.snl.com/irweblinkx/news.aspx?iid=1024452.