The latest news on global small hydroelectric facilities from July-August 2014

Chile's Schwager Energy and China-based Shenyang Yuanda Commercial & Investment Co. signed a memorandum of understanding on Nov. 3 to build the 3-MW Los Pinos run-of-the-river hydroelectric plant in southern Chile's Lagos region, according to BN Americas.
 

As Bruce Dear writes, “COVID-19 poses a threat of unparalleled potency to our real estate markets and economy. So our industry and government must unite behind a grand, generous and visionary response to match the scale of this once in a cent...

Court of Appeal upholds single collective bargaining unit for only 1.2% of employees in an otherwise non-unionised employer In a significant development for employers, particularly those without recognised trade unions and those with dispersed busin...

In May 2017, David Webb, an activist investor and former director of the Hong Kong Exchange and Clearing Limited, issued a report titled "The Enigma Network: 50 stocks not to own". This report mapped out a complex web of cross-shareholdings between ...

(MENAFN - EIN Presswire) Coronavirus - Africa: Commemorating Smallpox Eradication � a legacy of hope, for COVID-19 and other�diseases [To enable links... ......

(MENAFN - African Press Organization) [To enable links in your articles, contact MENAFN Click here ] [To enable links in your articles, contact MEN... ......

On a dusty plaza in a Native American village that dates back nearly a millennium, a steady trickle of vehicles inched through a pop-up coronavirus testing site.

PICURIS PUEBLO, N.M. (AP) — On a dusty plaza in a Native American village that dates back nearly a millennium, a steady trickle of vehicles inched through a pop-up coronavirus testing site. From the bed of a pickup truck...

Download logo On 8 May 1980, the 33rd World Health Assembly officially declared: ‘The world and all its peoples have won freedom from smallpox.’ The declaration marked the end of a disease that had plagued humanity for at least 3 000 years, killing 300 million people in the 20th century alone. It was ended, thanks to a 10-year global effort, spearheaded by the World Health Organization, that involved thousands of health workers around the world to administer half a billion vaccinations to stamp out smallpox. The US$ 300m price-tag to eradicate smallpox saves the world well over US$ 1 billion every year since 1980. Speaking at a virtual event hosted at WHO-HQ, involving key...

[WHO] Geneva -On 8 May 1980, the 33rd World Health Assembly officially declared: 'The world and all its peoples have won freedom from smallpox.'

[WHO] Geneva -Good morning, good afternoon and good evening.

A study by doctors at China's Shangqiu Municipal Hospital of 38 men hospitalized with the disease found that six of them, or 16%, tested positive for SARS-CoV-2 in their semen.

A huge 28,000 square metre retail centre is being earmarked for the Barbros construction plant next to the Lidl supermarket in Zejtun

Ankara’s haste to reopen shopping malls may be an effort to revive sagging consumption, but it also has to do with a tight nexus between politicians and businesses in the country.

Shopping malls, gyms and amusement parks, considered high-density venues, are expected to reopen next if the number of new Covid-19 infections continues to drop for another week.

Agricultural insurance has the potential to add immense value to agriculture value chains by facilitating access to means of production and changing behaviour by reducing uncertainty.

Police dispersed lunchtime protesters with pepper spray in an upscale Hong Kong shopping centre just 12 hours after the government relaxed some coronavirus social-distancing measures and allowed people to gather in groups of eight on Friday.Shortly after dozens of anti-government demonstrators began yelling slogans and belting out their anthem, officers entered the IFC Mall in Central to cordon off their protest site, forcing the Apple store to lower its shutters.Later, police used pepper spray…

Pamela Coke-Hamilton, Director, Division on International Trade and Commodities, UN Conference on Trade & Development (UNCTAD)

The post Impact of COVID-19 on Tourism in Small Island Developing States appeared first on Inter Press Service.

As the sun sets over the hills, Prafulla Debbarma, a small tea grower in Dhanbilash village in north eastern India, walks along the labyrinth path of his farm and past a thick blanket of well-grown tea plants. In the fading light, the farmer appears deeply worried. This tea farm, the sole source of his livelihood, […]

The post Has COVID-19 Reversed Progress for India’s Small Tea Growers? appeared first on Inter Press Service.

ISLAMABAD: The State Bank of Pakistan’s Refinance Scheme for Small Businesses has so far failed to take off due to multiple reasons as the commercial banks are not designed and fully equipped to provide credit line to Small and Medium Enterprises .“The SBP’s Refinance Scheme for...

ISLAMABAD: The State Bank of Pakistan’s Refinance Scheme for Small Businesses has so far failed to take off due to multiple reasons as the commercial banks are not designed and fully equipped to provide credit line to Small and Medium Enterprises .“The SBP’s Refinance Scheme for...

ISLAMABAD: The State Bank of Pakistan’s Refinance Scheme for Small Businesses has so far failed to take off due to multiple reasons as the commercial banks are not designed and fully equipped to provide credit line to Small and Medium Enterprises .“The SBP’s RefinanceScheme for...

The idea that rural water schemes are only sustainable if small, simple and locally managed is a bias that must be overcome to get more clean water to the people who need it.

Complex, carefully managed financing structures can provide the funding needed for island states and others seeking to develop energy projects.

Crafting small business support efforts to specific country circumstances could help save millions of livelihoods in poor communities and fortify economies against future shocks.

Colorado Springs is the beachhead. But it's always been clear In-N-Out Burger planned to feed its fanatical following along the Front Range by building more than just the one restaurant coming to that city in 2020.

The project aimed to improve access of micro, small, and medium enterprises (MSMEs) to commercial financing and market opportunities, thereby fostering growth, competitiveness, and employment creation in India. There were three targeted outputs. First was enhance credit delivery through Small Industries Development Bank of India (SIDBI) and participating financial institutions in the MSME subsector. Second was increased SME productive and managerial capacity and related new jobs created for new markets.

The Second Investment Climate Improvement Program has included help for the government in constructing the policy, legal, and financial framework needed to encourage, negotiate, and close agreements for sound PPPs.

Financial constraints are a significant barrier for India's SMEs participating in global value chains.

Financial constraints are a significant barrier for India's SMEs participating in global value chains.

Few that have bought or even rented real estate in India would be surprised by a recent survey showing the property market here can be maddeningly murky. Jones Lang LaSalle’s Global Real Estate Transparency Index showed that while things have improved, Indian cities still have to work on transparency. The Chicago-based real-estate consultant said India needs to go further to create more clarity on the rules connected to property purchases and real estate prices. “India still scores among the lowest in the transparency of its transaction process,” the report said. Jones Lang LaSalle looked at just over 100 markets around the world and rated them on a dozen parameters ranging […]

Josh Beasley and his fiancé bought Houston's Body3 Personal Fitness on July 1, less than two months before Tropical Storm Harvey swamped the gym with a foot of water and left behind the dank stench of fetid mildew.

Sara Pauly is not one of those small business owners scrambling to fill out paperwork for part of the more than $350 billion in government aid available through the Paycheck Protection Program or the...

After closing their doors to prevent the spread of the coronavirus, many small businesses face an uncertain future following government-ordered lockdowns.

Ditch the phone, don't stand too close and strive for optimal eye contact: the evidence-based approach to painless holiday schmoozing

Wealth Enhancement Group's Nicole Webb says small cap stocks make good bets emerging from a recession but not amid the current market volatility.

Title: Small Study Shows Lipodissolve Works
Category: Health News
Created: 4/28/2010 9:24:00 AM
Last Editorial Review: 4/28/2010 9:24:32 AM

Title: Analysis Finds Clinical Trials Often Small, of Poor Quality
Category: Health News
Created: 5/1/2012 6:05:00 PM
Last Editorial Review: 5/2/2012 12:00:00 AM

Title: Nail Salons' Drying Lamps Carry Small Cancer Risk
Category: Health News
Created: 4/30/2014 7:36:00 PM
Last Editorial Review: 5/1/2014 12:00:00 AM

Title: Mom's Money Worries May Mean Smaller Baby
Category: Health News
Created: 5/3/2017 12:00:00 AM
Last Editorial Review: 5/4/2017 12:00:00 AM

Title: In Small Study, Rheumatoid Arthritis Drug Appears to Help COVID-19 Patients
Category: Health News
Created: 5/7/2020 12:00:00 AM
Last Editorial Review: 5/8/2020 12:00:00 AM

ABSTRACT

Intracellular bacterial pathogens remodel cellular functions during their infectious cycle via the coordinated actions of effector molecules delivered through dedicated secretion systems. While the function of many individual effectors is known, how they interact to promote pathogenesis is rarely understood. The zoonotic bacterium Brucella abortus, the causative agent of brucellosis, delivers effector proteins via its VirB type IV secretion system (T4SS) which mediate biogenesis of the endoplasmic reticulum (ER)-derived replicative Brucella-containing vacuole (rBCV). Here, we show that T4SS effectors BspB and RicA display epistatic interactions in Brucella replication. Defects in rBCV biogenesis and Brucella replication caused by deletion of bspB were dependent on the host GTPase Rab2a and suppressed by the deletion of ricA, indicating a role of Rab2-binding effector RicA in these phenotypic defects. Rab2a requirements for rBCV biogenesis and Brucella intracellular replication were abolished upon deletion of both bspB and ricA, demonstrating that the functional interaction of these effectors engages Rab2-dependent transport in the Brucella intracellular cycle. Expression of RicA impaired host secretion and caused Golgi fragmentation. While BspB-mediated changes in ER-to-Golgi transport were independent of RicA and Rab2a, BspB-driven alterations in Golgi vesicular traffic also involved RicA and Rab2a, defining BspB and RicA’s functional interplay at the Golgi interface. Altogether, these findings support a model where RicA modulation of Rab2a functions impairs Brucella replication but is compensated by BspB-mediated remodeling of Golgi apparatus-associated vesicular transport, revealing an epistatic interaction between these T4SS effectors.

IMPORTANCE Bacterial pathogens with an intracellular lifestyle modulate many host cellular processes to promote their infectious cycle. They do so by delivering effector proteins into host cells via dedicated secretion systems that target specific host functions. While the roles of many individual effectors are known, how their modes of action are coordinated is rarely understood. Here, we show that the zoonotic bacterium Brucella abortus delivers the BspB effector that mitigates the negative effect on bacterial replication that the RicA effector exerts via modulation of the host small GTPase Rab2. These findings provide an example of functional integration between bacterial effectors that promotes proliferation of pathogens.

ABSTRACT

Burkholderia pseudomallei, the founding member of the B. pseudomallei complex (Bpc), is a biothreat agent and causes melioidosis, a disease whose treatment mainly relies on ceftazidime and meropenem. The concern is that B. pseudomallei could enhance its drug resistance repertoire by the acquisition of DNA from resistant near-neighbor species. Burkholderia ubonensis, a member of the B. cepacia complex (Bcc), is commonly coisolated from environments where B. pseudomallei is present. Unlike B. pseudomallei, in which significant primary carbapenem resistance is rare, it is not uncommon in B. ubonensis, but the underlying mechanisms are unknown. We established that carbapenem resistance in B. ubonensis is due to an inducible class A PenB β-lactamase, as has been shown for other Bcc bacteria. Inducibility is not sufficient for high-level resistance but also requires other determinants, such as a PenB that is more robust than that present in susceptible isolates, as well as other resistance factors. Curiously and diagnostic for the two complexes, both Bpc and Bcc bacteria contain distinct annotated PenA class A β-lactamases. However, the protein from Bcc bacteria is missing its essential active-site serine and, therefore, is not a β-lactamase. Regulated expression of a transcriptional penB'-lacZ (β-galactosidase) fusion in the B. pseudomallei surrogate B. thailandensis confirms that although Bpc bacteria lack an inducible β-lactamase, they contain the components required for responding to aberrant peptidoglycan synthesis resulting from β-lactam challenge. Understanding the diversity of antimicrobial resistance in Burkholderia species is informative about how the challenges arising from potential resistance transfer between them can be met.

IMPORTANCE Burkholderia pseudomallei causes melioidosis, a tropical disease that is highly fatal if not properly treated. Our data show that, in contrast to B. pseudomallei, B. ubonensis β-lactam resistance is fundamentally different because intrinsic resistance is mediated by an inducible class A β-lactamase. This includes resistance to carbapenems. Our work demonstrates that studies with near-neighbor species are informative about the diversity of antimicrobial resistance in Burkholderia and can also provide clues about the potential of resistance transfer between bacteria inhabiting the same environment. Knowledge about potential adverse challenges resulting from the horizontal transfer of resistance genes between members of the two complexes enables the design of effective countermeasures.

A growing number of small secreted peptides (SSPs) in plants are recognized as important regulatory molecules with roles in processes such as growth, development, reproduction, stress tolerance, and pathogen defense. Recent discoveries further implicate SSPs in regulating root nodule development, which is of particular significance for legumes. SSP-coding genes are frequently overlooked, because genome annotation pipelines generally ignore small open reading frames, which are those most likely to encode SSPs. Also, SSP-coding small open reading frames are often expressed at low levels or only under specific conditions, and thus are underrepresented in non-tissue-targeted or non-condition-optimized RNA-sequencing projects. We previously identified 4,439 SSP-encoding genes in the model legume Medicago truncatula. To support systematic characterization and annotation of these putative SSP-encoding genes, we developed the M. truncatula Small Secreted Peptide Database (MtSSPdb; https://mtsspdb.noble.org/). MtSSPdb currently hosts (1) a compendium of M. truncatula SSP candidates with putative function and family annotations; (2) a large-scale M. truncatula RNA-sequencing-based gene expression atlas integrated with various analytical tools, including differential expression, coexpression, and pathway enrichment analyses; (3) an online plant SSP prediction tool capable of analyzing protein sequences at the genome scale using the same protocol as for the identification of SSP genes; and (4) information about a library of synthetic peptides and root and nodule phenotyping data from synthetic peptide screens in planta. These datasets and analytical tools make MtSSPdb a unique and valuable resource for the plant research community. MtSSPdb also has the potential to become the most complete database of SSPs in plants.

Irene Verhagen, Barbara M. Tomotani, Phillip Gienapp, and Marcel E. Visser

Phenotypic plasticity is an important mechanism by which an individual can adapt its seasonal timing to predictable, short-term environmental changes by using predictive cues. Identification of these cues is crucial to forecast the response of species to long-term environmental change and to study their potential to adapt. Individual great tits (Parus major) start reproduction early under warmer conditions in the wild, but whether this effect is causal is not well known. We housed 36 pairs of great tits in climate-controlled aviaries and 40 pairs in outdoor aviaries, where they bred under artificial contrasting temperature treatments or in semi-natural conditions, respectively, for two consecutive years, using birds from lines selected for early and late egg laying. We thus obtained laying dates in two different thermal environments for each female. Females bred earlier under warmer conditions in climate-controlled aviaries, but not in outdoor aviaries. The latter was inconsistent with laying dates from our wild population. Further, early selection line females initiated egg laying consistently ~9 days earlier than late selection line females in outdoor aviaries, but we found no difference in the degree of plasticity (i.e. the sensitivity to temperature) in laying date between selection lines. Because we found that temperature causally affects laying date, climate change will lead to earlier laying. This advancement is, however, unlikely to be sufficient, thereby leading to selection for earlier laying. Our results suggest that natural selection may lead to a change in mean phenotype, but not to a change in the sensitivity of laying dates to temperature.

Endogenous viral elements (EVEs) are found in many eukaryotic genomes. Despite considerable knowledge about genomic elements such as transposons (TEs) and retroviruses, we still lack information about nonretroviral EVEs. Aedes aegypti mosquitoes have a highly repetitive genome that is covered with EVEs. Here, we identified 129 nonretroviral EVEs in the AaegL5 version of the A. aegypti genome. These EVEs were significantly associated with TEs and preferentially located in repeat-rich clusters within intergenic regions. Genome-wide transcriptome analysis showed that most EVEs generated transcripts although only around 1.4% were sense RNAs. The majority of EVE transcription was antisense and correlated with the generation of EVE-derived small RNAs. A single genomic cluster of EVEs located in a 143 kb repetitive region in chromosome 2 contributed with 42% of antisense transcription and 45% of small RNAs derived from viral elements. This region was enriched for TE-EVE hybrids organized in the same coding strand. These generated a single long antisense transcript that correlated with the generation of phased primary PIWI-interacting RNAs (piRNAs). The putative promoter of this region had a conserved binding site for the transcription factor Cubitus interruptus, a key regulator of the flamenco locus in Drosophila melanogaster. Here, we have identified a single unidirectional piRNA cluster in the A. aegypti genome that is the major source of EVE transcription fueling the generation of antisense small RNAs in mosquitoes. We propose that this region is a flamenco-like locus in A. aegypti due to its relatedness to the major unidirectional piRNA cluster in Drosophila melanogaster.