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Structure-mechanics statistical learning unravels the linkage between local rigidity and global flexibility in nucleic acids

Chem. Sci., 2020, Advance Article
DOI: 10.1039/D0SC00480D, Edge Article
Open Access
Yi-Tsao Chen, Haw Yang, Jhih-Wei Chu
The mechanical properties of nucleic acids underlie biological processes ranging from genome packaging to gene expression. We devise structural mechanics statistical learning method to reveal their molecular origin in terms of chemical interactions.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Integrated sustainability reporting [electronic resource] : linking environmental and social information to value creation processes / Laura Bini, Marco Bellucci

Bini, Laura




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Multi-corneal barrier-on-a-chip to recapitulate eye blinking shear stress forces

Lab Chip, 2020, 20,1410-1417
DOI: 10.1039/C9LC01256G, Paper
Rodi Abdalkader, Ken-ichiro Kamei
Human corneal epithelium coexists with tear fluids and shows its barrier functionality under the dynamic conditions of eye blinking. We developed a microfluidic platform enabling the dynamic culture of the human corneal barrier with recapitulation of eye blinking.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Express Newslist: Modi calls IS greatest challenge, Karnataka bandh, Hawala crackdown links to Dawood




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JioSaavn hires former LinkedIn exec Virginia Sharma as vice-president of brand solutions

Sharma will be based out of the Gurugam office, and will lead the company’s global digital ad monetisation efforts across platforms. She will be responsible for driving adoption of JioSaavn’s advertising solutions for brands, while overseeing agency and client relationships.




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Higher daily step count linked with lower all-cause mortality

In a new study, higher daily step counts were associated with lower mortality risk from all causes. Researchers found that the number of steps taken each day, but not the intensity of the stepping, had a strong association with mortality.




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[ASAP] Lattice Strain Induced by Linker Scission in Metal–Organic Framework Nanosheets for Oxygen Evolution Reaction

ACS Catalysis
DOI: 10.1021/acscatal.0c00989




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The woman on the stairs / Bernhard Schlink ; translated from the German by Joyce Hackett and Bradley Schmidt

Hayden Library - PT2680.L54 F7313 2016




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Science Podcast - 100 years of crystallography, linking malaria and climate, and a news roundup (7 Mar 2014)

Celebrating crystallography's centennial; how climate pushes malaria uphill; roundup of daily news with David Grimm.




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Podcast: A planet beyond Pluto, the bugs in your home, and the link between marijuana and IQ

Online News Editor David Grimm shares stories on studying marijuana use in teenage twins, building a better maze for psychological experiments, and a close inspection of the bugs in our homes. Science News Writer Eric Hand joins host Sarah Crespi to discuss the potential for a ninth planet in the solar system that circles the sun just once every 15,000 years.  [Image: Gilles San Martin/CC BY-SA 2.0]




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Podcast: Patent trolls, the earthquake-volcano link, and obesity in China

Online News Editor Catherine Matacic shares stories on how earthquakes may trigger volcanic eruptions, growing obesity in China’s children, and turning salty water sweet on the cheap.   Lauren Cohen joins host Sarah Crespi to discuss the rise of patent trolls in the United States and a proposal for cutting back on their sizable profits.     [Image: © Alberto Garcia/Corbis]




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Podcast: What ants communicate when kissing, stars birthed from gas, and linking immune strength and social status

This week, we chat about kissing communication in ants, building immune strength by climbing the social ladder, and a registry for animal research with Online News Editor David Grimm. Plus, Science’s Alexa Billow talks to Bjorn Emonts about the birth of stars in the Spiderweb Galaxy 10 billion years ago.   Related research on immune function and social hierarchy.   Listen to previous podcasts.   [Image: Lauren Brent; Music: Jeffrey Cook]




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Podcast: Bringing back tomato flavor genes, linking pollution and dementia, and when giant otters roamed Earth

This week, we chat about 50-kilogram otters that once stalked southern China, using baseball stats to show how jet lag puts players off their game, and a growing link between pollution and dementia, with Online News Editor David Grimm. Also in this week’s show: our very first monthly book segment. In the inaugural segment, Jen Golbeck interviews Helen Pilcher about her new book Bring Back the King: The New Science of De-extinction. Plus Denise Tieman joins Alexa Billow to discuss the genes behind tomato flavor, or lack thereof.   Listen to previous podcasts.    [Image: Dutodom; Music: Jeffrey Cook]




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A Stone Age skull cult, rogue Parkinson’s proteins in the gut, and controversial pesticides linked to bee deaths

This week we have stories on what the rogue Parkinson’s protein is doing in the gut, how chimps outmuscle humans, and evidence for an ancient skull cult with Online News Editor David Grimm. Jen Golbeck is back with this month’s book segment. She interviews Alan Alda about his new book on science communication: If I Understood You, Would I Have This Look on My Face? Sarah Crespi talks to Jeremy Kerr about two huge studies that take a nuanced looked at the relationship between pesticides and bees. Read the research in Science: Country-specific effects of neonicotinoid pesticides on honey bees and wild bees, B.A. Woodcock et al. Chronic exposure to neonicotinoids reduces honey bee health near corn crops, Tsvetkov et al. Listen to previous podcasts. [Image: webted/Flickr; Music: Jeffrey Cook]




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The biology of color, a database of industrial espionage, and a link between prions and diabetes

This week we hear stories on diagnosing Alzheimer’s disease in chimps, a potential new pathway to diabetes—through prions—and what a database of industrial espionage says about the economics of spying with Online News Editors David Grimm and Catherine Matacic. Sarah Crespi talks to Innes Cuthill about how the biology of color intersects with behavior, development, and vision. And Mary Soon Lee joins to share some of her chemistry haiku—one poem for each element in the periodic table. Listen to previous podcasts. [Image: Zoltan Tasi/Unsplash; Music: Jeffrey Cook]




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Animals that don’t need people to be domesticated; the astonishing spread of false news; and links between gender, sexual orientation, and speech

Did people domesticate animals? Or did they domesticate themselves? Online News Editor David Grimm talks with Sarah Crespi about a recent study that looked at self-domesticating mice. If they could go it alone, could cats or dogs have done the same in the distant past? Next, Sinan Aral of the Massachusetts Institute of Technology in Cambridge joins Sarah to discuss his work on true and false rumor cascades across all of Twitter, since its inception. He finds that false news travels further, deeper, and faster than true news, regardless of the source of the tweet, the kind of news it was, or whether bots were involved. In a bonus segment recording during a live podcasting event at the AAAS Annual Meeting in Austin, Sarah first speaks with Ben Munson of the University of Minnesota in Minneapolis about markers of gender and sexual orientation in spoken language and then Adrienne Hancock of The George Washington University in Washington, D.C., talks about using what we know about gender and communication to help transgender women change their speech and communication style. Live recordings sessions at the AAAS meeting were supported by funds from the European Commission. This week’s episode was edited by Podigy. Listen to previous podcasts. [Image: Rudolf Jakkel (CC0); Music: Jeffrey Cook]




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A possible cause for severe morning sickness, and linking mouse moms’ caretaking to brain changes in baby mice

Researchers are converging on which genes are linked to morning sickness—the nausea and vomiting associated with pregnancy—and the more severe form: hyperemesis gravidarum (HG). And once we know what those genes are—can we help pregnant women feel better? News intern Roni Dengler joins Sarah Crespi to talk about a new study that suggests a protein already flagged for its role in cancer-related nausea may also be behind HG. In a second segment, Tracy Bedrosian of the Neurotechnology Innovations Translator talks about how the amount of time spent being licked by mom might be linked to changes in the genetic code of hippocampal neurons in mice pups. Could these types of genomic changes be a new type of plasticity in the brain? This week’s episode was edited by Podigy. Listen to previous podcasts. [Image: Jacob Bøtter/Flickr; Music: Jeffrey Cook]




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Researchers flouting clinical reporting rules, and linking gut microbes to heart disease and diabetes

Though a law requiring clinical trial results reporting has been on the books for decades, many researchers have been slow to comply. Now, 2 years after the law was sharpened with higher penalties for noncompliance, investigative correspondent Charles Piller took a look at the results. He talks with host Sarah Crespi about the investigation and a surprising lack of compliance and enforcement. Also this week, Sarah talks with Brett Finlay, a microbiologist at the University Of British Columbia, Vancouver, about an Insight in this week’s issue that aims to connect the dots between noncommunicable diseases like heart disease, diabetes, and cancer and the microbes that live in our guts. Could these diseases actually spread through our microbiomes? This week’s episode was edited by Podigy. Listen to previous podcasts. About the Science Podcast Download a transcript (PDF). [Image: stu_spivack/Flickr; Music: Jeffrey Cook]




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Chiral separations with crosslinked cellulose derivatives attached onto hybrid silica monolith particles via thiol-ene click reaction

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00772B, Paper
Yuhong Zhou, Qian Liang, Zhilun Zhang, Zhaodi Wang, Mingxian Huang
Hybrid silica monolith containing vinyl groups was synthesized by a sol-gel method and then ground and treated, yielding silica particles with 3-5 μm in particles size and 10-20 nm in...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Solid-phase microextraction using a β-ketoenamine-linked covalent organic framework coating for efficient enrichment of synthetic musks in water samples

Anal. Methods, 2020, Advance Article
DOI: 10.1039/C9AY02755F, Paper
Lian Wen, Peng Wu, Lei-Lei Wang, Li-Zong Chen, Ming-Lin Wang, Xia Wang, Jin-Ming Lin, Ru-Song Zhao
This study indicated the promising applicability of the TpPa-1 as a solid-phase microextraction fiber coating for reliably detecting synthetic musks at trace levels from environmental samples.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Sample selection in tax data sets of intergenerational links [electronic resource] : evidence from the Longitudinal and International Study of Adults / by Gaëlle Simard-Duplain and Xavier St-Denis

Ottawa : Statistics Canada = Statistique Canada, 2020




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BSEB 12th board exam: Link to apply for scrutiny opens at biharboardonline.bihar.gov.in

Along with the scrutiny process. students can also apply for copies of answer sheets and OMR sheets at the official website.




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Assistive Technology Services for Youth in the Vermont Linking Learning to Careers Program

The Vermont Division of Vocational Rehabilitation’s Linking Learning to Careers (LLC) program provides enhanced services to help high school students with disabilities as they make the transition to careers or postsecondary education. These enhanced services include access to assistive technology.




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Science and Technology Parks and Regional Economic Development: An International Perspective / Sara Amoroso, Albert N. Link, Mike Wright, editors

Online Resource




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Collaborative research in fisheries: co-creating knowledge for fisheries governance in Europe / Petter Holm, Maria Hadjimichael, Sebastian Linke, Steven Mackinson, editors

Online Resource




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Evaluation of the subtle trade-off between physical stability and thermo-responsiveness in crosslinked methylcellulose hydrogels

Soft Matter, 2020, Accepted Manuscript
DOI: 10.1039/D0SM00269K, Paper
Lorenzo Bonetti, Luigi De Nardo, Fabio Variola, Silvia Fare
Methylcellulose (MC) hydrogels, undergoing sol-gel reversible transition upon temperature changes, lend themselves to smart system applications. However, their reduced stability in aqueous environment and unsatisfactory mechanical properties limit the breadth...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Kudankulam-1 trips on launch but NPCIL says linked to grid

The grid control room said the unit is not likely to come back on before Wednesday night.




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Patna serial blasts: Terror attack suspected, cops say person held has IM links

Arrested person is suspected to have supplied explosives with the help of IM commander Riyaz Bhatkal.




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Extending the Scalability of Linkage Learning Genetic Algorithms [electronic resource] / Ying-ping Chen

Secaucus : Springer, 2006




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Presidency vandalism: Report hints at Trinamool link in campus row



  • DO NOT USE West Bengal
  • India

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10 positive cases with Koyambedu links emerge in Chittoor district

Most of them are involved in transporting vegetables to the Chennai market




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098 JSJ Assemble.io with Brian Woodward and Jon Schlinkert

The panelists speak with Brian Woodward and Job Schlinkert about Assemble.io.




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MJS #008: Jon Schlinkert

On today's episode of My JS Story, Charles Max Wood welcomes Jon Schlinkert. Jon was on JavaScript Jabber episode 98 where he talked about Assemble.io. Tune in to My JS Story Jon Schlinkert to learn how his journey began in programming and what's keeping him busy these days.




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JSJ 308: D3.js with Ben Clinkinbeard

Panel:

  • Joe Eames
  • Cory House
  • Aimee Knight

Special Guests: Ben Clinkinbeard

In this episode, the JavaScript Jabber panelists talk about D3.js with Ben Clinkinbeard. D3.js is a JavaScript library that has you use declarative code to tell it what you want and then it figures out all of the browser inconsistencies and creates the notes for you. He talks about the two main concepts behind D3, scales and selections, which once you understand make D3 a lot more user friendly. He then touches on SPGs and discusses his Learn D3 in 5 Days course.

In particular, we dive pretty deep on:

  • What is D3.js?
  • Stands for Data Driven Documents
  • JavaScript
  • How much of the learning curve is attributed to learning D3?
  • SPG
  • 2 main concepts behind D3: scales and selections
  • Is learning about SPGs a prerequisite to leaning D3?
  • How serious are you talking when saying idiosyncrasies?
  • SPG tag
  • Understanding positioning in SPG
  • Positions with CSS transforms
  • Are you required to use SPG?
  • Not required to use SPG with D3
  • Canvas
  • SPG is vector based
  • SPG utility function
  • Responseivefy
  • Learn D3 in 5 Days course
  • Is there and overlap with D3 and React?
  • And much, much more!

Links:

Picks:

Cory

Joe Eames

Aimee

Ben




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Young children, parents and professionals [electronic resource] : enhancing the links in early childhood / Margaret Henry

Henry, Margaret, 1931-




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Tricarabrols A–C, three anti-inflammatory sesquiterpene lactone trimers featuring a methylene-tethered linkage from Carpesium faberi

Org. Chem. Front., 2020, Advance Article
DOI: 10.1039/D0QO00093K, Research Article
Jie Yuan, Xuelan Wen, Chang-Qiang Ke, Tian Zhang, Ligen Lin, Sheng Yao, Jason D. Goodpaster, Chunping Tang, Yang Ye
Three anti-inflammatory trimeric compounds constructed from carabrol-type sesquiterpenoids through a methylene-tethered linkage were characterized from Carpesium faberi.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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[ASAP] The First Quantitative Synthesis of a Closed Three-Link Chain (6<sub arrange="stack">1</sub><sup arrange="stack">3</sup>) Using Coordination and Noncovalent Interactions-Driven Self-Assembly

Journal of the American Chemical Society
DOI: 10.1021/jacs.0c01406




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Databook of curatives and crosslinkers / Malgorzata Hanson and Anna Wypych

Online Resource




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Handbook of curatives and crosslinkers / George Wypych

Online Resource




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Palladium supported on triazolyl-functionalized hypercrosslinked polymers as a recyclable catalyst for Suzuki–Miyaura coupling reactions

RSC Adv., 2020, 10,17123-17128
DOI: 10.1039/D0RA01190H, Paper
Open Access
Cijie Liu, Lijuan Zheng, Dexuan Xiang, Shasha Liu, Wei Xu, Qionglin Luo, You Shu, Yuejun Ouyang, Hongwei Lin
A novel hypercrosslinked polymer-palladium catalyst was prepared via external cross-linking reactions and applied in Suzuki–Miyaura reactions as a recyclable catalyst, resulting in TON numbers up to 1.66 × 104 and yields reaching 99%.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Post-synthetic modification of imine linkages of a covalent organic framework for its catalysis application

RSC Adv., 2020, 10,17396-17403
DOI: 10.1039/D0RA02142C, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Qianqian Yan, Huanjun Xu, Xuechao Jing, Hui Hu, Shenglin Wang, Chaoyuan Zeng, Yanan Gao
A new approach for post-synthetic modification of covalent organic frameworks has been developed based on the modification of the linkages and the resulting COF exhibited excellent catalytic performance towards cycloaddition of epoxides and CO2.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Jump links and viewport positioning

Using within-page links presses the jumped-to content right at the very top of the viewport. This can be a problem when using a fixed header. With a bit of hackery, there are some CSS methods to insert space between the top of the viewport and the target element within a page.

Demo: Jump links and viewport positioning

Known support: varies depending on method used.

This experiment is the result of a post Chris Coyier made on Forrst. Chris’ method was to add an empty span element to the target element, shift the id attribute onto the span, and then absolutely position the span somewhere above it’s parent element.

That method works but it requires changes to the HTML. The comments on Chris’ post suggested the use of psuedo-elements or padding. This experiment expands on, and combines, some of those suggestions to show the limitations of each method and document their browser support.

Simplest method

If you need to jump to an element with simple styling then using the :before pseudo-element is a quick and simple approach.

#target:before {
   content: "";
   display: block;
   height: 50px;
   margin: -30px 0 0;
}

The drawbacks are that it requires browser support for pseudo-elements and it will fail if the target element has a background colour, a repeated background image, padding-top, or border-top as part of its rule set.

More robust method

The more robust method uses a transparent border, negative margin, and the background-clip property. If a top border is required then it can be mimicked using a pseudo-element, as described in Multiple Backgrounds and Borders with CSS 2.1.

#target {
   position: relative;
   border-top: 52px solid transparent;
   margin: -30px 0 0;
   -webkit-background-clip: padding-box;
   -moz-background-clip: padding;
   background-clip: padding-box;
}

#target:before {
   content: "";
   position: absolute;
   top: -2px;
   left: 0;
   right: 0;
   border-top: 2px solid #ccc;
}

There are still drawbacks: it requires browser support for background-clip if there is a background color, gradient, or repeating image set on the target element; it requires browser support for pseudo-elements and their positioning if a top border is desired; and it interferes with the standard use of margins.

To see these methods in action – as well as more details on the code, browser support, and drawbacks – have a look at the demo page. Please let me know if you know of better techniques.




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Probing the limits of linker substitution in aluminum MOFs through water vapor sorption studies: Mixed-MOF instead of mixed-linker CAU-23 and MIL-160 materials

Dalton Trans., 2020, Accepted Manuscript
DOI: 10.1039/D0DT01044H, Paper
Carsten Schlüsener, Dustin Nils Jordan, Mergime Xhinovci, Tobie J. Matemb Ma Ntep, Alexa Schmitz, Beatriz Giesen, Christoph Janiak
We report the systematic study on the possibility of forming mixed-linker MOFs spanning between the aluminum metal-organic frameworks CAU-23 and MIL-160 with their 2,5-thiophenedicarboxylate (TDC) and 2,5 furandicarboxylate (FDC) linkers,...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Genetic signature links bacterial toxin to colon cancer

Colibactin causes key cancer mutations




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Genetic signature links bacterial toxin to colon cancer

Colibactin causes key cancer mutations




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Olga Malinkiewicz wants to make good on the promise of perovskites

Her company, Saule Technologies, has a low-cost process to print the solar cells on a multitude of materials




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No evidence to support link between ibuprofen and COVID-19, experts say

WHO does not recommend against taking the drug for fever caused by novel coronavirus infection




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DuPont, APC Microbiome Ireland link up for babies




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DHFL to face transaction audit on Yes Bank links

“Grant Thornton has already started scrutinising documents related to transactions,” said one of the persons in the know. “The existing administrators want to make things transparent so that the matter does not impact the valuation of DHFL assets.”




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One in three Indian professionals now have decreased income: LinkedIn survey

IT, media, and manufacturing employees think their firms will do worse in the next 6 months. However, they’re confident about long-term growth - 77% of manufacturing professionals, 67% of media professionals, and 65% of IT professionals thought their companies would pick up in the next 2 years.