In this issue of JAMA Cardiology, Lim and colleagues report on cardiovascular functional reserve in people with end-stage renal disease before and after kidney transplant. They performed a 3-arm, prospective, concurrent cohort study to assess change in cardiovascular functional reserve after kidney transplant using state-of-the-art cardiopulmonary exercise testing (CPET). They also assessed left ventricular morphologic findings 1 year after transplant. They enrolled 81 participants with stage 5 chronic kidney disease (CKD) who underwent kidney transplant, 85 wait-listed participants with stage 5 CKD who had not undergone transplant, and 87 controls treated for hypertension only. The authors quantified cardiovascular functional reserve using CPET in parallel with transthoracic echocardiography. One year after transplant, a significant improvement in maximum oxygen consumption was found in the transplant group compared with the nontransplant group. Moreover, left ventricular function improved but not the body mass index.

To the Editor We read the recent article by Klauser et al with great interest. While the potential implications of the findings are exciting, we have several concerns. First, the authors do not explicitly state whether electrocardiogram gating was used in their study. This is an important detail because cardiac motion artifact is a source of artifactual coloration with dual-energy computed tomography (DECT), particularly with dual-source scanners given the approximately 80-millisecond temporal difference between the 2 radiography beams. Furthermore, beam hardening artifact from calcified atheromas and partial volume effect, known sources of artifacts in the 2-material decomposition algorithm of DECT, may largely explain the findings. While patients with gout had higher prevalence of coronary calcification (55 of 59 patients [93%]) and cardiovascular monosodium urate (MSU) deposition (51 of 59 patients [86%]) than controls, the authors do not report whether the 4 patients with gout without coronary calcifications exhibited MSU deposition nor the number of controls or cadaveric hearts with coronary calcification. The images from the article show areas of green pixelization occurring adjacent to calcified plaques on grayscale computed tomography images (eg, Figure 2A and D, left anterior descending artery [yellow arrowhead]), which would favor this artifact hypothesis without additional data.

In Reply We appreciate the valuable comments of Becce et al on our article. We applied prospective electrocardiography gating using a thin-slice cardiac protocol to ensure highest spatial resolution with minimal motion artifact. A noncontrast electrocardiography-gated computed tomography (CT) examination with standardized scan parameters was performed using a 128-slice dual-source CT (SOMATOM Definition Flash; Siemens) with a detector collimation of 2 × 64 × 0.6 mm, rotation time of 0.28 seconds, and prospective electrocardiography triggering for heart rates less than 65 beats per minute (diastolic padding, 70% of RR interval) and more than 65 beats per minute (systolic padding, 40% of RR interval). Axial images were reconstructed with 0.75-mm slice width, increment of 0.5, and a medium-smooth convolution kernel (B26f). When motion artifact was present, it was distinguished by visual analysis of an experienced observer and colorized pixels related to motion were excluded.

This cohort study assesses cardiovascular functional reserve before and after kidney transplant in patients with end-stage renal disease.

Lowering low-density lipoprotein cholesterol (LDL-C) levels remains a mainstay of cardiovascular disease prevention, but gaps in treatment remain, even in persons with hypercholesterolemia and greatly elevated LDL-C levels. Although well-described gene variants in the apolipoprotein B (APOB), low-density lipoprotein receptor (LDLR), and proprotein convertase subtilisin/kexin type 9 (PCSK9) genes explain small but important fractions of monogenic hypercholesterolemia, recent attention has turned to prognostication of cardiovascular disease using polygenic risk scores (PRS) that incorporate common genetic variants derived from large-scale genome-wide association studies of lipid subfractions. Earlier PRS considered only variants with genome-wide significance, and newer studies have focused on methods that better capture the variance conferred by millions of variants, suggesting an ability to identify risk equivalent to monogenic mutations. There remains a gap in evidence from prospective observational studies or treatment trials regarding the appropriate placement of PRS in risk assessment and lipid treatment decisions relative to information on rare monogenic gene variants, particularly in multiethnic populations.

This cohort study uses the UK Biobank cohort data to compare the association of monogenic vs polygenic hypercholesterolemia with the risk of atherosclerotic cardiovascular disease among individuals with comparable levels of low-density lipoprotein cholesterol.

This randomized clinical trial assesses the effectiveness of an implantable loop recorder plus 24-hour Holter electrocardiographic monitoring vs standard 24-hour Holter electrocardiographic monitoring alone for detecting arrhythmias in pregnant women with structural heart disease and/or symptoms suggestive of arrhythmias.

Mission Statement: JAMA Cardiology publishes exceptional original research, state-of-the-art reviews, and informative opinions that advance the science and practice of cardiology, enhance cardiovascular health, and inform health care policy. JAMA Cardiology is the definitive journal for clinical investigators, clinicians, and trainees in cardiovascular medicine worldwide. JAMA Cardiology focuses on all aspects of cardiovascular medicine, including epidemiology and prevention, diagnostic testing, interventional and pharmacologic therapeutics, translational research, health care policy and outcomes, and global health.

With no definite treatment protocol in place and a vaccine yet to be introduced, a coronavirus screening survey in the state looks likely. Asha workers are likely to get the responsibility to conduct this survey. “They (Asha workers) are already burdened and any additional work will need additional payment. This needs to be worked out” said an official adding that each worker can be allotted about 1,000 people and a decision may be taken soon.

Vanhoye, Albert, author

Interview with Alexander T. Sandhu, MD, MS, author of Association Between Offering Limited Left Ventricular Ejection Fraction Echocardiograms and Overall Use of Echocardiography

Interview with Marc S. Sabatine, MD, MPH, author of Efficacy and Safety of Further Lowering of Low-Density Lipoprotein Cholesterol in Patients Starting With Very Low Levels: A Meta-analysis

Interview with Jeroen J. Bax, MD, PhD, author of Association of Left Ventricular Global Longitudinal Strain With Asymptomatic Severe Aortic Stenosis: Natural Course and Prognostic Value, and James D. Thomas, author of Moving Past Ejection Fraction in Timing of Aortic Stenosis Intervention

Interview with Nehal N. Mehta, MD, MSCE, author of Association Between Aortic Vascular Inflammation and Coronary Artery Plaque Characteristics in Psoriasis, and Jagat Narula, MD, PhD, author of Inflammation, Superadded Inflammation, and Out-of-Proportion Inflammation in Atherosclerosis

Interview with Suzanne V. Arnold, MD, MHA, author of Association of Transcatheter Mitral Valve Repair With Quality of Life Outcomes at 30 Days and 1 Year: Analysis of the Transcatheter Valve Therapy Registry

Interview with Utibe R Essien, MD, and Daniel E. Singer, MD, authors of Association of Race/Ethnicity With Oral Anticoagulant Use in Patients With Atrial Fibrillation: Findings From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II

Interview with Andreas M. Zeiher, MD, author of Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure, and Peter Libby, MD, author of CHIPping Away at the Pathogenesis of Heart Failure

Interview with Benjamin D. Levine, author of Association of All-Cause and Cardiovascular Mortality With High Levels of Physical Activity and Concurrent Coronary Artery Calcification

Interview with Paul A Heidenreich, MD, MS, author of Association of Statin Adherence With Mortality in Patients With Atherosclerotic Cardiovascular Disease

Interview with Scott David. Solomon, MD, author of Association of Influenza-like Illness Activity With Hospitalizations for Heart Failure: The Atherosclerosis Risk in Communities Study

Interview with Barry H. Greenberg, author of Association of Rivaroxaban With Thromboembolic Events in Patients With Heart Failure, Coronary Disease, and Sinus Rhythm: A Post Hoc Analysis of the COMMANDER HF Trial, and Marvin A. Konstam, MD, author of Antithrombotic Therapy in Heart Failure—The Clot Thickens

Interview with Amit Khera, MD, MSc, author of Identifying Familial Hypercholesterolemia Using a Blood Donor Screening Program With More Than 1 Million Volunteer Donors and and Stephen Daniels, MD, author of Screening for Familial Hypercholesterolemia.

Interview with Stephen W. Waldo, MD, author of Association of Coronary Anatomical Complexity With Clinical Outcomes After Percutaneous or Surgical Revascularization in the Veterans Affairs Clinical Assessment Reporting and Tracking Program

Interview with Richard G. Bach, MD, author of Effect of Simvastatin-Ezetimibe Compared With Simvastatin Monotherapy After Acute Coronary Syndrome Among Patients 75 Years or Older: A Secondary Analysis of a Randomized Clinical Trial, and Antonio M. Gotto, MD DPhil, author of Intensive Lipid Lowering in Elderly Patients

Interview with Paaladinesh Thavendiranathan, MD, MSc, FRCPC, FASE, author of Assessment of Prognostic Value of Left Ventricular Global Longitudinal Strain for Early Prediction of Chemotherapy-Induced Cardiotoxicity: A Systematic Review and Meta-analysis

Interview with Kausik K. Ray, MD, author of Effect of 1 or 2 Doses of Inclisiran on Low-Density Lipoprotein Cholesterol Levels: One-Year Follow-up of the ORION-1 Randomized Clinical Trial, and Maarten JG. Leening, MD, PhD, author of Safety and Tolerability of Sustained Lipid-Lowering Therapy: Trial Data and Public Perception in a World Where Vaccines and Statins Are About to Collide

Interview with Scott David Solomon, MD, and Stephen Yishu Wang, BS, authors of Longitudinal Associations Between Income Changes and Incident Cardiovascular Disease: The Atherosclerosis Risk in Communities Study, and Edward P. Havranek, MD, author of The Influence of Social and Economic Factors on Heart Disease

Interview with Michael J. Reardon, MD, Martin B. Leon, MD, and Patrick T. O'Gara, MD, authors of Transcatheter Aortic Valve Replacement for Patients at Low Surgical Risk—Selective or Ubiquitous?

Interview with Tsuyoshi Kaneko, MD, and Sameer A Hirji, MD, authors of Utility of 90-Day Mortality vs 30-Day Mortality as a Quality Metric for Transcatheter and Surgical Aortic Valve Replacement Outcomes, and Michael J. Mack, MD, author of Ninety-Day Outcome Assessment After Transcatheter and Surgical Aortic Valve Replacement—Is the Juice Worth the Squeeze?

Interview with Susan Cheng, MD, MPH, author of Sex Differences in Blood Pressure Trajectories Over the Life Course, and Nanette K. Wenger, MD, author of Adverse Cardiovascular Outcomes for Women—Biology, Bias, or Both?

Interview with Aaron L. Baggish, MD, author of Association of Ascending Aortic Dilatation and Long-term Endurance Exercise Among Older Masters-Level Athletes

Interview with Schuyler Jones, MD, and Adrian F Hernandez, MD, MHS, authors of Rationale and Design of the Aspirin Dosing—A Patient-Centric Trial Assessing Benefits and Long-term Effectiveness (ADAPTABLE) Trial

Interview with Robert O. Bonow, MD, Patrick T. O'Gara, MD, Clyde W. Yancy, MD, and Gregg C. Fonarow, MD, authors of Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality and Ajay J. Kirtane, MD

Interview with Brad Spellberg, MD, author of Evaluation of a Paradigm Shift From Intravenous Antibiotics to Oral Step-Down Therapy for the Treatment of Infective Endocarditis: A Narrative Review

Here's a look at the top stocks that may remain in focus today

Online Resource

£Funded position: Cardiff University
For more latest jobs and jobs in Wales visit brightrecruits.com

London : Springer, c2006

Milano : Springer Milan, 2006

London : Springer, ©2007

Milan ; New York : Springer, 2007

A bureaucrat-turned politician, Ajit Jogi had served as the first CM of Chhattisgarh from November 2000 to November 2003 in then Congress government, after the state came into existence.

Privacy breaches like the one at present not only dent consumer confidence but also highlight the need to develop coping mechanisms.

Always try to pay the full dues to avoid high interest charges