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Beta-thalassemia: Causes, Symptoms, Risk Factors, Treatment and Prevention

Thalassemia is a group of inherited blood disorders that has a similar characteristic: defective and reduced production of haemoglobin, the iron-containing protein in red blood cells that helps in carrying oxygen throughout the body. Beta-thalassemia (BT) is one of








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Selbstbetrug: Woran viele Freundschaften und Liebesbeziehungen leiden

Die Therapeutin und Autorin Lori Gottlieb erklärt, wie Freundschaften und Liebesbeziehungen besser gelingen, wenn man ehrlich mit eigenen Fehlern umgeht – und berichtet dabei von sich selbst.




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Sport24.co.za | Russell explains diffrence between real and sim racing

Williams driver George Russell is enjoying sim racing online while Formula 1 is suspended but admits he doesn't get the same sense of speed or fear.




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Assessing the danger of war: parallels and differences between Europe in 1914 and East Asia in 2014

12 November 2014 , Volume 90, Number 6

Joachim Krause




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Development of a novel {beta}-1,6-glucan-specific detection system using functionally-modified recombinant endo-{beta}-1,6-glucanase [Methods and Resources]

β-1,3-d-Glucan is a ubiquitous glucose polymer produced by plants, bacteria, and most fungi. It has been used as a diagnostic tool in patients with invasive mycoses via a highly-sensitive reagent consisting of the blood coagulation system of horseshoe crab. However, no method is currently available for measuring β-1,6-glucan, another primary β-glucan structure of fungal polysaccharides. Herein, we describe the development of an economical and highly-sensitive and specific assay for β-1,6-glucan using a modified recombinant endo-β-1,6-glucanase having diminished glucan hydrolase activity. The purified β-1,6-glucanase derivative bound to the β-1,6-glucan pustulan with a KD of 16.4 nm. We validated the specificity of this β-1,6-glucan probe by demonstrating its ability to detect cell wall β-1,6-glucan from both yeast and hyphal forms of the opportunistic fungal pathogen Candida albicans, without any detectable binding to glucan lacking the long β-1,6-glucan branch. We developed a sandwich ELISA-like assay with a low limit of quantification for pustulan (1.5 pg/ml), and we successfully employed this assay in the quantification of extracellular β-1,6-glucan released by >250 patient-derived strains of different Candida species (including Candida auris) in culture supernatant in vitro. We also used this assay to measure β-1,6-glucan in vivo in the serum and in several organs in a mouse model of systemic candidiasis. Our work describes a reliable method for β-1,6-glucan detection, which may prove useful for the diagnosis of invasive fungal infections.




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Diabetes Core Update: COVID-19 – The Role of Community Health Workers as First Responders, May 2019

This special issue focuses on The Role of Community Health Workers as First Responders in the COVID-19 Outbreak. 

Recorded May 5, 2020.

This is a part of the American Diabetes Associations ongoing project providing resources for practicing clinicians on the care of Diabetes during the Covid-19 pandemic.  Today’s discussion is an audio version of a webinar recorded on May 5, 2020.

Presented by:

Betsy Rodriguez, BSN, MSN, DCES
Centers for Disease Control and Prevention

Colleen Barbero, PhD
Centers for Disease Control and Prevention

Denise Octavia Smith, MBA, CHW, PN, SFC
National Association of Community Health Workers




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Investing Wisely in the Future: How the U.S. Immigration System Can Better Meet U.S. Labor Market Needs

With the prospects for immigration reform greater than they have been in more than a decade and the U.S. economy slowly shrugging off the effects of the recession, the United States may be on the cusp of historic changes that make the immigration system a more effective tool for innovation, economic growth and the competitiveness of its firms—large and small. 




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Investing Wisely in the Future: How the U.S. Immigration System Can Better Meet U.S. Labor Market Needs

The release of MPI's book Immigrants in a Changing Labor Market and discussion with Jason Furman, Assistant to the President for Economic Policy and Principal Deputy Director of the National Economic Council; Harry Holzer, Georgetown University Professor of Public Policy; and MPI's Demetrios G. Papademetriou, Madeleine Sumption, and Michael Fix.




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Better Work for Immigrants: Tackling Joblessness and Stunted Progression in the European Union

This day-long conference in Brussels, co-sponsored by the International Labour Office and the European Commision’s Directorate-General for Employment, Social Affairs, and Inclusion, focuses on the dynamics by which migrants get stuck in low-skilled work, and the role of training and employment services in helping them progress in their occupations.




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Better Work for Immigrants: Tackling Joblessness and Stunted Progression in the European Union

A day-long conference in Brussels, co-sponsored by the International Labour Office and the European Commision’s Directorate-General for Employment, Social Affairs, and Inclusion, where panelists discuss the dynamics by which migrants get stuck in low-skilled work, and the role of training and employment services in helping them progress in their occupations. The conference concludes a project and series of reports prepared on the Labor Market Integration of New Arrivals in Europe




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Executive Action on Immigration: Six Ways to Make the System Work Better

In the absence of new U.S. immigration reform legislation, this report examines the opportunities that exist within the executive branch and the administration to refine and strengthen current U.S. immigration laws and policies. The administration can exercise its authority to field policies, programs, and procedures that are effective and fair in advancing the goals of the U.S. immigration system. 




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Fortified foods vs. supplements: What is better? – Times of India

Fortified foods vs. supplements: What is better?  Times of India



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First Gurbet-Serbian-English picture dictionary

“This publication is a tool to help those who will join Goran in sharing the gospel among Gurbet-speaking Roma, and lays the foundation for future Christian materials.”




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Counter-cultural faith among the Gurbet

Goran’s decision to follow Jesus challenged the cultural values and traditions he grew up with, causing him to live differently in his community.




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Mission trip to France, better than Chanel perfume! OM Transform

Transform mission conference one year, outreach team in France the following year, the sisters from Mexico are eager to share the love of Christ, realising the audience was different from what they expected.




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Mission trip to France, better than Chanel perfume! OM Transform

Transform mission conference one year, outreach team in France the following year, the sisters from Mexico are eager to share the love of Christ, realising the audience was different from what they expected.




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Don't bet on Premiership clubs learning to live together during lockdown

ESTABLISHING a consensus to maintain the peace has never been trickier. Being stuck at home for 23 hours a day has taken the already onerous challenge of preserving civil relations and lifted to it a new level altogether.




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Mission trip to France, better than Chanel perfume! OM Transform

Transform mission conference one year, outreach team in France the following year, the sisters from Mexico are eager to share the love of Christ, realising the audience was different from what they expected.




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Mission trip to France, better than Chanel perfume! OM Transform

Transform mission conference one year, outreach team in France the following year, the sisters from Mexico are eager to share the love of Christ, realising the audience was different from what they expected.




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Mission trip to France, better than Chanel perfume! OM Transform

Transform mission conference one year, outreach team in France the following year, the sisters from Mexico are eager to share the love of Christ, realising the audience was different from what they expected.




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Mission trip to France, better than Chanel perfume! OM Transform

Transform mission conference one year, outreach team in France the following year, the sisters from Mexico are eager to share the love of Christ, realising the audience was different from what they expected.




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FOX RUN CIR IS CLOSED BETWEEN OWLS NEST RD AND RT 72 UNTIL MAY 17, 2020




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N ADAMS ST IS EXPERIENCING A LEFT LN CLOSURE BETWEEN 10TH STREET/12TH STREET DUE TO CONSTRUCTION TIL 5PM




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DE-141 NB BETWEEN JAY DR AND COMMONS BLVD IS EXPERIENCING A RIGHT LANE CLOSURE DUE TO CONSTRUCTION UNTIL 7/1/20 UNTIL MIDNIGHT




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DE-141 NB BETWEEN DE-48 AND BARLEY MILL PLAZA IS EXPERIENCING A RIGHT LANE CLOSURE DUE TO CONSTRUCTION UNTIL 6:00 AM




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LOW BRIDGE ON CASHO MILL RD BETWEEN JULIE LN AND MUNRO RD - VEHICLES OVER 8' 7" WILL NOT FIT.



  • Special Travel Alert

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RT 26 EB BTWN CLARKSVILLE & BETHANY BEACH IS CURRENTLY EXPERIENCING A 5-10 MINUTE DELAY.




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2020 Triumph Street Triple RS launched in India: More power, better features, same price

2020 Triumph Street Triple RS India Launch: The new 2020 Street Triple RS has been updated with new design and styling, but most importantly the engine now puts out more torque than the previous model.




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Mercedes-AMG GLC 43 Coupe Road Test Review: Great balance between performance and daily drive

Most performance cars are not designed for Indian conditions, but does the GLC 43 AMG strike the perfect balance to be usable every day of the week and satisfy the enthusiast?




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Mahindra TUV300 facelift review: Better than earlier but not the best

The TUV300 has got most of the rough edges sorted but then it still isn't the urban dweller's dream vehicle and is more at home plying on rural roads




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Hyundai Grand i10 Nios First Drive Review: Better than the Maruti Swift or not?

Does the Hyundai Grand i10 Nios get what it takes to take the fight to the Swift and what are its pros and cons? Read on to find out.




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Mahindra XUV300 diesel automatic review: One of the better AMTs in the business

The XUV300 AMT is perhaps one of the best in the business and promises to deliver fuel efficiency, easy city driveability as well as highway cruising capabilities.




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Mavox FX22.D2P Helmet Review | Looks better than its worth, but can perform better than it does

Now we've got Indian helmet brands launching new products with one of the latest one being Mavox. We had to try out an IS:4151 standard helmet, so folks at Mavox sent us an FX22.D2P full-face helmet.




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Renault Triber review: A 7-seater that packs in a lot of space, features but deserves a better engine

The Renault Triber is a spacious, budget 7-seater that packs in all the modern day goodies, looks good but the 1.0-litre engine could do with a bit more power.




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Isuzu D-Max V-Cross diesel AT Review: Easier to live with and better than faux SUVs

New updates, features, a smaller and more refined engine with the convenience of an automatic gearbox, has the V-Cross become a better and easier everyday utility vehicle to live with? We find out.




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BS-VI Honda Activa 125 Fi Review: More fuel-efficient, costlier but how much better?

BS-VI Honda Activa 125 Fi Review: The very first BS6-compliant to launch in India, the Activa 125 Fi now boasts of a host of new features besides the BS-VI compliance but all this for an upgraded price. So, how much better is it really?




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BS-VI Honda SP125 First Ride Review | Better comfort & refinement in a peppier looking package

BS-VI Honda SP125 Review: Honda's second BS6 compliant two-wheeler not only is now more fuel-efficient and cleaner for the environment, but it also offers several new features. We rode it around the streets of Mumbai to find out more.




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2020 TVS Apache RR 310 First Ride Review | Better enough to keep up?

2020 TVS Apache RR 310 Track Ride Review: The RR 310 has undoubtedly always been a performance machine with great looks, but it now it reaffirms its position with better handling and features.




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Honda Activa 6G First Ride Review: King of scooters now bigger and better!

Honda Activa 6G gains multiple new features and now has a more environmental-friendlier engine. So, what all it packs in, how it is to ride and most importantly, does it justify the Rs 8,000 premium in pricing? All these questions answered below.




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Toyota Glanza hybrid review: Is the disguised Baleno better or not?

The Toyota Glanza hybrid is one car which is hard to find faults with; perhaps just a bit more of creature comforts will have made it the go-to vehicle.




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OgilvyOne's Fletcher on Ending the Battle Between Data and Creativity

In Focus: Marketing Hall of Femme honoree Mish Fletcher, chief marketer of OgilvyOne Worldwide, discusses the rewards of not-so-delicately balancing data with creativity.




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Why Having Fresh Data is Better than Driving Daily Action

Our Marketing&Tech Innovation Summit partner delves into data acquisition, insights, and ownership.




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Ransomware: Banks better prepared to deal with Wannacry-like threats, says SBI Dy MD & CIO Mrutyunjay Mahapatra

Interview: Mrutyunjay Mahapatra, deputy MD and chief information officer, State Bank of India.