Edinburgh, Scotland : ANSR, 1993.

Edinburgh, Scotland : ANSR, 1993.

Washington, D.C. : Department of Transportation, Federal Railroad Administration, 1976.

Broadcasting Health and Disease: Bodies, markets and television, 1950s–1980s An ERC BodyCapital international conference to be held at the Wellcome Trust, 19–21 February 2018 In the television age, health and the body have been broadcasted in many ways: in short… Continue reading

While President Donald Trump traveled to the battleground state of Arizona this week, his Democratic opponent for the White House, Joe Biden, campaigned from his basement as he has done throughout the coronavirus pandemic. The freeze on in-person campaigning during the outbreak has had an upside for Biden, giving the former vice president more time to court donors and shielding him from on-the-trail gaffes. "I personally would like to see him out more because he's in his element when he's meeting people," said Tom Sacks-Wilner, a fundraiser for Biden who is on the campaign's finance committee.

Jeremy R. Manning
Oct 28, 2009; 29:13613-13620
BehavioralSystemsCognitive

Select Andrew Lloyd Webber productions will stream on YouTube for 48 hours at a time

Historian Ellen Carol DuBois chronicles the twists and turns of the 75-year-path to securing the vote for women in her new book

The remote cabin could be the difference between life and death for travellers stuck on the territory’s long winter road. It was built to remember Stella Barnaby, who would have been 55 this Saturday.

Serving in West and Central Asia for many years, Paul and Soonok have one lasting dream: to see a church planting movement there.

Much like a prehistoric pest trapped in amber, our summer plans remain in suspended animation.

Imagining America between the crisis and the cure.

Canadian basketball players Dylan Ennis and Kevin Pangos, who both play in Liga ACB, opted to stay and weather the COVID-19 pandemic in Spain.

LACO AT HOME Features Sheku Kanneh-Mason Interview and Performance & More  Broadway World

The COVID-19 pandemic won’t slow down road construction in Saskatoon. The city says it re-evaluated all planned projects for the year and determined it can move forward with the majority of the projects.

Gus has been captivating visitors to the Nova Scotia Museum of Natural History for more than seven decades.

Throughout the year Bus4Life provides encouragement to local pastors and OM teams in Eastern Europe, partnering with them to share the Gospel.

Located on Huron Church Road, the lab was one of 12 such facilities run by the Ontario government, and processed tests for diseases like tuberculosis and West Nile virus. But it was demolished to make way for the Herb Gray Parkway.

Amid one of the worst economic downturns in years, Apple has outperformed most expectations that analysts have placed on it. Just shy of two months into the COVID-19 pandemic, its share price has returned to levels not seen since before the crisis.

The situation in Zimbabwe is deteriorating again under a new wave of political violence organised by Robert Mugabe’s ZANU-PF party, and the country faces another illegitimate election and crisis unless credible, enforceable reforms can first be implemented.

Two OMers are riding unicycles across the US this summer in aid of Syrian refugees and displaced people.

A new missions experience in Namibia is not as much a programme as it is a journey.

Christiana, a short term mission participant from Great Britain, shares insights from her visit to Crossroads church plant in Odessa, Ukraine.

Profile of a veteran driver with OM EAST

Pamir Productions, formed in 1991, passionately uses all forms of media to spread the gospel to Afghans worldwide.

When Mom, from Cambodia, reassures a sexually-abused girl that God cares, her words are like a healing salve applied to an open wound.

Zinfandel Gastro Bar

The sight of Scottish ministers boarding flights to far-flung destinations in order to “sell Scotland to the world” has been a familiar one for more than half a century.

THE SCOTTISH Government has been urged to empower the country’s towns and cities can be transformed into healthier hubs for walking and cycling amid the Covid-19 pandemic.

In the wake of the 'Janus' Supreme Court case, teachers' unions are facing more than a dozen legal challenges backed by right-leaning groups that could further dampen their membership numbers and finances.

There are many entrepreneurs who can claim that "they've always known they would start their own business," but I am not one of them. So how did I end up as an entrepreneur writing this blog?

AS expected, the UK and Scottish governments have decided, after the first three weeks of restrictions to contain the spread of coronavirus, that they should remain in place. Strictly speaking, that is not an extension, but the default position; the legislation allows for the lockdown to continue for six months (when it must then be renewed by the parliaments). Interim reviews are to see whether the circumstances allow for relaxation, or indeed, require tightening of the measures.

Lopsided votes in the U.S. Senate and House obscure stark differences in their bills to overhaul the outdated Elementary and Secondary Education Act.

Recent guidelines for the management of childhood pneumonia recommend narrow-spectrum antimicrobial agents (eg, ampicillin) for most children; however, few studies have directly compared the effectiveness of narrow-spectrum agents to the broader spectrum third-generation cephalosporins commonly used among children hospitalized with pneumonia.

By using data from 43 children’s hospitals in the United States, we demonstrate equivalent outcomes and costs for children hospitalized with pneumonia and treated empirically with either narrow- (ampicillin/penicillin) or broad-spectrum (ceftriaxone/cefotaxime) antimicrobial therapy. (Read the full article)

See the dates for the season and leading contenders in the 2019/20 campaign, ending in Vienna.

The United States, France, and the United Nations are falling into an all too familiar trap in the Central African Republic (CAR) of financing transition elections before armed militias have been disarmed and their communal hold broken. Exclusionary and botched elections could trigger another wave of violence and deepen the crisis.

QPX7728 is a new ultra-broad-spectrum inhibitor of serine and metallo beta-lactamases from a class of cyclic boronates that gave rise to vaborbactam. The spectrum and mechanism of beta-lactamase inhibition by QPX7728 were assessed using purified enzymes from all molecular classes. QPX7728 inhibits class A ESBLs (IC₅₀ range 1-3 nM) and carbapenemases such as KPC (IC₅₀ 2.9±0.4 nM) as well as class C P99 (IC₅₀ of 22±8 nM) with a potency that is comparable or higher than recently FDA approved BLIs avibactam, relebactam and vaborbactam. Unlike those other BLIs, QPX7728 is also a potent inhibitor of class D carbapenemases such as OXA-48 from Enterobacteriaceae and OXA enzymes from A. baumannii (OXA-23/24/58, IC₅₀ range 1-2 nM) as well as MBLs such as NDM-1 (IC₅₀ 55±25 nM), VIM-1 (IC₅₀ 14±4 nM) and IMP-1 (IC₅₀ 610±70 nM). Inhibition of serine enzymes by QPX7728 is associated with progressive inactivation with a high efficiency k₂/K ranging from of 6.3 x 10⁴ (for P99) to 9.9 x 10⁵ M^-1 s^-1 (for OXA-23). This inhibition is reversible with variable stability of the QPX7728-beta-lactamase complexes with target residence time ranging from minutes to several hours: 5-20 minutes for OXA carbapenemases from A. baumanii, ~50 minutes for OXA-48 and 2-3 hours for KPC and CTX-M-15. QPX7728 inhibited all tested serine enzymes at 1:1 molar ratio. Metallo-beta-lactamases NDM, VIM, and IMP were inhibited by a competitive mechanism with fast-on-fast-off kinetics, with K_is of 7.5±2.1 nM, 32±14 nM and 240±30 nM for VIM-1, NDM-1 and IMP-1, respectively. QPX7728 ultra-broad-spectrum of BLI inhibition combined with its high potency enables combinations with multiple different beta-lactam antibiotics.

QPX7728 is an ultra-broad-spectrum boronic acid beta-lactamase inhibitor with potent inhibition of key serine and metallo beta-lactamases observed in biochemical assays. Microbiological studies using characterized strains were used to provide a comprehensive characterization of the spectrum of beta-lactamase inhibition by QPX7728. The MIC of multiple IV only (ceftazidime, piperacillin, cefepime, ceftolozane and meropenem) and orally bioavailable (ceftibuten, cefpodoxime, tebipenem) antibiotics alone and in combination with QPX7728 (4 μg/ml), as well as comparator agents, were determined against the panels of laboratory strains of P. aeruginosa and K. pneumoniae expressing over 55 diverse serine and metallo beta-lactamases. QPX7728 significantly enhanced the potency of antibiotics against the strains expressing Class A extended spectrum beta-lactamases (CTX-M, SHV, TEM, VEB, PER) and carbapenemases (KPC, SME, NMC-A, BKC-1), consistent with beta-lactamase inhibition demonstrated in biochemical assays. It also inhibits both plasmidic (CMY, FOX, MIR, DHA) and chromosomally encoded (P99, PDC, ADC) Class C beta-lactamases and Class D enzymes including carbapenemases such as OXA-48 from Enterobacteriaceae and OXA enzymes from Acinetobacter baumannii (OXA-23/24/72/58). QPX7728 is also a potent inhibitor of many class B metallo beta-lactamases (NDM, VIM, CcrA1, IMP, GIM but not SPM or L1). Addition of QPX7728 (4 μg/ml) reduced the MICs in a majority of strains to the level observed for the vector alone control, indicative of complete beta-lactamase inhibition. The ultra-broad-spectrum beta-lactamase inhibition profile makes QPX7728 a viable candidate for further development.

QPX7728 is an ultra-broad-spectrum boronic acid beta-lactamase inhibitor that demonstrates inhibition of key serine and metallo beta-lactamases at a nano molar range in biochemical assays with purified enzymes. The broad-spectrum inhibitory activity of QPX7728 observed in biochemical experiments translates into enhancement of the potency of many beta-lactams against strains of target pathogens producing beta-lactamases. The impact of bacterial efflux and permeability on inhibitory potency were determined using isogenic panels of KPC-3 producing isogenic strains of K. pneumoniae and P. aeruginosa and OXA-23-producing strains of A. baumannii with various combinations of efflux and porin mutations. QPX7728 was minimally affected by multi-drug resistance efflux pumps in either Enterobacteriaceae, or in non-fermenters such as P. aeruginosa or A. baumannii. In P. aeruginosa, the potency of QPX7728 was further enhanced when the outer membrane is permeabilized. The potency of QPX7728 in P. aeruginosa is not affected by inactivation of the carbapenem porin OprD. While changes in OmpK36 (but not OmpK35) reduced the potency of QPX7728 (8-16-fold), QPX7728 (4 μg/ml) nevertheless completely reversed KPC-mediated meropenem resistance in strains with porin mutations, consistent with a lesser effect of these mutations on the potency of QPX7728 compared to other agents. The ultra-broad-spectrum beta-lactamase inhibition profile combined with enhancement of the activity of multiple beta-lactam antibiotics with varying sensitivity to the intrinsic resistance mechanisms of efflux and permeability indicate QPX7728 is a useful inhibitor for use with multiple beta-lactam antibiotics.

Seasonal and pandemic influenza causes 650,000 deaths annually in the world. The emergence of drug-resistance to specific anti-influenza drugs such as oseltamivir and baloxavir marboxil highlights the urgency of novel anti-influenza chemical entity discovery. In this study, we report a series of novel thiazolides derived from an FDA-approved drug nitazoxanide with antiviral activity against influenza and a broad range of viruses. The preferred candidates 4a and 4d showed significantly enhanced anti-influenza potentials with 10-fold improvement, compared with nitazoxanide, and were effective against a variety of influenza subtypes including oseltamivir-resistant strains. Notably, the combination using of compounds 4a/4d and oseltamivir carboxylate or zanamivir displayed synergistic antiviral effect against oseltamivir-resistant strain. Mode of action analysis demonstrated that compounds 4a/4d acted at the late phase of viral infection cycle through inhibiting viral RNA transcription and replication. Further experiments showed that treatment with compounds 4a/4d significantly inhibited influenza virus infection in human lung organoids, suggesting the druggability of the novel thiazolides. In-depth transcriptome analysis revealed a series of up-regulated cellular genes that may contribute to the antiviral activities of 4a/4d. Together, our study pointed the optimization direction of nitazoxanide as anti-influenza drug, and discovered two novel-structured candidates 4a/4d with relatively broad-spectrum antiviral potential.

Penn State Harrisburg senior Jessica Sheets and her father, Ethan, have a lot in common, including both having had their commencement ceremonies preempted by historic events — hers by the coronavirus epidemic, and his by Hurricane Agnes in 1972.

'With no incentive to innovate or invest, these conglomerates charge sky-high internet prices to reap profits from consumers,' the Democratic Presidential candidate said in unveiling his 'high-speed internet access for all plan' on Friday.

The choice to let Huawei access non-core parts of the country's networks could place strain on the UK's relationship with the US. But with Brexit looming, the cost of cutting Huawei out could be too great.

See the dates for the season and a full access list for the 2020/21 competition ending at Gamla Ullevi, Gothenburg.

OM team members and former electrical training programme students help a disabled man get back into business after two teenagers steal his motorised rickshaw.