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Ligand-centred phenotype-driven development of potent kinase inhibitors against oesophageal cancer

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00579A, Research Article
Open Access
Cecilia C. Ayala-Aguilera, Yang Ge, Álvaro Lorente-Macías, Benjamin N. Jones, Catherine Adam, Neil O. Carragher, Asier Unciti-Broceta
A ligand-centred strategy combined with phenotypic screening was used to develop novel antiproliferative inhibitors against oesophageal cancer and identified a lead compound that induces potent anticancer activity and inhibits Aurora kinase A.
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Generation and capture of naphthoquinonynes: a new frontier in the development of trypanocidal quinones via aryne chemistry

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00558A, Research Article
Laura P. R. Figueroa, Renato L. de Carvalho, Renata G. Almeida, Esther R. S. Paz, Emilay B. T. Diogo, Maria H. Araujo, Warley S. Borges, Victor F. S. Ramos, Rubem F. S. Menna-Barreto, James M. Wood, John F. Bower, Eufrânio N. da Silva Júnior
This article presents A-ring functionalized quinones via a modern and efficient new strategy involving the generation and capture of benzyne quinones and their evaluation against Trypanosoma cruzi.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Technical, preclinical, and clinical developments of Fc-glycan-specific antibody–drug conjugates

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00637B, Review Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Qiang Yang, Yunpeng Liu
Fc-glycan-specific ADC is a significant advance in site-specific ADCs for cancer therapy. Notably, JSKN003 and IBI343 have demonstrated promising results in phase 1 clinical trials and are advancing into phase 3 studies.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Ensure time-bound implementation of development schemes, says Thirumavalavan




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Udhayanidhi lays foundation stone for infrastructure development projects in Thanjavur district

Buildings at the Government Arts and Science College, Thirukkattupalli, construction of compound wall and an indoor stadium at the Government Rajah Serfoji College, Thanjavur, are among the projects




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627: Getting Comfortable with the Struggle and Vibe Driven Development

Chris brings some blog posts to talk about including being comfortable with the struggle of developer life, Cloudflare Workers + monorepos, vibe driven development, and questions about database migrations, and whether we think AI free blogs are going to be a rarity in the future?




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632: Adam Coster on Game Development and Crashlands 2

Adam Coster talks with us about working with his family in game development, how they get started making games, what all is involved with publishing games, deciding to go Steam and Netflix only for Crashlands 2, how web tech is involved in game development, and the fun of testing and doing Q&A for games.




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Climate-resilient agriculture is prerequisite for sustainable development, says ICAR chief

Tobacco industry contributes ₹32,516 crore annually to national economy through exports and excise tax reviews and sustains employment for 45.7 million people, says Director General of ICAR




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PM Modi expresses condolences over demise of renowned organic farmer Pappammal

In 2021, she was given the Padma Shri award for popularising organic farming in India and was regarded as a pioneer in the agriculture field




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Tata Motors signs MoU with ASDC for skill development




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PMK functionary assaulted in Villupuram

Police suspect previous enmity to be the reason behind the incident




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25 tribal girls to undergo skill development training under Tholkudi scheme




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T.N. lists achievements of Rural Development Department




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Development of a coarse-grained molecular dynamics model for poly(dimethyl-co-diphenyl)siloxane

Soft Matter, 2024, 20,8480-8492
DOI: 10.1039/D4SM00875H, Paper
Weikang Xian, Amitesh Maiti, Andrew P. Saab, Ying Li
Polydimethylsiloxane and its copolymer systems have a wide range of application. We systematically develop a coarse-grained MD model for PDMS-co-PDPS system. The model preserves the structural and dynamic properties of the material quantitatively.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Aim is to provide a tractor load of sand for ₹900, says A.P. Urban Development Minister Narayana

Construction workers across the State have benefited from the free sand policy, he says, adding the NDA government will fulfil all its promises one after the other




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Andhra Pradesh Budget highlights: ₹29,909 crore for school education, ₹16,739 crore for Panchayat Raj and Rural Development for FY25

The Andhra Pradesh Government presented its Budget with an outlay of ₹2,94,427.25 crore for the Financial Year 2024-25; revenue expenditure is estimated at ₹2,35,916.99 crore, and capital expenditure at ₹32,712.84 crore




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India’s SDG focus and its human development issues

Countries that aspire to achieve sustainable development need to take steps to boost human development




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Growing mathematical minds [electronic resource] : conversations between developmental psychologists and early childhood teachers / edited by Jennifer S. McCray, Jie-Qi Chen, and Janet Eisenband-Sorkin.

New York, NY : Routledge, 2019.




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PM Vishwakarma scheme intends to make nationalised banks pro-people once more, says Kota Srinivas Poojary




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Cabinet approves PM-Vidyalaxmi scheme for higher education

Under the scheme, a student who secures admission in top higher education institutions, both government and private, will be eligible to get collateral-free, guarantor-free loan from banks and financial institutions




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ED attaches assets in EMAAR-MGF PMLA case; Hooda says he has nothing to do with it

It is alleged that Hooda had colluded with real estate to arrange land for them at cheaper rates




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Interest subsidy to be provided only once for a property under PMAY-U 2.0

Affordable housing transactions could be impacted due to clause




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General ppm-level Pd-catalysed asymmetric diarylalkyne hydrosilylation to access structurally diverse Si-stereogenic vinylsilanes

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01698J, Research Article
Heng Xu, Han-Xiao Yu, An-Jiu Wen, Fang-Ying Ling, Fei Ye, Li Li, Fuk Yee Kwong, Li-Wen Xu
The first example of enantioselective Pd-catalyzed hydrosilylation of symmetric and asymmetric diarylalkynes to access novel Si-stereogenic vinylsilanes with excellent ee and a high TON is realized under mild reaction conditions.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Recent developments in the ring-opening transformations of gem-difluorocyclopropanes

Org. Chem. Front., 2024, 11,6518-6533
DOI: 10.1039/D4QO01583E, Review Article
Leiyang Lv, Junqi Su, Zhiping Li
This review summarizes the advances of gem-F2CPs as fluoroallylic synthons in transition metal-catalysed ring-opening/cross-coupling reactions via single, double or no C-F bond cleavage on the last two years.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Telangana delegation to embark on 3-day study tour in Karnataka for fisheries development




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Hyderabad-based Raghu Vamsi Group acquires British precision machining firm PMC Group 

The Hyderabad-based MSME, Raghu Vamsi Group, has completed the acquisition of British precision machining firm PMC GGroup, that traces its roots to over 100 years




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Investigation and development of novel synthetic approaches for synthesis of euxanthone and derived dyes

RSC Adv., 2024, 14,35601-35609
DOI: 10.1039/D4RA06475E, Paper
Open Access
M. Mustafa Cetin
This work explores new synthetic methods for euxanthone and its derived dye Indian yellow through euxanthic acid formation, confirming structures with analytical techniques and proposing a mechanism for the euxanthone synthesis.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Why Himalayan towns need a different kind of development | Explained

Do cities along the Indian Himalayan Range have adequate funds and resources to manage civic issues?




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PM Modi to release 109 climate resilient crop seeds developed by ICAR, says Shivraj Singh Chouhan

The aim is to ensure that the benefits of science and research directly reach the farmers, says the Agriculture Minister




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Stay calm, sleep well: PM Modi tells Paris-bound athletes; asks for mom-made ‘churma’ from Neeraj

The upcoming Games will be held from July 26 to August 11 and India would be hoping to better its best ever tally of seven medals, including Chopra's historic javelin throw gold, achieved in the Tokyo Games.




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Nijjar killing: Canadian PM Trudeau admits he had no hard proof when he alleged Indian agents' involvement

Trudeau admits intelligence, not evidence, behind claims of Indian involvement in Nijjar’s killing.




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Drone strike launched toward Israeli PM Benjamin Netanyahu’s house

Neither Israel’s Prime Minister Benjamin Netanyahu nor his wife were home and there were no casualties, says spokesperson




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PM Narendra Modi to meet Spanish PM Pedro Sanchez in Vadodara to boost bilateral ties

Bilateral trade between India and Spain has increased from $6.77 billion in 2021-22 to $7.24 billion in 2023-24




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Many supporters of Khalistan in Canada, but they do not represent Sikh Community: PM Trudeau

His comments came during Diwali celebrations at Ottawa’s Parliament Hill recently amid an ongoing diplomatic row with India over the killing of Khalistan extremist Hardeep Singh Nijjar




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Japan’s Ishiba wins runoff vote to stay as PM ahead of likely Trump meeting

Japanese government officials are trying to arrange a meeting for him with Trump toward the end of the trip, potentially during a stopover in the US before Ishiba returns to Japan




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Rhenium(I) and technetium(I) complexes with megazol derivatives: towards the development of a theranostic platform for Chagas disease

Dalton Trans., 2024, Accepted Manuscript
DOI: 10.1039/D4DT02714K, Paper
Ana Cristina Resende Gonçalves, Silvia Helena Libardi, Júlio Cesar Borges, Ronaldo Junio de Oliveira, Carla Gotzmann, Olivier Blacque, Sergio Albuquerque, Carla Duque Lopes, Roger Alberto, Pedro Ivo da Silva Maia
The diagnosis and treatment of Chagas disease (CD) in the chronic phase remains a challenge. With that in mind, a potential theranostic device based on the trypanocidal agent known as...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Development of Polyoxometalate-loaded MOF for Heterogeneous Catalysis and Enhanced Dye Adsorption

Dalton Trans., 2024, Accepted Manuscript
DOI: 10.1039/D4DT02645D, Paper
Ketan Maru, Sarita Kalla, Ritambhara Jangir
The study focuses here on the enhancement of MIL-117 functionality by incorporating well-known polyoxometalate (POM); tetrabutylammonium octamolybdate [(n-C4H9)4N]4[Mo8O26]. Using an encapsulation method with conventional heating, Mo8O264- anions were first time...
The content of this RSS Feed (c) The Royal Society of Chemistry




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β-Cyclodextrin and cucurbit[7]uril as protective encapsulation agents of the CO-releasing molecule [CpMo(CO)3Me]

Dalton Trans., 2024, Advance Article
DOI: 10.1039/D4DT01863J, Paper
Rodrigo P. Monteiro, Isabel B. Calhau, Ana C. Gomes, André D. Lopes, José P. Da Silva, Isabel S. Gonçalves, Martyn Pillinger
For inclusion compounds between the complex [CpMo(CO)3Me] (1) and β-cyclodextrin or cucurbit[7]uril, the macrocyclic hosts modulate to different degrees the UV light-mediated CO release from encapsulated 1.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Siddaramaiah, Shivakumar term PM’s allegations of raising ₹700 cr. to fund Maharashtra polls as a ‘lie’




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Allocation for development works nails BJP’s lie of resource crunch in State, says Siddaramaiah




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D’Cunha report revealed ₹918 crore misappropriated in COVID equipment procurement: Sharan Prakash Patil




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Effective development of human resources facilitates growth: Pralhad Joshi




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Maha: Under PMBJP, Nalasopara residents buying cheaper medicines; thank PM Modi




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PMAY beneficiaries in Maharashtra's Beed thank PM Modi for affordable housing




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Morning Digest: NSCN-IM threatens armed violence for first time since 2015 agreement; Article 370 cannot be restored by anyone, says PM Modi, and more

Here is a select list of stories to start the day




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Fe3+ and H2O2 assisted dopamine rapid polymerization on melamine foam to activate PMS for organic pollutant degradation

Environ. Sci.: Water Res. Technol., 2024, 10,2698-2708
DOI: 10.1039/D4EW00596A, Paper
Haoxiang Yan, Jianzheng Zhen, Yuyuan Yao
A bulk sponge catalytic material was prepared by rapid polymerization of DA and utilized for PMS activation to degrade BPA. The coexistence of HCO3 enhanced 1O2 generation, accelerating BPA degradation.
The content of this RSS Feed (c) The Royal Society of Chemistry




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India becoming part of global drug development operation of BMS: Samit Hirawat 

Samit Hirawat discussed India’s growing significance as a site for clinical trials, innovations in drug development, and how technology is poised to help bring new products to market faster




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Ratan Tata’s absence deeply felt across the world, writes PM Narendra Modi

He wore his achievements lightly, with humility and kindness.




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Centre for Development Studies: Looking to the future, evolving strategies to meet present-day challenges

CDS is evolving strategies for research and financial self-sufficiency while maintaining original mandate, exploring new programmes and training opportunities.




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Centre greenlights ₹177-crore Muthalapozhi harbour development

Six villages chosen for climate resilient scheme, and five fishing harbours in line for modernisation project