pm Ligand-centred phenotype-driven development of potent kinase inhibitors against oesophageal cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00579A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Cecilia C. Ayala-Aguilera, Yang Ge, Álvaro Lorente-Macías, Benjamin N. Jones, Catherine Adam, Neil O. Carragher, Asier Unciti-BrocetaA ligand-centred strategy combined with phenotypic screening was used to develop novel antiproliferative inhibitors against oesophageal cancer and identified a lead compound that induces potent anticancer activity and inhibits Aurora kinase A.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pm Generation and capture of naphthoquinonynes: a new frontier in the development of trypanocidal quinones via aryne chemistry By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00558A, Research ArticleLaura P. R. Figueroa, Renato L. de Carvalho, Renata G. Almeida, Esther R. S. Paz, Emilay B. T. Diogo, Maria H. Araujo, Warley S. Borges, Victor F. S. Ramos, Rubem F. S. Menna-Barreto, James M. Wood, John F. Bower, Eufrânio N. da Silva JúniorThis article presents A-ring functionalized quinones via a modern and efficient new strategy involving the generation and capture of benzyne quinones and their evaluation against Trypanosoma cruzi.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pm Technical, preclinical, and clinical developments of Fc-glycan-specific antibody–drug conjugates By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00637B, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Qiang Yang, Yunpeng LiuFc-glycan-specific ADC is a significant advance in site-specific ADCs for cancer therapy. Notably, JSKN003 and IBI343 have demonstrated promising results in phase 1 clinical trials and are advancing into phase 3 studies.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pm Ensure time-bound implementation of development schemes, says Thirumavalavan By www.thehindu.com Published On :: Wed, 06 Nov 2024 18:29:00 +0530 Full Article Tiruchirapalli
pm Udhayanidhi lays foundation stone for infrastructure development projects in Thanjavur district By www.thehindu.com Published On :: Thu, 07 Nov 2024 18:48:04 +0530 Buildings at the Government Arts and Science College, Thirukkattupalli, construction of compound wall and an indoor stadium at the Government Rajah Serfoji College, Thanjavur, are among the projects Full Article Tiruchirapalli
pm 627: Getting Comfortable with the Struggle and Vibe Driven Development By shoptalkshow.com Published On :: Mon, 05 Aug 2024 08:52:17 +0000 Chris brings some blog posts to talk about including being comfortable with the struggle of developer life, Cloudflare Workers + monorepos, vibe driven development, and questions about database migrations, and whether we think AI free blogs are going to be a rarity in the future? Full Article All Episodes cloudflare workers database struggle
pm 632: Adam Coster on Game Development and Crashlands 2 By shoptalkshow.com Published On :: Mon, 09 Sep 2024 08:00:41 +0000 Adam Coster talks with us about working with his family in game development, how they get started making games, what all is involved with publishing games, deciding to go Steam and Netflix only for Crashlands 2, how web tech is involved in game development, and the fun of testing and doing Q&A for games. Full Article All Episodes Apple Arcade Development netflix Publishing steam video games
pm Climate-resilient agriculture is prerequisite for sustainable development, says ICAR chief By www.thehindu.com Published On :: Wed, 19 Jun 2024 21:06:45 +0530 Tobacco industry contributes ₹32,516 crore annually to national economy through exports and excise tax reviews and sustains employment for 45.7 million people, says Director General of ICAR Full Article Andhra Pradesh
pm PM Modi expresses condolences over demise of renowned organic farmer Pappammal By www.thehindu.com Published On :: Sat, 28 Sep 2024 07:49:43 +0530 In 2021, she was given the Padma Shri award for popularising organic farming in India and was regarded as a pioneer in the agriculture field Full Article India
pm Tata Motors signs MoU with ASDC for skill development By www.thehindu.com Published On :: Wed, 01 Jun 2016 00:00:00 +0530 Full Article Mumbai Capital
pm PMK functionary assaulted in Villupuram By www.thehindu.com Published On :: Sun, 10 Nov 2024 14:58:08 +0530 Police suspect previous enmity to be the reason behind the incident Full Article Tamil Nadu
pm 25 tribal girls to undergo skill development training under Tholkudi scheme By www.thehindu.com Published On :: Mon, 11 Nov 2024 00:31:41 +0530 Full Article Tamil Nadu
pm T.N. lists achievements of Rural Development Department By www.thehindu.com Published On :: Mon, 11 Nov 2024 21:24:43 +0530 Full Article Tamil Nadu
pm Development of a coarse-grained molecular dynamics model for poly(dimethyl-co-diphenyl)siloxane By pubs.rsc.org Published On :: Soft Matter, 2024, 20,8480-8492DOI: 10.1039/D4SM00875H, PaperWeikang Xian, Amitesh Maiti, Andrew P. Saab, Ying LiPolydimethylsiloxane and its copolymer systems have a wide range of application. We systematically develop a coarse-grained MD model for PDMS-co-PDPS system. The model preserves the structural and dynamic properties of the material quantitatively.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pm Aim is to provide a tractor load of sand for ₹900, says A.P. Urban Development Minister Narayana By www.thehindu.com Published On :: Sat, 09 Nov 2024 19:08:11 +0530 Construction workers across the State have benefited from the free sand policy, he says, adding the NDA government will fulfil all its promises one after the other Full Article Andhra Pradesh
pm Andhra Pradesh Budget highlights: ₹29,909 crore for school education, ₹16,739 crore for Panchayat Raj and Rural Development for FY25 By www.thehindu.com Published On :: Mon, 11 Nov 2024 10:29:00 +0530 The Andhra Pradesh Government presented its Budget with an outlay of ₹2,94,427.25 crore for the Financial Year 2024-25; revenue expenditure is estimated at ₹2,35,916.99 crore, and capital expenditure at ₹32,712.84 crore Full Article Andhra Pradesh
pm India’s SDG focus and its human development issues By www.thehindu.com Published On :: Fri, 18 Oct 2024 00:08:00 +0530 Countries that aspire to achieve sustainable development need to take steps to boost human development Full Article Comment
pm Growing mathematical minds [electronic resource] : conversations between developmental psychologists and early childhood teachers / edited by Jennifer S. McCray, Jie-Qi Chen, and Janet Eisenband-Sorkin. By darius.uleth.ca Published On :: New York, NY : Routledge, 2019. Full Article
pm PM Vishwakarma scheme intends to make nationalised banks pro-people once more, says Kota Srinivas Poojary By www.thehindu.com Published On :: Tue, 29 Oct 2024 20:19:12 +0530 Full Article Mangaluru
pm Cabinet approves PM-Vidyalaxmi scheme for higher education By www.thehindu.com Published On :: Wed, 06 Nov 2024 15:55:20 +0530 Under the scheme, a student who secures admission in top higher education institutions, both government and private, will be eligible to get collateral-free, guarantor-free loan from banks and financial institutions Full Article India
pm ED attaches assets in EMAAR-MGF PMLA case; Hooda says he has nothing to do with it By www.thehindubusinessline.com Published On :: Fri, 30 Aug 2024 20:37:36 +0530 It is alleged that Hooda had colluded with real estate to arrange land for them at cheaper rates Full Article Real Estate
pm Interest subsidy to be provided only once for a property under PMAY-U 2.0 By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 18:43:29 +0530 Affordable housing transactions could be impacted due to clause Full Article Real Estate
pm General ppm-level Pd-catalysed asymmetric diarylalkyne hydrosilylation to access structurally diverse Si-stereogenic vinylsilanes By pubs.rsc.org Published On :: Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO01698J, Research ArticleHeng Xu, Han-Xiao Yu, An-Jiu Wen, Fang-Ying Ling, Fei Ye, Li Li, Fuk Yee Kwong, Li-Wen XuThe first example of enantioselective Pd-catalyzed hydrosilylation of symmetric and asymmetric diarylalkynes to access novel Si-stereogenic vinylsilanes with excellent ee and a high TON is realized under mild reaction conditions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pm Recent developments in the ring-opening transformations of gem-difluorocyclopropanes By pubs.rsc.org Published On :: Org. Chem. Front., 2024, 11,6518-6533DOI: 10.1039/D4QO01583E, Review ArticleLeiyang Lv, Junqi Su, Zhiping LiThis review summarizes the advances of gem-F2CPs as fluoroallylic synthons in transition metal-catalysed ring-opening/cross-coupling reactions via single, double or no C-F bond cleavage on the last two years.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pm Telangana delegation to embark on 3-day study tour in Karnataka for fisheries development By www.thehindu.com Published On :: Sun, 10 Nov 2024 19:30:13 +0530 Full Article Telangana
pm Hyderabad-based Raghu Vamsi Group acquires British precision machining firm PMC Group By www.thehindu.com Published On :: Mon, 11 Nov 2024 14:55:02 +0530 The Hyderabad-based MSME, Raghu Vamsi Group, has completed the acquisition of British precision machining firm PMC GGroup, that traces its roots to over 100 years Full Article Hyderabad
pm Investigation and development of novel synthetic approaches for synthesis of euxanthone and derived dyes By pubs.rsc.org Published On :: RSC Adv., 2024, 14,35601-35609DOI: 10.1039/D4RA06475E, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.M. Mustafa CetinThis work explores new synthetic methods for euxanthone and its derived dye Indian yellow through euxanthic acid formation, confirming structures with analytical techniques and proposing a mechanism for the euxanthone synthesis.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pm Why Himalayan towns need a different kind of development | Explained By www.thehindu.com Published On :: Fri, 09 Aug 2024 08:30:00 +0530 Do cities along the Indian Himalayan Range have adequate funds and resources to manage civic issues? Full Article India
pm PM Modi to release 109 climate resilient crop seeds developed by ICAR, says Shivraj Singh Chouhan By www.thehindu.com Published On :: Sun, 11 Aug 2024 01:23:00 +0530 The aim is to ensure that the benefits of science and research directly reach the farmers, says the Agriculture Minister Full Article Other States
pm Stay calm, sleep well: PM Modi tells Paris-bound athletes; asks for mom-made ‘churma’ from Neeraj By www.thehindu.com Published On :: Fri, 05 Jul 2024 11:37:09 +0530 The upcoming Games will be held from July 26 to August 11 and India would be hoping to better its best ever tally of seven medals, including Chopra's historic javelin throw gold, achieved in the Tokyo Games. Full Article Athletics
pm Nijjar killing: Canadian PM Trudeau admits he had no hard proof when he alleged Indian agents' involvement By www.thehindubusinessline.com Published On :: Thu, 17 Oct 2024 00:45:22 +0530 Trudeau admits intelligence, not evidence, behind claims of Indian involvement in Nijjar’s killing. Full Article World
pm Drone strike launched toward Israeli PM Benjamin Netanyahu’s house By www.thehindubusinessline.com Published On :: Sat, 19 Oct 2024 13:38:37 +0530 Neither Israel’s Prime Minister Benjamin Netanyahu nor his wife were home and there were no casualties, says spokesperson Full Article World
pm PM Narendra Modi to meet Spanish PM Pedro Sanchez in Vadodara to boost bilateral ties By www.thehindubusinessline.com Published On :: Sat, 26 Oct 2024 17:49:41 +0530 Bilateral trade between India and Spain has increased from $6.77 billion in 2021-22 to $7.24 billion in 2023-24 Full Article World
pm Many supporters of Khalistan in Canada, but they do not represent Sikh Community: PM Trudeau By www.thehindubusinessline.com Published On :: Sat, 09 Nov 2024 15:47:31 +0530 His comments came during Diwali celebrations at Ottawa’s Parliament Hill recently amid an ongoing diplomatic row with India over the killing of Khalistan extremist Hardeep Singh Nijjar Full Article World
pm Japan’s Ishiba wins runoff vote to stay as PM ahead of likely Trump meeting By www.thehindubusinessline.com Published On :: Mon, 11 Nov 2024 14:27:26 +0530 Japanese government officials are trying to arrange a meeting for him with Trump toward the end of the trip, potentially during a stopover in the US before Ishiba returns to Japan Full Article World
pm Rhenium(I) and technetium(I) complexes with megazol derivatives: towards the development of a theranostic platform for Chagas disease By pubs.rsc.org Published On :: Dalton Trans., 2024, Accepted ManuscriptDOI: 10.1039/D4DT02714K, PaperAna Cristina Resende Gonçalves, Silvia Helena Libardi, Júlio Cesar Borges, Ronaldo Junio de Oliveira, Carla Gotzmann, Olivier Blacque, Sergio Albuquerque, Carla Duque Lopes, Roger Alberto, Pedro Ivo da Silva MaiaThe diagnosis and treatment of Chagas disease (CD) in the chronic phase remains a challenge. With that in mind, a potential theranostic device based on the trypanocidal agent known as...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pm Development of Polyoxometalate-loaded MOF for Heterogeneous Catalysis and Enhanced Dye Adsorption By pubs.rsc.org Published On :: Dalton Trans., 2024, Accepted ManuscriptDOI: 10.1039/D4DT02645D, PaperKetan Maru, Sarita Kalla, Ritambhara JangirThe study focuses here on the enhancement of MIL-117 functionality by incorporating well-known polyoxometalate (POM); tetrabutylammonium octamolybdate [(n-C4H9)4N]4[Mo8O26]. Using an encapsulation method with conventional heating, Mo8O264- anions were first time...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pm β-Cyclodextrin and cucurbit[7]uril as protective encapsulation agents of the CO-releasing molecule [CpMo(CO)3Me] By pubs.rsc.org Published On :: Dalton Trans., 2024, Advance ArticleDOI: 10.1039/D4DT01863J, PaperRodrigo P. Monteiro, Isabel B. Calhau, Ana C. Gomes, André D. Lopes, José P. Da Silva, Isabel S. Gonçalves, Martyn PillingerFor inclusion compounds between the complex [CpMo(CO)3Me] (1) and β-cyclodextrin or cucurbit[7]uril, the macrocyclic hosts modulate to different degrees the UV light-mediated CO release from encapsulated 1.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pm Siddaramaiah, Shivakumar term PM’s allegations of raising ₹700 cr. to fund Maharashtra polls as a ‘lie’ By www.thehindu.com Published On :: Sun, 10 Nov 2024 21:32:57 +0530 Full Article Karnataka
pm Allocation for development works nails BJP’s lie of resource crunch in State, says Siddaramaiah By www.thehindu.com Published On :: Tue, 12 Nov 2024 20:02:22 +0530 Full Article Karnataka
pm D’Cunha report revealed ₹918 crore misappropriated in COVID equipment procurement: Sharan Prakash Patil By www.thehindu.com Published On :: Tue, 12 Nov 2024 21:01:16 +0530 Full Article Karnataka
pm Effective development of human resources facilitates growth: Pralhad Joshi By www.thehindu.com Published On :: Tue, 12 Nov 2024 21:07:23 +0530 Full Article Karnataka
pm Maha: Under PMBJP, Nalasopara residents buying cheaper medicines; thank PM Modi By www.newkerala.com Published On :: Sun, 10 Nov 2024 09:15:34 +0530 Full Article
pm PMAY beneficiaries in Maharashtra's Beed thank PM Modi for affordable housing By www.newkerala.com Published On :: Mon, 11 Nov 2024 22:48:01 +0530 Full Article
pm Morning Digest: NSCN-IM threatens armed violence for first time since 2015 agreement; Article 370 cannot be restored by anyone, says PM Modi, and more By www.thehindu.com Published On :: Sat, 09 Nov 2024 06:24:33 +0530 Here is a select list of stories to start the day Full Article News
pm Fe3+ and H2O2 assisted dopamine rapid polymerization on melamine foam to activate PMS for organic pollutant degradation By pubs.rsc.org Published On :: Environ. Sci.: Water Res. Technol., 2024, 10,2698-2708DOI: 10.1039/D4EW00596A, PaperHaoxiang Yan, Jianzheng Zhen, Yuyuan YaoA bulk sponge catalytic material was prepared by rapid polymerization of DA and utilized for PMS activation to degrade BPA. The coexistence of HCO3− enhanced 1O2 generation, accelerating BPA degradation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pm India becoming part of global drug development operation of BMS: Samit Hirawat By www.thehindu.com Published On :: Mon, 04 Nov 2024 18:53:28 +0530 Samit Hirawat discussed India’s growing significance as a site for clinical trials, innovations in drug development, and how technology is poised to help bring new products to market faster Full Article Industry
pm Ratan Tata’s absence deeply felt across the world, writes PM Narendra Modi By www.thehindu.com Published On :: Sat, 09 Nov 2024 10:26:23 +0530 He wore his achievements lightly, with humility and kindness. Full Article India
pm Centre for Development Studies: Looking to the future, evolving strategies to meet present-day challenges By www.thehindu.com Published On :: Sun, 27 Oct 2024 19:15:42 +0530 CDS is evolving strategies for research and financial self-sufficiency while maintaining original mandate, exploring new programmes and training opportunities. Full Article Kerala
pm Centre greenlights ₹177-crore Muthalapozhi harbour development By www.thehindu.com Published On :: Sun, 27 Oct 2024 19:38:25 +0530 Six villages chosen for climate resilient scheme, and five fishing harbours in line for modernisation project Full Article Kerala