A limited number of fans will be allowed to enter ballparks for games in Taiwan for the first time this season as stay-at-home orders continue to loosen amid the coronavirus pandemic.

A Florida sheriff's office said a driver reversing out of a bank parking lot accidentally ended up backing up onto two other cars.

Halley's Comet only orbits the sun once every 75 years, but each year in early May, the Earth passes through some of the debris that it left behind.

While the coordinated attacks of Velociraptor dinosaurs depicted in the 1993 blockbuster made for compelling movie viewing, a study published this week claims raptors most likely hunted solo, not in packs.

Darren Sammy and Devendra Bishoo shared five wickets to trigger India's collapse on the second day of the opening Test against the West Indies in New Delhi.

Australian Joel Parkinson has lost the final of the Rip Curl Pro Search to rising Brazilian teenage sensation Gabriel Medina in San Francisco.

A couple years ago, Washington State switched the default rule on state park fees that drivers pay (or don’t pay) when they renew their licenses. Reader Steve Loeb nicely captures what this switch looks like on the Washington State Department of Licensing site.

Author Priya Parker shares tools for creating meaningful connections with friends, family and coworkers during the coronavirus pandemic -- and shows how we can take advantage of gatherings that are unique to this moment of social distancing. "We don't necessarily need to gather more," she says. "We need to gather better." (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and current affairs curator Whitney Pennington Rodgers. Recorded March 27, 2020)

Curious how stuff works? Do a hands-on experiment at home, says physicist Nadya Mason. She shows how you can demystify the world around you by tapping into your scientific curiosity -- and performs a few onstage experiments of her own using magnets, dollar bills, dry ice and more.

While most teachers have online access at home, internet service for many educators in rural areas is spotty, expensive, or nonexistent.

While most teachers have online access at home, internet service for many educators in rural areas is spotty, expensive, or nonexistent.

While most teachers have online access at home, internet service for many educators in rural areas is spotty, expensive, or nonexistent.

Detective Inspector Carl West investigates the murder of the mayor of East Park - businessman and political insider - Doug Clarke.Carl struggles to find a motive for Clarke's murder until his detectives explore the activities of the poker playing East Park Syndicate. If you like a story with twists and surprises, you'll enjoy The East Park Syndicate, the sixth book in Peter Mulraney's Inspector West series.

Dawkins, Richard, 1941- -- Religion.

London : Dublin, 1843.

London : H.K. Lewis, 1891.

London : Macmillan, 1897.

London : Macmillan, 1886.

London : J. & A. Churchill, 1873.

The state's Republican governor is in a pitched battle with the state's educators over the process he used to fire Missouri's commissioner of education.

Application and use of deep learning algorithms for different healthcare applications is gaining interest at a steady pace. However, use of such algorithms can prove to be challenging as they require large amounts of training data that capture different possible variations. This makes it difficult to use them in a clinical setting since in most health applications researchers often have to work with limited data. Less data can cause the deep learning model to over-fit. In this paper, we ask how can we use data from a different environment, different use-case, with widely differing data distributions. We exemplify this use case by using single-sensor accelerometer data from healthy subjects performing activities of daily living - ADLs (source dataset), to extract features relevant to multi-sensor accelerometer gait data (target dataset) for Parkinson's disease classification. We train the pre-trained model using the source dataset and use it as a feature extractor. We show that the features extracted for the target dataset can be used to train an effective classification model. Our pre-trained source model consists of a convolutional autoencoder, and the target classification model is a simple multi-layer perceptron model. We explore two different pre-trained source models, trained using different activity groups, and analyze the influence the choice of pre-trained model has over the task of Parkinson's disease classification.

The transcription factor Nurr1 has been identified to be ectopically induced in the striatum of rodents expressing l-DOPA-induced dyskinesia (LID). In the present study, we sought to characterize Nurr1 as a causative factor in LID expression. We used rAAV2/5 to overexpress Nurr1 or GFP in the parkinsonian striatum of LID-resistant Lewis or LID-prone Fischer-344 (F344) male rats. In a second cohort, rats received the Nurr1 agonist amodiaquine (AQ) together with l-DOPA or ropinirole. All rats received a chronic DA agonist and were evaluated for LID severity. Finally, we performed single-unit recordings and dendritic spine analyses on striatal medium spiny neurons (MSNs) in drug-naïve rAAV-injected male parkinsonian rats. rAAV-GFP injected LID-resistant hemi-parkinsonian Lewis rats displayed mild LID and no induction of striatal Nurr1 despite receiving a high dose of l-DOPA. However, Lewis rats overexpressing Nurr1 developed severe LID. Nurr1 agonism with AQ exacerbated LID in F344 rats. We additionally determined that in l-DOPA-naïve rats striatal rAAV-Nurr1 overexpression (1) increased cortically-evoked firing in a subpopulation of identified striatonigral MSNs, and (2) altered spine density and thin-spine morphology on striatal MSNs; both phenomena mimicking changes seen in dyskinetic rats. Finally, we provide postmortem evidence of Nurr1 expression in striatal neurons of l-DOPA-treated PD patients. Our data demonstrate that ectopic induction of striatal Nurr1 is capable of inducing LID behavior and associated neuropathology, even in resistant subjects. These data support a direct role of Nurr1 in aberrant neuronal plasticity and LID induction, providing a potential novel target for therapeutic development.

SIGNIFICANCE STATEMENT The transcription factor Nurr1 is ectopically induced in striatal neurons of rats exhibiting levodopa-induced dyskinesia [LID; a side-effect to dopamine replacement strategies in Parkinson's disease (PD)]. Here we asked whether Nurr1 is causing LID. Indeed, rAAV-mediated expression of Nurr1 in striatal neurons was sufficient to overcome LID-resistance, and Nurr1 agonism exacerbated LID severity in dyskinetic rats. Moreover, we found that expression of Nurr1 in l-DOPA naïve hemi-parkinsonian rats resulted in the formation of morphologic and electrophysiological signatures of maladaptive neuronal plasticity; a phenomenon associated with LID. Finally, we determined that ectopic Nurr1 expression can be found in the putamen of l-DOPA-treated PD patients. These data suggest that striatal Nurr1 is an important mediator of the formation of LID.

Autumn Ray's goal: 59 national parks before she turns 40 in four years

An independent survey finds that although NPS's annual budget is around $3 billion, Americans are willing to pay much more

Early conservation research and scientific expeditions laid the groundwork and helped to convince the public national parks were a good idea

These parks are less popular, but no less spectacular

For the first time, the indigenous community is allowed to gather the cherished plant on protected land

Some sites have closed completely, while others are making modifications to promote social distancing

A rare bloom of microscopic organisms capable of making their own blue light has transformed several of the state’s beaches

Coyotes, bears and more are enjoying areas usually reserved for crowds of human visitors

The Beaker man was buried alongside four cowhide "rugs," an eight-inch copper dagger and a wrist guard made of rare green stone

<span class="topsy_trackback_comment"><span class="topsy_twitter_username"><span class="topsy_trackback_content">Squeekville, model train amusement park, on display at Children's ...: Squeekville, model train amusement park, ... http://bit.ly/9x4oFS</span></span>

A new study facilitated by the Workplace Safety and Insurance Board of Ontario states miners who were forced to inhale an aluminum powder were found to have a higher risk of Parkinson’s disease.

A former miner who was forced to breathe in a fine aluminum dust before each shift says he’s not surprised a new report links that dust and a higher risk of Parkinson’s disease.

The Los Angeles Dodgers are being sued for negligence by a man who was attacked in the parking lot of Dodger Stadium and left with brain damage, his lawyers announced Friday.

Making Tierra Mía, says the director of the Smithsonian Latino Center, proved transformative in giving voice to the people

"Park ambassadors" will soon be on patrol at some of Ottawa's busiest public green spaces to help confused residents navigate the newly loosened COVID-19 restrictions, Mayor Jim Watson announced Friday.

"This video footage clearly shows why La Loche Saskatchewan won't be opening up so soon," says Rita Briggs.

Vancouver police officers have seized an eight-foot boa constrictor and multiple weapons from a tent at the Oppenheimer park encampment in Vancouver.

Tennis courts in Vancouver, along with several other Metro Vancouver municipalities, will be open this weekend as municipalities across Metro Vancouver lift restrictions put in place in March due to the COVID-19 crisis. There are rules for getting out to play, however.

Karla Bell was outside an Orangeville hospital waiting to start her nursing shift when she heard a cry for help from a car in the parking lot. She ran up to find a woman in labour in the passenger seat. Natalie Kalata tells us the incredible story of how this baby was born.