iva Medicinal chemistry-based perspective on thiophene and its derivatives: Exploring the structural insights to discover plausible druggable leads By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00450G, Review ArticleShikha Thakur, Devendra Kumar, shivani jaiswal, Kapil Kumar Goel, Pramod Rawat, Vivek Srivastava, Sonia Dhiman, Hemant R Jadhav, Ashish Ranjan DwivediThiophene is a privileged pharmacophore in medicinal chemistry owing to its diversified biological attributes. The thiophene moiety has been ranked 4th in US FDA drug approval of small drug molecules,...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
iva Synthesis and anti-tumor activity of new benzofuran-based chalcone derivatives as potent VEGFR-2 inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00621F, Research ArticleChunfei Zhang, Yixin Liu, Xiao Zhang, Chunping Wan, Zewei MaoA series of novel benzofuran-based chalcone derivatives could be considered as potent VEGFR-2 inhibitors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
iva Novel quinoxaline-derived derivatives: design, synthesis, bioactive evaluation, SARs and preliminary antibacterial mechanism By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00670D, Research ArticleYuting Liu, Pengju Yang, Yunyun Zhou, Zhiwen ZhouIn the current study, we have designed and prepared a series of quinoxaline-based compounds, which were derived from o-phenylenediamine. Among which, compounds 5m-p displayed good to moderate antibacterial activity with...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
iva Design and synthesis of (E)-3-benzylideneindolin-2-one derivatives as potential allosteric inhibitors of Aurora A kinase By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00373J, Research ArticleYongLai Jiao, Jie Zhong, Jin-Fang Xu, Shaobo Ning, Taigang Liang, Mingzhu Zhao, Jian ZhangThe mitotic kinase Aurora A, a pivotal regulator of cell cycle, is overexpressed in various cancers and has emerged as one of the most promising targets for anticancer drug discovery....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
iva Synthesis, in silico and bio-evaluation studies of new isothiocyanate derivatives with respect to COX inhibition and H2S release profiles By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00495G, Research ArticleYakup Berkay Yilmaz, Tuğba Güngör, Serhat Dönmez, Hazal Nazlıcan Atalay, Pınar Siyah, Serdar Durdağı, Mehmet Ay, Tugba Boyunegmez TumerNew isothiocyanate derivatives (I1–3 and I1a–e) were synthesized and screened for their anti-inflammatory activities and H2S-releasing capacities. Compounds I1 and I1c demonstrated the most potent and selective COX-2 inhibition.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
iva Synthesis and antifungal evaluation of new azole derivatives containing 1,2,3-triazole By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00724G, Research ArticleZhengxiao Huang, Hongjie Chen, Xiao Zhang, Ruirui Wang, Chunyan Hu, Zewei MaoA series of novel azole derivatives containing 1,2,3-triazole have been synthesized with good antifungal effects on sensitive and drug-resistant C. albicans.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
iva Ernakulam Express to stop at Muthupettai during Kandhoori festival By www.thehindu.com Published On :: Thu, 07 Nov 2024 18:51:18 +0530 Full Article Tiruchirapalli
iva Tiruchi district SHGs compete to prepare healthy millet-based recipes at food festival By www.thehindu.com Published On :: Fri, 08 Nov 2024 07:51:25 +0530 Women entrepreneurs urged to take advantage of social media platforms to advertise and market their products to a wider customer base Full Article Tiruchirapalli
iva Guidelines issued for fertilizer distribution in Karaikal for samba, thaladi paddy cultivation By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:25:49 +0530 Full Article Tiruchirapalli
iva Perez vs Lawson: A new F1 rivalry By www.rediff.com Published On :: RB driver Liam Lawson apologised to Sergio Perez after the pair clashed at the Mexican Grand Prix but the New Zealand rookie said he would not change his aggressive approach to Formula One racing. Full Article
iva Delhi to host 12th edition of North East Festival By www.thehindu.com Published On :: Wed, 06 Nov 2024 19:31:38 +0530 More than 200 communities from the eight north-eastern States are expected to showcase their cultural traits on a single platform Full Article India
iva Amateur Radio Activated for Late Season Hurricane By www.arrl.org Published On :: Fri, 08 Nov 2024 13:05:00 -0600 A rare November hurricane made landfall in western Cuba as a Category 3 storm Wednesday and continued to move slowly toward the northwest Thursday morning. Volunteer ham radio operators were there to provide surface reports to the National Hurricane Center in Miami.Hurricane Rafael left Cuba’s 10 million residents without power and on Thursday afternoon was a Category 2 storm moving away from C... Full Article
iva Rare California Island to be Activated for Armed Forces Day, First Time in 53 Years By www.arrl.org Published On :: Fri, 08 Nov 2024 13:40:00 -0600 On Armed Forces Day, May 1971, 53 years ago, two amateur operators working as WZ6SNI, activated San Nicolas Island, IOTA NA-066. At 61 miles, San Nicolas is the most remote of the Channel Islands off the coast of Southern California and is owned by the US Navy.Now, weather permitting, Will Costello, WC6DX, has been authorized to be active from San Nicolas Island November 8 - 12, 2024. He is tak... Full Article
iva West Bengal farmers organise indigenous seed festival By www.thehindu.com Published On :: Thu, 28 Dec 2023 04:51:00 +0530 Hundreds of farmers from different districts brought native varieties of paddy, pulses and vegetables and exchanged traditional knowledge Full Article Kolkata
iva Debt private placements hit record high of Rs. 4,92,000 crore in FY16 By www.thehindu.com Published On :: Tue, 31 May 2016 00:00:00 +0530 Total mobilisation six per cent higher than previous financial year Full Article Mumbai Capital
iva Litigant withdraws PIL seeking revival of 2001 flyover construction scam case against T.N. CM Stalin By www.thehindu.com Published On :: Tue, 12 Nov 2024 12:17:53 +0530 The Madras High Court also permits him to withdraw ₹1 lakh deposited in April this year to prove his bona fide intention Full Article Tamil Nadu
iva Optimality and cooperativity in superselective surface binding by multivalent DNA nanostars By pubs.rsc.org Published On :: Soft Matter, 2024, 20,8515-8523DOI: 10.1039/D4SM00704B, Paper Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Christine Linne, Eva Heemskerk, Jos W. Zwanikken, Daniela J. Kraft, Liedewij LaanOur study shows that DNA nanostars with three binding sites (ligands) can (1) bind superselectively to surfaces based on receptor density, and (2) that interactions between ligands affect the optimum number of ligands required for superselectivity.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
iva Banana DNA derivatives as homeotropic alignment layers in optical devices By pubs.rsc.org Published On :: Soft Matter, 2024, 20,8561-8569DOI: 10.1039/D4SM00322E, PaperRafał Węgłowski, Anna Spadło, Dorota WęgłowskaIn this study, DNA extracted from bananas was functionalized and used as a homeotropic alignment layer for liquid crystals.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
iva Ensuring private sector collaborations in India’s national climate strategy By www.thehindu.com Published On :: Wed, 16 Oct 2024 10:10:00 +0530 For this, the Competition Commission of India needs to focus on the interplay between competition law and sustainability Full Article Comment
iva The private sector holds the key to India’s e-bus push By www.thehindu.com Published On :: Mon, 28 Oct 2024 02:18:00 +0530 If there is to be scale in the electric bus market in India, private sector participation is critical Full Article Comment
iva Topological and bivariant K-theory [electronic resource] / Joachim Cuntz, Ralf Meyer, Jonathan M. Rosenberg By darius.uleth.ca Published On :: Basel ; Boston : Birkhauser, 2007 Full Article
iva Konkan Railway to run Karwar-Bengaluru special train for festival returnees By www.thehindu.com Published On :: Mon, 28 Oct 2024 21:55:53 +0530 A train to be operated from Karwar to Sir M. Visvesvaraya Terminal, Bengaluru, on November 3 Full Article Mangaluru
iva Kerala fire: 27 injured being treated at private hospital in Mangaluru By www.thehindu.com Published On :: Tue, 29 Oct 2024 19:31:59 +0530 Full Article Mangaluru
iva PM Vishwakarma scheme intends to make nationalised banks pro-people once more, says Kota Srinivas Poojary By www.thehindu.com Published On :: Tue, 29 Oct 2024 20:19:12 +0530 Full Article Mangaluru
iva BJP is embarrassed at being forced to copy guarantee schemes of Congress in BJP-ruled States: D. K. Shivakumar By www.thehindu.com Published On :: Sat, 02 Nov 2024 13:07:27 +0530 On BJP allegation that the Congress government is not been able to manage its guarantee schemes, Mr. Shivakumar said that Karnataka’s financial strength is stronger than the country’s financial strength Full Article Mangaluru
iva Don’t delay loan sanction and disbursal to central schemes beneficiaries, Srinivas Poojary tells banks By www.thehindu.com Published On :: Thu, 07 Nov 2024 07:00:00 +0530 Full Article Mangaluru
iva Kudla Samskrutika Prathishtana to hold ‘Mangaluru Street Food Festival’ from January 15 to 19 By www.thehindu.com Published On :: Thu, 07 Nov 2024 07:00:00 +0530 Full Article Mangaluru
iva Kota Srinivas Poojary urges Union government to employ people who know local language in nationalised banks By www.thehindu.com Published On :: Fri, 08 Nov 2024 20:50:35 +0530 Full Article Mangaluru
iva Indian HEIs tuning to global rankings; private ones taking the lead By www.thehindu.com Published On :: Wed, 30 Oct 2024 06:30:00 +0530 While government HEIs have improved their positions in THE and QS rankings, private ones that have implemented various measures for research and international engagement have done better. Full Article Education
iva Mudinja Ivana Pudi: Mixed doubles By www.thehindu.com Published On :: Sat, 13 Aug 2016 16:14:37 +0530 The film tries to subvert the classic evil-twin template. Full Article Cinema
iva 'Shivaay': stylish with an archaic heart By www.thehindu.com Published On :: Fri, 28 Oct 2016 16:19:41 +0530 The film turns out almost three hours long with just a wisp of a story. Full Article Reviews
iva Ivanhoe Cambridge divests stake in three joint ventures to partner Lodha By www.thehindubusinessline.com Published On :: Fri, 20 Sep 2024 08:50:27 +0530 Following the acquisition, Macrotech’s stakes in the entities — Bellissimo Digital Infrastructure Development Management, Palava Induslogic 4, and Bellissimo In City FC Mumbai 1 — will increase to 70%, 66.67%, and 66.67%, respectively. Full Article Real Estate
iva Real estate transactions drop 71% in Q3 2024, private equity dominates By www.thehindubusinessline.com Published On :: Mon, 14 Oct 2024 13:41:56 +0530 Despite the overall fall, the number of deals rose 5% quarter-on-quarter and 54% year-on-year, with a potential revival in Q4. Full Article Real Estate
iva Kerala govt planning to organise international bamboo festival By www.thehindu.com Published On :: Sat, 08 Dec 2012 10:34:08 +0530 Full Article Kochi
iva Delhi International Kite Festival 2012 By www.thehindu.com Published On :: Sun, 09 Dec 2012 16:22:46 +0530 Delhi Tourism hosted the second edition of its International Kite Festival. Full Article Delhi
iva Visitors throng crafts festival By www.thehindu.com Published On :: Sat, 02 Mar 2013 14:52:51 +0530 The 10-day carnival has a wide range of products on display Full Article Vijayawada
iva Mamallapuram to host Tamil Nadu International Kite Festival for the first time By www.thehindu.com Published On :: Thu, 28 Jul 2022 13:01:43 +0530 The maiden edition of Tamil Nadu Kite Festival is set to see custom kites, brought in by professionals from USA, Thailand, Malaysia and India, take flight Full Article Life & Style
iva Photocatalytic hydrotrichloromethylation of unactivated alkenes with chloroform By pubs.rsc.org Published On :: Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO01496K, Research ArticleDawei Gong, Caiyu Gao, Qixuan Li, Yufei Li, Lina Zhao, Degong KongTrichloromethyl compounds are essential constituents in synthetic and medicinal chemistry.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
iva Visible-light excited copper activating unactivated alkyl iodides for radical addition/cyclization to access oxindole derivatives By pubs.rsc.org Published On :: Org. Chem. Front., 2024, 11,6380-6384DOI: 10.1039/D4QO01329H, Research ArticleHang Luo, Fangnian Yu, Luqing LinThe photocopper catalyst facilitates halogen atom transfer to give unactivated alkyl radicals, which is critical for achieving radical cyclization in the absence of an exogenous photocatalyst.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
iva Phosphine-controlled divergent reactions of MBH-carbonates with azaheptafulvenes: access to o-anilinyl diene and benzazepine derivatives By pubs.rsc.org Published On :: Org. Chem. Front., 2024, 11,6418-6425DOI: 10.1039/D4QO01298D, Research ArticleWei Hao, Yiwen Zhang, Xiao Han, Zhen Wang, Weijun YaoA phosphine controlled divergent cascade reaction of MBH-carbonates with azaheptafulvenes was disclosed. PPh3 provided o-aminophenyl diene while PCy3 offered benzazepine derivative through formal [8 + 3] annulation/ring contraction cascade.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
iva Well-defined chiral dinuclear copper-catalyzed tandem asymmetric propargylic amination–carboxylative cyclization sequence toward chiral 2-oxazolidinone derivatives By pubs.rsc.org Published On :: Org. Chem. Front., 2024, 11,6319-6326DOI: 10.1039/D4QO01368A, Research ArticleYu Lan, Peng Liu, Zekai Fang, Lili Shao, Qilong Cai, Xiaoming WangA variety of chiral 2-oxazolidinones was obtained via a dinuclear copper-catalyzed asymmetric propargylic amination–carboxylative cyclization sequence of propargylic esters with alkyl amine hydrochlorides and CO2.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
iva Theoretical insights into Pd-catalyzed dual γ-1,1-C(sp3)–H activation of aliphatic carboxylic acids: mechanistic pathways, substituent influence on product selectivity, diastereoselectivity, and additive effects By pubs.rsc.org Published On :: Org. Chem. Front., 2024, 11,6393-6410DOI: 10.1039/D4QO01451K, Research ArticleJiaoyang Liu, Li-juan Huang, Zeang Sun, Juan LiDFT calculations were employed to explore the detailed reaction mechanism and the origins of the experimentally observed product, regio-, and diastereoselectivities in the Pd-catalyzed dual-γ-1,1-C(sp3)–H activation of aliphatic carboxylic acids.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
iva Activation of donor–acceptor cyclopropanes under basic conditions: ring opening of 2-(p-siloxyaryl)cyclopropane 1,1-dicarboxylates with nitro compounds and other C-nucleophiles By pubs.rsc.org Published On :: Org. Chem. Front., 2024, 11,6483-6494DOI: 10.1039/D4QO01472C, Research ArticleYulia A. Antonova, Andrey A. TabolinA new activation mode for donor–acceptor cyclopropanes was proposed and implemented in their reaction with nitro compounds and other common C-nucleophiles.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
iva Regio- and stereoselective azidation of activated N-allenamides: an entry to α, β, γ and δ-amido-azides By pubs.rsc.org Published On :: Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO01802H, Research ArticleDorian Schutz, Maxime Hourtoule, Laurence MieschA totally controlled regiodivergent azidation of activated N-allenamides is described, offering a broad range of diverse functionalized amido-azide derivatives.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
iva Catalyst-free C–H methylation of heteroarenes enabled by electron donor–acceptor complex photoactivation By pubs.rsc.org Published On :: Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO01309C, Research ArticleJiayang Wang, Baoer Shao, Haixia Ge, Huiyu Xue, Xiangyuan Ding, Yuqi Li, Peiyao ShengA visible-light-induced direct C–H methylation of heterocycles (including quinoxalinones, pyrazinones, quinolinones and coumarins) with methylamines via EDA complex photoactivation was developed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
iva Stereocontrolled synthesis of heterocycles from unactivated alkynes by photoredox/nickel dual-catalyzed cyclization By pubs.rsc.org Published On :: Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO01627K, Research ArticleBo-Rong Leng, Feng Yang, Jin-Lian Bai, Yu-Wen Huang, Qing-Quan Liu, Ping Wei, De-Cai Wang, Yi-Long ZhuWe report a nickel/photoredox dual catalysis method for synthesizing heterocyclics from unactivated alkynes and aryl iodides, offering a direct, selective, and green alternative to traditional synthesis with potential in medicinal chemistry.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
iva Hemilabile P,N-Ligand-Assisted Gold Catalyzed Hiyama Allylation to Access Allylarenes and 1,4-Dienes Derivatives By pubs.rsc.org Published On :: Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01879F, Research ArticleYuanhao He, Wanping Ma, Yu Zhong, Yanfei Hu, Mingou Li, Fen Zhao, Zhonghua Xia, Baomin FanOxidant-free gold-catalyzed reactions are emerging as a novel synthetic tool for organic transformations. Here in, we reported a hemilabile P,N-ligand-assisted gold-catalyzed Hiyama cross coupling reaction of aryl and alkenyl iodides...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
iva Mechanistic insights into rhodium-catalyzed C−H activation and annulation using vinyl acetate to access cinnolines and cinnolin-4(1H)-ones By pubs.rsc.org Published On :: Org. Chem. Front., 2025, Accepted ManuscriptDOI: 10.1039/D4QO01734J, Research ArticleYuqin Wang, Yiling Zeng, Ya-Nan Tian, Zheng Liu, Jinhua Wang, Shuyou Chen, Shiqing LiTransition metal-catalyzed C−H activation and annulation involving vinyl acetate remains a significant challenge, and the mechanistic process following vinyl insertion is ambiguous. Herein, we report the Rh(III)-catalyzed two-fold C−H activation...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
iva ‘Sadar festival’ held in Karimnagar By www.thehindu.com Published On :: Sun, 10 Nov 2024 22:50:38 +0530 Full Article Telangana
iva Modi’s parivar stands for division of people and Gandhi parivar works for country’s unity: Telangana CM Revanth By www.thehindu.com Published On :: Mon, 11 Nov 2024 16:51:35 +0530 Referring to the lack of minority representation in his Cabinet, the Chief Minister attributed it to the absence of a Muslim MLA in Telangana Full Article Telangana
