Discover essential tips for maintaining a clean and hygienic dish rack in our latest article. Learn about the right cleaning methods, frequency, and products to keep your dish rack germ-free. This guide is a must-read for every homeowner seeking a healthier kitchen.

The post Ultimate Guide: Keep Your Dish Rack Sparkling Clean & Hygienic appeared first on Unclutterer.

This website has now been folded into my main DebbieOhi.com website, so please adjust your bookmarks. Thank you!

Hyperbaric Oxygen Therapy (HBOT) is a medical treatment that involves breathing pure oxygen in a pressurized environment. This unique treatment method has shown effectiveness in healing various conditions, from complex wound healing to treating decompression sickness in divers. HBOT works on the principle of increasing oxygen concentration in the body, which can enhance the body’s ... Read more

The post How Much Does Hyperbaric Oxygen Therapy Cost? Price Tips appeared first on Star Two.

Jorge H. Capdevila
Feb 1, 2000; 41:163-181
Reviews

Martin Ehler and Karlheinz Gröchenig
Math. Comp. 93 (), 2885-2919.
Abstract, references and article information

Ivan Soprunov and Jenya Soprunova
Proc. Amer. Math. Soc. 152 (), 5313-5325.
Abstract, references and article information

Heme oxygenase-2 (HO2) and -1 (HO1) catalyze heme degradation to biliverdin, CO, and iron, forming an essential link in the heme metabolism network. Tight regulation of the cellular levels and catalytic activities of HO1 and HO2 is important for maintaining heme homeostasis. HO1 expression is transcriptionally regulated; however, HO2 expression is constitutive. How the cellular levels and activity of HO2 are regulated remains unclear. Here, we elucidate the mechanism of post-translational regulation of cellular HO2 levels by heme. We find that, under heme-deficient conditions, HO2 is destabilized and targeted for degradation, suggesting that heme plays a direct role in HO2 regulation. HO2 has three heme binding sites: one at its catalytic site and the others at its two heme regulatory motifs (HRMs). We report that, in contrast to other HRM-containing proteins, the cellular protein level and degradation rate of HO2 are independent of heme binding to the HRMs. Rather, under heme deficiency, loss of heme binding to the catalytic site destabilizes HO2. Consistently, an HO2 catalytic site variant that is unable to bind heme exhibits a constant low protein level and an enhanced protein degradation rate compared with the WT HO2. Finally, HO2 is degraded by the lysosome through chaperone-mediated autophagy, distinct from other HRM-containing proteins and HO1, which are degraded by the proteasome. These results reveal a novel aspect of HO2 regulation and deepen our understanding of HO2's role in maintaining heme homeostasis, paving the way for future investigation into HO2's pathophysiological role in heme deficiency response.

Born October 30 to parents Gloria and Otto at the Edinburgh Zoo in Scotland, the hippo is already gaining popularity, following in the footsteps of viral sensation Moo Deng

These grounded planes in the Congo have captured the imagination of these children

An Ontario court has declined to review a decision to deny Peter Nygard bail while the former fashion mogul appeals his sexual assault convictions and sentence.

No public playground exists in Bar, Montenegro. This year, OM Montenegro plans to build one with the help of an outreach team.

Four volunteers from Switzerland. One empty park. Ten days to build a playground. Could it be done?

3D mechanical design and analysis software dramatically increases productivity and reduces revision for precision optical manufacturer

SOLIDWORKS Solution Partner develops lifelike, detailed 3D models of human body used in biomedical research, entertainment

Transform your iPhone 16 into a digital art studio with iOS 18.2's Image Playground, the latest tool for creating custom visuals with a few taps.

With the release of iOS 18.2, Apple's Image Playground app offers users an accessible way to create custom digital images, sparking creative possibilities for iPhone owners. Part of Apple's expanding Apple Intelligence suite, Image Playground debuted in developer betas in late 2024.

With each update, Apple has strived to make Image Playground more responsive and intuitive, aiming to provide a smoother user experience as the feature matures. In the second developer beta of iOS 18.2, notable improvements are already evident, particularly in rendering speed and the alignment between user prompts and generated images.


Continue Reading on AppleInsider | Discuss on our Forums

iOS 18.2 with access to ChatGPT integrations, Image Playground, and Genmoji could finally roll out to the general public on December 9 based on a notice recently posted by a UK carrier.

On Monday, Apple released the third developer beta of iOS 18.2. Along with the various changes and quality-of-life improvements, the software also contains an update for carrier-specific settings.

The third developer beta contains an update for devices using the British carrier EE. The carrier settings shipped with iOS 18.1 and the second developer beta of iOS 18.2 had the version number 59.5.1, while iOS 18.2 developer beta 3 increased the EE carrier settings version to 60.5.2.


Continue Reading on AppleInsider | Discuss on our Forums

The Centre on Monday informed the Supreme Court of framing the "Menstrual Hygiene Policy for School Going Girls" approved by the Union Health Ministry.

OnePlus 12R was launched in India in January this year with a Snapdragon 8 Gen 2 chipset paired with up to 16GB of LPDDR5x RAM. It runs on Android 14-based OxygenOS 14 out-of-the-box. Now the stable version of the Android 15-based OxygenOS 15 update with updated features and fixes is rolling out to OnePlus 12R users.

Soan Papdi Viral Video: Just after Diwali, an unexpected video of the making process of Soan Papdi surfaced online

Read the in depth Review of PlayGo T44 Audio Video. Know detailed info about PlayGo T44 configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of PlayGo BH70 Audio Video. Know detailed info about PlayGo BH70 configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of PlayGo BH47 Audio Video. Know detailed info about PlayGo BH47 configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of PlayGo N37 Audio Video. Know detailed info about PlayGo N37 configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Hi All,

I'm using a code (abConvertPolygonToPath.ils) that I found in other posts to convert a rect object to a path object inside a pcell code, but when I try to run a DRC, the layout export fails due to a warning message, here is the log message

*WARNING* (DB-270001): Pcell evaluation for 18A_asaavedr/lay_mesh_BM0_BM4_3p6_3p6/layout has the following error(s):

*WARNING* (DB-270002): ("eval" 0 t nil ("*Error* eval: undefined function" abConvertPolygonToPath))

 

ERROR (XOASIS-231): Pcell evaluation failed for '18A_asaavedr/lay_mesh_BM0_BM4_3p6_3p6/layout' because the Pcell SKILL code contains either a syntax error or an unsupported XOasis function. Check the standard output or the Virtuoso log file for more information. Cadence recommends correcting the Pcell SKILL code to resolve the issue. However, to ignore these errors and continue the translation, you may use the 'ignorePcellEvalFail' option.

INFO (XOASIS-282): Translation Failed. '1' error(s) and '3' warning(s) found.

And when compile the code I get the following message:

*WARNING* defgeneric function already defined - abConvertPolygonToPath

I will aprreciate any help in how to waive this error, or fix it.

Thank you

Washington — Following President-elect Donald Trump’s victory, leaders in the Uyghur American community are advocating for renewed U.S. attention on human rights abuses in Xinjiang in northwest China, where Uyghurs and other ethnic minorities have reportedly faced severe repression. Advocates urge Trump to continue his administration’s previous measures against China, citing the impact of his first-term policies on Uyghur rights. During Trump’s first term, his administration formally labeled China’s actions in Xinjiang as genocide, leading to sanctions on Chinese officials and entities connected with alleged abuses, including mass detentions, forced labor and sterilizations. China has consistently denied accusations of abuses against ethnic minorities, asserting its policies aim to combat extremism and terrorism. Nury Turkel, a senior fellow at the Hudson Institute and former chairman of the U.S. Commission on International Religious Freedom, pointed to the bipartisan support for Uyghur rights, underscoring that these concerns resonate across both U.S. legislative and executive branches. “[Uyghur rights] concerns extend beyond typical human rights issues. They have profound national security implications tied to America’s long-term economic and strategic security,” Turkel told VOA. Turkel expressed cautious optimism that Trump’s new administration will build on its previous actions, referencing the Uyghur Human Rights Policy Act and the genocide designation. “I am optimistic that the incoming administration will take concrete steps to address these urgent concerns affecting Uyghurs, as it had previously,” he said. VOA contacted the Trump campaign for a comment regarding the new administration’s plans for Uyghur rights in China but did not receive a response at the time of publication. Renewed calls for action Uyghur American leaders plan to press Trump’s administration to bolster sanctions on Chinese officials and entities involved in abuses against Uyghurs, with the hope of strengthening the U.S. response. “I anticipate that the Trump administration will impose additional sanctions on Chinese officials and entities responsible for atrocity crimes against the Uyghurs, potentially strengthening U.S. efforts to confront these abuses,” Turkel added. Rushan Abbas, executive director of the Washington-based Campaign for Uyghurs, emphasized the need for strict enforcement of the Uyghur Forced Labor Prevention Act of 2021. “Uyghurs are enduring a genocide, and Americans should know that addressing the genocide of Uyghurs is not just a foreign policy matter; it’s about preventing the U.S. from becoming complicit through the consumption of Chinese products tainted by forced labor,” Abbas told VOA. “[I]t’s about stopping China from using Americans’ hard-earned money to fuel their imperial ambitions and undermine the United States, and rejecting foreign intimidation on U.S. soil.” Salih Hudayar, prime minister of the Washington-based East Turkistan Government in Exile, echoed these sentiments, urging the Trump administration to formally recognize the region — referred to as Xinjiang by China but called East Turkistan by many Uyghurs —as an occupied nation. “An independent East Turkistan would directly challenge China’s ambitions for dominance across Central Asia and the Indo-Pacific, safeguarding American and broader global interests,” Hudayar told VOA. He suggested appointing a special coordinator for Uyghur issues to demonstrate U.S. support for Uyghur rights and those of other minorities in the region. Current policy challenges Despite calls for stronger actions, Uyghur American advocates remain concerned that economic and strategic interests with China may take precedence. Turkel highlighted that various advocacy groups have influenced the U.S. response to Uyghur issues in recent years. “Climate activists have lobbied for closer cooperation with China on environmental initiatives; pro-engagement China watchers have advocated a softer, more conciliatory approach to 'lower the temperature' in U.S.-China relations; and business interests have warned of the economic risks of escalating tensions, pushing for policies that protect U.S.-China trade relations,” he said. “These pressures have contributed to a more nuanced stance and a quieter approach to human rights and Uyghur-related policies.” Turkel added, “While steps like the Uyghur Forced Labor Prevention Act were commendable [during the Biden administration], the focus on Uyghur rights has often been eclipsed by broader geopolitical priorities,” pointing to how shifting U.S. economic priorities have impacted the response. Addressing transnational repression In addition to actions on Uyghur rights, Uyghur American leaders are urging the Trump administration to address transnational repression by China, specifically targeting covert operations that intimidate Uyghur Americans on U.S. soil. “The administration should take immediate steps to multiply the efforts to counter transnational repression by Chinese authorities, particularly targeting the presence of covert Chinese police stations and agents who monitor and intimidate Uyghur Americans and China dissidents in the U.S.,” Abbas said. Abbas noted Trump’s efforts in securing hostage releases in his first term, urging him to prioritize Uyghur detainees held in China. “China continues to detain Uyghur [American] family members and community leaders as a tactic to silence Uyghurs abroad … with many forced to self-censor to protect their families,” she said, advocating for strong U.S. efforts to secure their release and end repression tactics targeting Uyghurs in the diaspora.

Geneva — U.N. High Commissioner for Human Rights Michelle Bachelet on Thursday cast doubt on whether she will release a long-awaited report on the mass incarceration of Uyghurs in China's Xinjiang region before she leaves office on August 31. When she announced her departure in June, Bachelet said she would publish the report before her term ended. In her final briefing as high commissioner, she said she hoped it would be possible but indicated its release, once again, might be delayed. Bachelet said her office has received substantial input from the Chinese government that must be carefully reviewed before the report can be issued. She said that was normal procedure for all country reports published by her office. "In my meeting with high level national officials and regional authorities in Xinjiang, I raised concern about human rights violations, including reports of arbitrary detention and ill-treatment in institutions," she said. "And the report looks in depth on to these and other serious human rights violations concerning the Uyghurs and other predominantly Muslim minorities in Xinjiang." Human rights activists accuse China of the mass detention, torture, and cultural persecution of a million Uyghurs and other Turkic Muslims in so-called vocational camps. China denies the allegations, saying people in training centers receive skills they need to get good jobs. Bachelet said she raised many concerns with Chinese authorities during her visit to Xinjiang in May. In July, the Reuters news agency reported that China had sent Bachelet a letter asking her not to publish the report. She has confirmed receipt of that letter, which was signed by diplomats of some 40 countries. The high commissioner said such solicitations from countries under the human rights spotlight are not unusual, adding she does not give in to pressure. "I have been receiving pressures from countries who want to publish or not to publish," Bachelet said. "You cannot imagine the numbers of letters, meetings asking for the non-publication. Huge numbers … I have been under tremendous pressure to publish or not to publish. But I will not publish or withhold publication due to any such pressure. I can assure you of that." Work on the report has been ongoing for the past three years. The high commissioner has one week left on her mandate. She assured journalists that she was trying very hard to do what she had promised, namely to release the report before she leaves on August 31.

The books, TV, games and more that New Scientist staff have enjoyed this week

Billions of years ago, crushed quartz reacting with water could have created the conditions needed for the evolution of the photosynthetic microbes responsible for most of the oxygen now in Earth’s atmosphere

Sea-floor nodules raise oxygen levels in the deep ocean, suggesting they may have a valuable role in ecosystems and adding to concerns about the impact of deep-sea mining

Title: Infant Car Seats May Lower Oxygen Levels
Category: Health News
Created: 8/24/2009 12:00:00 AM
Last Editorial Review: 8/24/2009 12:00:00 AM

Title: Blood Oxygen Test Finds Heart Defects in Newborns
Category: Health News
Created: 8/22/2011 11:00:00 AM
Last Editorial Review: 8/22/2011 12:00:00 AM

Title: Oxygen Therapy Doesn't Boost Heart Attack Survival
Category: Health News
Created: 8/30/2017 12:00:00 AM
Last Editorial Review: 8/31/2017 12:00:00 AM

The human major histocompatibility complex (MHC) is a ~4 Mb genomic segment on Chromosome 6 that plays a pivotal role in the immune response. Despite its importance in various traits and diseases, its complex nature makes it challenging to accurately characterize on a routine basis. We present a novel approach allowing targeted sequencing and de novo haplotypic assembly of the MHC region in heterozygous samples, using long-read sequencing technologies. Our approach is validated using two reference samples, two family trios, and an African-American sample. We achieved excellent coverage (96.6%–99.9% with at least 30x depth) and high accuracy (99.89%–99.99%) for the different haplotypes. This methodology offers a reliable and cost-effective method for sequencing and fully characterizing the MHC without the need for whole-genome sequencing, facilitating broader studies on this important genomic segment and having significant implications in immunology, genetics, and medicine.

BACKGROUND:PEEP is a cornerstone treatment for children with pediatric ARDS. Unfortunately, its titration is often performed solely by evaluating oxygen saturation, which can lead to inadequate PEEP level settings and consequent adverse effects. This study aimed to assess the impact of increasing PEEP on hemodynamics, respiratory system mechanics, and oxygenation in children with ARDS.METHODS:Children receiving mechanical ventilation and on pressure-controlled volume-guaranteed mode were prospectively assessed for inclusion. PEEP was sequentially changed to 5, 12, 10, 8 cm H2O, and again to 5 cm H2O. After 10 min at each PEEP level, hemodynamic, ventilatory, and oxygenation variables were collected.RESULTS:A total of 31 subjects were included, with median age and weight of 6 months and 6.3 kg, respectively. The main reasons for pediatric ICU admission were respiratory failure caused by acute viral bronchiolitis (45%) and community-acquired pneumonia (32%). Most subjects had mild or moderate ARDS (45% and 42%, respectively), with a median (interquartile range) oxygenation index of 8.4 (5.8–12.7). Oxygen saturation improved significantly when PEEP was increased. However, although no significant changes in blood pressure were observed, the median cardiac index at PEEP of 12 cm H2O was significantly lower than that observed at any other PEEP level (P = .001). Fourteen participants (45%) experienced a reduction in cardiac index of > 10% when PEEP was increased to 12 cm H2O. Also, the estimated oxygen delivery was significantly lower, at 12 cm H2O PEEP. Finally, respiratory system compliance significantly reduced when PEEP was increased. At a PEEP of 12 cm H2O, static compliance had a median reduction of 25% in relation to the initial assessment (PEEP of 5 cm H2O).CONCLUSIONS:Although it may improve arterial oxygen saturation, inappropriately high PEEP levels may reduce cardiac output, oxygen delivery, and respiratory system compliance in pediatric subjects with ARDS with low potential for lung recruitability.

Purpose Health care professionals (HCPs) working collaboratively can improve patient outcomes and also increase their understanding of each other’s professional roles. This descriptive study aimed to explore dental hygienists’ perceptions of collaboration with dentists and intraprofessional educational (IntraPE) experiences.Methods A convenience sampling method was used to assess DHs perceptions of collaboration with dentists using the Interprofessional Collaboration Scale (ICS), a validated scale that measures perceptions of communication, accommodation, and isolation among HCPs. One open-ended question was added to explore IntraPE. Demographics, work characteristics and responses from the ICS were analyzed using frequency, mean, standard deviation, Pearson’s correlation, t-test, ANOVA, and multivariable regression. Responses from the open-ended question were transcribed, organized, and coded. Themes were identified using the Delve Qualitative Analysis Tool.Results Of the 264 participants, the average age was 38.9, and most identified as female (98.9%). Data analysis revealed that DHs had positive perceptions of collaboration with dentists. Significant relationships were found between ICS factor accommodation and the average number of patients treated per day (rs = −0.242, p<0.001), dentists’ age (rs = −.145, p<0.05). Isolation showed a significant negative correlation with the average number of patients treated per day (rs = −0.156, p<0.05). Most reported having no opportunities for IntraPE education experiences with dentists. Five categories of themes were identified from the open-ended question: shared academic setting, clinic dentist, externships, desire for more shared learning, and shared patient experiences.Conclusion Dental hygienists in this study had an overall more positive than negative perception of collaboration with dentists. Dental and dental hygiene programs should focus on intraprofessional education experiences to continue to enhance collaboration.

Purpose Dental professionals are exposed to hazardous noise levels on a daily basis in clinical practice. The purpose of this study was to compare the hearing status of dental hygienists who utilize ultrasonic scalers in the workplace compared to age-matched control participants (non-dental hygienists) who were not exposed to ultrasonic noise.Methods A convenience sample of nineteen dental hygienists (experimental) and nineteen non-dental hygienists (control) was recruited for this study. A matched pairs design was utilized; participants in each group were matched based on age and gender to eliminate confounding variables. The testing procedure consisted of an audiologist performing a series of auditory tests including otoacoustic emissions test, pure-tone audiometry, and tympanometry on the experimental and control groups.Results In the right ear, there were notable differences from 1000 Hz – 10,000 Hz and in the left ear from 6000 Hz – 10,000 Hz, with higher hearing thresholds in the experimental group of dental hygienists. While 56% of the univariate tests conducted on how many days were worked per week showed statistical significance, the regression line slope indicated those that worked more days had better hearing statuses. The variables for years in practice for dental hygienists, how many of those years were full-time employment, and how many years the dental hygienist had used an ultrasonic scaling device, also had many significant univariate tests for the experimental group only. These variables were more likely to serve as proxies representing true noise exposure. The paired t-test between the groups demonstrated statistically significant differences between the experimental and control group at 9000 Hz in both ears.Conclusion While results from this study demonstrated various qualitative differences in hearing status of the control group (non-dental hygienists) and experimental group (dental hygienists), age was found to be the most critical variable. Furthermore, this data demonstrated differences in hearing status based on various frequencies between dental hygienists and age-matched controls that should be further explored with a larger population.

Découvrez ci-dessous comment notre caricaturiste Ygreck a imagé son dessin.

Vet Aquadent FR3SH, a medlinkpomegranate/medlink extract water additive, limits the formation of plaque and tartar in dogs' teeth, ultimately helping

Researchers at the Johns Hopkins Kimmel Cancer Center have identified 16 genes that enable breast cancer cells to survive in the bloodstream after escaping the low-oxygen areas of a tumor.

bHighlights:/bul class="group-list punch-points" liActress Samantha Ruth Prabhu open about her health struggles on social media in late 2022/li liShe

Washing your hands often and keeping them clean could be the best way to avoid healthcare-associated infections (HAIs). Five medical organizations

Companies as well as individual entrepreneurs looking for oxygen or nitrogen seek out an oxygen nitrogen plant in India. India is a developing country nourished with high quality raw materials. In addition, qualified workforce is also...

Sonnalli Seygall has revealed how she has been having a special 'pregnancy ghee' made from cow dung, cow urine and milk.

Varun Dhawan has recalled the two instances when his heart sank seeing Samantha Ruth Prabhu using oxygen, collapsing on the sets of Citadel: Hunny Bunny