recognition

System, method and program product for providing automatic speech recognition (ASR) in a shared resource environment

A speech recognition system, method of recognizing speech and a computer program product therefor. A client device identified with a context for an associated user selectively streams audio to a provider computer, e.g., a cloud computer. Speech recognition receives streaming audio, maps utterances to specific textual candidates and determines a likelihood of a correct match for each mapped textual candidate. A context model selectively winnows candidate to resolve recognition ambiguity according to context whenever multiple textual candidates are recognized as potential matches for the same mapped utterance. Matches are used to update the context model, which may be used for multiple users in the same context.




recognition

Speech recognition and synthesis utilizing context dependent acoustic models containing decision trees

A speech recognition method including the steps of receiving a speech input from a known speaker of a sequence of observations and determining the likelihood of a sequence of words arising from the sequence of observations using an acoustic model. The acoustic model has a plurality of model parameters describing probability distributions which relate a word or part thereof to an observation and has been trained using first training data and adapted using second training data to said speaker. The speech recognition method also determines the likelihood of a sequence of observations occurring in a given language using a language model and combines the likelihoods determined by the acoustic model and the language model and outputs a sequence of words identified from said speech input signal. The acoustic model is context based for the speaker, the context based information being contained in the model using a plurality of decision trees and the structure of the decision trees is based on second training data.




recognition

Image-based character recognition

Various embodiments enable a device to perform tasks such as processing an image to recognize and locate text in the image, and providing the recognized text an application executing on the device for performing a function (e.g., calling a number, opening an internet browser, etc.) associated with the recognized text. In at least one embodiment, processing the image includes substantially simultaneously or concurrently processing the image with at least two recognition engines, such as at least two optical character recognition (OCR) engines, running in a multithreaded mode. In at least one embodiment, the recognition engines can be tuned so that their respective processing speeds are roughly the same. Utilizing multiple recognition engines enables processing latency to be close to that of using only one recognition engine.




recognition

Speech recognition apparatus with means for preventing errors due to delay in speech recognition

When a speech sound of at least a predetermined sound pressure is externally input while a time measurement is not being performed, a time measuring circuit starts a time measurement responsive to a signal from a speech detector. When another speech sound of at least a predetermined sound pressure is externally input while a time measurement is being performed by the time measuring circuit, a measurement time measured by the time measuring circuit at this moment is stored in a time information memory. After a predetermined time has elapsed, if a speech recognition circuit recognizes that the externally input speech sound is a "stop" command, the time measurement operation performed by the time measuring circuit is stopped, and the time information stored in the time information memory is read out and displayed as measurement time information on a display unit.




recognition

Disposable electrode and automatic information recognition apparatus

A disposable electrode includes: an electrode pad; and a connector, connecting the electrode pad to a defibrillator, and including an information holder that can be provided with a transmissive opening or a light reflective member, the information holder holding information about at least an expiration date, depending on presence or absence of the transmissive opening or the light reflective member, the information holder allowing the information to be notified from the defibrillator when the connector is connected to the defibrillator.




recognition

Number of players determined using facial recognition

There is provided a system and method for determining a number of players present using facial recognition. There is provided a method comprising capturing an image of the players present, and determining the number of players present based on the image. In this manner, players may more easily configure game settings, whereas spectators may be presented a more engaging experience.




recognition

Method and system for quantitative assessment of word recognition sensitivity

A method and system are presented to address quantitative assessment of word recognition sensitivity of a subject, where the method comprises the steps of: (1) presenting at least one scene, comprising a plurality of letters and a background, to a subject on a display; (2) moving the plurality of letters relative to the scene; (3) receiving feedback from the subject via at least one; (4) quantitatively refining the received feedback; (5) modulating the saliency of the plurality of letters relative to accuracy of the quantitatively refined feedback; (6) calculating a critical threshold parameter; and (7) recording a critical threshold parameter onto a tangible computer readable medium.




recognition

Amusement ride comprising a facial expression recognition system

The amusement ride 1 comprises a track 2 and a vehicle 3 being moveable along the track 2 at a velocity v. Within the vehicle 3 a video camera 4 is installed. The video camera 4 takes a video film of the face of a passenger received within the vehicle 3 during a ride. A sender 5 transmits the data 6 to a facial expression recognition system 7. The result 10 of the process carried out by facial expression recognition system 7 may be downloaded from a server 11 by a client 13.




recognition

Bezel assembly comprising image recognition for use with an automated transaction device

The bezel assembly for data reception, for use with a bill validator in a financial transactional device, includes a bezel housing and a data reception assembly. The bezel housing includes a customer-facing front portion and a back plate connectable to the bill validator that is mounted within the transactional device cabinet. The front portion includes an insertion/dispensing slot for receiving currency and a projecting protrusion forward of the casing. The forward-extending protrusion accommodates at least a portion of the data reception assembly. The bezel assembly can include a wireless communication function that is communicably connectable with a mobile device via a wireless communication method, a manual entry function, a biometric reader, one or more cameras for scanning and decrypting 2D barcodes and the like, thus enhancing the overall functionality of the financial transactional device.




recognition

CONTINUOUS KEYBOARD RECOGNITION

Methods, systems, and apparatus for receiving data indicating a location of a particular touchpoint representing a latest received touchpoint in a sequence of received touchpoints; identifying candidate characters associated with the particular touchpoint; generating, for each of the candidate characters, a confidence score; identifying different candidate sequences of characters each including for each received touchpoint, one candidate character associated with a location of the received touchpoint, and one of the candidate characters associated with the particular touchpoint; for each different candidate sequence of characters, determining a language model score and generating a transcription score based at least on the confidence score for one or more of the candidate characters in the candidate sequence of characters and the language model score for the candidate sequence of characters; selecting, and providing for output, a representative sequence of characters from among the candidate sequences of characters based at least on the transcription scores.




recognition

Latency enhanced note recognition method in gaming

The present invention relates to the field of audio recognition, in particular to computer implemented note recognition methods in a gaming application. Furthermore, the present invention relates to improving latency of such audio recognition methods. One of the embodiments of the invention described herein is a method for note recognition of an audio source. The method includes: dividing an audio input into a plurality of frames, each frame having a pre-determined length, conducting a frequency analysis of at least a set of the plurality of frames, based on the frequency analysis, determining if a frame is a transient frame with a frequency change between the beginning and end of the frame, comparing the frequency analysis of each said transient frame to the frequency analysis of an immediately preceding frame and, based on said comparison, determining at least one probable pitch present at the end of each transient frame, and for each transient frame, outputting pitch data indicative of the probable pitch present at the end of the transient frame.




recognition

Indigo Paints takes to aggressive advertising to improve brand recognition

Established in 2000, Indigo Paints is a relatively new entrant to the decorative paints industry that is dominated by the like of Asian Paints, Berger and Nerolac.




recognition

Letters: NHS staff deserve permanent recognition - not just a clap

CLAPPING the NHS each week is all well and good but surely we can think of a more permanent recognition?




recognition

Treaty's value questioned by Indigenous elders, but recognition of Australia's first people important

This year's NAIDOC Week theme is Voice. Treaty. Truth. But the truth is that many Indigenous people feel voiceless when it comes to expressing where Australia stands on treaty today.




recognition

Australian anthem rewritten to represent all Australians and promote Indigenous constitutional recognition

The national anthem has been rewritten and performed for the first time in Alice Springs by a group that says it should be more inclusive of all Australians.



  • 783 ABC Alice Springs
  • alicesprings
  • Community and Society:All:All
  • Community and Society:Community Organisations:All
  • Community and Society:Indigenous (Aboriginal and Torres Strait Islander):All
  • Community and Society:Indigenous (Aboriginal and Torres Strait Islander):Indigenous Culture
  • Human Interest:All:All
  • Australia:All:All
  • Australia:NT:Alice Springs 0870
  • Australia:NT:All

recognition

Indigenous constitutional recognition is needed to 'shift national consciousness'

Dani Larkin knows the struggles of a young Indigenous woman in a "nation of divisiveness", and insists that constitutional recognition is the key to unlocking meaningful change.



  • ABC Gold Coast
  • northcoast
  • goldcoast
  • Community and Society:Indigenous (Aboriginal and Torres Strait Islander):All
  • Community and Society:Indigenous (Aboriginal and Torres Strait Islander):Indigenous Culture
  • Community and Society:Indigenous (Aboriginal and Torres Strait Islander):Indigenous Protocols
  • Government and Politics:All:All
  • Government and Politics:Federal Government:All
  • Government and Politics:Indigenous Policy:All
  • Human Interest:All:All
  • Australia:NSW:Baryulgil 2460
  • Australia:QLD:Mermaid Beach 4218

recognition

What is constitutional recognition?

The constitution was written more than a century ago, but Aboriginal and Torres Strait Islander people are not mentioned in it at all, despite having lived here for more than 50,000 years. What is constitutional recognition and why is it important? What are some of the perceived barriers to changing the constitution?




recognition

Harrisburg University Researchers Claim Their 'Unbiased' Facial Recognition Software Can Identify Potential Criminals

Given all we know about facial recognition tech, it is literally jaw-dropping that anyone could make this claim… especially without being vetted independently.

A group of Harrisburg University professors and a PhD student have developed an automated computer facial recognition software capable of predicting whether someone is likely to be a criminal.

The software is able to predict if someone is a criminal with 80% accuracy and with no racial bias. The prediction is calculated solely based on a picture of their face.

There's a whole lot of "what even the fuck" in CBS 21's reprint of a press release, but let's start with the claim about "no racial bias." That's a lot to swallow when the underlying research hasn't been released yet. Let's see what the National Institute of Standards and Technology has to say on the subject. This is the result of the NIST's examination of 189 facial recognition AI programs -- all far more established than whatever it is Harrisburg researchers have cooked up.

Asian and African American people were up to 100 times more likely to be misidentified than white men, depending on the particular algorithm and type of search. Native Americans had the highest false-positive rate of all ethnicities, according to the study, which found that systems varied widely in their accuracy.

The faces of African American women were falsely identified more often in the kinds of searches used by police investigators where an image is compared to thousands or millions of others in hopes of identifying a suspect.

Why is this acceptable? The report inadvertently supplies the answer:

Middle-aged white men generally benefited from the highest accuracy rates.

Yep. And guess who's making laws or running police departments or marketing AI to cops or telling people on Twitter not to break the law or etc. etc. etc.

To craft a terrible pun, the researchers' claim of "no racial bias" is absurd on its face. Per se stupid af to use legal terminology.

Moving on from that, there's the 80% accuracy, which is apparently good enough since it will only threaten the life and liberty of 20% of the people it's inflicted on. I guess if it's the FBI's gold standard, it's good enough for everyone.

Maybe this is just bad reporting. Maybe something got copy-pasted wrong from the spammed press release. Let's go to the source… one that somehow still doesn't include a link to any underlying research documents.

What does any of this mean? Are we ready to embrace a bit of pre-crime eugenics? Or is this just the most hamfisted phrasing Harrisburg researchers could come up with?

A group of Harrisburg University professors and a Ph.D. student have developed automated computer facial recognition software capable of predicting whether someone is likely going to be a criminal.

The most charitable interpretation of this statement is that the wrong-20%-of-the-time AI is going to be applied to the super-sketchy "predictive policing" field. Predictive policing -- a theory that says it's ok to treat people like criminals if they live and work in an area where criminals live -- is its own biased mess, relying on garbage data generated by biased policing to turn racist policing into an AI-blessed "work smarter not harder" LEO equivalent.

The question about "likely" is answered in the next paragraph, somewhat assuring readers the AI won't be applied to ultrasound images.

With 80 percent accuracy and with no racial bias, the software can predict if someone is a criminal based solely on a picture of their face. The software is intended to help law enforcement prevent crime.

There's a big difference between "going to be" and "is," and researchers using actual science should know better than to use both phrases to describe their AI efforts. One means scanning someone's face to determine whether they might eventually engage in criminal acts. The other means matching faces to images of known criminals. They are far from interchangeable terms.

If you think the above quotes are, at best, disjointed, brace yourself for this jargon-fest which clarifies nothing and suggests the AI itself wrote the pullquote:

“We already know machine learning techniques can outperform humans on a variety of tasks related to facial recognition and emotion detection,” Sadeghian said. “This research indicates just how powerful these tools are by showing they can extract minute features in an image that are highly predictive of criminality.”

"Minute features in an image that are highly predictive of criminality." And what, pray tell, are those "minute features?" Skin tone? "I AM A CRIMINAL IN THE MAKING" forehead tattoos? Bullshit on top of bullshit? Come on. This is word salad, but a salad pretending to be a law enforcement tool with actual utility. Nothing about this suggests Harrisburg has come up with anything better than the shitty "tools" already being inflicted on us by law enforcement's early adopters.

I wish we could dig deeper into this but we'll all have to wait until this excitable group of clueless researchers decide to publish their findings. According to this site, the research is being sealed inside a "research book," which means it will take a lot of money to actually prove this isn't any better than anything that's been offered before. This could be the next Clearview, but we won't know if it is until the research is published. If we're lucky, it will be before Harrisburg patents this awful product and starts selling it to all and sundry. Don't hold your breath.




recognition

Racial justice groups criticize city teachers union’s use of controversial face recognition technology

The United Federation of Teachers tested security camera technology from a company affiliated with Clearview AI




recognition

Communities come face-to-face with the growing power of facial recognition technology

As law enforcement agencies deploy AI-powered facial recognition systems, some communities are pushing back, insisting on having a say in how they’re used.




recognition

Substrate recognition and ATPase activity of the E. coli cysteine/cystine ABC transporter YecSC-FliY [Microbiology]

Sulfur is essential for biological processes such as amino acid biogenesis, iron–sulfur cluster formation, and redox homeostasis. To acquire sulfur-containing compounds from the environment, bacteria have evolved high-affinity uptake systems, predominant among which is the ABC transporter family. Theses membrane-embedded enzymes use the energy of ATP hydrolysis for transmembrane transport of a wide range of biomolecules against concentration gradients. Three distinct bacterial ABC import systems of sulfur-containing compounds have been identified, but the molecular details of their transport mechanism remain poorly characterized. Here we provide results from a biochemical analysis of the purified Escherichia coli YecSC-FliY cysteine/cystine import system. We found that the substrate-binding protein FliY binds l-cystine, l-cysteine, and d-cysteine with micromolar affinities. However, binding of the l- and d-enantiomers induced different conformational changes of FliY, where the l- enantiomer–substrate-binding protein complex interacted more efficiently with the YecSC transporter. YecSC had low basal ATPase activity that was moderately stimulated by apo FliY, more strongly by d-cysteine–bound FliY, and maximally by l-cysteine– or l-cystine–bound FliY. However, at high FliY concentrations, YecSC reached maximal ATPase rates independent of the presence or nature of the substrate. These results suggest that FliY exists in a conformational equilibrium between an open, unliganded form that does not bind to the YecSC transporter and closed, unliganded and closed, liganded forms that bind this transporter with variable affinities but equally stimulate its ATPase activity. These findings differ from previous observations for similar ABC transporters, highlighting the extent of mechanistic diversity in this large protein family.




recognition

Facial recognition on the rise: can current laws protect the public?

The ICO is investigating reports that a property developer has quietly installed a facial recognition system in London's King's Cross. We spoke to experts from the legal and technology sectors to find some clarity about the rules




recognition

CBD News: The Society for Ecological Restoration has conferred its 2011 Special Recognition Award to the Parties to the Convention on Biological Diversity (CBD) at the Gala Awards Banquet on 23 August 2011 in Mérida, Yucatán, Mexico, on the marg




recognition

CBD News: The Natural Capital Declaration (NCD) has been declared a Biodiversity Champion by the Secretariat of the Convention on Biological Diversity (CBD) in recognition of its important contribution to the implementation of the Convention's Strateg




recognition

CBD News: The World Public Health Nutrition Association (WPHNA) has been declared a Biodiversity Champion by the Executive Secretary of the Convention on Biological Diversity (CBD) in recognition of its important contribution to the implementation of th




recognition

CBD News: Bringing international recognition and a substantial monetary prize to three outstanding individuals, nominations are now invited for The MIDORI Prize for Biodiversity 2014. The call for nominations remains open from 1 March to 31 May 2014.




recognition

Recognition




recognition

Substrate recognition and ATPase activity of the E. coli cysteine/cystine ABC transporter YecSC-FliY [Microbiology]

Sulfur is essential for biological processes such as amino acid biogenesis, iron–sulfur cluster formation, and redox homeostasis. To acquire sulfur-containing compounds from the environment, bacteria have evolved high-affinity uptake systems, predominant among which is the ABC transporter family. Theses membrane-embedded enzymes use the energy of ATP hydrolysis for transmembrane transport of a wide range of biomolecules against concentration gradients. Three distinct bacterial ABC import systems of sulfur-containing compounds have been identified, but the molecular details of their transport mechanism remain poorly characterized. Here we provide results from a biochemical analysis of the purified Escherichia coli YecSC-FliY cysteine/cystine import system. We found that the substrate-binding protein FliY binds l-cystine, l-cysteine, and d-cysteine with micromolar affinities. However, binding of the l- and d-enantiomers induced different conformational changes of FliY, where the l- enantiomer–substrate-binding protein complex interacted more efficiently with the YecSC transporter. YecSC had low basal ATPase activity that was moderately stimulated by apo FliY, more strongly by d-cysteine–bound FliY, and maximally by l-cysteine– or l-cystine–bound FliY. However, at high FliY concentrations, YecSC reached maximal ATPase rates independent of the presence or nature of the substrate. These results suggest that FliY exists in a conformational equilibrium between an open, unliganded form that does not bind to the YecSC transporter and closed, unliganded and closed, liganded forms that bind this transporter with variable affinities but equally stimulate its ATPase activity. These findings differ from previous observations for similar ABC transporters, highlighting the extent of mechanistic diversity in this large protein family.




recognition

Structural insight into the recognition of pathogen-derived phosphoglycolipids by C-type lectin receptor DCAR [Protein Structure and Folding]

The C-type lectin receptors (CLRs) form a family of pattern recognition receptors that recognize numerous pathogens, such as bacteria and fungi, and trigger innate immune responses. The extracellular carbohydrate-recognition domain (CRD) of CLRs forms a globular structure that can coordinate a Ca2+ ion, allowing receptor interactions with sugar-containing ligands. Although well-conserved, the CRD fold can also display differences that directly affect the specificity of the receptors for their ligands. Here, we report crystal structures at 1.8–2.3 Å resolutions of the CRD of murine dendritic cell-immunoactivating receptor (DCAR, or Clec4b1), the CLR that binds phosphoglycolipids such as acylated phosphatidyl-myo-inositol mannosides (AcPIMs) of mycobacteria. Using mutagenesis analysis, we identified critical residues, Ala136 and Gln198, on the surface surrounding the ligand-binding site of DCAR, as well as an atypical Ca2+-binding motif (Glu-Pro-Ser/EPS168–170). By chemically synthesizing a water-soluble ligand analog, inositol-monophosphate dimannose (IPM2), we confirmed the direct interaction of DCAR with the polar moiety of AcPIMs by biolayer interferometry and co-crystallization approaches. We also observed a hydrophobic groove extending from the ligand-binding site that is in a suitable position to interact with the lipid portion of whole AcPIMs. These results suggest that the hydroxyl group-binding ability and hydrophobic groove of DCAR mediate its specific binding to pathogen-derived phosphoglycolipids such as mycobacterial AcPIMs.




recognition

Smart Energy Council calls for state to abandon facial recognition

Some users have been brought to tears by 'broken' facial recognition software now required to approve solar rebate applications.




recognition

Episode 89 - The Internet of Pirates (IoP) Hacker pirates, face recognition ethics and Elon Musk

Back once again like the Renegade Master, the UK Tech Weekly Podcast is coming to you from its new, earlier-in-the-week time slot.


Host Scott Carey is joined by Tamlin Magee to talk about pirate-obsessed Nigerian hacking syndicates, and Charlotte Jee is on board to discuss the ethics of facial (and racial) recognition technology.


We wrap things up with an Elon Musk news roundup, from his latest bae to building bricks.

 

See acast.com/privacy for privacy and opt-out information.




recognition

Substrate recognition and ATPase activity of the E. coli cysteine/cystine ABC transporter YecSC-FliY [Microbiology]

Sulfur is essential for biological processes such as amino acid biogenesis, iron–sulfur cluster formation, and redox homeostasis. To acquire sulfur-containing compounds from the environment, bacteria have evolved high-affinity uptake systems, predominant among which is the ABC transporter family. Theses membrane-embedded enzymes use the energy of ATP hydrolysis for transmembrane transport of a wide range of biomolecules against concentration gradients. Three distinct bacterial ABC import systems of sulfur-containing compounds have been identified, but the molecular details of their transport mechanism remain poorly characterized. Here we provide results from a biochemical analysis of the purified Escherichia coli YecSC-FliY cysteine/cystine import system. We found that the substrate-binding protein FliY binds l-cystine, l-cysteine, and d-cysteine with micromolar affinities. However, binding of the l- and d-enantiomers induced different conformational changes of FliY, where the l- enantiomer–substrate-binding protein complex interacted more efficiently with the YecSC transporter. YecSC had low basal ATPase activity that was moderately stimulated by apo FliY, more strongly by d-cysteine–bound FliY, and maximally by l-cysteine– or l-cystine–bound FliY. However, at high FliY concentrations, YecSC reached maximal ATPase rates independent of the presence or nature of the substrate. These results suggest that FliY exists in a conformational equilibrium between an open, unliganded form that does not bind to the YecSC transporter and closed, unliganded and closed, liganded forms that bind this transporter with variable affinities but equally stimulate its ATPase activity. These findings differ from previous observations for similar ABC transporters, highlighting the extent of mechanistic diversity in this large protein family.




recognition

Structural insight into the recognition of pathogen-derived phosphoglycolipids by C-type lectin receptor DCAR [Protein Structure and Folding]

The C-type lectin receptors (CLRs) form a family of pattern recognition receptors that recognize numerous pathogens, such as bacteria and fungi, and trigger innate immune responses. The extracellular carbohydrate-recognition domain (CRD) of CLRs forms a globular structure that can coordinate a Ca2+ ion, allowing receptor interactions with sugar-containing ligands. Although well-conserved, the CRD fold can also display differences that directly affect the specificity of the receptors for their ligands. Here, we report crystal structures at 1.8–2.3 Å resolutions of the CRD of murine dendritic cell-immunoactivating receptor (DCAR, or Clec4b1), the CLR that binds phosphoglycolipids such as acylated phosphatidyl-myo-inositol mannosides (AcPIMs) of mycobacteria. Using mutagenesis analysis, we identified critical residues, Ala136 and Gln198, on the surface surrounding the ligand-binding site of DCAR, as well as an atypical Ca2+-binding motif (Glu-Pro-Ser/EPS168–170). By chemically synthesizing a water-soluble ligand analog, inositol-monophosphate dimannose (IPM2), we confirmed the direct interaction of DCAR with the polar moiety of AcPIMs by biolayer interferometry and co-crystallization approaches. We also observed a hydrophobic groove extending from the ligand-binding site that is in a suitable position to interact with the lipid portion of whole AcPIMs. These results suggest that the hydroxyl group-binding ability and hydrophobic groove of DCAR mediate its specific binding to pathogen-derived phosphoglycolipids such as mycobacterial AcPIMs.




recognition

Structural basis of substrate recognition and catalysis by fucosyltransferase 8 [Protein Structure and Folding]

Fucosylation of the innermost GlcNAc of N-glycans by fucosyltransferase 8 (FUT8) is an important step in the maturation of complex and hybrid N-glycans. This simple modification can dramatically affect the activities and half-lives of glycoproteins, effects that are relevant to understanding the invasiveness of some cancers, development of mAb therapeutics, and the etiology of a congenital glycosylation disorder. The acceptor substrate preferences of FUT8 are well-characterized and provide a framework for understanding N-glycan maturation in the Golgi; however, the structural basis of these substrate preferences and the mechanism through which catalysis is achieved remain unknown. Here we describe several structures of mouse and human FUT8 in the apo state and in complex with GDP, a mimic of the donor substrate, and with a glycopeptide acceptor substrate at 1.80–2.50 Å resolution. These structures provide insights into a unique conformational change associated with donor substrate binding, common strategies employed by fucosyltransferases to coordinate GDP, features that define acceptor substrate preferences, and a likely mechanism for enzyme catalysis. Together with molecular dynamics simulations, the structures also revealed how FUT8 dimerization plays an important role in defining the acceptor substrate-binding site. Collectively, this information significantly builds on our understanding of the core fucosylation process.




recognition

Female athletes need more recognition – Clayton

National 400m hurdles champion Rushell Clayton is concerned about what she says are inequalities between men and women in track and field. Clayton was speaking at a Women in Sports Conference in Kingston recently and discussed issues of inequality...




recognition

{beta}-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Posttranscriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1

The signal peptide of preproinsulin is a major source for HLA class I autoantigen epitopes implicated in CD8 T cell (CTL)–mediated β-cell destruction in type 1 diabetes (T1D). Among them, the 10-mer epitope located at the C-terminal end of the signal peptide was found to be the most prevalent in patients with recent-onset T1D. While the combined action of signal peptide peptidase and endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) is required for processing of the signal peptide, the mechanisms controlling signal peptide trimming and the contribution of the T1D inflammatory milieu on these mechanisms are unknown. Here, we show in human β-cells that ER stress regulates ERAP1 gene expression at posttranscriptional level via the IRE1α/miR-17-5p axis and demonstrate that inhibition of the IRE1α activity impairs processing of preproinsulin signal peptide antigen and its recognition by specific autoreactive CTLs during inflammation. These results underscore the impact of ER stress in the increased visibility of β-cells to the immune system and position the IRE1α/miR-17 pathway as a central component in β-cell destruction processes and as a potential target for the treatment of autoimmune T1D.




recognition

ADA House rescinds The Dentist’s Prayer, amends recognition of religious diversity policy to be more inclusive

In an effort to advance the Association’s diversity and inclusion efforts, the ADA House of Delegates voted at its meeting in September to rescind the policy titled “The Dentist’s Prayer,” used by some state and local dental societies during their meetings, and amend its policy on recognition of religious diversity.




recognition

Dental Assistants Recognition Week set for March 1-7

The ADA Council on Dental Practice is encouraging dentists to acknowledge the dedication and contributions of their dental assistants during Dental Assistants Recognition Week.




recognition

Marketplace, power, prestige : the healthcare professions' struggle for recognition (19th-20th century) / edited by Pierre Pfütsch.

Stuttgart : Franz Steiner Verlag, 2019.




recognition

The Hysteria Over Face Recognition

The fear is that instead of using it to prevent crime and catch terrorists, facial recognition is instead used for political purposes. But we won't stop it or protect privacy by freaking out.




recognition

Structure and molecular recognition mechanism of IMP-13 metallo-{beta}-lactamase [Mechanisms of Resistance]

Multi-drug resistance among Gram-negative bacteria is a major global public health threat. Metallo-β-lactamases (MBLs) target the most widely-used antibiotic class, the β-lactams, including the most recent-generation carbapenems. Interspecies spread renders these enzymes a serious clinical threat and there are no clinically-available inhibitors. We present crystal structures of IMP-13, a structurally-uncharacterized MBL from Gram-negative Pseudomonas aerugionasa found in clinical outbreaks globally, and characterize the binding using solution NMR-spectroscopy and molecular-dynamics simulations. Crystal structures of apo IMP-13 and bound to four clinically-relevant carbapenem antibiotics (doripenem, ertapenem, imipenem and meropenem) are presented. Active site plasticity and the active-site loop, where a tryptophan residue stabilizes the antibiotic core scaffold, are essential to the substrate-binding mechanism. The conserved carbapenem scaffold plays the most significant role in IMP-13 binding, explaining the broad substrate specificity. The observed plasticity and substrate-locking mechanism provide opportunities for rational drug design of novel metallo-β-lactamase inhibitors, essential in the fight against antibiotic resistance.




recognition

Structural recognition of spectinomycin by resistance enzyme ANT(9) from Enterococcus faecalis [Mechanisms of Resistance]

Spectinomycin is a ribosome-binding antibiotic that blocks the translocation step of translation. A prevalent resistance mechanism is the modification of the drug by aminoglycoside nucleotidyl transferase (ANT) enzymes of the spectinomycin-specific ANT (9) family or by the dual-specificity ANT(3") (9) family that also acts on streptomycin. We previously reported the structural mechanism of streptomycin modification by the ANT(3") (9) AadA from Salmonella enterica. ANT (9) from Enterococcus faecalis adenylates the 9-hydroxyl of spectinomycin. We here present the first structures of spectinomycin bound to an ANT enzyme. Structures were solved for ANT (9) in apo form, in complex with ATP, spectinomycin and magnesium or in complex with only spectinomycin. ANT (9) shows similar overall structure as AadA with an N-terminal nucleotidyltransferase domain and a C-terminal α-helical domain. Spectinomycin binds close to the entrance of the interdomain cleft, while ATP is buried at the bottom. Upon drug binding, the C-terminal domain rotates by 14 degrees to close the cleft, allowing contacts of both domains with the drug. Comparison with AadA shows that spectinomycin specificity is explained by a straight α5 helix and a shorter α5-α6 loop that would clash with the larger streptomycin substrate. In the active site, we observe two magnesium ions, one of them in a previously un-observed position that may activate the 9-hydroxyl for deprotonation by the catalytic base Glu-86. The observed binding mode for spectinomycin suggests that also spectinamides and aminomethyl spectinomycins, recent spectinomycin analogues with expansions in position 4 of the C ring, will be subjected to modification by ANT (9) and ANT(3") (9) enzymes.




recognition

Senior and Faculty, Staff Diversity Recognition Awards announced

The Multicultural Resource Center at Penn State has announced this year’s Senior and Faculty/Staff Diversity Recognition Awards recipients. The 2020 awards honor multicultural University Park graduating seniors who excel in academics, leadership, and service, as well as faculty and staff throughout Penn State who demonstrate a commitment to diversity, equity and inclusion efforts beyond the responsibilities of their position.




recognition

Six students earn recognition as Bellisario College student marshals

Six accomplished seniors will celebrate the culmination of their collegiate involvement and success by representing the Donald P. Bellisario College of Communications as student marshals for the Class of 2020.




recognition

New Kensington students, faculty celebrated in virtual awards recognition

Penn State New Kensington announced its academic, teaching and extracurricular award winners on May 1, and shared a dedicated, virtual recognition web page, including video messages, photos and award winners.




recognition

Facial Recognition Is Tech's Biggest Mistake

Biometrics are generally a good alternative to passwords, but authentication via face-scanning is a terrible idea, according to security expert Max Eddy.




recognition

Facial-Recognition Technology Doesn't Have to Destroy Privacy

Regulation moves at a snail's pace, so it's up to CEOs, executives, and employees to reject projects that put profit over privacy. Clearview AI facial-recognition tech is just the latest example of 'innovation' that could quickly get out of hand.




recognition

Scranton campus invited to attend this year's virtual Student Recognition Dinner

In keeping with Penn State Scranton's current continuing adjustment to an all-virtual environment, the annual Student Recognition Dinner will be held virtually at 6 p.m. on Wednesday, April 22.




recognition

Students, staff, faculty honored at virtual annual awards recognition

In an inspiring show of support, a large contingent of Penn State Scranton’s campus community logged onto their computers the evening of April 22 to celebrate the accomplishments of the student body.