Cities as climate leaders: Progress and ambition 1 December 2021 — 12:00PM TO 1:00PM Anonymous (not verified) 16 November 2021 Online

This panel discusses the progress cities have already made, whether progress at COP26 was enough, and what more needs to be done to scale action and ambition internationally.

Cities are critical to tackling the pressing environmental challenges of our time. While they now account for an estimated 75 per cent of global CO2 emissions, cities also offer a unique opportunity for devolved leadership on climate action. At the recent COP26, some significant progress was made in elevating cities’ position on climate action with a flurry of announcements and commitments.

For example, more than 1,000 cities are now committed to the Cities Race to Zero and C40’s Clean Construction Declaration saw multiple cities committing to at least halving emissions from initial construction of buildings by 2030. A raft of financing commitments were also made to improve urban resilience in the face of climate change.

This builds on existing momentum before COP26. Over 50 world cities are now on track to meet Paris Agreement and the Marrakech Partnership is further enabling collaboration between governments and cities within the UNFCCC processes.

Therefore, how we design, build, govern and use our urban places will be a key factor for decarbonization and climate change adaptation.

On the back of COP26, this panel brings together leaders from across urban development sectors to discuss the progress cities have already made, whether progress at COP26 was enough, and what more needs to be done to scale action and ambition internationally. 

Torin Greenwood, Jonathan Kariv and Noah Williams
Math. Comp. 93 (), 2959-2983.
Abstract, references and article information

Visual Abstract

Jessica Y. Franco
Dec 1, 2020; 19:1936-1951
Research

Tirsa L. E. van Westering
Dec 1, 2020; 19:2047-2067
Research

Chiara Pavanello
Dec 1, 2020; 61:1784-1788
Patient-Oriented and Epidemiological Research

Atherosclerosis is characterized by the pathological accumulation of cholesterol-laden macrophages in the arterial wall. Atherosclerosis is also the main underlying cause of CVDs, and its development is largely driven by elevated plasma cholesterol. Strong epidemiological data find an inverse association between plasma β-carotene with atherosclerosis, and we recently showed that β-carotene oxygenase 1 (BCO1) activity, responsible for β-carotene cleavage to vitamin A, is associated with reduced plasma cholesterol in humans and mice. In this study, we explore whether intact β-carotene or vitamin A affects atherosclerosis progression in the atheroprone LDLR-deficient mice. Compared with control-fed Ldlr^–/– mice, β-carotene-supplemented mice showed reduced atherosclerotic lesion size at the level of the aortic root and reduced plasma cholesterol levels. These changes were absent in Ldlr^–/–/Bco1^–/– mice despite accumulating β-carotene in plasma and atherosclerotic lesions. We discarded the implication of myeloid BCO1 in the development of atherosclerosis by performing bone marrow transplant experiments. Lipid production assays found that retinoic acid, the active form of vitamin A, reduced the secretion of newly synthetized triglyceride and cholesteryl ester in cell culture and mice. Overall, our findings provide insights into the role of BCO1 activity and vitamin A in atherosclerosis progression through the regulation of hepatic lipid metabolism.

Familial LCAT deficiency (FLD) is a rare genetic disorder of HDL metabolism, caused by loss-of-function mutations in the LCAT gene and characterized by a variety of symptoms including corneal opacities and kidney failure. Renal disease represents the leading cause of morbidity and mortality in FLD cases. However, the prognosis is not known and the rate of deterioration of kidney function is variable and unpredictable from patient to patient. In this article, we present data from a follow-up of the large Italian cohort of FLD patients, who have been followed for an average of 12 years. We show that renal failure occurs at the median age of 46 years, with a median time to a second recurrence of 10 years. Additionally, we identify high plasma unesterified cholesterol level as a predicting factor for rapid deterioration of kidney function. In conclusion, this study highlights the severe consequences of FLD, underlines the need of correct early diagnosis and referral of patients to specialized centers, and highlights the urgency for effective treatments to prevent or slow renal disease in patients with LCAT deficiency.

MS-based proteome profiling has become increasingly comprehensive and quantitative, yet a persistent shortcoming has been the relatively large samples required to achieve an in-depth measurement. Such bulk samples, typically comprising thousands of cells or more, provide a population average and obscure important cellular heterogeneity. Single-cell proteomics capabilities have the potential to transform biomedical research and enable understanding of biological systems with a new level of granularity. Recent advances in sample processing, separations and MS instrumentation now make it possible to quantify >1000 proteins from individual mammalian cells, a level of coverage that required an input of thousands of cells just a few years ago. This review discusses important factors and parameters that should be optimized across the workflow for single-cell and other low-input measurements. It also highlights recent developments that have advanced the field and opportunities for further development.

The absence of the dystrophin protein in Duchenne muscular dystrophy (DMD) results in myofiber fragility and a plethora of downstream secondary pathologies. Although a variety of experimental therapies are in development, achieving effective treatments for DMD remains exceptionally challenging, not least because the pathological consequences of dystrophin loss are incompletely understood. Here we have performed proteome profiling in tibialis anterior muscles from two murine DMD models (mdx and mdx52) at three ages (8, 16, and 80 weeks of age), all n = 3. High-resolution isoelectric focusing liquid chromatography-tandem MS (HiRIEF-LC–MS/MS) was used to quantify the expression of 4974 proteins across all 27 samples. The two dystrophic models were found to be highly similar, whereas multiple proteins were differentially expressed relative to WT (C57BL/6) controls at each age. Furthermore, 1795 proteins were differentially expressed when samples were pooled across ages and dystrophic strains. These included numerous proteins associated with the extracellular matrix and muscle function that have not been reported previously. Pathway analysis revealed multiple perturbed pathways and predicted upstream regulators, which together are indicative of cross-talk between inflammatory, metabolic, and muscle growth pathways (e.g. TNF, INF, NF-B, SIRT1, AMPK, PGC-1α, PPARs, ILK, and AKT/PI3K). Upregulation of CAV3, MVP and PAK1 protein expression was validated in dystrophic muscle by Western blot. Furthermore, MVP was upregulated during, but not required for, the differentiation of C2C12 myoblasts suggesting that this protein may affect muscle regeneration. This study provides novel insights into mutation-independent proteomic signatures characteristic of the dystrophic phenotype and its progression with aging.

Huanglongbing (HLB) is the most devastating and widespread citrus disease. All commercial citrus varieties are susceptible to the HLB-associated bacterium, Candidatus Liberibacter asiaticus (CLas), which resides in the phloem. The phloem is part of the plant vascular system and is involved in sugar transport. To investigate the plant response to CLas, we enriched for proteins surrounding the phloem in an HLB susceptible sweet orange variety, Washington navel (Citrus sinensis (L) Osbeck). Quantitative proteomics revealed global changes in the citrus proteome after CLas inoculation. Plant metabolism and translation were suppressed, whereas defense-related proteins such as peroxidases, proteases and protease inhibitors were induced in the vasculature. Transcript accumulation and enzymatic activity of plant peroxidases in CLas infected sweet orange varieties under greenhouse and field conditions were assessed. Although peroxidase transcript accumulation was induced in CLas infected sweet orange varieties, peroxidase enzymatic activity varied. Specific serine proteases were up-regulated in Washington navel in the presence of CLas based on quantitative proteomics. Subsequent activity-based protein profiling revealed increased activity of two serine proteases, and reduced activity of one protease in two C. sinensis sweet orange varieties under greenhouse and field conditions. The observations in the current study highlight global reprogramming of the citrus vascular proteome and differential regulation of enzyme classes in response to CLas infection. These results open an avenue for further investigation of diverse responses to HLB across different environmental conditions and citrus genotypes.

The complexity and dynamics of the immensely heterogeneous glycoproteome of the prostate cancer (PCa) tumour micro-environment remain incompletely mapped, a knowledge gap that impedes our molecular-level understanding of the disease. To this end, we have used sensitive glycomics and glycoproteomics to map the protein-, cell- and tumour grade-specific N- and O-glycosylation in surgically-removed PCa tissues spanning five histological grades (n = 10/grade) and tissues from patients with benign prostatic hyperplasia (n = 5). Quantitative glycomics revealed PCa grade-specific alterations of the oligomannosidic-, paucimannosidic- and branched sialylated complex-type N-glycans, and dynamic remodelling of the sialylated core 1- and core 2-type O-glycome. Deep quantitative glycoproteomics identified ~7,400 unique N-glycopeptides from 500 N-glycoproteins and ~500 unique O-glycopeptides from nearly 200 O-glycoproteins. With reference to a recent Tissue and Blood Atlas, our data indicate that paucimannosidic glycans of the PCa tissues arise mainly from immune cell-derived glycoproteins. Further, the grade-specific PCa glycosylation arises primarily from dynamics in the cellular makeup of the PCa tumour microenvironment across grades involving increased oligomannosylation of prostate-derived glycoproteins and decreased bisecting GlcNAcylation of N-glycans carried by the extracellular matrix proteins. Further, elevated expression of several oligosaccharyltransferase subunits and enhanced N-glycoprotein site occupancy were observed associated with PCa progression. Finally, correlations between the protein-specific glycosylation and PCa progression were observed including increased site-specific core 2-type O-glycosylation of collagen VI. In conclusion, integrated glycomics and glycoproteomics have enabled new insight into the complexity and dynamics of the tissue glycoproteome associated with PCa progression generating an important resource to explore the underpinning disease mechanisms.

Economic Recovery and Anticorruption in South Africa: Assessing Progress on the Reform Agenda 4 December 2019 — 3:00PM TO 4:00PM Anonymous (not verified) 25 November 2019 Chatham House | 10 St James's Square | London | SW1Y 4LE

South Africa has significant economic potential based on its resource endowment, quality human capital and well-developed infrastructure compared to the region. However, the country’s economic growth rate has not topped 2 per cent since 2013, and in 2018, was below 1 per cent. This has put a strain on citizens and communities in a country that still suffers from structural inequality, poverty and high unemployment. Economic recovery and anti-corruption were the central pillars of President Cyril Ramaphosa’s 2019 electoral campaign and he has set an investment target of $100 billion. However, voters and investors alike are demanding faster and more visible progress from the country’s enigmatic leader who has a reputation for caution and calculation.

At this event, Professor Nick Binedell will discuss the progress of and opposition to the president’s economic reform agenda and the opportunities for international investment to support long term inclusive and sustainable growth in South Africa.

Attendance at this event is by invitation only.

Angola's Business Promise: Evaluating the Progress of Privatization and Other Economic Reforms 21 January 2020 — 2:30PM TO 3:30PM Anonymous (not verified) 16 January 2020 Chatham House | 10 St James's Square | London | SW1Y 4LE

Minister Nunes Júnior will discuss the progress of the Angolan government’s economic stabilization plans and business reform agenda including the privatization of some state-owned enterprises. These reforms could expand Angola’s exports beyond oil and stimulate new industries and more inclusive economic growth.

THIS EVENT IS NOW FULL AND REGISTRATION HAS CLOSED.

An arms contractor is making "good progress" on the production of five B-21 Raider stealth bombers, U.S. Air Force Secretary Frank Kendall disclosed during a speech on Monday.

Academic and health offerings have increased in McDowell County, W.Va., due to a private-public partnership.

FAO Director-General José Graziano da Silva today expressed confidence that “significant progress against hunger, food insecurity and malnutrition,” will be achieved in the next four years. He made the [...]

OM EAST develop new booklet for red light ministries.

Identifies Areas of Compliance and Opportunities to Continue Health Care Payment Transformation Early in March, Insurance Commissioner Trinidad Navarro and Cristine Vogel, the Director of the Department’s Office of Value-Based Health Care Delivery, issued the Annual Review of Carrier Progress Towards Meeting Affordability Standards. Vogel leads the Department’s efforts relating to value-based care, primary care, […]

THE China (Shanghai) Pilot Free Trade Zone has almost witnessed the establishment of a new enterprise every hour over the past decade, statistics show. By the end of 2022, the Shanghai FTZ, which was

Jerusalem/Beirut — Israel said on Monday there was progress in talks about a Lebanon cease-fire and indicated Russia could play a part by stopping Hezbollah rearming via Syria, although the Iran-backed group said it had not received any new truce proposals. Pummeled by Israel's offensive, Hezbollah said diplomatic contacts were under way involving its backers in Tehran, Washington and Moscow, whilst reiterating its readiness to fight on, saying it had enough weapons for a "long war." In Jerusalem, Israeli Foreign Minister Gideon Saar said the war against Hezbollah was not yet over. The main challenge facing any cease-fire deal would be enforcement, he said, though there was "a certain progress" in talks. After previous rounds of fruitless U.S.-led diplomacy to secure a Lebanon truce, the comments indicate renewed focus on the issue as President Joe Biden prepares to leave office in January, with President-elect Donald Trump set to replace him. Hopes of a Gaza truce have meanwhile suffered a setback, with Qatar suspending its mediation role. Ignited by the war in Gaza, the conflict at the Lebanese-Israeli border had been rumbling on for a year before Israel went on the offensive in late September, pounding wide areas of Lebanon with airstrikes and sending troops into the south. Saar, addressing a Jerusalem news conference, said Israel was working with the United States on a cease-fire. Israel wants Hezbollah north of the Litani river – some 30 km from the border - and unable to rearm, he said. Saar said a basic principle for any agreement had to be that Hezbollah would not be able to bring weapons into Lebanon from Syria. "It is vital to the success of any arrangement in Lebanon," he said. "And the Russians are, as you know, present in Syria. And if they are in agreement with this principle, I think they can contribute effectively to this objective." Russia deployed forces into Syria nearly a decade ago to support President Bashar al-Assad in the civil war there. Hezbollah also sent fighters to help Assad, and carved out big sway on the ground alongside other Iran-backed groups. Syria is widely seen as a major conduit for Iran to supply weapons to Hezbollah in Lebanon, and Israel has struck targets in Syria regularly during the conflict. An Israeli airstrike temporarily cut Syria's main Homs-Damascus highway on Monday, Syrian media reported. In Lebanon, relatives held funerals for 20 people killed in a strike on the southern town of Deir Qanoun-Ras al-Ain, including seven medics from rescue groups affiliated with Hezbollah and its Shiite ally Amal. 'Testing the waters' In Beirut, Hezbollah official Mohammad Afif linked intensified political contacts to the looming change of U.S. leadership. "There is a great movement between Washington and Moscow and Tehran and a number of capitals," he said. "We hear a lot of talk, but so far, according to my information, nothing official has reached Lebanon or us in this regard," he told a news conference. The contacts were "in the phase of testing the waters and presenting initial ideas." Israel Hayom reported on Sunday that substantial progress has been made in diplomatic negotiations over a proposed Lebanon cease-fire that would require Hezbollah to withdraw north of the Litani River, barring its military presence near the Israeli border, while the IDF would return to the international border. Yedioth Ahronoth, Israel's best-selling newspaper, reported on Monday that Israel and Lebanon have exchanged drafts through U.S. envoy Amos Hochstein, signaling progress in efforts to reach a final agreement. The Lebanese government, which includes Hezbollah, has repeatedly called for a cease-fire based on the full implementation of a U.N. resolution that ended a war between the group and Israel in 2006. The resolution calls for the area south of the Litani river to be free of all weapons other than those of the Lebanese state. Lebanon and Israel have accused each other of violating the resolution. Israel says its campaign aims to secure the return home of tens of thousands of people forced to evacuate the north due to rockets fired by Hezbollah, which opened fire on Oct. 8, 2003, in solidarity with Hamas. Israel's offensive has forced more than 1 million people to flee their homes in Lebanon in the last seven weeks. Since the eruption of hostilities a year ago, Israeli attacks have killed more than 3,189 people in Lebanon, the majority of them since late September, according to health ministry figures, which do not distinguish between civilians and combatants. Hezbollah attacks have killed roughly 100 civilians and soldiers in northern Israel, the Israeli-occupied Golan Heights, and southern Lebanon over the last year.

The Apex Committee of the Special Investment Facilitation Council (SIFC) met to evaluate advancements in fostering investments in Pakistan. Chaired by the caretaker prime minister, discussions encompassed strategies such as the privatization of financially struggling government institutions. In a separate interaction, the Army Chief reiterated the armed forces’ dedication to supporting the nation’s economic stability. ... Read more

The post Special Investment Facilitation Council Reviews Progress and Strategies for Economic Stability in Pakistan appeared first on Pakistan Tribune.

to write a progress report paper

Title: Brain Lesions Predict MS Progression
Category: Health News
Created: 8/29/2007 2:00:00 AM
Last Editorial Review: 8/29/2007 12:00:00 AM

Title: U.S. Schools Show Progress in Healthy Behaviors, CDC Says
Category: Health News
Created: 8/26/2013 4:36:00 PM
Last Editorial Review: 8/27/2013 12:00:00 AM

Title: Progress Slows Against Heart Disease Deaths for Adults Under 55, Study Shows
Category: Health News
Created: 8/24/2015 12:00:00 AM
Last Editorial Review: 8/25/2015 12:00:00 AM

Title: Make Exercise a Work-in-Progress
Category: Health News
Created: 8/29/2017 12:00:00 AM
Last Editorial Review: 8/29/2017 12:00:00 AM

Title: Drug Slows Brain Shrinkage in Progressive MS
Category: Health News
Created: 8/29/2018 12:00:00 AM
Last Editorial Review: 8/30/2018 12:00:00 AM

Extract

We read with great interest the correspondence by T. Bitter and co-workers in the European Respiratory Review, about our recently published review entitled "Central sleep apnoea: not just one phenotype" [1]. We first want to express our gratefulness to the authors for their support and appreciation of our work, particularly regarding the urgent need for an increasingly differentiated view of central sleep apnoea (CSA) in the context of precision medicine.

Diffuse large B-cell lymphoma (DLBCL) is a heterogenous group of lymphoid malignancies. Based on gene expression profiling, it has been subdivided into germinal center (GC)-derived and activated B-cell (ABC) types. Advances in molecular methodologies have further refined the subclassification of DLBCL, based on recurrent genetic abnormalities. Here, we describe a distinct case of DLBCL that presented in leukemic form. DNA sequencing targeting 275 genes revealed pathogenically relevant mutations of CD79B, MyD88, TP53, TBL1XR1, and PIM1 genes, indicating that this lymphoma would be best classified as MCD/C5 DLBCL, an ABC subtype. Despite an initial good clinical response to BTK inhibitor ibrutinib, anti-CD20 antibody rituxan, alkylating agent bendamustine, and hematopoietic stem-cell transplant, the lymphoma relapsed, accompanied by morphologic and molecular evidence of disease progression. Specifically, the recurrent tumor developed loss of TP53 heterozygosity (LOH) and additional chromosomal changes central to ABC DLBCL pathogenesis, such as PRDM1 loss. Acquired resistance to ibrutinib and rituxan was indicated by the emergence of BTK and FOXO1 mutations, respectively, as well as apparent activation of alternative cell-activation pathways, through copy-number alterations (CNAs), detected by high-resolution chromosomal microarrays. In vitro, studies of relapsed lymphoma cells confirmed resistance to standard BTK inhibitors but sensitivity to vecabrutinib, a noncovalent inhibitor active against both wild-type as well as mutated BTK. In summary, we provide in-depth molecular characterization of a de novo leukemic DLBCL and discuss mechanisms that may have contributed to the lymphoma establishment, progression, and development of drug resistance.

Oakland's mayor and district attorney were both sent packing in a recall vote. Leaders in other Democratic-run cities should take notice.

The European Commission has revealed the progress of potential European Union countries in areas including food safety. As part of the Enlargement Package, the EU Commission has assessed how prepared Albania, Bosnia and Herzegovina, Kosovo, Montenegro, North Macedonia, Serbia, Georgia, Moldova, Ukraine, and Turkey are as they work towards EU... Continue Reading

While most fans have been looking forward to Warhammer 40,000: Space Marine 2 or basically a sequel to Warhammer 40,000: …

Continue reading "Warhammer 40,000: Space Marine 2 Steam Deck Review (in Progress) – GOTY Contender, but Play It Elsewhere for Now"

Looking back over the last 40 years at FDA (as I have), there are three characteristics that create a more progressive environment at the agency: continuity of leadership, presidential support, and increased funding. For FDA in 2013 (as the saying goes): 2 out of 3 ain’t bad. In particular, medical innovation seems poised to flourish in an FDA environment where there is continuity of policy and leadership, instead of a new team learning the ropes. I explore this and other themes in the latest issue of Pharmaphorum.com. You can read my thoughts at: http://www.pharmaphorum.com/2013/01/29/fda-post-election-continuity-and-progress-likely-to-mark-2013/.

Apr 25, 2024

On April 23, the final session examined healthcare access policies and public health initiatives across Africa. In our discussions, we explored the politics of health and healthcare policy, particularly in light of the COVID-19 pandemic. We identified political barriers to expanding healthcare coverage and access, and the dialogue centered on areas of progress in addressing infectious and chronic diseases. Beyond focusing on the challenges in implementing effective healthcare policies, in this session we invited participants to propose policy solutions as we look towards the future. The study group counted with the presence of external expert guest Dr. Salma Abdalla. Dr. Abdalla is a Sudanese medical doctor and Assistant Professor in Global Health and Epidemiology at Boston University School of Public Health. She was the Director of the Rockefeller-Boston University 3-D Commission on Determinants of health, Data science, and Decision making. She also served as a secretariat member for the WHO Independent Panel for Pandemic Preparedness and Response during the COVID-19 pandemic. Furthermore, Katie Chen, Master in Public Administration/ International Development Candidate at Harvard Kennedy School, delivered a memo briefing on how to boost childhood immunization rates in African countries, including through increased vaccine manufacturing, drone delivery., and behavioural interventions to combat vaccine hesitancy.

Jun 28, 2024

Ensuring that space remains a domain for peaceful exploration and mutual benefit rather than a new frontier for conflict will significantly depend on the global community's ability to navigate the complex interplay of technological advancements, regulatory frameworks, economic opportunities, and geopolitical challenges. 

This paper was written for the final assignment of IGA-250, a Harvard Kennedy School course on emerging technology: security, strategy, and risk.

Christine Attia lost her fianc� just two years ago after he lost a courageous six-month battle with acute myeloid leukemia. She reminds everyone, while breakthrough therapies are saving lives, work still needs to be done to find cures.

AACR Survey and Cancer Progress Report 2015 Video

Heavyweight Warren Baister moves closer to Olympic qualification with a thrilling win over France's Abdoulaye Diane in Turkey.

The OECD/G20 Inclusive Framework on BEPS has published the outcome of more reviews into territories' preferential tax regimes and on tax dispute resolution through the Mutual Agreement Procedure.

The OECD/G20 Inclusive Framework on BEPS has published the outcome of more reviews into territories' preferential tax regimes and on tax dispute resolution through the Mutual Agreement Procedure.

As part of its commitment to fighting cross-border tax evasion and profit shifting, Switzerland sent information on over 3m financial accounts in 2021, according to a new review of the Swiss financial center by the State Secretariat for International Financial Matters.