New research on where feral pigs live and how far they travel is being hailed as "one of the best data sets in the world" by a shooter contracted to manage the invasive species, while also raising alarm bells about serious diseases.

Wangaratta Council has issued the pig's owner with a cease and desist notice, stating he has broken a local law by walking Grunt the pig in public and will be fined $806 if he continues.

Wangaratta's Grunt the pig is back walking on council land after a public campaign led council to reverse the ban with strict conditions.

The deadly march of pig-killing African swine fever is continuing, with one quarter of the world's pigs now dead, according to meat and livestock analysts.

African swine fever is believed to have first emerged early last century, but due to a lack of commercial interest no vaccine was developed. Now the world is racing to find a way to stop the spread of the disease.

A deadly pig disease that has decimated herds across Asia has spread closer to Australia with the Philippines confirming it has tested positive to African swine fever.

It's estimated that African swine fever has killed 25 per cent of the world's pig population. The deadly disease has now reached Timor-Leste, about 650 kilometres from Darwin.

A Gold Coast principal is asked to make pig snorting noises amid a defamation case in which she is suing five families over comments made about her on social media.

Far north Queensland's largest and oldest piggery is closing after 49 years, impacted by drought, cheap imports, and rising costs as the agricultural profile of the area changes.

Betty, the piglet born with just two hind hooves, is saved from slaughter just in time for the Lunar Year of the Pig.

Pig producers in New South Wales battle a combination of factors that have seen up to 80 per cent of them selling all their pigs and leaving the industry.

(United States Seventh Circuit) - Held that a manufacturer of cellphone cases did not hold a valid trademark in the term CAPSULE. Affirmed a summary judgment in favor of the defendant in this trademark infringement lawsuit.

(United States Seventh Circuit) - Held that a manufacturer of cellphone cases did not hold a valid trademark in the term CAPSULE. Affirmed a summary judgment in favor of the defendant in this trademark infringement lawsuit.

Whether mutations in cancer driver genes directly affect cancer immune phenotype and T cell immunity remains a standing question. ARID1A is a core member of the polymorphic BRG/BRM-associated factor chromatin remodeling complex. ARID1A mutations occur in human cancers and drive cancer development. Here, we studied the molecular, cellular, and clinical impact of ARID1A aberrations on cancer immunity. We demonstrated that ARID1A aberrations resulted in limited chromatin accessibility to IFN-responsive genes, impaired IFN gene expression, anemic T cell tumor infiltration, poor tumor immunity, and shortened host survival in many human cancer histologies and in murine cancer models. Impaired IFN signaling was associated with poor immunotherapy response. Mechanistically, ARID1A interacted with EZH2 via its carboxyl terminal and antagonized EZH2-mediated IFN responsiveness. Thus, the interaction between ARID1A and EZH2 defines cancer IFN responsiveness and immune evasion. Our work indicates that cancer epigenetic driver mutations can shape cancer immune phenotype and immunotherapy.

The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. Although gene-environment interactions have been implicated in the etiology of several disorders, the impact of paternal and/or maternal metabolic syndrome on the clinical phenotypes of offspring and the underlying genetic and epigenetic contributors of NAFLD have not been fully explored. To this end, we used the liver-specific insulin receptor knockout (LIRKO) mouse, a unique nondietary model manifesting 3 hallmarks that confer high risk for the development of NAFLD: hyperglycemia, insulin resistance, and dyslipidemia. We report that parental metabolic syndrome epigenetically reprograms members of the TGF-β family, including neuronal regeneration–related protein (NREP) and growth differentiation factor 15 (GDF15). NREP and GDF15 modulate the expression of several genes involved in the regulation of hepatic lipid metabolism. In particular, NREP downregulation increases the protein abundance of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and ATP-citrate lyase (ACLY) in a TGF-β receptor/PI3K/protein kinase B–dependent manner, to regulate hepatic acetyl-CoA and cholesterol synthesis. Reduced hepatic expression of NREP in patients with NAFLD and substantial correlations between low serum NREP levels and the presence of steatosis and nonalcoholic steatohepatitis highlight the clinical translational relevance of our findings in the context of recent preclinical trials implicating ACLY in NAFLD progression.

Fibroblasts are key effector cells in tissue remodeling. They remain persistently activated in fibrotic diseases, resulting in progressive deposition of extracellular matrix. Although fibroblast activation may be initiated by external factors, prolonged activation can induce an “autonomous,” self-maintaining profibrotic phenotype in fibroblasts. Accumulating evidence suggests that epigenetic alterations play a central role in establishing this persistently activated pathologic phenotype of fibroblasts. We demonstrated that in fibrotic skin of patients with systemic sclerosis (SSc), a prototypical idiopathic fibrotic disease, TGF-β induced the expression of DNA methyltransferase 3A (DNMT3A) and DNMT1 in fibroblasts in a SMAD-dependent manner to silence the expression of suppressor of cytokine signaling 3 (SOCS3) by promoter hypermethylation. Downregulation of SOCS3 facilitated activation of STAT3 to promote fibroblast-to-myofibroblast transition, collagen release, and fibrosis in vitro and in vivo. Reestablishment of the epigenetic control of STAT3 signaling by genetic or pharmacological inactivation of DNMT3A reversed the activated phenotype of SSc fibroblasts in tissue culture, inhibited TGF-β–dependent fibroblast activation, and ameliorated experimental fibrosis in murine models. These findings identify a pathway of epigenetic imprinting of fibroblasts in fibrotic disease with translational implications for the development of targeted therapies in fibrotic diseases.

Piggy Poggy Pog - is quite a complex, nice-looking 2D platformer in which you must escape from the farm playing for a pig named Poggy . In this game you go through the levels, collecting a certain number of acorns. After you collect all the acorns on the level, you have go to the next level. Be careful on your way there are various traps, such as sharp peaks and life-threatening Poggy plant. Coming into contact with them, the pig will instantly die and the level starts over. Try your luck and maybe you will get off this damn farm... KEY FEATURES: - Animated graphics. - Simple, funny gameplay. - A large number of levels.

This patented technology is undergoing clinical testing in Australia for use against sun damage to the skin, and as a therapeutic for vitiligo, psoriasis and albinism. It is expected to enter Phase III testing in late 2006.

My virtual trip has taken me to Denmark . Another country added to the list and another magnet purchased for the board in the kitchen . So thoughts on Denmark . I wonder what the roads will be like. Will they resemble the de dum de dum roads of Belgium or

Chicago real estate experts bust myths portrayed by home improvement shows, from actors subbing in as buyers to unrealistically low renovation costs.

A swine virus that appeared in the U.S. in 2013 has proven hard to track. But an algorithm might help researchers predict the next outbreak.

Olivia Head, 17, founded Oinking Acres in Brownsburg and has rescued up to 160 potbellied pigs and some other animals.

Oinking Acres Pig Rescue and Sanctuary is making a difference in the Brownsburg community by saving more than 150 potbellied pigs.

Olivia Head discovered there was a high demand for fostering and adopting potbellied pigs. Thus, Oinking Acres Pig Rescue and Sanctuary was born.

Lee Call
Apr 29, 2020; 0:jlr.RA120000652v1-jlr.RA120000652
Research Articles

Multi-component lipid emulsions, rather than soy-oil emulsions, prevent cholestasis by an unknown mechanism. Here, we quantified liver function, bile acid pools, and gut microbial and metabolite profiles in premature, parenterally fed pigs given a soy-oil lipid emulsion, Intralipid (IL); a multi component lipid emulsion, SMOFlipid (SMOF); a novel emulsion with a modified fatty-acid composition (EXP); or a control enteral diet (ENT) for 22 days. We assayed serum cholestasis markers; measured total bile acid levels in plasma, liver, and gut contents; and analyzed colonic bacterial 16S rRNA gene sequences and metabolomic profiles. Serum cholestasis markers (i.e. bilirubin, bile acids, and g-glutamyl transferase) were highest in IL-fed pigs and normalized in those given SMOF, EXP, or ENT. Gut bile acid pools were lowest in the IL treatment and were increased in the SMOF and EXP treatments and comparable to ENT. Multiple bile acids, especially their conjugated forms, were higher in the colon contents of SMOF and EXP than in IL pigs. Colonic microbial communities of SMOF and EXP pigs had lower relative abundance of several Gram-positive anaerobes, including Clostridrium XIVa, and higher abundance of Enterobacteriaceae than those of IL and ENT pigs. Differences in lipid and microbial-derived compounds were also observed in colon metabolite profiles. These results indicate that multi-component lipid emulsions prevent cholestasis and restore enterohepatic bile flow in association with gut microbial and metabolomic changes. We conclude that sustained bile flow induced by multi-component lipid emulsions likely exerts a dominant effect in reducing bile acid–sensitive, Gram-positive bacteria.

Hepatosteatosis, which is frequently associated with development of metabolic syndrome and insulin resistance, manifests when triglyceride (TG) input in the liver is greater than TG output, resulting in the excess accumulation of TG. Dysregulation of lipogenesis therefore has the potential to increase lipid accumulation in the liver, leading to insulin resistance and type 2 diabetes. Recently, efforts have been made to examine the epigenetic regulation of metabolism by histone-modifying enzymes that alter chromatin accessibility for activation or repression of transcription. For regulation of lipogenic gene transcription, various known lipogenic transcription factors, such as USF1, ChREBP, and LXR, interact with and recruit specific histone modifiers, directing specificity toward lipogenesis. Alteration or impairment of the functions of these histone modifiers can lead to dysregulation of lipogenesis and thus hepatosteatosis leading to insulin resistance and type 2 diabetes.

Type 2 diabetes accounts for 90% of the population with diabetes, and these patients are generally obese and hyperlipidemic. In addition to hyperglycemia, hyperlipidemia is also closely related with diabetic retinopathy. The aim was to investigate retinopathy in a model closely mimicking the normal progression and metabolic features of the population with type 2 diabetes and elucidate the molecular mechanism. Retinopathy was evaluated in rats fed a 45% kcal as fat diet for 8 weeks before administering streptozotocin, 30 mg/kg body weight (T2D), and compared with age- and duration-matched type 1 diabetic rats (T1D) (60 mg/kg streptozotocin). The role of epigenetic modifications in mitochondrial damage was evaluated in retinal microvasculature. T2D rats were obese and severely hyperlipidemic, with impaired glucose and insulin tolerance compared with age-matched T1D rats. While at 4 months of diabetes, T1D rats had no detectable retinopathy, T2D rats had significant retinopathy, their mitochondrial copy numbers were lower, and mtDNA and Rac1 promoter DNA methylation was exacerbated. At 6 months, retinopathy was comparable in T2D and T1D rats, suggesting that obesity exaggerates hyperglycemia-induced epigenetic modifications, accelerating mitochondrial damage and diabetic retinopathy. Thus, maintenance of good lifestyle and BMI could be beneficial in regulating epigenetic modifications and preventing/retarding retinopathy in patients with diabetes.

OBJECTIVE

To investigate the role of epigenetics in statins’ diabetogenic effect comparing DNA methylation (DNAm) between statin users and nonusers in an epigenome-wide association study in blood.

Alan Rochford was living the dream when he started Stone Cottage, an idyllic French restaurant nestled in the Adelaide Hills. He had everything going for him apart from experience, money, and the first idea about what he was doing. After two years and one divorce, he began to see the funny side, fed on an endless diet of characters and occurrences so crazy that you couldn't make them up. Australia's answer to Basil Fawlty, Alan serves up a degustation of lip-smacking anecdotes, from his side-line in snail trading across the French countryside, to the time two customers got a touch too 'intimate' in the middle of his dining room. Guinea Pig in White Wine Sauce is the tale of one man trying to keep his head in the certifiably insane world of fine dining.

Wildlife conservation -- Australia.

UK : Institute of Ophthalmology, 1951.

UK : Institute of Ophthalmology, 1951.

Paris : Georges Carre, 1896.