Title: Too Many Antibiotics, Opioids Given to Dental Patients in the ER
Category: Health News
Created: 2/25/2020 12:00:00 AM
Last Editorial Review: 2/25/2020 12:00:00 AM

Title: After Tooth Pull, Opioids Don't Relieve Pain Better Than Other Meds: Study
Category: Health News
Created: 3/13/2020 12:00:00 AM
Last Editorial Review: 3/16/2020 12:00:00 AM

Title: Babies Born Addicted to Opioids Often Struggle With Learning
Category: Health News
Created: 5/3/2017 12:00:00 AM
Last Editorial Review: 5/4/2017 12:00:00 AM

Title: Opioid Crisis Means More Newborns With Hepatitis C, But Few Get Tested
Category: Health News
Created: 5/2/2018 12:00:00 AM
Last Editorial Review: 5/2/2018 12:00:00 AM

Title: The Other Opioid Crisis: Shortages at U.S. Hospitals
Category: Health News
Created: 5/2/2018 12:00:00 AM
Last Editorial Review: 5/2/2018 12:00:00 AM

Title: U.S. Teen Opioid Deaths Soaring
Category: Health News
Created: 4/30/2019 12:00:00 AM
Last Editorial Review: 5/1/2019 12:00:00 AM

Title: Not Just Opioids: Deaths Tied to Cocaine, Meth Are Soaring, Too
Category: Health News
Created: 5/2/2019 12:00:00 AM
Last Editorial Review: 5/3/2019 12:00:00 AM

G protein-coupled receptor (GPCR) kinases (GRKs) play a key role in terminating signals initiated by agonist-bound GPCRs. However, chronic stimulation of GPCRs, such as that which occurs during heart failure, leads to the overexpression of GRKs and maladaptive downregulation of GPCRs on the cell surface. We previously reported the discovery of potent and selective families of GRK inhibitors based on either the paroxetine or GSK180736A scaffold. A new inhibitor, CCG258747, which is based on paroxetine, demonstrates increased potency against the GRK2 subfamily and favorable pharmacokinetic parameters in mice. CCG258747 and the closely related compound CCG258208 also showed high selectivity for the GRK2 subfamily in a kinome panel of 104 kinases. We developed a cell-based assay to screen the ability of CCG258747 and 10 other inhibitors with different GRK subfamily selectivities and with either the paroxetine or GSK180736A scaffold to block internalization of the μ-opioid receptor (MOR). CCG258747 showed the best efficacy in blocking MOR internalization among the compounds tested. Furthermore, we show that compounds based on paroxetine had much better cell permeability than those based on GSK180736A, which explains why GSK180736A-based inhibitors, although being potent in vitro, do not always show efficacy in cell-based assays. This study validates the paroxetine scaffold as the most effective for GRK inhibition in living cells, confirming that GRK2 predominantly drives internalization of MOR in the cell lines we tested and underscores the utility of high-resolution cell-based assays for assessment of compound efficacy.

PURPOSE

Although cesarean delivery is the most common surgical procedure in the United States, postoperative opioid prescribing varies greatly. We hypothesized that patient characteristics, procedural characteristics, or both would be associated with high vs low opioid use after discharge. This information could help individualize prescriptions.

Despite a national opioid-related overdose epidemic that continues to claim tens of thousands of lives annually, a new nationwide study shows that a scant proportion of hospitalized patients with opioid use disorder receive proven life-saving medications both during and after they're discharged.

Also, CMS chief vows to lessen docs' record-keeping burden

Braeburn Pharmaceuticals' CAM2038 gets positive FDA review

Click to view a price quote on AGN.

Calling prescription drug addiction an “urgent and growing threat” to our nation’s public health, Attorney General Eric Holder on Monday announced a new Drug Enforcement Administration(DEA) regulation that would allow pharmacies, hospitals, clinics, and other authorized collectors to serve as authorized drop-off sites for unused prescription drugs.

Individuals with opioid use disorder (OUD) struggle to get effective care: Of 2 million Americans with the illness, only 26% receive treatment. Now, as the coronavirus pandemic presents an added strain on the U.S. health care system, it is creating greater hardships for those seeking OUD treatment.

At least 95 percent of individuals in state prisons will eventually return to communities. In fact, in a typical year more than half a million people do so, with many more coming from jails. A disproportionate share of these individuals have one or more chronic illnesses.

The most effective therapy for people with opioid use disorder (OUD) involves the use of Food and Drug Administration-approved medications—methadone, buprenorphine, and naltrexone. Despite evidence that this approach, known as medications for opioid use disorder (MOUD), reduces relapse and saves lives, the vast majority of jails and prisons do not offer this treatment. This brief examines what...

More than 2 million Americans suffer from opioid use disorder, but only about 25% of people receive any sort of care. For many, inpatient treatment often means leaving a job and loved ones behind to seek recovery.

The treatment gap continues to be an obstacle in addressing opioid use disorder (OUD) in the U.S. In 2018, an estimated 2 million Americans had OUD but only about 26% received specialty addiction treatment.

In a 2018 article for Foreign Affairs, we detailed what set off the North American opioid crisis and what other nations can learn from mistakes the U.S. and Canada made. Here, we describe the opioid situation in other countries and then reflect on what U.S. and Canadian officials could learn from them. Key lessons include…

Introduction Recent high-profile litigation and settlements among states and local governments with drug companies have highlighted the costs of the opioid epidemic on communities. The dollar amounts discussed in some of these cases have been huge. For example, Purdue Pharma and Mallinckrodt agreed to a national settlements of about $10 billion and $1.6 billion, respectively,…

Today, the Brown Center on Education Policy is releasing a new report on one of the unexplored effects of the opioid crisis: the link between the opioid epidemic and the educational outcomes of children in hard-hit areas. Written by Rajeev Darolia and John Tyler, the report suggests a need to be aware of the potentially…

Over the course of three months, previously clean mussels picked up a slew of contaminants from the waters of Puget Sound.

Dental painkillers put teens and young adults at increased risk for opioid addiction in the following year, a study from the Stanford University School of Medicine has found.

Around half of the opioids prescribed by dentists in the United States exceed the three-day supply recommended by federal dental pain-management guidelines.

Knowing the dose of opioids taken after cesarean delivery and before discharge can inform individualized prescriptions and reduce unnecessary, leftover

Pharmaceuticals companies which market their drugs tend to target physicians, which encourages them to prescribe more opioids which is what is causing

Opioid use has been linked with low testosterone in men. But the number of men screened is unknown. /br A new study by researchers from The University

Governments should treat the opioid epidemic as a public health crisis and improve treatment, care and support for people misusing opioids. Overdose deaths continue to rise, fuelled by an increase in prescription and over-prescription of opioids for pain management and the illicit drugs trade, according to a new OECD report.

Governments should treat the opioid epidemic as a public health crisis and improve treatment, care and support for people misusing opioids. Overdose deaths continue to rise, fuelled by an increase in prescription and over-prescription of opioids for pain management and the illicit drugs trade, according to a new OECD report.

In the past decade, overdose deaths have surged, particularly as (illicit) synthetic opioids have become more available. Opioid-related deaths touch urban and rural communities alike and are spreading to affect all demographic groups.

New Jersey doctor Robert Delagente, 45, has pleaded guilty to distribution of controlled dangerous substances, conspiracy and falsifying medical records for dolling out opioids to patients.

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On this episode of On the Evidence, April Yanyuan Wu, a researcher at Mathematica, discusses a project that used supervised machine learning to estimate prescription opioid use among applicants for Social Security Disability Insurance.

Last year, Mathematica worked with researchers at Montana State University (MSU) to help assess the policy value of municipal wastewater testing, an innovative approach that can augment existing data by providing more rapid, cost-effective, and unbiased measures of drug use.

Online Resource

In August the DEA announced plans to ban Kratom, a herbal substance used to treat pain, anxiety and in some cases opioid addiction. A group of tenacious users got the agency to back down and extend public comment until December 1st. Now a tough decision lies before the DEA.

This week, news writer Greg Miller chats with us about how the legalization of marijuana in certain U.S. states is having an impact on the nation’s opioid problem. Plus, Sarah Crespi talks to Sascha Drewlo about a new method for profiling the DNA of fetuses very early on in pregnancy.   [Image: OpenRangeStock/iStockphoto/Music: Jeffrey Cook] ++   Authors: Sarah Crespi; Alexa Billow

This literature review was conducted as part of an evaluation of the National Health Emergency demonstration grants awarded by the U.S. Department of Labor to states that using their workforce systems to address problems presented by the opioid crisis.

This guide supports state recipients of the U.S. Department of Labor National Health Emergency demonstration grants that leverage their workforce systems to address problems presented by the opioid crisis.

Cambridge, Mass. : National Bureau of Economic Research, 2020

Dewey Library - HV8738.S835 2019

Interview with Sam P. Most, MD, author of Assessment of Persistent and Prolonged Postoperative Opioid Use Among Patients Undergoing Plastic and Reconstructive Surgery

Interview with Brian L. VanderBeek, MD, MPH, MSCE, author of Association of Opioids With Incisional Ocular Surgery

Interview with Sarah Larney, PhD, author of All-Cause and Cause-Specific Mortality Among People Using Extramedical Opioids: A Systematic Review and Meta-analysis