Juan Carlos Flórez habla sobre el informe de la ONU respecto a la situación de los líderes sociales

Ana Bejarano habla sobre el informe de la ONU respecto a la situación de los líderes sociales

Panelistas debatieron sobre el impacto político y las sumas y restas que genera el hundimiento del Presupuesto General. También una mirada a los escenarios a futuro con la expedición por decreto del PGN.

En este episodio, La Luciérnaga se enciende para analizar a fondo los temas que tocó el Presidente de la República, Gustavo Petro, ante la asamblea general de las Naciones Unidas. La Luciérnaga, un espacio de humor, análisis y opinión de Caracol Radio que acompaña desde hace 30 años a sus oyentes en el regreso a casa.

Escuche el programa de este miércoles 31 de julio. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que desde hace 31 años acompaña a sus oyentes en su regreso casa.

Liliana Fernández, embajadora de Panamá en Colombia, habló en 10AM HOY por HOY sobre los resultados del encuentro bilateral en el que hablaron sobre la crisis migratoria en la frontera

La ONU entregó un informe sobre la implementación de la paz en Colombia: ¿qué dice?

El representante de la ONU en Colombia destacó en Caracol Radio, en el programa 6AM, este hecho como algo alarmante 

Después de una larga investigación, el documentalista David Baute llega a una conclusión. “A estas alturas ya no podemos ir con muchos paños calientes”, dice. via Pocket

Here are five especially delicious options for the week ahead and those to come.

Monument Re announced today that its Isle of Man subsidiary Monument International Life Assurance Company Limited [MILAC] has completed the acquisition of the closed book portfolio of Zurich International Life Limited’s [ZILL] Singapore long term life insurance business. A spokesperson said, “The ZILL Singapore branch portfolio and employees have transferred into the Singapore branch of […]

Monument Re announced today that its Belgian subsidiary Monument Assurance Belgium has completed the acquisition of a run-off block of retail life policies, annuities and associated assets from Federale Verzekering [Federale]. Koen Depaemelaere, CEO of Monument Assurance Belgium stated that “We are pleased to have completed this transaction with Federale as it represents a positive […]

Monument Re Limited announced today that its Belgian subsidiary Monument Assurance Belgium N.V. has completed the acquisition of a branch 21 closed book classical group life insurance portfolio from Contassur – Contibel Assurances Vie – Contibel Levensverzekeringen SA/NV [Contassur], following receipt of regulatory approval from the National Bank of Belgium. Koen Depaemelaere, CEO of Monument […]

S Trumpem v Bílém domě má Musk příležitost posunout svůj vliv na novou úroveň a významně ovlivnit pravidla hry v technologickém světě. Těžit může například z možného vlivu na regulace v klíčových sektorech, kde působí. Muskova podpora Trumpovi byla sázkou na nejistotu, ale první reakce trhu naznačují, že se tento risk možná vyplácí.

Z návratu Donalda Trumpa do Bílého domu bude profitovat jeden z jeho nejviditelnějších příznivců: Elon Musk. Přiznaně transakční vztah obou idiosynkratických sólistů je v moderní historii bezprecedentní.

The $20 Secret Santa limit applies to everyone except your friends who work in finance. Wall Street bankers are about to cash substantially bigger bonus checks at the end of this year, according to a report released yesterday by Johnson Associates. Coming after two consecutive years of lower…

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The post The Sad Story of the Unique Monument appeared first on English Russia.

Welcome to an enlightening exploration into the world of macronutrients. These fundamental components of our diet — proteins, carbohydrates, and fats — play integral roles in our body’s physiological functions. While they’re clearly important to our health and well-being, they often remain shrouded in mystery for most of us. By learning more about macronutrients, you’ll understand how ... Read more

The post Macronutrients Unveiled: A Comprehensive Look at Their Roles in a Balanced Diet appeared first on Star Two.

I don’t know how old our dog Posey is. She’s a rescue pup that we found at the city shelter back in 2011. We took her home, somewhat unexpectedly, that same day. It was Super Bowl Sunday, so every year at about that time we celebrate (our oh-so-creatively-named) birthday alternative, “Dog Day,” by taking her […]

The article Dog Day & Donuts in Half Moon Bay, CA originated at EverInTransit.com

Lars Jønson
May 1, 2007; 6:798-811
Research

Visual Abstract

In eukaryotic DNA replication, DNA polymerase ε (Polε) is responsible for leading strand synthesis, whereas DNA polymerases α and δ synthesize the lagging strand. The human Polε (hPolε) holoenzyme is comprised of the catalytic p261 subunit and the noncatalytic p59, p17, and p12 small subunits. So far, the contribution of the noncatalytic subunits to hPolε function is not well understood. Using pre-steady-state kinetic methods, we established a minimal kinetic mechanism for DNA polymerization and editing catalyzed by the hPolε holoenzyme. Compared with the 140-kDa N-terminal catalytic fragment of p261 (p261N), which we kinetically characterized in our earlier studies, the presence of the p261 C-terminal domain (p261C) and the three small subunits increased the DNA binding affinity and the base substitution fidelity. Although the small subunits enhanced correct nucleotide incorporation efficiency, there was a wide range of rate constants when incorporating a correct nucleotide over a single-base mismatch. Surprisingly, the 3'→5' exonuclease activity of the hPolε holoenzyme was significantly slower than that of p261N when editing both matched and mismatched DNA substrates. This suggests that the presence of p261C and the three small subunits regulates the 3'→5' exonuclease activity of the hPolε holoenzyme. Together, the 3'→5' exonuclease activity and the variable mismatch extension activity modulate the overall fidelity of the hPolε holoenzyme by up to 3 orders of magnitude. Thus, the presence of p261C and the three noncatalytic subunits optimizes the dual enzymatic activities of the catalytic p261 subunit and makes the hPolε holoenzyme an efficient and faithful replicative DNA polymerase.

An Education Week analysis found that at least 140 schools, almost all below the Mason-Dixon line, still bear the names of figures from that era.

The Hirshhorn Museum and Sculpture Garden is renowned for its striking architecture and impressive collection of contemporary art. Whether you're an art enthusiast, a history buff, or simply curious about that concrete donut on the National Mall, learn more about its Brutalist background in this new episode of National Treasure. --------- To find out more about the Hirshhorn Museum and Sculpture Garden, read below: https://www.smithsonianmag.com/smithsonian-institution/hirshhorn-museum-building-went-from-iconoclast-icon-180984914/ Digital Editorial Director: Brian Wolly Director of Programming: Nicki Marko Supervising Producer & Scriptwriter: Michelle Mehrtens Producer & Editor: Sierra Theobald Motion Designer: Ricardo Jaimes

Lonnie Bunch, the director of the National Museum of African American History and Culture, discusses the Martin Luther King, Jr. memorial, one of America's greatest monuments.

When the war ended, Allied soldiers tracked down Nicolas de Largillierre's "Portrait de femme à mi-corps" with the help of a savvy French curator who had been working for the resistance

The ancient burial structures, strikingly similar all across Europe and the mediterranean, have puzzled scientists and historians for centuries

"People actually reached out and hugged it and they told their [stories] about residential school," master carver Stanley C. Hunt says.

All-stainless PRO 48 brings professional kitchen capabilities to people who love food and entertaining

The trailer of Pushpa 2 will release on November 17

Madhuri Dixit and Vidya Balan shared screen space in the film for the first time

While commerce apps are charging a high price for coconut, the local vendors viral ad is gaining traction for a low price.

Temporary changes to the Work Bonus offer an opportunity for the visitor economy to employ mature-aged workers and overcome labour shortfalls.

Some say it was the taking down of the Robert E. Lee monument that caused the torch-wielding Nazi/white supremacists to rage. Others are confident that it had nothing to do with the statue, and everything to do with racist and anti-Semitic rage of monumental proportions that inspired the Nazis/white supremacists/white nationals to storm Charlottesville, Virginia.    

Lolita Abril urged the CHR to conduct an independent investigation into the killing of her husband Ronel Abril and another coconut farmer Roger Clores last September 26. The two were allegedly killed by elements of the 2nd Infantry Battalion (2nd IB) in an “armed encounter.”

Wall Street firms are expected to pay heftier bonuses for this year, the first increase since a bumper year in 2021, according to a report by compensation consultancy Johnson Associates. Payouts will probably rise after financiers benefited from several factors in recent months: a recovery in dealmaking, the Federal Reserve cutting interest rates and equity […]

A monument in southern Spain that dates to between 3600 and 3800 BC appears to have been built with an understanding of geology and physics

Title: Why Is Coconut Oil Good for Your Teeth?
Category: Health and Living
Created: 8/26/2022 12:00:00 AM
Last Editorial Review: 8/26/2022 12:00:00 AM

The role of gastrin-releasing peptide receptor (GRPR) in various diseases, including cancer, has been extensively studied and has emerged as a promising therapeutic target. In this study, we successfully achieved the use of [²¹²Pb]Pb-DOTAM-GRPR1, comprising the α-particle generator, ²¹²Pb, combined with a GRPR-targeting peptide, GRPR1, in a prostate cancer model. Methods: Pharmacokinetics, toxicity, radiation dosimetry, and efficacy were assessed in GRPR-positive prostate tumor–bearing mice after intravenous administration of [²¹²Pb]Pb-DOTAM-GRPR1 (where DOTAM is 1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane). Results: Preclinical studies have shown tumor targeting of up to 5 percent injected dose per gram over 24 h, and optimization of the drug formulation and quantity has led to minimized oxidation and off-target binding, respectively. Particularly, an increase in peptide amount from 28 to 280 ng was shown to reduce off-target uptake, especially at the level of the pancreas, by about 30%. Furthermore, dosimetry studies confirmed the kidney as the dose-limiting organ, and toxicity studies revealed that a nontoxic dose of up to 1,665 kBq could be injected into mice. Efficacy studies indicated a median survival time of 9 wk in the control group, which received only a buffer solution, compared with 19 wk in the group that received 4 injections of 370 kBq at 3-wk intervals. Conclusion: Taken together, these combined data demonstrate the safety, tolerability, and efficacy of [²¹²Pb]Pb-DOTAM-GRPR1, thus warranting further exploration in clinical trials.