1. Second Nine news executive leaves in wake of cultural review  Sydney Morning Herald
2. Nine executive quits embattled network  news.com.au
3. Another executive departs beleaguered Nine Network  Daily Telegraph

WE MUST LEAVE our love it's forbidden

Independence Day and fireworks go hand in hand, but fireworks shouldn’t go in consumers’ hands. That’s the message the National Fire Protection Association (NFPA) is reinforcing this Fourth of July. Fireworks annually cause devastating burns, injuries, fires, and even death, making them too dangerous to be used safely by consumers.

At least 10 Ukrainian soldiers died in the Donetsk region after the Kurakhovo Reservoir dam was blown up, TASS reported, citing Russian security forces. The blast flooded nearby areas, trapping soldi...

Welcome back to Harvest Hues, our current stitch-along here on Needle ‘n Thread, where we are exploring the embroidering of …

Evaluation report for the inter-authority learning exchange between Shetland Islands, Falkirk and Glasgow Councils throughcare and aftercare teams. In February 2014 a member of the Throughcare and Aftercare team from Shetland, spent two weeks in each host authority as a means of developing and sharing practice, experience and learning. The report describes the planning process, in-situ experience, and post-exchange learning of participants, it also report highlights the positive learning outcomes and benefits achieved for all participating local authorities. The report identifies ideas for future applications of such a learning and practice exchange model to improve practice for looked after young people and care leavers.

It’s a hot and beautiful summer day at the bottom of the Grand Canyon as I stand in line for a sandwich. Our rafting guides have set up an amazing spread of fixings. There’s even vegan cheese for me. All that’s missing are plates and napkins. After washing our hands with river water and soap in a foot-pumped bucket sink, we put our bread on one hand and try to layer on all the sandwich ingredients with the other. Scooping out avocado is especially difficult one-handed. It's clumsy, but admirable when you realize we are generating no paper or plastic[...]

Imagine slipping into a tranquil space, the soft aroma of essential oils filling the air, as the world outside slowly fades away. For many, this is the sanctuary sought after a long week of work or dealing with chronic pain. In that moment, whether it’s the gentle caress of a Swedish massage or the deep ... Read more

The post Swedish vs. Deep Tissue – Which Massage Will Leave You More Bruised? appeared first on Star Two.

Aston Martin technical director Dan Fallows leaves his role with the Formula 1 team.

The World Meteorological Organisation (WMO) has raised the alarm over climate change, reporting 2024 is the world's hottest year yet.

The following article, Forty-Seven Percent Of Harris Voters Believe Trump Will Not Be A Legitimate President; 54 Percent Want To Leave The Country, was first published on Conservative Firing Line.

I really wish that everyone would just calm down.  Emotions always run high immediately after an election, but what we are witnessing this time around is truly frightening.  We live at a time when people feel free to express their deepest, darkest emotions on social media, and right now “freak out video” after “freak out …

Continue reading Forty-Seven Percent Of Harris Voters Believe Trump Will Not Be A Legitimate President; 54 Percent Want To Leave The Country ...

Jesper V. Olsen
Jun 1, 2004; 3:608-614
Technology

Carlota Oleaga
Nov 17, 2020; 0:jlr.RA120000964v1-jlr.RA120000964
Research Articles

Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates cholesterol metabolism by inducing the degradation of hepatic low-density lipoprotein receptor (LDLR). Plasma PCSK9 has two main molecular forms: a 62-kDa mature form (PCSK9_62) and a 55-kDa, furin-cleaved form (PCSK9_55). PCSK9_55 is considered less active than PCSK9_62 in degrading LDLR. We aimed to identify the site of PCSK9_55 formation (intra- vs. extracellular) and to further characterize the LDLR-degradative function of PCSK9_55 relative to PCSK9_62. Co-expressing PCSK9_62 with furin in cell culture induced formation of PCSK9_55, most of which was found in the extracellular space. Under the same conditions we found that: i) adding a cell-permeable furin inhibitor preferentially decreased the formation of PCSK9_55 extracellularly; ii) using pulse-chase, we observed the formation of PCSK9_55 exclusively extracellularly in a time-dependent manner. A recombinant form of PCSK9_55 was efficiently produced but displayed impaired secretion that resulted in its intracellular trapping. However, the non-secreted PCSK9_55 was able to induce degradation of LDLR, though with 50% lower efficiency compared with PCSK9_62. Collectively, our data show that PCSK9_55 is generated in the extracellular space, and that intracellular PCSK9_55 is not secreted but retains the ability to degrade the LDLR through an intracellular pathway.

Tsvangirai Leaves an Important Political Legacy in Southern Africa Expert comment sysadmin 21 February 2018

The story of Zimbabwe’s ‘people’s champion’ offers a powerful example to a region in need of new political compromises.

The death of Movement for Democratic Change (MDC) leader Morgan Tsvangirai is a loss for Zimbabwe. In nearly three decades of speaking truth to power, Tsvangirai helped to change his nation and the region.

Southern Africa’s new politics

His death marks a period of transition for regional governments and opposition parties alike. The Zuma era has ended in South Africa while Mozambique, Namibia and Angola have also seen political transitions, pushing modernization agendas to appeal to young citizenries that increasingly see politics in separate terms from the liberationist struggles of the previous generation.

Regional opposition movements also face winds of change: the longstanding opposition leader in the Democratic Republic of the Congo, Etienne Tshekedi, passed away in 2017, and Mozambique’s Afonso Dhlakama and Kenya’s Raila Odinga are both aging. These movements similarly need to appeal to a younger audience or risk losing relevance.

From trade unionist to opposition leader

Tsvangirai’s career is an eloquent illustration of these challenges. Born in Buhera in rural eastern Zimbabwe, Tsvangirai worked in textiles and mining before politics – diverse experience which gave him crucial exposure to the lives of ordinary people across the country. In his early years, he also worked for ZANU-PF, before leaving to forge his own political path. He became increasingly active in mining politics, rising to the executive of the National Mineworker’s Union and, in 1989, to secretary-general of the powerful Zimbabwe Congress of Trade Unions.

In the late 1990’s, Zimbabwe was riven by questions over land, war veterans, the Congo conflict, a shrinking economy and growing doubts about ZANU-PF itself. Opposition leaders of the time could not answer them; those such as Edgar Tekere and Margaret Dongo struggled to win support beyond their local constituencies, and liberation leader Joshua Nkomo’s ZAPU had been merged with ZANU-PF in the 1987 Unity Accord.

But in 2000, Zimbabwe’s ‘perfect storm’ of a divisive constitutional referendum, land redistribution and a June election made Tsvangirai and the newly minted MDC, formed in 1999, a national rival to ZANU-PF. Through subsequent national elections in 2002, 2005, 2008 and 2013, Zimbabwe remained polarized between competing visions of Zimbabwe future: ZANU-PF’s powerful black liberationist politics of identity and the opposition’s equally compelling liberal democracy agenda.

Tsvangirai’s achievement was to provide a credible alternative to liberation icon Robert Mugabe. Tsvangirai also resuscitated Zimbabwe’s tradition of urban nationalism, and was a successor to Benjamin Burombo and other mid-century Zimbabwean urban leaders. Tsvangirai would in turn be a touchstone for contemporary urban activists Evans Mawarire, Linda Masarira and others.

From opposition to coalition

The political struggle for Zimbabwe became global, with Mugabe and Tsvangirai both winning support from rival international power blocs. In March 2007, pictures of a beaten and bloodied Tsvangirai helped to galvanize support for the MDC in the 2008 elections. But the disputed result and violent subsequent run-off between Tsvangirai and Mugabe led the regional community to push both men into a coalition government, with Tsvangirai as prime minister.

Despite continuous ructions, the Government of National Unity (GNU) held, and stabilized Zimbabwe’s collapsed economy, until 2013. Although often politically out-manoeuvred by Mugabe, Tsvangirai deserves credit for getting the opposition a share of political power and for holding his nerve against many who wanted to collapse the GNU.

Tsvangirai was no saint; his complicated love life, and tacit approval of violent attacks on party dissenters, do him no credit. More importantly, the MDC neglected its grassroots supporters during the GNU, and paid the price in its comprehensive 2013 electoral defeat. But although diminished, Tsvangirai remained Zimbabwe’s most popular opposition politician, and the MDC’s new leaders will have quite a task ahead of them, even if they have been planning since his courageous 2016 public admission of colon cancer.

The MDC after Tsvangirai

Nelson Chamisa, one of the three MDC vice presidents, has now been appointed as acting president by the party’s national committee. Chamisa inherits a fractured and fractious party, and one which has also fallen out with the Tsvangirai family. The other two vice presidents, Thokozani Khupe and Elias Mudzuri, have also set their sights on party leadership.

At 40, Chamisa, an orator with grassroots appeal, has a huge task. With general elections due by July, he has to unite the party, counter Zimbabwe’s rising ethno-politics, prove himself as leader of a broader opposition coalition and take on a resurgent President Emmerson Mnangagwa and ZANU-PF.

Electorally, the opposition’s strongest card has always been the urban vote and the economy. But Mnangagwa has fast forwarded a comprehensive economic reform and internationalist agenda. This, and Mugabe’s exit, have forced Chamisa, Joice Mujuru and other opposition leaders to play catch-up. Zimbabwe’s elections, the first since 2000 without Mugabe and Tsvangirai as contenders, will be of global interest as the country navigates the new political dynamics.

The people’s champion

Morgan Tsvangirai’s resilience earned him respect from friends and foes alike, with Zimbabwe’s President Mnangagwa and Vice President Constantino Chiwenga visiting him at home a few weeks ago. A former nominee for the Nobel Peace Prize, Tsvangirai, popularly known by his totem of ‘Save’ and also called mudhara [the old man] deserves national hero status. He will certainly be remembered as the ‘people’s champion’, and a pioneer in bridging the generational and ideological fissures that have shaped Southern Africa’s politics.

With their leader now gone, the turbulent MDC will undoubtedly be hoping for a ‘remembrance vote’ in his memory to carry them through the elections. But beyond that, his story offers a powerful example to a region in need of new political compromises.

Background: Faced with the limits of synthetic antipyretic substances, in particular their involvement in the occurrence of numerous and often serious adverse effects; the challenge is in search of new antipyretics especially from the African traditional pharmacopoeia. The objective of this study was to evaluate the antipyretic activity of an aqueous extract and a formulation of Ceiba pentandra, with a view to designing an herbal antipyretic drug. Methods: Trials of formulation of an antipyretic syrup with leaves extract of Ceiba pentandra were carried out. The antipyretic activity was investigated by the bewer's yeast induced pyrexia. Physicochemical and microbiological stability tests were carried out on the syrup. Results: It was found with the extract an antipyretic activity at doses of 125 mg/kg and 150 mg/kg. The effect was greater for the 125 mg/kg dose with inhibition percentages ranging from 27.58% to 71.25%. This antipyretic activity was early (from 30 minutes) and was preserved during the four hours of the experiment. The syrup dosed at 125 mg/kg gave an activity similar to that of the extract by significantly reducing the hyperthermia in the rats. Regarding the stability tests, the syrup remained stable both physico-chemically and microbiologically throughout the study period (28 days) both when exposed to low temperature (5 °±3 ° C) and at high temperature (40°±2° C). Conclusions: Ceiba pentandra leaves have antipyretic activity and could be used for the development of an herbal antipyretic drug.

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A bill approved in both houses of the California legislature would allow certified teachers six paid weeks of maternity leave.

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A sea of red swept the capitals of North and South Carolina on Wednesday, as thousands of teachers turned out to demand higher pay and more school funding.

The switch to remote learning in rural New Mexico has left some students profoundly isolated—cut off from others and the grid by sheer distance.

Although we have made progress towards building a better world, too many people have been left behind. People who are unable to benefit from human development, innovation or economic growth.

In [...]

Read more at http://blogs.smithsonianmag.com/aroundthemall/2009/12/tai-shan-will-return-to-china/ Visitors to the National Zoo have enjoyed watching their baby panda grow up over the last four years.

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Send your best snaps and video from across the province to cbcnb@cbc.ca

With P.E.I's only full-time blood oncologist leaving at the end of November, Health P.E.I. was planning to transfer his patients to Dr. Philip Champion. Now Champion says he intends to retire in the spring.

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The Mackinac Center for Public Policy is partnering with think tanks and advocacy groups across the country in a campaign encouraging public employees to consider dropping their union memberships.

A federal grant that enhanced services for veteran students at Pennsylvania College of Technology recently ended, but its benefits will endure.

A worker shares the story of one girl who recently took the courageous step to leave her life of prostitution for the freedom Christ offers.

This week Carin Smith explains why Kulula.com operator Comair grounded its planes, and what it will take to get them back in the air.

OM writer Ellyn shares firsthand accounts from those who fled for their lives to Bangladesh and now reside with thousands in camps in Cox’s Bazar.

US-based comedian Austin Nasso is going viral online for his hilarious impersonation of US-President-elect Donald Trump during a fictional visit to India.

The first shipment of American Turkey products for India left on Tuesday, marking a new phase in the bilateral trade relations between the two countries.

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The marriage ceremony of Adnan Muhammad, a resident of Bilaspur, had to be performed virtually as the company for which he works in Turkiye refused to grant him leave, his family members said.

Proposal offers 12 weeks of paid parental leave, would make Delaware the 6th state to offer the benefit to public workers DOVER, Del. – Governor John Carney joined members of the General Assembly on Tuesday to call for passage of legislation that would offer 12 weeks of paid parental leave to state workers. The bill, […]

Insurers approved to offer plans with benefits equal to or greater than the forthcoming state plan Insurance Commissioner Trinidad Navarro announced today that the Department of Insurance has approved Delaware’s first private Paid Family Medical Leave plans. These filings, reviewed by independent actuaries and against state requirements, provide options for businesses who wish to purchase […]

Tehran, Iran — A militant attack near the Pakistani border with Iran left five Iranian forces dead, the state-run IRNA news agency reported Sunday. The report said the dead were ethnic Baluch members of the paramilitary Revolutionary Guard's volunteer Basij force and were killed in Saravan city in Sistan and Baluchistan province. Saravan is some 1,400 km (870 miles) southeast of the capital Tehran. No group immediately claimed responsibility for the attack. Earlier in the day, state TV reported that Revolutionary Guard forces killed three terrorists and arrested nine others in a military operation. The report did not specify which group the suspects belonged to. Last month, unknown gunmen killed four people, including the chief of the Revolutionary Guard in the province. In September, gunmen killed four border guards in Sistan and Baluchistan province in two separate attacks. The militant group Jaish al-Adl, which seeks greater rights for the ethnic Baluch minority, claimed responsibility for one attack in which one officer and two soldiers were killed. The province, which borders Afghanistan and Pakistan, has been the site of occasional deadly clashes involving militant groups, armed drug smugglers and Iranian security forces. It is one of the least developed parts of Iran. Relations between the predominantly Sunni Muslim residents of the region and Iran's Shiite theocracy have long been strained.

ROME — A chipper-sounding Pope Francis was discharged Saturday from the Rome hospital where he was treated for bronchitis, quipping to journalists before being driven away that he's “still alive.” Francis, 86, was hospitalized at Gemelli Polyclinic on Wednesday following his weekly public audience in St. Peter's Square after reportedly experiencing breathing difficulties. The pontiff received antibiotics administered intravenously during his stay, the Vatican said. In a sign of his improved health, the Vatican released details of Francis' Holy Week schedule. It said he would preside at this weekend's Palm Sunday Mass and at Easter Mass on April 9, both held in St. Peter's Square and expected to draw tens of thousands of faithful. A Vatican cardinal will be at the altar to celebrate both Masses, a recent practice due to the pontiff having a troublesome knee issue. But Francis is scheduled to celebrate Holy Thursday Mass, which this year will be held in a juvenile prison in Rome. Still unclear was whether he would attend the late-night, torch-lit Way of the Cross procession at Rome's Colosseum to mark Good Friday. Before departing Gemelli Polyclinic late Saturday morning, Francis comforted a Rome couple whose 5-year-old daughter died Friday night at the Catholic hospital. Outside, Serena Subania, mother of Angelica, sobbed as she pressed her head into the chest of the pope, who held her close and whispered words of comfort. Francis seemed eager to linger with well-wishers. When a boy showed him his arm cast, the pope made a gesture as if to ask, “Do you have a pen?” Three papal aides whipped out theirs. Francis took one of the pens and added his signature to the child's already well-autographed cast. Asked how he felt now, Francis joked, “Still alive, you know.” He gave a thumbs-up sign. Francis exited the hospital from a side entrance, but his car stopped in front of the main entrance, where a gaggle of journalists waited. He opened the car door himself and got out from the front passenger seat. Francis had a cane ready to lean on. After chatting, he got back into the white Fiat 500 car that drove him away from Gemelli Polyclinic. But instead of heading straight home, his motorcade sped right past Vatican City and went to St. Mary Major Basilica, a Rome landmark that is one of his favorites. There, startled tourists rushed to snap photos of him as he sat in a wheelchair, which he has used often to navigate longer distances in recent years due to a chronic knee problem. When he emerged after praying, residents and tourists in the street called out repeatedly, “Long live the pope!” and clapped. Francis spent 10 days at the same hospital in July 2021 following intestinal surgery for a bowel narrowing, After his release back then, he also stopped to offer prayers of thanksgiving at St. Mary Major Basilica, which is home to an icon depicting the Virgin Mary. He also visits the church upon returning from trips abroad. Before leaving the hospital Saturday, Francis, while chatting with journalists, praised medical workers, saying they "show great tenderness." “We sick are capricious. I much admire the people who work in hospitals,” he said. Francis also said he read journalists' accounts of his illness, including in a Rome daily newspaper, and pronounced them well done. Francis stopped to talk to reporters again before he was driven into the Vatican through a gate of the tiny walled city-state, where he lives at a Holy See hotel. Speaking through an open car window, he said: “Happy Easter to all, and pray for me.'' Then, indicating he was eager to resume his routine, he said, “Forward, thanks.” In response to a shouted question from a reporter, who asked if the pope would visit Hungary at the end of April as scheduled, Francis answered, “Yes.” On yet another stop, he got out of his car to distribute chocolate Easter eggs to the police officers who drove the motorcycles at the head of his motorcade. Given his strained voice, it was unclear if the pope would read the homily at the Palm Sunday service or deliver the usually lengthy “Urbi et Orbi” [Latin for to the city and to the world] address, a review of the globe's conflicts, at the end of Easter Mass. He told reporters that after Palm Sunday Mass, he would keep his weekly appointment to greet and bless the public in St. Peter's Square. As a young man in his native Argentina, Francis had part of a lung removed, leaving him particularly vulnerable to any respiratory illness.

The Asian Development Bank has launched a new country partnership strategy (CPS) to support the Philippines’ transformation in the next 6 years. It is designed to ensure sustainable, inclusive and resilient growth in the face of climate challenges.

“While the investigation takes place, the town will refrain from any additional comment on this matter," according to a press release.

Ancient humans are said to have evolved to leave the trees, where our primate ancestors lived, in favour of open grassy savannahs – but we may have this idea wrong

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