iom Bingeing Halloween Candy Can Overload Gut Microbiome By www.discovermagazine.com Published On :: Wed, 23 Oct 2024 18:00:00 GMT It’s probably best to enjoy your Halloween spoils in moderation. Full Article Health
iom Regenerative Medicine - from Protocol to Patient 3. Tissue Engineering, Biomaterials and Nanotechnology By search.lib.uiowa.edu Published On :: Location: Electronic Resource- Full Article
iom Quantitative biomedical optics : theory, methods, and applications By search.lib.uiowa.edu Published On :: Location: Engineering Library- R857.O6B54 2016 Full Article
iom Biomedical imaging : the chemistry of labels, probes, and contrast agents By search.lib.uiowa.edu Published On :: Location: Sciences Library Library- RC78.7.D53B56 2012 Full Article
iom Immunotherapy and Biomarkers in Neurodegenerative Disorders By search.lib.uiowa.edu Published On :: Location: Electronic Resource- Full Article
iom Orthopaedic biomechanics By search.lib.uiowa.edu Published On :: Location: Engineering Library- QP301.O715 2013 Full Article
iom Adopting biometric technology : challenges and solutions By search.lib.uiowa.edu Published On :: Location: Engineering Library- TK7882.B56D367 2016 Full Article
iom Supermacroporous cryogels : biomedical and biotechnological applications By search.lib.uiowa.edu Published On :: Location: Engineering Library- R857.M3S853 2016 Full Article
iom Smelling Illness: Volatile Organic Compounds as Neurological Disease Biomarkers By www.the-scientist.com Published On :: Wed, 23 Oct 2024 14:53:39 GMT Scientists advance Parkinson’s disease biomarker research one sniff at a time. Full Article Podcasts
iom Día del Idioma: lectura y uso del lenguaje en Colombia By www.spreaker.com Published On :: Fri, 23 Apr 2021 21:44:45 +0000 Escritores debatieron cómo es escribir en pandemia, por qué los colombianos leemos poco y qué uso le estamos dando al lenguaje. Full Article
iom ¿Qué es el microbioma intestinal y cuál es su importancia en la salud humana? By www.spreaker.com Published On :: Thu, 20 Jun 2024 17:54:00 +0000 Full Article
iom La última encuesta, idioma alienígena y corrupción en el PAE By www.spreaker.com Published On :: Fri, 10 Jun 2022 23:48:00 +0000 En este episodio, Luciérnaga se enciende para hablar de la última encuesta presidencial antes de la segunda vuelta. Además, nos visita Mafe Walker con su idioma solar. También, revisamos que está pasando con los escándalos de corrupción en el Programa de Alimentación Escolar (PAE).La Luciérnaga es un espacio de humor, análisis y opinión de Caracol Radio que acompaña desde hace 30 años a sus oyentes en el regreso a casa. Full Article
iom Reforma pensional, investigación en la Unidad de Riesgo y día del idioma By www.spreaker.com Published On :: Wed, 24 Apr 2024 00:26:00 +0000 Escuche el programa de este martes 23 de abril. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que desde hace 31 años acompaña a sus oyentes en su regreso casa. Full Article
iom Entrevista sobre documental de Diomedes Díaz en Netflix By www.spreaker.com Published On :: Thu, 07 Apr 2022 17:51:00 +0000 Full Article
iom “La concentración espermática es un biomarcador de la salud global del hombre” By www.spreaker.com Published On :: Thu, 17 Nov 2022 17:53:00 +0000 Full Article
iom Andrés en Inglés, el colombiano que enseña el idioma en Tik Tok By www.spreaker.com Published On :: Sat, 02 Oct 2021 19:07:00 +0000 Full Article
iom Aprender un nuevo idioma fortalece la salud mental de adultos mayores By www.spreaker.com Published On :: Mon, 21 Mar 2022 16:28:00 +0000 Full Article
iom Yuligrafía, la instagrammer que enseña redacción, ortografía y las maneras correctas del idioma By www.spreaker.com Published On :: Sun, 17 Jul 2022 17:20:00 +0000 Full Article
iom José Antonio Ocampo: habla 3 idiomas y hoy es reciclador en Valledupar By www.spreaker.com Published On :: Sun, 25 Sep 2022 16:09:00 +0000 Full Article
iom 'Idioma en señas': campaña para cerrar brechas de exclusión social By www.spreaker.com Published On :: Mon, 03 Apr 2023 00:20:00 +0000 Full Article
iom Bermuda IOM National & Open Championships By bernews.com Published On :: Wed, 23 Oct 2024 12:58:40 +0000 The 2024 Bermuda IOM National & Open Championships took place at Stocks Bay, St. George’s with Adam Barbosa winning the series. Barbosa won 8 races to be crowned champion with 26 net points, Barbosa also recorded 9 second place finishes in the regatta. Heath Foggo finished in second place with a net point score of […] Full Article All Sports #BermudaSailing
iom Examination of Cantor’s proofs for uncountability and axiom for counting infinite sets By blogs.scienceforums.net Published On :: Sun, 11 Sep 2022 18:51:41 +0000 I do a detailed analysis of Cantor’s theory of uncountable sets. The logic of his proofs has some weaknesses. I propose an axiom and a solution to continuum hypothesis. The main idea is: Assumption of Cantor’s proofs: All real numbers (set R) are in a list (list L). This assumption means R=L, considering L as... Full Article SFN Blogs Uncategorized
iom Examination of Cantor’s proofs for uncountability and axiom for counting infinite sets By blogs.scienceforums.net Published On :: Fri, 23 Sep 2022 13:02:45 +0000 An analysis of Cantor’s theory of uncountable sets: The logic of his proofs has some weaknesses. Cantor assumes for both his proofs that all real numbers (set R) are in a list (list L). Considering L as a set this assumption assumes R belongs to L. This makes the claim “a real number is constructed... Full Article SFN Blogs Uncategorized
iom Why burning biomass is not zero-carbon By www.chathamhouse.org Published On :: Mon, 17 Oct 2022 14:02:50 +0000 Why burning biomass is not zero-carbon Explainer Video NCapeling 17 October 2022 Short animation explaining why burning biomass produces more carbon dioxide per unit of energy generated than almost all fossil fuels. The climate emergency requires countries to transition away from fossil fuels, but it is important to be careful about the alternative energy sources chosen. In particular, concern is growing over the use of biomass for energy, which is generated when wood or other plant material is burnt to generate heat and electricity. Many governments treat biomass energy as zero-carbon at the point of combustion, and subsidize it in the same way as renewables such as solar or wind, resulting in a large increase in the use of biomass for energy in the UK and the European Union (EU) over the past 15 years. The treatment of biomass as zero-carbon in policy frameworks rests on the argument that biomass emissions will be reabsorbed by forest growth, particularly from trees planted to replace those cut down to burn. But growing trees to maturity takes many years and, depending on the feedstock used, biomass burning increases global warming for decades to centuries. This is called the ‘carbon payback period’ – the time it takes for carbon dioxide levels to return to what they would have been if biomass had not been used. New research from Chatham House and the Woodwell Climate Research Center calculated the real climate impact of burning US wood pellets in the UK and EU. In 2019, according to this analysis, US-sourced pellets burned for energy in the UK were responsible for between 13 million and 16 million tonnes of carbon dioxide, equivalent to the annual greenhouse gas emissions from 6-7 million passenger vehicles. But because biomass is treated as zero-carbon, almost none of these emissions were included in the UK’s national greenhouse gas reports. And the removal of forest carbon from US forests is not included accurately in US reports, either. Full Article
iom Biosynthesis of the sactipeptide Ruminococcin C by the human microbiome: Mechanistic insights into thioether bond formation by radical SAM enzymes [Microbiology] By www.jbc.org Published On :: 2020-12-04T00:06:05-08:00 Despite its major importance in human health, the metabolic potential of the human gut microbiota is still poorly understood. We have recently shown that biosynthesis of Ruminococcin C (RumC), a novel ribosomally synthesized and posttranslationally modified peptide (RiPP) produced by the commensal bacterium Ruminococcus gnavus, requires two radical SAM enzymes (RumMC1 and RumMC2) catalyzing the formation of four Cα-thioether bridges. These bridges, which are essential for RumC's antibiotic properties against human pathogens such as Clostridium perfringens, define two hairpin domains giving this sactipeptide (sulfur-to-α-carbon thioether–containing peptide) an unusual architecture among natural products. We report here the biochemical and spectroscopic characterizations of RumMC2. EPR spectroscopy and mutagenesis data support that RumMC2 is a member of the large family of SPASM domain radical SAM enzymes characterized by the presence of three [4Fe-4S] clusters. We also demonstrate that this enzyme initiates its reaction by Cα H-atom abstraction and is able to catalyze the formation of nonnatural thioether bonds in engineered peptide substrates. Unexpectedly, our data support the formation of a ketoimine rather than an α,β-dehydro-amino acid intermediate during Cα-thioether bridge LC–MS/MS fragmentation. Finally, we explored the roles of the leader peptide and of the RiPP precursor peptide recognition element, present in myriad RiPP-modifying enzymes. Collectively, our data support a more complex role for the peptide recognition element and the core peptide for the installation of posttranslational modifications in RiPPs than previously anticipated and suggest a possible reaction intermediate for thioether bond formation. Full Article
iom A structural and kinetic survey of GH5_4 endoglucanases reveals determinants of broad substrate specificity and opportunities for biomass hydrolysis [Protein Structure and Folding] By www.jbc.org Published On :: 2020-12-18T00:06:18-08:00 Broad-specificity glycoside hydrolases (GHs) contribute to plant biomass hydrolysis by degrading a diverse range of polysaccharides, making them useful catalysts for renewable energy and biocommodity production. Discovery of new GHs with improved kinetic parameters or more tolerant substrate-binding sites could increase the efficiency of renewable bioenergy production even further. GH5 has over 50 subfamilies exhibiting selectivities for reaction with β-(1,4)–linked oligo- and polysaccharides. Among these, subfamily 4 (GH5_4) contains numerous broad-selectivity endoglucanases that hydrolyze cellulose, xyloglucan, and mixed-linkage glucans. We previously surveyed the whole subfamily and found over 100 new broad-specificity endoglucanases, although the structural origins of broad specificity remained unclear. A mechanistic understanding of GH5_4 substrate specificity would help inform the best protein design strategies and the most appropriate industrial application of broad-specificity endoglucanases. Here we report structures of 10 new GH5_4 enzymes from cellulolytic microbes and characterize their substrate selectivity using normalized reducing sugar assays and MS. We found that GH5_4 enzymes have the highest catalytic efficiency for hydrolysis of xyloglucan, glucomannan, and soluble β-glucans, with opportunistic secondary reactions on cellulose, mannan, and xylan. The positions of key aromatic residues determine the overall reaction rate and breadth of substrate tolerance, and they contribute to differences in oligosaccharide cleavage patterns. Our new composite model identifies several critical structural features that confer broad specificity and may be readily engineered into existing industrial enzymes. We demonstrate that GH5_4 endoglucanases can have broad specificity without sacrificing high activity, making them a valuable addition to the biomass deconstruction toolset. Full Article
iom Theranostics for Meningioma on the Rise: New EANM/EANO/RANO/SNMMI Guidelines Pave the Way to Improved Patient Outcomes Using Radiolabeled Somatostatin Receptor Ligands By jnm.snmjournals.org Published On :: 2024-10-10T08:33:38-07:00 Full Article
iom Intraarterial Administration of Peptide Receptor Radionuclide Therapy in Patients with Advanced Meningioma: Initial Safety and Efficacy By jnm.snmjournals.org Published On :: 2024-10-24T11:58:49-07:00 Visual Abstract Full Article
iom High-throughput and site-specific N-glycosylation analysis of human alpha-1-acid glycoprotein offers a great potential for new biomarker discovery By www.mcponline.org Published On :: 2020-12-29 Toma KeserDec 29, 2020; 0:RA120.002433v1-mcp.RA120.002433Research Full Article
iom Stoichiometry of Nucleotide Binding to Proteasome AAA+ ATPase Hexamer Established by Native Mass Spectrometry By www.mcponline.org Published On :: 2020-12-01 Yadong YuDec 1, 2020; 19:1997-2014Research Full Article
iom A Mouse Brain-based Multi-omics Integrative Approach Reveals Potential Blood Biomarkers for Ischemic Stroke By www.mcponline.org Published On :: 2020-12-01 Alba SimatsDec 1, 2020; 19:1921-1935Research Full Article
iom Dietary sphinganine is selectively assimilated by members of the mammalian gut microbiome [Research Articles] By www.jlr.org Published On :: 2020-07-09T14:33:39-07:00 Functions of the gut microbiome have a growing number of implications for host metabolic health, with diet being one of the most significant influences on microbiome composition. Compelling links between diet and the gut microbiome suggest key roles for various macronutrients, including lipids, yet how individual classes of dietary lipids interact with the microbiome remains largely unknown. Sphingolipids are bioactive components of most foods and are also produced by prominent gut microbes. This makes sphingolipids intriguing candidates for shaping diet–microbiome interactions. Here, we used a click chemistry–based approach to track the incorporation of bioorthogonal dietary omega-alkynyl sphinganine (sphinganine alkyne [SAA]) into the murine gut microbial community (Bioorthogonal labeling). We identified microbial and SAA-specific metabolic products through fluorescence-based sorting of SAA-containing microbes (Sort), 16S rRNA gene sequencing to identify the sphingolipid-interacting microbes (Seq), and comparative metabolomics to identify products of SAA assimilation by the microbiome (Spec). Together, this approach, termed Bioorthogonal labeling-Sort-Seq-Spec (BOSSS), revealed that SAA assimilation is nearly exclusively performed by gut Bacteroides, indicating that sphingolipid-producing bacteria play a major role in processing dietary sphinganine. Comparative metabolomics of cecal microbiota from SAA-treated mice revealed conversion of SAA to a suite of dihydroceramides, consistent with metabolic activities of Bacteroides and Bifidobacterium. Additionally, other sphingolipid-interacting microbes were identified with a focus on an uncharacterized ability of Bacteroides and Bifidobacterium to metabolize dietary sphingolipids. We conclude that BOSSS provides a platform to study the flux of virtually any alkyne-labeled metabolite in diet–microbiome interactions. Full Article
iom Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson's Disease [Research] By www.mcponline.org Published On :: 2020-09-01T00:05:24-07:00 Pathogenic mutations in the Leucine-rich repeat kinase 2 (LRRK2) are the predominant genetic cause of Parkinson's disease (PD). They increase its activity, resulting in augmented Rab10-Thr73 phosphorylation and conversely, LRRK2 inhibition decreases pRab10 levels. Currently, there is no assay to quantify pRab10 levels for drug target engagement or patient stratification. To meet this challenge, we developed an high accuracy and sensitivity targeted mass spectrometry (MS)-based assay for determining Rab10-Thr73 phosphorylation stoichiometry in human samples. It uses synthetic stable isotope-labeled (SIL) analogues for both phosphorylated and nonphosphorylated tryptic peptides surrounding Rab10-Thr73 to directly derive the percentage of Rab10 phosphorylation from attomole amounts of the endogenous phosphopeptide. The SIL and the endogenous phosphopeptides are separately admitted into an Orbitrap analyzer with the appropriate injection times. We test the reproducibility of our assay by determining Rab10-Thr73 phosphorylation stoichiometry in neutrophils of LRRK2 mutation carriers before and after LRRK2 inhibition. Compared with healthy controls, the PD predisposing mutation carriers LRRK2 G2019S and VPS35 D620N display 1.9-fold and 3.7-fold increased pRab10 levels, respectively. Our generic MS-based assay further establishes the relevance of pRab10 as a prognostic PD marker and is a powerful tool for determining LRRK2 inhibitor efficacy and for stratifying PD patients for LRRK2 inhibitor treatment. Full Article
iom Proteomics and Metaproteomics Add Functional, Taxonomic and Biomass Dimensions to Modeling the Ecosystem at the Mucosal-luminal Interface [Review] By www.mcponline.org Published On :: 2020-09-01T00:05:24-07:00 Recent efforts in gut microbiome studies have highlighted the importance of explicitly describing the ecological processes beyond correlative analysis. However, we are still at the early stage of understanding the organizational principles of the gut ecosystem, partially because of the limited information provided by currently used analytical tools in ecological modeling practices. Proteomics and metaproteomics can provide a number of insights for ecological studies, including biomass, matter and energy flow, and functional diversity. In this Mini Review, we discuss proteomics and metaproteomics-based experimental strategies that can contribute to studying the ecology, in particular at the mucosal-luminal interface (MLI) where the direct host-microbiome interaction happens. These strategies include isolation protocols for different MLI components, enrichment methods to obtain designated array of proteins, probing for specific pathways, and isotopic labeling for tracking nutrient flow. Integration of these technologies can generate spatiotemporal and site-specific biological information that supports mathematical modeling of the ecosystem at the MLI. Full Article
iom Correction: Concentration Determination of >200 Proteins in Dried Blood Spots for Biomarker Discovery and Validation [Addition and Correction] By www.mcponline.org Published On :: 2020-10-01T00:05:25-07:00 Full Article
iom Multiomics Reveals Ectopic ATP Synthase Blockade Induces Cancer Cell Death via a lncRNA-mediated Phospho-signaling Network [Research] By www.mcponline.org Published On :: 2020-11-01T00:05:37-07:00 The EGFR tyrosine kinase inhibitor gefitinib is commonly used for lung cancer patients. However, some patients eventually become resistant to gefitinib and develop progressive disease. Here, we indicate that ecto-ATP synthase, which ectopically translocated from mitochondrial inner membrane to plasma membrane, is considered as a potential therapeutic target for drug-resistant cells. Quantitative multi-omics profiling reveals that ecto-ATP synthase inhibitor mediates CK2-dependent phosphorylation of DNA topoisomerase IIα (topo IIα) at serine 1106 and subsequently increases the expression of long noncoding RNA, GAS5. Additionally, we also determine that downstream of GAS5, p53 pathway, is activated by ecto-ATP synthase inhibitor for regulation of programed cell death. Interestingly, GAS5-proteins interactomic profiling elucidates that GAS5 associates with topo IIα and subsequently enhancing the phosphorylation level of topo IIα. Taken together, our findings suggest that ecto-ATP synthase blockade is an effective therapeutic strategy via regulation of CK2/phospho-topo IIα/GAS5 network in gefitinib-resistant lung cancer cells. Full Article
iom Stoichiometry of Nucleotide Binding to Proteasome AAA+ ATPase Hexamer Established by Native Mass Spectrometry [Research] By www.mcponline.org Published On :: 2020-12-01T00:05:33-08:00 AAA+ ATPases constitute a large family of proteins that are involved in a plethora of cellular processes including DNA disassembly, protein degradation and protein complex disassembly. They typically form a hexametric ring-shaped structure with six subunits in a (pseudo) 6-fold symmetry. In a subset of AAA+ ATPases that facilitate protein unfolding and degradation, six subunits cooperate to translocate protein substrates through a central pore in the ring. The number and type of nucleotides in an AAA+ ATPase hexamer is inherently linked to the mechanism that underlies cooperation among subunits and couples ATP hydrolysis with substrate translocation. We conducted a native MS study of a monodispersed form of PAN, an archaeal proteasome AAA+ ATPase, to determine the number of nucleotides bound to each hexamer of the WT protein. We utilized ADP and its analogs (TNP-ADP and mant-ADP), and a nonhydrolyzable ATP analog (AMP-PNP) to study nucleotide site occupancy within the PAN hexamer in ADP- and ATP-binding states, respectively. Throughout all experiments we used a Walker A mutant (PANK217A) that is impaired in nucleotide binding as an internal standard to mitigate the effects of residual solvation on mass measurement accuracy and to serve as a reference protein to control for nonspecific nucleotide binding. This approach led to the unambiguous finding that a WT PAN hexamer carried – from expression host – six tightly bound ADP molecules that could be exchanged for ADP and ATP analogs. Although the Walker A mutant did not bind ADP analogs, it did bind AMP-PNP, albeit at multiple stoichiometries. We observed variable levels of hexamer dissociation and an appearance of multimeric species with the over-charged molecular ion distributions across repeated experiments. We posit that these phenomena originated during ESI process at the final stages of ESI droplet evolution. Full Article
iom A Mouse Brain-based Multi-omics Integrative Approach Reveals Potential Blood Biomarkers for Ischemic Stroke [Research] By www.mcponline.org Published On :: 2020-12-01T00:05:33-08:00 Stroke remains a leading cause of death and disability worldwide. Despite continuous advances, the identification of key molecular signatures in the hyper-acute phase of ischemic stroke is still a primary interest for translational research on stroke diagnosis, prognosis, and treatment. Data integration from high-throughput -omics techniques has become crucial to unraveling key interactions among different molecular elements in complex biological contexts, such as ischemic stroke. Thus, we used advanced data integration methods for a multi-level joint analysis of transcriptomics and proteomics data sets obtained from mouse brains at 2 h after cerebral ischemia. By modeling net-like correlation structures, we identified an integrated network of genes and proteins that are differentially expressed at a very early stage after stroke. We validated 10 of these deregulated elements in acute stroke, and changes in their expression pattern over time after cerebral ischemia were described. Of these, CLDN20, GADD45G, RGS2, BAG5, and CTNND2 were next evaluated as blood biomarkers of cerebral ischemia in mice and human blood samples, which were obtained from stroke patients and patients presenting stroke-mimicking conditions. Our findings indicate that CTNND2 levels in blood might potentially be useful for distinguishing ischemic strokes from stroke-mimicking conditions in the hyper-acute phase of the disease. Furthermore, circulating GADD45G content within the first 6 h after stroke could also play a key role in predicting poor outcomes in stroke patients. For the first time, we have used an integrative biostatistical approach to elucidate key molecules in the initial stages of stroke pathophysiology and highlight new notable molecules that might be further considered as blood biomarkers of ischemic stroke. Full Article
iom WITHDRAWN: Quantitative mass spectrometry analysis of PD-L1 protein expression, N-glycosylation and expression stoichiometry with PD-1 and PD-L2 in human melanoma [Research] By www.mcponline.org Published On :: 2017-04-28T07:30:39-07:00 This article has been withdrawn by the authors. We discovered an error after this manuscript was published as a Paper in Press. Specifically, we learned that the structures of glycans presented for the PD-L1 peptide were drawn and labeled incorrectly. We wish to withdraw this article and submit a corrected version for review. Full Article
iom High-throughput and site-specific N-glycosylation analysis of human alpha-1-acid glycoprotein offers a great potential for new biomarker discovery [Research] By www.mcponline.org Published On :: 2020-12-29T12:35:15-08:00 Alpha-1-acid glycoprotein (AGP) is an acute phase glycoprotein in blood, which is primarily synthetized in the liver and whose biological role is not completely understood. It consists of 45% carbohydrates that are present in the form of five N-linked complex glycans. AGP N-glycosylation was shown to be changed in many different diseases and some changes appear to be disease-specific, thus it has a great diagnostic and prognostic potential. However, AGP glycosylation was mainly analyzed in small cohorts and without detailed site-specific glycan information. Here, we developed a cost-effective method for a high-throughput and site-specific N-glycosylation LC-MS analysis of AGP which can be applied on large cohorts, aid in search for novel disease biomarkers and enable better understanding of AGP’s role and function in health and disease. The method does not require isolation of AGP with antibodies and affinity chromatography, but AGP is enriched by acid precipitation from 5 μl of bloodplasma in a 96 well format. After trypsinization, AGP glycopeptides are purified using a hydrophilic interaction chromatography based solid-phase extraction and analyzed by RP-LC-ESI-MS. We used our method to show for the first time that AGP N-glycan profile is stable in healthy individuals (14 individuals in 3 time points), which is a requirement for evaluation of its diagnostic potential. Furthermore, we tested our method on a population including individuals with registered hyperglycemia in critical illness (59 cases and 49 controls), which represents a significantly increased risk of developing type 2 diabetes. Individuals at higher risk of diabetes presented increased N-glycan branching on AGP’s second glycosylation site and lower sialylation of N-glycans on AGP’s third and AGP1’s fourth glycosylation site. Although this should be confirmed on a larger prospective cohort, it indicates that site-specific AGP N-glycan profile could help distinguish individuals who are at risk of type 2 diabetes. Full Article
iom Halloween candy binges can overload gut microbiome, spooking helpful bacteria By www.upi.com Published On :: Wed, 23 Oct 2024 13:50:45 -0400 While no candy is truly healthy, some options are better for your gut than others. And there are ways you can help wake your gut from its sugar "spell" after holiday indulgence. Full Article
iom Symposium: What Does the Microbiome Tell Us about Prevention and Treatment of AD/ADRD? By www.jneurosci.org Published On :: 2024-10-09T09:30:20-07:00 Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRDs) are broad-impact multifactorial neurodegenerative diseases. Their complexity presents unique challenges for developing effective therapies. This review highlights research presented at the 2024 Society for Neuroscience meeting which emphasized the gut microbiome's role in AD pathogenesis by influencing brain function and neurodegeneration through the microbiota–gut–brain axis. This emerging evidence underscores the potential for targeting the gut microbiota to treat AD/ADRD. Full Article
iom Climate risks projected to affect fish biomass around the world's ocean, FAO report says By www.fao.org Published On :: Mon, 08 Jul 2024 00:00:00 GMT Fish biomass faces steep falls by end of century under high-emissions scenario Full Article
iom Biomimicry and Butterflies: How Nature is Inspiring Design and Innovation By www.smithsonianmag.com Published On :: Thu, 31 Oct 2024 00:00:00 -0000 More on biomimicry: http://j.mp/RI3OOB Scientists believe the iridescent wings of the morphos butterfly could be used in technology to benefit humans. Full Article
iom Racehorse success may depend on their gut microbiome in early life By www.newscientist.com Published On :: Wed, 07 Aug 2024 11:00:27 +0100 Horses that are bred to race seem to perform better on the course if they had a diverse gut microbiome as foals Full Article
iom The vital viruses that shape your microbiome and your health By www.newscientist.com Published On :: Tue, 09 Jul 2024 17:00:00 +0100 Your body is home to trillions of beneficial viruses crucial for a healthy microbiome. We may one day be able to tweak this "virome" to treat obesity and anxiety Full Article
iom The brain has its own microbiome. Here's what it means for your health By www.newscientist.com Published On :: Wed, 25 Sep 2024 17:00:00 +0100 Neuroscientists have been surprised to discover that the human brain is teeming with microbes, and we are beginning to suspect they could play a role in neurodegenerative disorders like Alzheimer's Full Article
iom One course of antibiotics can change your gut microbiome for years By www.newscientist.com Published On :: Tue, 29 Oct 2024 15:00:35 +0000 Antibiotics can reduce diversity in the gut microbiome, raising the risk of infections that cause diarrhoea - and the effects may last years Full Article
iom Could Red Wine Boost Your 'Microbiome'? By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Could Red Wine Boost Your 'Microbiome'?Category: Health NewsCreated: 8/28/2019 12:00:00 AMLast Editorial Review: 8/29/2019 12:00:00 AM Full Article
iom Characterization and Prediction of Organic Anion Transporting Polypeptide 1B Activity in Prostate Cancer Patients on Abiraterone Acetate Using Endogenous Biomarker Coproporphyrin I [Articles] By dmd.aspetjournals.org Published On :: 2024-10-16T09:02:03-07:00 Organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 are important hepatic transporters. We previously identified OATP1B3 being critically implicated in the disposition of abiraterone. We aimed to further investigate the effects of abiraterone on the activities of OATP1B1 and OATP1B3 utilizing a validated endogenous biomarker coproporphyrin I (CP-I). We used OATP1B-transfected cells to characterize the inhibitory potential of abiraterone against OATP1B-mediated uptake of CP-I. Inhibition constant (Ki) was incorporated into our physiologically based pharmacokinetic (PBPK) modeling to simulate the systemic exposures of CP-I among cancer populations receiving either our model-informed 500 mg or clinically approved 1000 mg abiraterone acetate (AA) dosage. Simulated data were compared with clinical CP-I concentrations determined among our nine metastatic prostate cancer patients receiving 500 mg AA treatment. Abiraterone inhibited OATP1B3-mediated, but not OATP1B1-mediated, uptake of CP-I in vitro, with an estimated Ki of 3.93 μM. Baseline CP-I concentrations were simulated to be 0.81 ± 0.26 ng/ml and determined to be 0.72 ± 0.16 ng/ml among metastatic prostate cancer patients, both of which were higher than those observed for healthy subjects. PBPK simulations revealed an absence of OATP1B3-mediated interaction between abiraterone and CP-I. Our clinical observations confirmed that CP-I concentrations remained comparable to baseline levels up to 12 weeks post 500 mg AA treatment. Using CP-I as an endogenous biomarker, we identified the inhibition of abiraterone on OATP1B3 but not OATP1B1 in vitro, which was predicted and observed to be clinically insignificant. We concluded that the interaction risk between AA and substrates of OATP1Bs is low. SIGNIFICANCE STATEMENT The authors used the endogenous biomarker coproporphyrin I (CP-I) and identified abiraterone as a moderate inhibitor of organic anion transporting polypeptide (OATP) 1B3 in vitro. Subsequent physiologically based pharmacokinetic (PBPK) simulations and clinical observations suggested an absence of OATP1B-mediated interaction between abiraterone and CP-I among prostate cancer patients. This multipronged study concluded that the interaction risk between abiraterone acetate and substrates of OATP1Bs is low, demonstrating the application of PBPK-CP-I modeling in predicting OATP1B-mediated interaction implicating abiraterone. Full Article