Acousia Therapeutics GmbH, a Tübingen-based clinical stage biotech company focused on the enhancement and preservation of natural hearing, just announced the randomization of the first patient for the PROHEAR-Study. The PROHEAR-Study is a placebo-controlled, Phase 2a study with split-body design, which investigates the otoprotective efficacy of ACOU085 in patients with testicular cancer undergoing high-dose cisplatin-based chemotherapy regimens (cis-Pt ≥300 mg/m2).

Aachen, Germany, 22 October 2024 – Today, Grünenthal announced that the first participants have been enrolled in a first-in-human Phase I clinical trial for a nociceptin (NOP) receptor agonist. The trial will include 90 healthy volunteers and aims to demonstrate a favourable safety and tolerability profile and to confirm the pharmacokinetic characteristics of the compound after single and multiple ascending doses. The results of the trial are expected in Q3 2025.

On Saturday 18 June, A-ROSA's ground-breaking new river cruise ship, A-ROSA SENA, departed from Cologne on her maiden voyage.

AltamarCAM and Inbest-GPF, together with the Austrian Group Lanserhof, join forces to invest 100 million euros in the wellness sector.

Local artist was ticketed, tried, convicted, and fined under an outdated law after calling law enforcement "bullies" in Balboa Park within the City of San Diego.

A sheep farm in North Rhine-Westphalia in Germany produces the first textile made from the wool of gay rams, making a bold fashion statement for the LGBTQIA+ community.

- 29-year-old Anja Blacha from Bielefeld, supported by INTERSPORT, reached the South Pole within the planned 60 days and after more than 1,400km on her Antarctic expedition. - Anja Blacha is thus the first person to have made it to the South Pole solo, unassisted & unsupported and only on skis on this route length.

No one will be repeating this feat for a while: As the first German woman to do so, Nathalie Pohl completed the nearly 29-mile distance between the Hawaiian islands of Molokai and Oahu on August 17 (UTC–10).

With the 2024 National Squash League season upcoming in March 2024, the NSL, with the help of Louisville-based creative agency Honeywick, has launched a new site outlining news and events, including the first official National Squash League 2024 Draft Day, teams, players, results, and the official NSL rules.

The STIHL Group has published its first sustainability report, detailing the company's sustainability strategy and activities. The title of the report, "Acting for Tomorrow," reflects the philosophy by which the business has been guided since its founding over 95 years ago.

The Italian flag will be raised at the Navy Pier in Chicago 20-21 October for the debut of Vinitaly USA. This is the first Italian wine trade fair format in the United States organized by Veronafiere and Fiere Italiane with the support of ITA, the Italian Trade Agency.

Zug, Switzerland, 05.05.21 - 4ARTechnologies, the market leader in art security and digitization announces the next sensation: "We give art creators and collectors the exclusive opportunity to create the world's only secure NFT with our technology." - CEO Niko Kipouros.

ChessBase, the world leading chess software company, announces the auction of a unique collection of currently 14 artworks with the chess world champions. Each champion's artwork is a unique 1080 x 1080 px GIF showing the notation of one of his most famous games, a ray traced 3D rendering of the key position and a photo of the champion from his active time. These are all authorized by the champion himself or his family resp. descendants.

Falco's Fender electric bass guitar, played in the 70/80s during performances with the music group Drahdiwaberl, starting bid €10,000

Starting a small business is tough, but growing one — or just keeping it afloat — is even harder.

Even though more than 500,000 small businesses are created each year in the U.S., only half of them survive past their fifth year, according to the U.S. Small Business Administration.

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For many businesses, getting paid is not the problem – it’s when. Lumpy cash flow is a stressful experience for business owners because the consequences can include delayed paychecks to employees, missed bill payments or stalled growth due to an inability to take on new clients. So, how can business owners avoid putting themselves at the mercy of clients and when those clients mail their checks?

complete article

Perhaps it is time to embrace some new first principles.

Making a first impression is not easy. People are just so sensitive these days. Sensitive about themselves, that is.

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Twelve months later we have a full-time team and a company successful beyond our wildest dreams. Digital Press, named during one of our many coffee-on-an-apartment-balcony conversations, has been our attempt to empower the world's smartest people to share what they know. We work with carefully selected CEOs, entrepreneurs, investors, and venture capitalists (primarily at businesses doing $10M to $300M in revenue) to share their hard-earned insight with the internet. None of the atrocious writing most PR firms peddle as acumen. None of the ad-speak or jargon nobody finds helpful. Just the hard lessons learned and the personal stories of how these successful people learned them.

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Email is not going anywhere. There are 3.7 billion global email users, and that number is expected to grow to 4.1 billion by 2021. What is more, this communication channel is supremely popular: People check their emails multiple times a day, and when you're trying to market your company, you can get your name into thousands of inboxes just by launching an email marketing campaign.

The cost? Email marketing is also super-affordable, which makes it great for small businesses.

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Like departments and agencies throughout government, the Air Force is tuning its acquisition methods to get closer the speed of technology, and will be holding its first live pitch day in March, with an available funding pool of $40 million.

The Air Forces Small Business Innovation Research program has issued a call to start-ups and small businesses—those with fewer than 500 employees—to offer pitches on innovative technologies for secure communications, down-range battlefield operations and digital technologies.

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I'm finally experimenting with writing macros in clojure. Learning macros is (for me at least) a 4 stage process:

1. Learn to use them (pretty straightforward)
2. Learn to read their implementations (including the quoting)
3. Learning to write them (in progress)
4. Learning when to write them (in progress)

Those last two are iterative; #4 is especially tricky -- the web is full of general considerations ("when a function won't do", "when you want new syntax", "when you need to make decisions at compile time", etc) - but actually making that judgment in practice, takes... well practice.

Hence this exercise. Anyway to the code:

Clojure offers the if-let and when-let macros that allow you to combine a let block with testing the binding for nil:

(when-let [a (some-fn)]  
   (do-something-with a))

(if-let [a (some-fn)]  
   (do-something-with a)  
   (otherwise-fn)) 

I found myself (on some real code) wanting to be able to do something similar with try:

(try-let [a (some-potentially-exceptional-fn)]
  (do-something-with a))

(try-let [a (some-potentially-exceptional-fn)]
  (do-something-with a)
  ArithmeticException ((println (.getMessage e)) 42)
  :else (do-something-by-default-fn)
  :finally (println "always"))

etc.

So I wrote this (non-hygenic) macro that seems to do the job:

(defmacro try-let [let-expr good-expr & {fin-expr :finally else-expr :else :as handlers}]
  (letfn [(wrap [arg] (if (seq? arg) arg (list arg)))]
  `(try (let ~let-expr ~good-expr)
    ~@(map #(apply list 'catch (key %) 'e (wrap (val %))) (dissoc handlers :finally :else))
    ~(if else-expr `(catch Exception ~'e ~else-expr))
    (finally ~(if fin-expr `~fin-expr ())))))

Thing is... I don't if it's a good idea or not. For one thing its not hygienic (it implicitly declares e that can be used in the handler clauses) though this seems the kind of case that sort of thing is for.

For another... I don't know if its correct. It seems to be (I've tested all the scenarios I can think of), but this is kinda like security -- I suspect anyone can write a macro that they themselves can't break, but that doesn't mean its correct.

Some things to note: - e is available to handler expressions
- the local function wrap allows for a complex expression or single value to be spliced in
- any number of handlers can be included
- ':else' (default) handler and ':finally' handlers are optional (as are any others!)

In short: I'm interested in any opinions/feedback that aim at learning steps 3 & 4 (writing and when to write). Fire away!

The first annual “Sing 4 Fing” event, held on Saturday, October 5th, in Nashville, raised over $7,000 for the Alzheimer’s Foundation of America, making it a night to remember for both music lovers and supporters …

We started our 2015-2016 school year today! I know July 13th is early but I wanted our first semester to be completed by Charlotte Emma's due date. We finished last school year mid-May so we have had a 2 month summer break.

I have a regular Elementary School this year. :)
Kate-5th, Claire - 4th, Henry - 2nd, Jack - K, and Sims - K4

And every school needs a mascot or two. Here are ours:
Miles - 2, Luke - 8 months
I'm sure they will provide plenty of comic relief to our days.

Today was probably the best first day we've had. Everyone was excited, worked hard, and there was still plenty of time to play all afternoon.

Here are a few pictures from Charlotte's first week. I'm planning to write up the story of her birth in the next few days so I will not forget anything.

People tell the story of their first car on longtime TTM reader John's new blogsite.

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