Generation Xers accounted for half of all the people that died in smoking related fires and a third of injuries, according to new data from London Fire Brigade.

Edelman, 33, also said he has attended synagogue during the football season.

"Tammy's Always Dying" is a low-key, insightful comic drama about a striving woman and her albatross-like mother, played by Felicity Huffman.

As many as 75,000 Americans could die because of drug or alcohol misuse and suicide as a result of the coronavirus pandemic, according to an analysis conducted by the national public health group Well Being Trust.

Washington County principal Burke Staheli continues to motivate and inspire students who are studying from home by posting daily messages on Facebook.

On March 6, there were five people in the Lawrence Central gym who later died after testing positive for coronavirus.

The current best guess of a 1% death rate does not apply to everyone.

The Shelburne Retirement Residence has been devastated by an outbreak of COVID-19, with 90 per cent of its residents becoming infected.

(University of Iowa Health Care) A $3.7 million grant from the Centers for Disease Control and Prevention (CDC) has been awarded to the University of Iowa Carver College of Medicine and the David Geffen School of Medicine at UCLA to study ways to reduce the risk of COVID-19 infection among frontline health care workers in hospital emergency departments.

Bile acids (BAs) serve multiple biological functions, ranging from the absorption of lipids and fat-soluble vitamins to serving as signaling molecules through the direct activation of dedicated cellular receptors. Synthesized by both host and microbial pathways, BAs are increasingly understood as participating in the regulation of numerous pathways relevant to metabolic diseases, including lipid and glucose metabolism, energy expenditure, and inflammation. Quantitative analyses of BAs in biological matrices can be problematic due to their unusual and diverse physicochemical properties, making optimization of a method that shows good accuracy, precision, efficiency of extraction, and minimized matrix effects across structurally distinct human and murine BAs challenging. Herein we develop and clinically validate a stable-isotope-dilution LC/MS/MS method for the quantitative analysis of numerous primary and secondary BAs in both human and mouse biological matrices. We also utilize this tool to investigate gut microbiota participation in the generation of structurally specific BAs in both humans and mice. We examine circulating levels of specific BAs and in a clinical case-control study of age- and gender-matched type 2 diabetes mellitus (T2DM) versus nondiabetics. BAs whose circulating levels are associated with T2DM include numerous 12α-hydroxyl BAs (taurocholic acid, taurodeoxycholic acid, glycodeoxycholic acid, deoxycholic acid, and 3-ketodeoxycholic acid), while taurohyodeoxycholic acid was negatively associated with diabetes. The LC/MS/MS-based platform described should serve as a robust, high-throughput investigative tool for studying the potential involvement of structurally specific BAs and the gut microbiome on both physiological and disease processes.

apoB exists as apoB100 and apoB48, which are mainly found in hepatic VLDLs and intestinal chylomicrons, respectively. Elevated plasma levels of apoB-containing lipoproteins (Blps) contribute to coronary artery disease, diabetes, and other cardiometabolic conditions. Studying the mechanisms that drive the assembly, intracellular trafficking, secretion, and function of Blps remains challenging. Our understanding of the intracellular and intraorganism trafficking of Blps can be greatly enhanced, however, with the availability of fusion proteins that can help visualize Blp transport within cells and between tissues. We designed three plasmids expressing human apoB fluorescent fusion proteins: apoB48-GFP, apoB100-GFP, and apoB48-mCherry. In Cos-7 cells, transiently expressed fluorescent apoB proteins colocalized with calnexin and were only secreted if cells were cotransfected with microsomal triglyceride transfer protein. The secreted apoB-fusion proteins retained the fluorescent protein and were secreted as lipoproteins with flotation densities similar to plasma HDL and LDL. In a rat hepatoma McA-RH7777 cell line, the human apoB100 fusion protein was secreted as VLDL- and LDL-sized particles, and the apoB48 fusion proteins were secreted as LDL- and HDL-sized particles. To monitor lipoprotein trafficking in vivo, the apoB48-mCherry construct was transiently expressed in zebrafish larvae and was detected throughout the liver. These experiments show that the addition of fluorescent proteins to the C terminus of apoB does not disrupt their assembly, localization, secretion, or endocytosis. The availability of fluorescently labeled apoB proteins will facilitate the exploration of the assembly, degradation, and transport of Blps and help to identify novel compounds that interfere with these processes via high-throughput screening.

Maria Sörhede Winzell
Dec 1, 2004; 53:S215-S219
Section V: The Incretin Pathway

Never mind Lawyers, Children with no mouths, Never mind Inspiration, Write Now. Photo – ♦Personal♦ -short evocative poetry-

All doctors, irrespective of their specialty or the setting in which they work, will care for patients who die. Around half of all deaths occur in hospitals. Evidence suggests that the quality of communication around this process is poorer in hospitals than in other settings, according to responses from relatives who have experienced bereavement....

The BMJ publishes a lot of educational articles, and in an attempt to help you with your CPD, we have put together this round-up. Our authors and editors will reflect on the key learning points in the articles we discuss, and explain how they may change their practice in light of that new understanding. In this week's round up we're...

Bobbie Farsides is professor of clinical and biomedical ethics at Brighton and Sussex Medical School. She’s been described as one of the few people that is acceptable to “both sides” of the assisted dying debate. This week she joins us to talk about the way in which the debate on euthanasia has played out in the UK - and hear why she thinks it’s...

The Royal College of Physicians will survey all its members in February on this most controversial question. It says that it will move from opposition to neutrality on assisted dying unless 60% vote otherwise. The BMJ explores several conflicting views. From Canada, palliative care doctor Sandy Buchman explains why he sees medical aid in dying...

Boyer, Anne, 1973-

Death -- Psychological aspects.

Arkaprava Roy, Subhashis Ghosal, Jeffrey Prescott, Kingshuk Roy Choudhury.

Source: The Annals of Applied Statistics, Volume 13, Number 3, 1791--1816.

Abstract:
We study possible relations between Alzheimer’s disease progression and the structure of the connectome which is white matter connecting different regions of the brain. Regression models in covariates including age, gender and disease status for the extent of white matter connecting each pair of regions of the brain are proposed. Subject inhomogeneity is also incorporated in the model through random effects with an unknown distribution. As there is a large number of pairs of regions, we also adopt a dimension reduction technique through graphon ( J. Combin. Theory Ser. B 96 (2006) 933–957) functions which reduces the functions of pairs of regions to functions of regions. The connecting graphon functions are considered unknown but the assumed smoothness allows putting priors of low complexity on these functions. We pursue a nonparametric Bayesian approach by assigning a Dirichlet process scale mixture of zero to mean normal prior on the distributions of the random effects and finite random series of tensor products of B-splines priors on the underlying graphon functions. We develop efficient Markov chain Monte Carlo techniques for drawing samples for the posterior distributions using Hamiltonian Monte Carlo (HMC). The proposed Bayesian method overwhelmingly outperforms a competing method based on ANCOVA models in the simulation setup. The proposed Bayesian approach is applied on a dataset of 100 subjects and 83 brain regions and key regions implicated in the changing connectome are identified.

See how researchers at Smithsonian's National Zoo are trying to glean insight into elephant foraging behavior and more.

Authoritarian rule may be just around the corner.

A long-term OM worker in North Africa has the opportunity to study the Bible with local friends.

Vatican City, May 5, 2020 / 03:30 am (CNA).- Pope Francis prayed for those who have died alone during the coronavirus pandemic at his morning Mass Tuesday.

At the start of Mass in the chapel at Casa Santa Marta, his Vatican residence, he said May 5: "Today we pray for the deceased who have died because of the pandemic. They have died alone, without the caresses of their loved ones. So many did not even have a funeral. May the Lord welcome them in His glory."

More than 250,000 people have died of COVID-19 worldwide as of May 5, according to Johns Hopkins University Coronavirus Resource Center.

In his homily, the pope reflected on the day’s Gospel reading (John 10:22-30), in which Jesus is asked to declare openly whether he is the Christ. Jesus replies that he has already told his listeners, but they have not believed him because they are not among his sheep.  

Pope Francis urged Catholics to ask themselves: “What makes me stop outside the door that is Jesus?”

One major obstacle is wealth, the pope said.

“There are many of us who have entered the door of the Lord but then fail to continue because we are imprisoned by wealth,” he said, according to a transcript by Vatican News. 

“Jesus takes a hard line regarding wealth… Wealth keeps us from going ahead. Do we need to fall into poverty? No, but, we must not become slaves to wealth. Wealth is the lord of this world, and we cannot serve two masters.”

The pope added that another barrier to progress towards Jesus is rigidity of heart.  

He said: “Jesus reproached the doctors of the law for their rigidity in interpreting the law, which is not faithfulness. Faithfulness is always a gift of God; rigidity is only security for oneself.”

As an example of rigidity, the pope recalled that once when he visited a parish a woman asked him whether attending a Saturday afternoon nuptial Mass fulfilled her Sunday obligation. The readings were different to those on Sunday so she worried that she might have committed a mortal sin. 

Rigidity leads us away from the wisdom of Jesus and robs us of our freedom, he said.

The pope named two further obstacles: acedia, which he defined as a tiredness that “takes away our desire to strive forward” and makes us lukewarm, and clericalism, which he described as a disease that takes away the freedom of the faithful. 

He identified worldliness as the final obstacle to approaching Jesus. 

“We can think of how some sacraments are celebrated in some parishes: how much worldliness there is there,” he said. 

“These are some of the things that stop us from becoming members of Jesus’s flock. We are ‘sheep’ of all these things -- wealth, apathy, rigidity, worldliness, clericalism, ideologies. But freedom is lacking and we cannot follow Jesus without freedom. ‘At times freedom might go too far, and we might slip and fall.’ Yes, that’s true. But this is slipping before becoming free.”

After Mass, the pope presided at adoration and benediction of the Blessed Sacrament, before leading those watching via livestream in an act of spiritual communion.

The congregation then sang the Easter Marian antiphon "Regina caeli."

At the end of his homily, the pope prayed: “May the Lord enlighten us to see within ourselves if we have the freedom required to go through the door which is Jesus, to go beyond it with Jesus in order to become sheep of His flock.”

OM EAST is helping meet the need for Bible study booklets to help Bayash Christians grow in their faith.

Pediatric palliative care (PC) can be beneficial to children with life-threatening conditions and their families by providing symptom management and control, sibling support, bereavement services, spiritual guidance, support in decision-making about limiting burdensome medical interventions, and advance directives.

Little is known about actual receipt of PC by dying children. This study compares characteristics of dying children by receipt of PC and highlights underserved patient groups who could be targeted to improve access. (Read the full article)

The study is the second in a series, after an earlier report found that OPEC’s spare capacity reduces oil price volatility and generates as much as $200 bn of annual economic benefits for the world economy.

One or two new runners for the units at the 355-MW Brazeau Power Station in Alberta, Canada, would allow owner TransAlta Corp. to better optimize revenue and provide valuable ancillary services. Modeling of the various upgrade options allowed the utility to arrive at the most valuable solution.

By RNZ The cost of mandatory quarantine on both sides of the Tasman means a New Zealander living in Brisbane will not be reunited with his dying mother in Auckland.A close friend of the man - both of whom RNZ has agreed not...

Prague Daily Monitor

There are about 90 Czech students studying in China from all over the country. The Ministry of Foreign Affairs has said that due to the coronavirus, they will assist students in getting back to the Czech Republic if the students are interested. Students should follow updates from the ministry.

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The cosmos is stranger than we ever imagined and new bubbles of space-time may pop up and grow continuously with no beginning or end, writes Chanda Prescod-Weinstein

Pandemics of the past can teach us about the current one, says John Troyer, who studies how we use technology to alter the experience of death

From vintage satellites to lunar rovers, space archaeologist Alice Gorman is teasing out a unique history of humanity from the objects we've dispatched from Earth

Pandemics of the past can teach us about the current one, says John Troyer, who studies how we use technology to alter the experience of death

From vintage satellites to lunar rovers, space archaeologist Alice Gorman is teasing out a unique history of humanity from the objects we've dispatched from Earth

After stories of people not being allowed to say goodbye to loved ones dying of coronavirus, hospitals around the world are moving to change the rules.

No one knows exactly how the nocturnal hunters manage their whisper-soft flight, yet it's inspiring the design of quieter airplanes, fans and wind turbines

Follow our live coronavirus updates HERE Coronavirus: the symptoms

Learning more about flying reptiles that lived more than 200 million years ago could help more efficient drones be developed, scientists have said.

Most are doing their best to avoid other people's germs right now. But for cleaners and those who get rid of that trash, they're coming into contact with COVID-19 every shift.

As talk of reopening aspects of society continue across the country, the Chief Justice of the Supreme Court of Canada Richard Wagner and federal Justice Minister David Lametti have begun a study into how courts could safely begin to resume regular operations in light of COVID-19.

Exclusive: Data suggests that sick may be avoiding hospital because of coronavirus fears

• Coronavirus – latest updates
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About 8,000 more people have died in their own homes since the start of the coronavirus pandemic than in normal times, a Guardian analysis has found, as concerns grow over the number avoiding going to hospital.

Of that total, 80% died of conditions unrelated to Covid-19, according to their death certificates. Doctors’ leaders have warned that fears and deprioritisation of non-coronavirus patients are taking a deadly toll.

'She was shot by an airgun'

Lockdown has granted me the blessing of getting to know my father, but it has also underlined the severe health inequalities we face

• Coronavirus – latest updates
• See all our coronavirus coverage

I hardly recognise the man in front of me. He staggers on one leg, his eye twitches, his stomach stretches past his waist.

“I got some fry bread for us,” he grins, his toothless smile reminding me he is getting old and so am I.”

From headlining the Super Bowl to reading up on Plato...

Indonesia's government dithered for nearly two months before enacting social restrictions. Tens of thousands could die of COVID-19.

Researchers in America have been studying famotidine, the active ingredient in Pepcid, as a potential treatment for COVID-19.

Clifford Winston and Robert Crandall say that the bankruptcies of major, long-standing law firms signal a change in how businesses and the public are choosing to find legal services. Winston and Crandall argue that deregulation would revitalize the industry, bringing new ideas, technologies, talents and operating procedures into the practice of law.

To make America happy again, society has to figure out how to make our country whole. Understanding what divides Americans—and what gives them hope—could be critical to improving their well-being and the nation’s. By tracking patterns in well-being, and creating programs based on the results, we can take steps toward tackling the malaise that afflicts…

"The time for complacency has passed. We must treat this crisis as if our lives, and the lives of our friends, families, and neighbors, depend on it. "