The 2016 killing of a Canberra man is portrayed as a "cold-blooded plan", designed to silence him over an earlier machete attack, on the first day of an ACT Supreme Court trial.

Scott Alan Murdoch, the man who stabbed Melbourne woman Kylie Blackwood and left her bleeding to death to be found by her 11-year-old twins, will have to serve at least 36 years before he is eligible for parole.

A man who had half his face shot off in a 2017 home invasion has fought back tears after a second man pleaded guilty in relation to his violent home invasion.

The victim of a violent home invasion in Newcastle has described his ongoing suffering and lifelong trauma after half his face was shot off in December 2017.

Repair specialists say it is part of a growing trend which has seen the invasive Asian house gecko destroying cooling systems across New South Wales and Queensland.

About 34,000 troops from several countries are playing out high-end war games in a mammoth training exercise designed to improve military cooperation.

The 20-year-old was reportedly shot in Hollywood Hills.

We started going to a personal trainer at the end of the summer, and it’s been really good–building strength, getting healthier. But the one thing that she badgered me about was bread. “You have to stop eating bread! Gluten is terrible for you. It’s what’s making your knees hurt. It’s causing inflammation in your finger […]

The lawmakers say the city should turn its attention to pricey contracts, testing payments and administrative costs before axing $181 million from school budgets that cover the salaries of teachers, social workers, and other staff.

A LOCUST plague and the spreading coronavirus could cause famine of "biblical" proportions in East Africa, experts have warned.

Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts, play a critical role in the compartmentalization of signaling pathways. Physical segregation of proteins in lipid rafts may modulate the accessibility of proteins to regulatory or effector molecules. Thus, lipid rafts serve as sorting platforms and hubs for signal transduction proteins. Cancer cells contain higher levels of intracellular cholesterol and lipid rafts than their normal non-tumorigenic counterparts. Many signal transduction processes involved in cancer development (insulin-like growth factor system and phosphatidylinositol 3-kinase-AKT) and metastasis [cluster of differentiation (CD)44] are dependent on or modulated by lipid rafts. Additional proteins playing an important role in several malignant cancers (e.g., transmembrane glycoprotein mucin 1) are also being detected in association with lipid rafts, suggesting a major role of lipid rafts in tumor progression. Conversely, lipid rafts also serve as scaffolds for the recruitment and clustering of Fas/CD95 death receptors and downstream signaling molecules leading to cell death-promoting raft platforms. The partition of death receptors and downstream signaling molecules in aggregated lipid rafts has led to the formation of the so-called cluster of apoptotic signaling molecule-enriched rafts, or CASMER, which leads to apoptosis amplification and can be pharmacologically modulated. These death-promoting rafts can be viewed as a linchpin from which apoptotic signals are launched. In this review, we discuss the involvement of lipid rafts in major signaling processes in cancer cells, including cell survival, cell death, and metastasis, and we consider the potential of lipid raft modulation as a promising target in cancer therapy.