alzheimer

An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders




alzheimer

11 foods linked to lower risk of Alzheimer's dementia

Researchers find an intriguing link between foods + drinks rich in flavonol and staving off dementia.




alzheimer

Common herpes virus causes signs of Alzheimer's disease in brain cells

A study of brain cells in a dish adds to growing evidence that Alzheimer’s disease can be caused by herpes viruses, but antiviral treatment may help stop it




alzheimer

Berries, Apples and Tea can Help Fight Alzheimer's Disease

Highlights: Consuming flavonoid-rich foods can keep Alzheimer's disease at bay Foods rich in flavonoids a




alzheimer

Gum Bacteria Implicated in Alzheimer's, Rheumatoid Arthritis

Gum disease bacterium was found to travel throughout the body, exuding toxins linked to Alzheimer's disease, rheumatoid arthritis and aspiration pneumonia, reported new findings.




alzheimer

Androgen Deprivation Therapy Increases Vulnerability to Dementia (and) Alzheimer's

Androgen deprivation therapy is a hormone-suppressing therapy used to treat prostate cancer. New research has found that androgen suppression therapy




alzheimer

Hormone Therapy for Prostate Cancer May Up Alzheimer's, Dementia Risk

Hormone therapy for prostate cancer, known as androgen deprivation therapy (ADT), may increase the risk of developing Alzheimer's disease (AD) and dementia, reports a new study.




alzheimer

Unleashing the Power of Big Data for Alzheimer's Disease and Dementia Research

More than 35 million people worldwide had dementia in 2010 and this number is expected to exceed 115 million by 2050. This paper reports on the opportunities offered by the informatics revolution and big data to address Alzheimer’s Disease and dementia. This will require careful planning and multi-stakeholder collaboration as technical, administrative, regulatory, infrastructure and financial obstacles emerge.




alzheimer

Barbara Windsor, 82, can still remember all of her Carry On jokes amid Alzheimer's battle

he former EastEnders actress, 82, is battling Alzheimer's but Christopher says she still manages to make her friends and family laugh.




alzheimer

Blackburn legend Tony Parkes breaks down in interview where it is revealed he has Alzheimer's

Legendary Blackburn Rovers coach Tony Parkes broke down in tears during a revealing interview with his daughter about his struggles with Alzheimers.   




alzheimer

EXCLUSIVE: Celebrity Apprentice star Leeza Gibbons reveals love for her mother who died of Alzheimer's inspired new jewelry designs - and why she gifted pieces to Olivia Newton-John and Brandi Glanville

Leeza Gibbons, 57, has made it halfway through Celebrity Apprentice, and now she has something else to celebrate. She is set to introduce her newest line of jewelry Wishes & Dreams.




alzheimer

Britain's Gran Talent: Singer, 96, with Alzheimer's will become BGT's oldest ever contestant

Nora Barton, 96, who has Alzheimer's will tonight fulfil her dream of singing at the London Palladium - becoming the oldest ever contestant on Britain's Got Talent to boot - to prove life isn't for being put on hold.




alzheimer

New drug to protect against Alzheimer: Study

This drug could help activate these mechanisms that support nerve health and prevent dementia.




alzheimer

Driving Force to Detect Alzheimer's Disease Biomarkers: The Application Of A Thioflavine T@Er-MOF Ratiometric Fluorescent Sensor for Smart Detection of Presenilin 1, amyloid β-protein and Acetyl Choline

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00440E, Paper
Xing Ze Wang, jing du, Nannan Xiao, Yan Zhang, Ling Fei, Jed D. LaCoste, Zhuo Huang, Qian wang, Xin Rui Wang, Bin Ding
Currently, the highly sensitive detection of Alzheimer's Disease (AD) biomarkers, namely presenilin 1, amyloid β-protein (Aβ), and acetylcholine (ACh), are vital to helping us prevent and diagnose AD. In this...
The content of this RSS Feed (c) The Royal Society of Chemistry




alzheimer

[ASAP] PROTAC Compounds Targeting a-Synuclein Protein for Treating Neurogenerative Disorders: Alzheimer’s and Parkinson’s Diseases

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00192




alzheimer

[ASAP] Discovery of RO7185876, a Highly Potent ?-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer’s Disease

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00109




alzheimer

Understanding alzheimer's : the complete Australian guide to the management and prevention of alzheimer's / Professor Ralph Martins ; foreword by Ita Buttrose, AO, OBE

Martins, Ralph, author




alzheimer

Electrochemical synthesis of selenyl-dihydrofurans via anodic selenofunctionalization of allyl-naphthol/phenol derivatives and their anti-Alzheimer activity

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00629G, Communication
Marcos R. Scheide, Alex R. Schneider, Guilherme A. M. Jardim, Guilherme M. Martins, Daniele C. Durigon, Sumbal Saba, Jamal Rafique, Antonio L. Braga
Herein, we report an eco-friendly, electrosynthetic approach for the intramolecular oxyselenylation of allyl-naphthol/phenol derivatives.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




alzheimer

Alzheimer’s research reset

Despite clinical trial failures, Alzheimer’s research is getting a reboot thanks to increased funding opportunities and new directions in the data.




alzheimer

Lifestyle changes may help prevent half of Alzheimer’s cases




alzheimer

A test for early detection of Alzheimer’s




alzheimer

Bis(ethylmaltolato)oxidovanadium(IV) inhibited the pathogenesis of Alzheimer's disease in triple transgenic model mice

Metallomics, 2020, 12,474-490
DOI: 10.1039/C9MT00271E, Paper
Zhijun He, Shuangxue Han, Chong Wu, Lina Liu, Huazhang Zhu, Ang Liu, Qiying Lu, Jingqiang Huang, Xiubo Du, Nan Li, Qinguo Xie, Lu Wan, Jiazuan Ni, Lingling Chen, Xiaogai Yang, Qiong Liu
BEOV activates PPARγ to affect JAK2/STAT3/SOCS1 signaling and eventually prevents Aβ generation. Meanwhile, BEOV inactivates PTP1B to affect PI3K/Akt/GSK3β signaling and finally reduces tau hyperphosphorylation.
The content of this RSS Feed (c) The Royal Society of Chemistry




alzheimer

Correction: Bis(ethylmaltolato)oxidovanadium(IV) inhibited the pathogenesis of Alzheimer's disease in triple transgenic model mice

Metallomics, 2020, 12,631-631
DOI: 10.1039/D0MT90008G, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Zhijun He, Shuangxue Han, Chong Wu, Lina Liu, Huazhang Zhu, Ang Liu, Qiying Lu, Jingqiang Huang, Xiubo Du, Nan Li, Qingguo Xie, Lu Wan, Jiazuan Ni, Lingling Chen, Xiaogai Yang, Qiong Liu
The content of this RSS Feed (c) The Royal Society of Chemistry




alzheimer

Evidence that levels of nine essential metals in post-mortem human-Alzheimer's-brain and ex vivo rat-brain tissues are unaffected by differences in post-mortem delay, age, disease staging, and brain bank location

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00048E, Paper
Melissa Scholefield, Stephanie J. Church, Jingshu Xu, Sarah Kassab, Natalie J. Gardiner, Federico Roncaroli, Nigel M. Hooper, Richard D. Unwin, Garth J. S. Cooper
Metal findings in human Alzheimer brains are consistent despite differences in sample post-mortem delay, age, Braak stage and biobank location.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




alzheimer

[ASAP] Bifunctional Au@Pt/Au core@shell Nanoparticles As Novel Electrocatalytic Tags in Immunosensing: Application for Alzheimer’s Disease Biomarker Detection

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00760




alzheimer

[ASAP] 27-Plex Tandem Mass Tag Mass Spectrometry for Profiling Brain Proteome in Alzheimer’s Disease

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00655




alzheimer

Development of novel N-(6-methanesulfonyl-benzothiazol-2-yl)-3-(4-substituted-piperazin-1-yl)-propionamides with cholinesterase inhibition, anti-β-amyloid aggregation, neuroprotection and cognition enhancing properties for the therapy of Alzheimer's d

RSC Adv., 2020, 10,17602-17619
DOI: 10.1039/D0RA00663G, Paper
Open Access
Chandra Bhushan Mishra, Shruti Shalini, Siddharth Gusain, Amresh Prakash, Jyoti Kumari, Shikha Kumari, Anita Kumari Yadav, Andrew M. Lynn, Manisha Tiwari
A novel series of benzothiazole–piperazine hybrids were rationally designed, synthesized, and evaluated as multifunctional ligands against Alzheimer's disease (AD).
The content of this RSS Feed (c) The Royal Society of Chemistry






alzheimer

Lilly and Roche antiamyloid drugs fail in trial of early-onset Alzheimer's trial




alzheimer

Biogen bets big on Sangamo's zinc fingers to treat Alzheimer's

Biogen will pay the biotech firm $350 million upfront and get rights to its therapies for up to 12 neurological diseases




alzheimer

[ASAP] Mesenchymal Stem Cells Could Be Considered as a Candidate for Further Studies in Cell-Based Therapy of Alzheimer’s Disease via Targeting the Signaling Pathways

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.0c00052




alzheimer

[ASAP] A Multifunctional Chemical Agent as an Attenuator of Amyloid Burden and Neuroinflammation in Alzheimer’s Disease

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.0c00114




alzheimer

Variants in the ATP-Binding Cassette Transporter (ABCA7), Apolipoprotein E ε4, and the Risk of Late-Onset Alzheimer Disease in African Americans

Interview with Richard Mayeux, MD, MSc, author of Variants in the ATP-Binding Cassette Transporter (ABCA7), Apolipoprotein E ε4, and the Risk of Late-Onset Alzheimer Disease in African Americans




alzheimer

Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease: The TEAM-AD VA Cooperative Randomized Trial

Interview with Maurice W. Dysken, MD, author of Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease: The TEAM-AD VA Cooperative Randomized Trial




alzheimer

Effect of Citalopram on Agitation in Alzheimer Disease

Interview with Constantine G. Lyketsos, MD, MHS, author of Effect of Citalopram on Agitation in Alzheimer Disease





alzheimer

Alzheimer Outlook Far From Bleak

Rudolph Tanzi, PhD, of Harvard University, and Berislav Zlokovic, MD, PhD, of the University of Southern California, discuss what the future holds for Alzheimer Disease research and treatment.




alzheimer

The influence of amyloid-beta, a major pathological marker in Alzheimer's disease, on molecular cognitive processes of APP+PS1 transgenic mice




alzheimer

Microglia activation in Alzheimer's disease




alzheimer

An assessment of cognitive and sensorimotor deficits associated with appsw and p301l mouse models of alzheimer's disease




alzheimer

Effects of hyperoxia in alzheimers transgenic mice




alzheimer

Neuroinflammation in Alzheimers disease




alzheimer

Promoting and preventing alzheimer's disease in a transgenic mouse model




alzheimer

Dissecting out the contribution of cognitive, social, and physical activities to environmental enrichment's ability to protect Alzheimer's mice against cognitive impairment




alzheimer

Effects of adoptive transfer of beta-amyloid sensitive immune cells in a mouse model for Alzheimer's disease




alzheimer

Effects of long-term administration of caffeine in a mouse model for Alzheimer's disease




alzheimer

Effects of A-beta immunotherapy and Omega-3 fatty acid administration in Alzheimer's transgenic mice




alzheimer

Chromosome missegregation in Alzheimer's disease caused by presenilin 1




alzheimer

Tyrosinase-like activity of several Alzheimer's disease related and model peptides and their inhibition by natural antioxidants