En este episodio, La Luciérnaga se enciende para revisar las últimas decisiones comunicadas por la Jurisdicción Especial para la Paz. También, porqué han aumentado las quejas sobre los servicios de las aerolíneas. Además, Claudia López le dejó su carro a Don Hidráulico, el mecánico de La Luciérnaga.La Luciérnaga, un espacio de humor, análisis y opinión de Caracol Radio que acompaña desde hace 30 años a sus oyentes en el regreso a casa.

La Luciérnaga se enciende para hablar sobre el decreto que firmó Gustavo Petro, el cual aumentaría el salario de los congresistas en un 24,62%. Así, la asignación de los miembros del Congreso se reajustará cada año en proporción igual al promedio ponderado de los cambios ocurridos en la remuneración de los servidores de la administración central. También, este martes se firmó el acta con la que se da permiso a la construcción del viaducto de la primera línea del Metro de Bogotá. A esto se le añade la compra de predios y el traslado de redes principales. Además, el aeropuerto El Dorado de Bogotá nuevamente está en la mira por el alto costo de los servicios y artículos que ofrece. Una mujer tuvo que pagar 7.000 pesos por imprimir una hoja y usar el computador durante cuatro minutos.La Luciérnaga, un espacio de humor y opinión de Caracol Radio que acompaña desde hace más de 30 años a sus oyentes en el regreso a casa.

Escuche el programa de este martes 19 de diciembre. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que acompaña por más de 30 años a sus oyentes en el regreso a casa.

Escuche el programa de este miércoles 20 de diciembre. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que acompaña por más de 30 años a sus oyentes en el regreso a casa.

Escuche el programa de este miércoles 10 de abril. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que desde hace 31 años acompaña a sus oyentes en su regreso casa.

Escuche el programa de este lunes 30 de septiembre. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que desde hace 31 años acompaña a sus oyentes en su regreso casa.

Caracol Radio habló con la familias que llegaron desde un vuelo de El Paso, Texas, quienes  denuncian malos tratos por parte de las autoridades de ese país

Alexandre Guimaraes, director técnico del América de Cali, destacó, en diálogo con El Alargue de Caracol Radio, la actualidad de su grupo de jugadores en el presente campeonato. El estratega brasileño habló de la madurez del grupo y el compromiso colectivo por lograr el título, además de la posibilidad de sumar nuevos jugadores a su nómina para este semestre, principalmente un portero.

Tulio Gómez, máximo accionista del América de Cali, no se guardó nada en diálogo con El Alargue de Caracol Radio. Gómez habló de la llegada de Tulio Gómez, la ilusión de alcanzar la estrella 16, los refuerzos que se han sumado al equipo y la situación de algunos jugadores. Aunque no se arrepintió por no haber fichado a Hugo Rodallega, contó que no se sumó al equipo por el anterior cuerpo técnico de Alexandre Guimaraes.

A través de un informe, la Aerocivil contó la forma en que los 4 menores sobrevivieron durante 40 días en la selva del Guaviare.

En 6AM Hoy por Hoy de Caracol Radio, que se transmite desde la ciudad de Cali este viernes 28 de junio, estuvo Alejandro Eder, alcalde de la capital del Valle del Cauca, para brindar un panorama general de la situación actual de la ciudad.

En Caracol Radio estuvo Paula Bernal, country manager (Gerente) de IATA en Colombia

The Clipper Round the World Yacht Race fleet — which consists of eleven 70-foot ocean racing yachts — arrived on the island earlier this week, marking the first time the race has stopped in Bermuda. The Clipper race spans some 40,000 nautical miles as the vessels circumnavigate the globe, with Bermuda one of the eight stops the […]

Videographer Conor Outerbridge recently struck gold with his drone, capturing a pod of ten whales cavorting a few miles off Bermuda, with his drone, moving quietly just above the whales, capturing their behaviour in incredible detail. The animals do not stay in Bermuda year-round, but as the island lies in the middle of their annual migratory […]

As is traditional, supporters of the winning team made their way onto the field after their club won the Cup Match Classic, with Somerset supporters rushing out after Somerset claimed an emphatic victory at the 2024 Cup Match Classic. For all our coverage of Cup Match click here and for comprehensive coverage of all aspects of Cup Match please […]

Хотелось сказать пару слов о самом альбоме. Мы сделали просто колоссальное количество отсылок и скрытых смыслов, альбом буквально пропитан ими. В нём абсолютно нет места случайностям и совпадениям, каждая мысль, вложенная нами, была четко выверена и ювелирно врезана в музыку, слова, дизайн и даже числа. Все эти вещи образуют единую концепцию всего альбома. Как вы могли обратить внимание из названия альбома и обложки, в этой работе мы затронули довольно сложную тему равенства. Постарались раскрыть наиболее темные и ужасающие стороны людских поступков, показать, насколько человеческая природа еще несовершенна и неразумна.

В очередной раз скромно надеемся на вашу поддержку, делитесь вашим впечатлением об альбоме (даже негативным), нам важно мнение каждого, ведь впереди еще более глобальная работа над третьим альбомом.
#Atra_Haeresis #AtraHaeresis

The Iranian threat actor known as TA455 has been observed taking a leaf out of a North Korean hacking group's playbook to orchestrate its own version of the Dream Job campaign targeting the aerospace industry by offering fake jobs since at least September 2023. "The campaign distributed the SnailResin malware, which activates the SlugResin backdoor," Israeli cybersecurity company ClearSky said

A new study traces the farming heritage of Wales and shows there's more to the common sheep pen than meets the eye.

The dominant role of CaV2 voltage-gated calcium channels for driving neurotransmitter release is broadly conserved. Given the overlapping functional properties of CaV2 and CaV1 channels, and less so CaV3 channels, it is unclear why there have not been major shifts toward dependence on other CaV channels for synaptic transmission. Here, we provide a structural and functional profile of the CaV2 channel cloned from the early-diverging animal Trichoplax adhaerens, which lacks a nervous system but possesses single gene homologues for CaV1–CaV3 channels. Remarkably, the highly divergent channel possesses similar features as human CaV2.1 and other CaV2 channels, including high voltage–activated currents that are larger in external Ba2+ than in Ca2+; voltage-dependent kinetics of activation, inactivation, and deactivation; and bimodal recovery from inactivation. Altogether, the functional profile of Trichoplax CaV2 suggests that the core features of presynaptic CaV2 channels were established early during animal evolution, after CaV1 and CaV2 channels emerged via proposed gene duplication from an ancestral CaV1/2 type channel. The Trichoplax channel was relatively insensitive to mammalian CaV2 channel blockers ω-agatoxin-IVA and ω-conotoxin-GVIA and to metal cation blockers Cd2+ and Ni2+. Also absent was the capacity for voltage-dependent G-protein inhibition by co-expressed Trichoplax Gβγ subunits, which nevertheless inhibited the human CaV2.1 channel, suggesting that this modulatory capacity evolved via changes in channel sequence/structure, and not G proteins. Last, the Trichoplax channel was immunolocalized in cells that express an endomorphin-like peptide implicated in cell signaling and locomotive behavior and other likely secretory cells, suggesting contributions to regulated exocytosis.

TROY, Mich., Oct. 17, 2024 — Altair, a global leader in computational intelligence, is proud to announce its collaboration with Motivo, a product engineering firm for clients in the mobility, […]

The post Altair’s HPC and Simulation Solutions Advance Motivo’s Aerospace Prototyping appeared first on HPCwire.

TROY, Mich., Nov. 12, 2024 — Altair, a global leader in computational intelligence, has entered into collaboration agreement with the European Space Agency (ESA) through the ESA Partnership Initiative for […]

The post Altair Partners with European Space Agency to Advance AI-Driven Aerospace Innovation appeared first on HPCwire.

This fall, five South Carolina high schools will offer an aerospace curriculum to develop the next generation of aviation technology talent in a state where officials say the industry is thriving.

We used virus-mediated anterograde and retrograde tracing, optogenetic modulation, immunostaining, in situ hybridization, and patch-clamp recordings in acute brain slices to study the release mechanism and μ-opioid modulation of the dual glutamatergic/GABAergic inputs from the ventral tegmental area and supramammillary nucleus to the granule cells of the dorsal hippocampus of male and female mice. In keeping with previous reports showing that the two transmitters are released by separate active zones within the same terminals, we found that the short-term plasticity and pharmacological modulation of the glutamatergic and GABAergic currents are indistinguishable. We further found that glutamate and GABA release at these synapses are both virtually completely mediated by N- and P/Q-type calcium channels. We then investigated μ-opioid modulation of these synapses and found that activation of μ-opioid receptors (MORs) strongly inhibits the glutamate and GABA release, mostly through inhibition of presynaptic N-type channels. However, the modulation by MORs of these dual synapses is complex, as it likely includes also a disinhibition due to downmodulation of local GABAergic interneurons which make direct axo-axonic contacts with the dual glutamatergic/GABAergic terminals. We discuss how this opioid modulation may enhance LTP at the perforant path inputs, potentially contributing to reinforce memories of drug-associated contexts.

GABAergic inhibitory interneurons comprise many subtypes that differ in their molecular, anatomical, and functional properties. In mouse visual cortex, they also differ in their modulation with an animal’s behavioral state, and this state modulation can be predicted from the first principal component (PC) of the gene expression matrix. Here, we ask whether this link between transcriptome and state-dependent processing generalizes across species. To this end, we analysed seven single-cell and single-nucleus RNA sequencing datasets from mouse, human, songbird, and turtle forebrains. Despite homology at the level of cell types, we found clear differences between transcriptomic PCs, with greater dissimilarities between evolutionarily distant species. These dissimilarities arise from two factors: divergence in gene expression within homologous cell types and divergence in cell-type abundance. We also compare the expression of cholinergic receptors, which are thought to causally link transcriptome and state modulation. Several cholinergic receptors predictive of state modulation in mouse interneurons are differentially expressed between species. Circuit modelling and mathematical analyses suggest conditions under which these expression differences could translate into functional differences.

Hyperbilirubinemia (HB) is a key risk factor for hearing loss in neonates, particularly premature infants. Here, we report that bilirubin (BIL)-dependent cell death in the auditory brainstem of neonatal mice of both sexes is significantly attenuated by ZD7288, a blocker for hyperpolarization-activated cyclic nucleotide-gated (HCN) channel-mediated current (I_h), or by genetic deletion of HCN1. GABAergic inhibitory interneurons predominantly express HCN1, on which BIL selectively acts to increase their intrinsic excitability and mortality by enhancing HCN1 activity and Ca²⁺-dependent membrane targeting. Chronic BIL elevation in neonatal mice in vivo increases the fraction of spontaneously active interneurons and their firing frequency, I_h, and death, compromising audition at the young adult stage in HCN1^+/+, but not in HCN1^–/– genotype. We conclude that HB preferentially targets HCN1 to injure inhibitory interneurons, fueling a feedforward loop in which lessening inhibition cascades hyperexcitability, Ca²⁺ overload, neuronal death, and auditory impairments. These findings rationalize HCN1 as a potential target for managing HB encephalopathy.

High-speed video captures the unique ability of a leaping praying mantis to control its spin in mid-air and precisely land on a target.

StandardAero says new funding from the provincial and federal governments will help expand its Winnipeg operations by training more specialized technicians, managers, support personnel and engineers.

Stress, fluid flow, and motion analysis lend credence to company's designs for Boeing, Airbus, and other major aerospace companies

Keynote sessions will inspire attendees to “Design Without Limits”

ICTSI said it will use all legal channels to make sure that a Maersk subsidiary, "is not successful in holding the Durban port, and indeed the South African economy hostage to their interests".

Five Penn State aerospace engineering graduate students, including two brothers, were selected for the Science, Mathematics, and Research for Transformation Scholarship-for-Service Program, which is administered by the U.S. Department of Defense.

Firefly Aerospace has raised $175 million in a late-stage funding round led by RPM Ventures, valuing the space startup at more than $2 billion, it said on Tuesday.

Read the in depth Review of HP ProBook 635 Aero G7 Laptops. Know detailed info about HP ProBook 635 Aero G7 configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of GIGABYTE GeForce RTX 4070 Ti AERO OC 12G Graphics Card PC Components. Know detailed info about GIGABYTE GeForce RTX 4070 Ti AERO OC 12G Graphics Card configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of HP Pavilion Aero 13 (2023) Laptops. Know detailed info about HP Pavilion Aero 13 (2023) configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

An IRGC commander discusses Iran's missile expansion strategy and its implications for Israel.

Title: Aerobic Exercise
Category: Health and Living
Created: 7/3/2007 12:00:00 AM
Last Editorial Review: 7/22/2022 12:00:00 AM

Memory formation is contingent on molecular and structural changes in neurons in response to learning stimuli—a process known as neuronal plasticity. The initiation step of mRNA translation is a gatekeeper of long-term memory by controlling the production of plasticity-related proteins in the brain. The mechanistic target of rapamycin complex 1 (mTORC1) controls mRNA translation, mainly through phosphorylation of the eukaryotic initiation factor 4E (eIF4E)-binding proteins (4E-BPs) and ribosomal protein S6 kinases (S6Ks). mTORC1 signaling decreases throughout brain development, starting from the early postnatal period. Here, we discovered that in mice, the age-dependent decrease in mTORC1 signaling occurs selectively in excitatory but not inhibitory neurons. Using a gene conditional knockout (cKO) strategy, we demonstrate that either up- or downregulating the mTORC1-4E-BP2 axis in GAD65 inhibitory interneurons, but not excitatory neurons, results in long-term object recognition and object location memory deficits. Our data indicate that the mTORC1 pathway in inhibitory but not excitatory neurons plays a key role in memory formation.

Extract

In cystic fibrosis (CF), Pseudomonas aeruginosa acquisition represents a turning point in disease progression. The presence of chronic P. aeruginosa infection is associated with worsening lung function and increased risk of earlier death, whereas treatment substantially improves lung function and survival [1, 2]. Efforts to diagnose and eradicate early P. aeruginosa provide lasting benefits for children with CF [3, 4]. However, the timing of infection varies considerably between individuals with CF, treatment centres [5, 6], and different birth cohorts of people with the disease [7, 8].

Background

Pseudomonas aeruginosa is a common pathogen that contributes to progressive lung disease in cystic fibrosis (CF). Genetic factors other than CF-causing CFTR (CF transmembrane conductance regulator) variations contribute ~85% of the variation in chronic P. aeruginosa infection age in CF according to twin studies, but the susceptibility loci remain unknown. Our objective is to advance understanding of the genetic basis of host susceptibility to P. aeruginosa infection.

An activist investor with a $5 billion stake in Honeywell International is calling for the company to separate its Phoenix-based aerospace division into a separate business.