There is described herein a knitting technique for creating a garment having one or more 3D textile electrodes integrated therein. The knitting technique involves knitting the item with integrated electrodes and transmission channels in one single step. The electrode is knit using conducting thread while a base fabric is knit using non-conducting thread. The electrode is knit on a first needle bed and the base fabric is knit on a second needle bed opposite to and facing the first needle bed, the two needle beds being separated by a few millimeters. During the knitting process, the surface knit on the first needle bed and the surface knit on the second needle bed may be linked using an isolating thread network that is simply deposited, without forming a mesh, on the fabric, in order to provide the three-dimensional effect.

A fryer unit includes a vat and heat exchange system with multiple passes within the fryer vat. Additional heat exchange passes may be provided in ductwork along the exterior surface of the lateral vat sidewalls.

Machine (1) for extracting puree, or fruit juice starting from vegetable or animal food, such as a rough extractor or a fine extractor. The machine (1) comprises essentially a cylindrical body (2) having an inlet (3) for the product to treat, an outlet (4) for a part of the product that can be used and an outlet (5) for another part of product to dispose of. The rotor (6) is wheeled to a motor (80) by a shaft (15). The product that is put in the cylindrical body (2) of the machine (1) is pushed by centrifugal force by a plurality of blades (20) of the rotor (6) to pass through a sieve (7) having holes (8) and a cylindrical or conical shape. The blades (20) of the rotor (6) comprise, in particular a first portion (21) having a first concavity and a second portion (22) having a second concavity opposite to the first.

Disclosed is a beverage extraction filter that can extract in a plurality of extraction machine types. The beverage extraction filter comprises a filter unit (40) where coffee powder is housed and a planar lid unit (41) mounted to the top section of the filter unit (40). The lid unit (41) is formed in a layer structure created by a non-permeable first sheet member (42) positioned on the filter unit side (40) and a permeable second sheet member (43) layered on top of the first sheet member (42), and a hole section (42a) through which hot water is made to pass is formed in the center of the first sheet member (42).

The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders.

The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing B-Klotho, and or FGF21-like mediated signaling. In embodiments, the antigen binding proteins specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.

In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobic ally modified oligonucleotide cargo, and uses thereof, are also provided.

The present invention concerns cancer biomarkers. In particular, the invention concerns HGF as a biomarker for patient selection and patient prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.

A measurement apparatus and method for in-situ quantitative texture measurement of a food snack. The apparatus includes an acoustic capturing device and a data processing unit. The physical interaction in the mouth with saliva, when a human being eats/drinks a food snack, sends pressure waves that propagate through the ear bone and produce an acoustic signal. The acoustic capturing device records and forwards the signal to a data processing unit. The data processing unit further comprises a digital signal processing module that smoothens, transforms and filters the received acoustic signal. A statistical processing module further filters the acoustic signal from the data processing unit and generates a quantitative acoustic model for texture attributes such as hardness and fracturability. The quantitative model is correlated with a qualitative texture measurement from a descriptive expert panel. Another method includes a food snack fingerprinting using an in-situ quantitative food property measurement.

A torque-exerting device includes a clutch arranged between a handle and an axle. The handle includes a chamber defined therein by a wall. The clutch includes a movable element, a rotatable element, recesses and balls. The movable element is placed in the chamber in an axially movable manner. The rotatable element is placed in the chamber in a rotatable manner and secured to the axle. The rotatable element is in releasable engagement with the movable element. The recesses are defined in the movable element or the wall of the chamber of the handle. Each of the balls is partially placed in a respective one of the recesses and in contact with the wall of the chamber of the handle or the movable element.

An extendable handled tool may include: a shaft; a hollow shaft extension encompassing the shaft and configured to move axially on the shaft so that the shaft moves in and out of the hollow space in the shaft extension; a locking collar attached to the shaft extension, the locking collar configured to rotate on the shaft; a tooth connected to the locking collar such that the tooth rotates with the locking collar; and a locking ring mounted on the shaft, the locking ring configured to fit with the tooth to rotate between a locked position and an unlocked position, wherein the locked position prevents the shaft extension from moving axially with respect to the shaft and the unlocked position permits the shaft extension to move axially with respect to the shaft. A method of exting a handle on a tool may also be provided.

A wrench including a handle having a first yoke at a first end and a first plurality of tool heads coupled to the first yoke at a first pivot axis, at least a first tool head of the first plurality of tool heads having a drive cavity. Each tool head of the first plurality of tool heads is pivotable about the first pivot axis independently of the other tool heads of the first plurality of tool heads.

A process for the production of a textile product includes placing a flat motif template on a textile substrate, sewing the motif template onto the textile substrate in such a way that a perforation defining a desired motif in the motif template is produced, removing the part of the motif template, that is outside the motif defined by the perforation, and permanently fixing the remaining part, having the motif, of the motif template to the textile substrate.

A machine for generating mechanical energy and functioning on the principle of exploitation of centrifugal forces of masses being displaced along a closed mechanical circuit over at least a curved section of the circuit. Optionally, the machines also functions on the principle of energy gain caused by masses falling under the influence of gravity in the closed circuit that is permanently maintained in a state of dynamic unbalance with an input, continuous or not, of external energy.

An exposure device includes: a board on which light emitting elements are arranged; an optical system disposed opposite to the board; a support member which supports the board and the optical system; and a cured body disposed on the support member and including a board contact surface to come into contact with the board, wherein the cured body is formed by curing a deformable material.

In one embodiment of the present invention, an expandable suitcase comprises: a front portion; a back portion; a plurality of side panels, each side panel aligning with one of a top, a bottom, a first side, and a second side of the suitcase, and each side panel having a primary board, at least a first side board rotatably connected to the primary board about a common edge therewith, and a first side flap rotatably connected to the first side board about a common edge opposing the common edge with the primary board; and a plurality of hinges disposed at an intersection of two side panels, each hinge comprising a first hinge panel attached to one of the side panels and a second hinge panel connected to the other side panel, wherein the hinge remains in a substantially planar position in a rested state.

An expandable travel bag system to aid in organizing toiletries when travelling features a flexible, planar anterior bag panel. A pair of item holding straps is located on an anterior bag panel front surface. An attachment strap is located on an anterior bag panel rear surface. The system features a posterior bag panel. A pair of item holding straps is located on a posterior bag panel front surface. An attachment pad is located on a posterior bag panel rear surface. The anterior bag panel is attached to the posterior bag panel via a second anterior hook and loop component attached to a first posterior hook and loop component. The anterior bag panel and the posterior bag panel are flexibly rolled into a cylindrical form for transport and held into a rolled up position via the attachment strap attached to the attachment pad.

An expandable multi-compartment luggage having a second luggage bag hingeably attached to the first luggage bag. The second luggage bag having an upper portion and a collapsible lower portion. The collapsible lower portion being moveable between a collapsed position to an expanded position defining a lower interior compartment. The luggage also including a dividing wall disposed between the upper and lower portions of the second luggage bag, and which is movable from a closed position dividing the upper interior compartment of the second luggage bag and the lower interior compartment of the second luggage bag and an open position with the upper interior compartment of the second luggage bag being in communication with the lower interior compartment of the second luggage bag.

A cover-type containing structure for flexible enclosures primarily includes a front cover sheet, a rear cover sheet and a flexible enclosure. The front cover sheet includes a first joining edge and a cover piece, whereas the rear cover sheet includes a cover assembly corresponding to the cover piece. The flexible enclosure includes a second joining edge and by engaging the first joining edge with the second joining edge, the front cover sheet and the flexible enclosure are fixed. Besides, the containing structure further includes a holding portion. Under a contained state, the holding portion is used to contain smaller objectives; whereas, in an unfolded state, in addition to using the flexible enclosure to contain larger objectives, the holding portion can be also used to contain smaller objectives. The present invention can be also applied to a piece of clothing combined with a bag unit or other flexible enclosure.

An expandable item carrying device facilitates carrying items such as groceries and the like. The device includes a container having a bottom wall and a perimeter wall coupled to and extending upwardly from a perimeter edge of the bottom wall defining an interior space. A top edge of the perimeter wall defines an opening into the interior space. The perimeter wall has a pair of opposed ends sides and a pair of longitudinal sides extending between the opposed end sides. The longitudinal sides and the bottom wall are compactable along a longitudinal axis of the bottom wall. A primary handle comprises opposed ends coupled to a first one of the longitudinal sides of the perimeter wall.

Disclosed is a drillship having a vortex suppression block with a recessed flow stabilizing part in a moon pool. The flow stabilizing section is formed so that a bottom of the vortex suppression block that protrudes from a bottom of a hull toward a stern in the moon pool is recessed in an upward direction of the hull to stabilize a flow in the moon pool and reduce a variation in resistance of the drillship. The flow stabilizing section (30) is formed by partly recessing the bottom of the vortex suppression block toward an upper portion of the hull. The drillship having this configuration provides resistance performance improvement and flow stabilization of the drillship.

A boat protective extension platform apparatus for use in connection with watercraft lifting platforms is provided. The extension platform is preferably attached to the stern of a boat and serves to at least partially cover a gap created between the boat and the lifting platform when the lifting platform is in a lowered position. The extension platform can include a retractable screen that is removably attachable to the lifting platform such than when said screen is extended, the aforementioned gap is further covered, thus preventing items carried by passengers and crew from falling or rolling into said gap and being lost or damaged.

Planing hull extensions for watercraft are disclosed which may be mounted along the sides of the hull of a watercraft such as a boat or yacht. Typically, the hull extensions may be disposed along the side chines of the hull such that they extend the effective beam of the hull. The hull extensions may aid stabilizing the watercraft and/or inhibit wetting of the sides of the hull as well. In some cases, the hull extensions may be hydraulically operated between a closed position against the hull (or into a pocket along the side of the hull) and a fully open position substantially extending the width of the hull bottom. The position of the hull extensions may be automatically varied based upon throttle position, e.g. fully open at low throttle to fully closed against the hull at full throttle. Different hull extension position profiles may be used according to loading and water conditions.

Cutting device, method and use are for cutting of a line extending from a floating vessel. The cutting device is structured for placement on the vessel. The cutting device comprises: at least one guide structured for directional steering of the line past a cutting area for the line; and at least one of the following cutting-promoting devices: at least one induction coil device directed inwards toward the cutting area and structured for heating, hence weakening, of the line within the cutting area; and at least one moveable cutting knife with an opposite contact surface directed inwards toward the cutting area and also structured for cutting of the line within the cutting area.

A method and an apparatus for drying a piece of textile which is impinged upon by an air flow having a varied partial steam pressure to evacuate moisture. The method and apparatus are particularly suitable for drying a piece of textile with a layered structure having a semi-permeable membrane.

An expandable and collapsible enclosure is provided for a garment refreshing appliance. The appliance has at least either a top or a bottom rigid housing structure. The enclosure comprises a wall structure extending substantially an entire height of the enclosure. The wall structure is made of a flexible material. An opening is provided in the wall structure through which garments can be introduced into or removed from the enclosure. A zipper is attached at the opening to selectively open and close the opening. A snap attachment mechanism is located at either or both of the top and a bottom of the wall structure for securing the wall structure to the top and/or bottom rigid housing structures.

Systems and methods for efficient microwave drying of extruded honeycomb structures are disclosed. The methods include conveying first and second sets of honeycomb structures in opposite directions through multiple applicator cavities. Each honeycomb structure has a moisture content MC, and the honeycomb structures within each cavity define an average moisture content MCA between 40% and 60% therein. The methods include irradiating the first and second sets of honeycomb structures within the cavities with microwave radiation having an amount of input microwave power PI that results in an amount of reflected microwave power PR from the honeycomb structures, where PR

An elliptical climbing exercise apparatus includes a base frame, a swing unit including a pair of swing arms, a pedal unit including a pair of pedal shafts respectively pivotally connected to the swing arms, a damping unit including a rotating wheel with a spindle, a guiding unit including a pair of cranks respectively affixed to the two opposite ends of the spindle, a pair of rockers respectively pivotally connected to the cranks and a pair of links respectively pivotally connected to the rocker. Cooperation between the base frame, the swing unit, the pedal unit, the resistance unit and the guiding unit is used to achieve a training of the leg muscles.

In one example, a muscle exercise device includes a first arm, and a second arm rotatably connected to the first arm, and the second arm and first arm are movable to cooperatively define a recess. The muscle exercise device also includes a resistance element configured to reside in the recess and be compressed between the arms.

A multi-purpose balance exercise device designed to be used in multiple positions and for diverse exercises. For example, various embodiments allow for the multipurpose device to be use as an aerobic step device as well as the ability to easily adjust the device to various heights to easily decrease the level of difficulty of the device for use during various exercises. The balance exercise device can provide a polarity of handles and grab points both horizontally and vertically, which allow for an enhanced number of exercises or movements using either the top and/or bottom of the device. The balance exercise device includes a flexible bladder filled with air, other gases, or gels attached to a substantially rigid base. The base can include an interior within which features such as handles are disposed to provide a gripping or lifting exercise to which the balance exercise device can be used.

Apparatus (2) for exercising a person's calves (4) in two different ways, which apparatus (2) comprises a footrest (8), a kneerest (10), and a length of stretchable material (12) for extending between the footrest (8) and the kneerest (10), and the apparatus (2) being such that: (i) the length of stretchable material (12) is flat sided;(ii) the footrest (8) has roller means (14);(iii) the roller means (14) allows the length of stretchable material (12) to connect to the footrest (8) such that the flat sides of the length of stretchable material (12) slide over the roller means (16);(iv) the kneerest (10) has anchor means (16) for the length of stretchable material (12);(v) the anchor means (16) allows the length of stretchable material (12) to connect to the kneerest (10) such that the flat sides of the length of stretchable material (12) pass over the anchor means (16); and(vi) the footrest (8), the kneerest (10), and the length of flexible material (12) are separable from each other.

A multiple position locking handle for an exercise machine for that is movable into a plurality of different positions when unlocked and that is retained in a single secure position when locked. The multiple position locking handle for an exercise machine generally includes a tubular base having a lower end and an upper end, an elongated member extending through the opening of the upper end of the tubular base and extending downwardly through at least a portion of the tubular base, a handle extending outwardly from the elongated member at an angle, and a locking device. The elongated member is movable within the tubular base when the locking device is in the unlocked state and is substantially not movable within the tubular base when the locking device is in the locked state.

The invention provides an exercise device for a rotator cuff of a shoulder of a user comprising a container housing, wherein the container housing comprises a first container shell, wherein the first container shell comprises a first container shell exterior surface and a first container shell interior surface surrounding a first container shell void, wherein the first container shell interior surface forms a substantially spherical surface; a second container shell, wherein the second container shell comprises a second container shell exterior surface and a second container shell interior surface, wherein the second container shell interior surface surrounds the first container shell exterior surface whereby the first container shell is nested inside the second container shell; and a spherical ball positioned within the first container shell void; wherein when the exercise device is in use, movement and rotation of an arm of a user causes movement and rotation of the container housing and movement and rotation of the ball within the container housing in a direction that follows a circumference of the first container shell interior surface, thereby exercising the rotator cuff of the shoulder of the user.

A machine for exercising the rotator cuff muscles that is operable to individually and separately isolate and exercise each of the four rotator cuff muscles while the user is in a seated position. The exercise machine includes a plurality of structural elements including a main vertical beam and a base frame operable to be positioned on the ground, where the main beam extends vertically from the base frame. The machine includes a plurality of pulleys mounted to the structural elements and a plurality of exercise cables running through the pulleys, where handles are coupled to the exercise cables. A seat is mounted to the vertical beam and the handles are positioned relative thereto to allow the user to grasp the handles and perform the several exercises for each arm.

A layered exercise contact counter display tracking and showing repetitive contacts with the lens contact surface of a housing covering a sensor pad, which responds to contacts sending a signal to a powered circuit board and remote tracking devices to record and display the number of repetitive hits adapted for mounting on an exercise device or a support surface to encourage an exerciser to complete and exercise or contact event.

An exercise machine includes a motor that drives a belt to move, and an analysis system to collect a peak energy from the motor and to convert the peak energy into different user exercising data.

A portable paddleboard exercise apparatus having a balance platform, an elongated member, a paddle handle, and a number of resistance bands. The apparatus may further include a frame with one or more support members configured to support the balance platform. The balance platform includes an upper surface for a user to balance thereon. The elongated member extends from the balance platform. The resistance bands extend from a distal end of the elongated member to the paddle handle. A user may balance on the balance platform in one of a number of positions while pulling the paddle handle against a resistive force generated by the resistance bands.

Exercise equipment, particularly a linear movable structure and associated selectable elastic resistance bands with or without guide track members are designed to allow low-impact exercises for one or two persons at the same time while permitting either or both participants to remain stationary when utilizing the equipment.

An exercise machine rail system for improved exerciser mounting and dismounting, improved functional ergonomics, and reduced risk of exerciser injury when using an exercise machine. The exercise machine rail system generally includes either two rails in close relationship which are linked together via connectors or a singular rail. Bias members are disclosed as either extending along either outer side of the rails, internally to the rail, or underneath the rail. Due to the narrow nature of the rails used by the present invention, an exerciser is able to mount and dismount the exercise machine easily and efficiently.

An exercise device that includes a frame, a user interface; a connection cable and a plurality of components that provide resistance to the cable and user interface. These components include a programmable, driven carriage capable of vertical movement between first and second positions and including one or more pulleys mounted thereon, wherein the cable extending away from the first end and user interface passes around the one or more pulleys on the carriage, a slider mechanism moveable between first and second positions and including one or more pulleys mounted thereon, and a pneumatic resistance device that is secured to the frame and that is operatively associated with the slider mechanism to provide resistance to slider mechanism movement between the first and second positions.

An exercise device that includes a frame, a user interface; a connection cable and a plurality of components that provide resistance to the cable and user interface. These components include a programmable, driven carriage capable of vertical movement between first and second positions and including one or more pulleys mounted thereon, wherein the cable extending away from the first end and user interface passes around the one or more pulleys on the carriage, a slider mechanism moveable between first and second positions and including one or more pulleys mounted thereon, and a pneumatic resistance device that is secured to the frame and that is operatively associated with the slider mechanism to provide resistance to slider mechanism movement between the first and second positions.

An exercise apparatus comprising a foot support movable by the user on the frame back and forth through any one of a plurality of complete, reproducible and different arc segments of a master arcuate path, the foot support being interconnected to an arc segment selection device that is manually actuatable to enable the user to manually select any one of the plurality of different arc segments, the foot support being interconnected to an arm having a handle manually graspable by the user to reduce or increase power or energy required by the user to move the foot support.

An exercise device includes a base frame having a first baseboard member, a second baseboard member, and a base pad disposed in between. The first baseboard member includes a first locking member disposed on a first headend of the first baseboard member, and the second baseboard member includes a second locking member disposed on a second headend of the second baseboard member. The exercise device further includes a pole frame having a top crossbar, a bottom crossbar, a first side pole, and a second side pole. The first lock member of the first baseboard member is inserted into a cross section of the first side pole and the second lock member of the second baseboard member is inserted into a cross section of the second side pole, such that the pole frame is interlocked with the base frame substantially perpendicularly.

An abdominal twist exercise device includes a device frame, front and rear rotational axles, a main handle bar, a rotation converter, an adjustable gear, a disengaging lever, a weight, a weight bar, a support rail, a safety handle bar, rotation counters, and a user platform, such that when the main handle bar rotates to one side, the user platform rotates to an opposing side. A rotation converter can include a front chain sprocket, an intermediate rotational axle, an intermediate chain sprocket, a roller chain, an intermediate gear, a rear gear; or a front belt sprocket, a rear belt sprocket, and a twisted belt, connecting the sprockets. Optionally, the front and rear axles can be telescoping.

An exercise tracker includes a force sensor programmed to output a force signal representing a force applied to a cable associated with a piece of exercise equipment. The exercise tracker further includes a processing device programmed to receive the force signal and determine, from the force signal, exercise data including an amount of weight lifted.

An exercise device includes a first tubular frame having a flexible fabric attached thereon, a second tubular frame having a rigid board mounted thereon, and at least three elongate support members disposed between and separate the first tubular frame and the second tubular frame. Each of the elongate members includes a first end fixedly mounted on the first tubular frame and a second end fixedly mounted on the second tubular frame, such that a first cross plane of the first tubular frame is substantially parallel to a second cross plane of the second tubular frame. When the second tubular frame is placed on a substantially flat surface, the exercise device can be used as a jumping exercise device. When the first tubular frame is placed on the substantially flat surface, the exercise device can be used as a stepping exercise device.

The present invention provides an active and passive exercise training equipment comprising a swinging device, a supporting device, and a front supporting device. The swinging device comprises a seat cushion with moving function for a user to sit. The supporting device comprises a telescopic rack and a top rack for the user to grip. The top rack is set on the telescopic rack for being located at different heights. The front supporting device comprises a front telescopic rack and a front grip for the user to bend forward to grip. The grip is set on the front telescopic rack for being located at different horizontal distances and vertical heights. The height and the distance can be adjusted according to the stature or requirement of the user so that the user can train his muscular strength efficiently and also make his body to achieve a relaxed state.

An assisted chin/dip exercise apparatus has a main frame and an assist or foot bar pivotally mounted on the frame and linked to a weight stack or resistance for assisting a user standing on the foot bar during performance of chin and dip exercises. The main frame has a first, overhead handle assembly and a second, dip handle assembly below the first handle assembly. The first handle assembly includes a pair of adjustably mounted handles freely pivotable between a first, chin-up position in which the handles extend towards one another at a rearward angle with a small spacing between the handles and a second, pull-up position in which the handles extend in a forward direction and are spaced apart by a larger spacing sufficient to provide head clearance for a user stepping onto the foot bar or while performing a dip exercise.

An exercise apparatus comprises an elongate support member extending along a length between first and second ends. The rigid member has a passage extending therethrough between the first and second ends. The apparatus further comprises a handle extending between first and second handle ends, the handle having connectors proximate to each of the first and second ends and a grip section therebetween and at least one elongate flexible member extending through the passage of the support member and having end connectors on each end thereof, the at least end connectors being connectable to one of the connectors of the handle.

A wall-mounted exercise apparatus, including a plurality of elongate anchor members fixed to a first wall and a second wall; a plurality of hooks fixed to each elongate anchor member; a first strap configured to be attached to a first hook of the plurality of hooks, the first hook being located on a first elongate anchor member fixed to the first wall; and a second strap configured to be attached to a second hook of the plurality of hooks, the second hook being located on a second elongate anchor member fixed to the second wall; wherein the first and second hooks are selected based on a desired difficulty of a selected exercise to be performed.