THE EDITOR, Madam: Humour exists in the rough times. Creative individuals have made social distancing with serious body language codes attractive and endearing. The king of the jungle knows just how to cheer you up, even across a wide football...

Fibroblast activation protein (FAP), which promotes tumor growth and progression, is overexpressed in cancer-associated fibroblasts of many human epithelial cancers. Because of its low expression in normal organs, FAP is an excellent target for theranostics. In this study, we used radionuclides with relatively long half-lives, ⁶⁴Cu (half-life, 12.7 h) and ²²⁵Ac (half-life, 10 d), to label FAP inhibitors (FAPIs) in mice with human pancreatic cancer xenografts. Methods: Male nude mice (body weight, 22.5 ± 1.2 g) were subcutaneously injected with human pancreatic cancer cells (PANC-1, n = 12; MIA PaCa-2, n = 8). Tumor xenograft mice were investigated after the intravenous injection of ⁶⁴Cu-FAPI-04 (7.21 ± 0.46 MBq) by dynamic and delayed PET scans (2.5 h after injection). Static scans 1 h after the injection of ⁶⁸Ga-FAPI-04 (3.6 ± 1.4 MBq) were also acquired for comparisons using the same cohort of mice (n = 8). Immunohistochemical staining was performed to confirm FAP expression in tumor xenografts using an FAP-α-antibody. For radioligand therapy, ²²⁵Ac-FAPI-04 (34 kBq) was injected into PANC-1 xenograft mice (n = 6). Tumor size was monitored and compared with that of control mice (n = 6). Results: Dynamic imaging of ⁶⁴Cu-FAPI-04 showed rapid clearance through the kidneys and slow washout from tumors. Delayed PET imaging of ⁶⁴Cu-FAPI-04 showed mild uptake in tumors and relatively high uptake in the liver and intestine. Accumulation levels in the tumor or normal organs were significantly higher for ⁶⁴Cu-FAPI-04 than for ⁶⁸Ga-FAPI-04, except in the heart, and excretion in the urine was higher for ⁶⁸Ga-FAPI-04 than for ⁶⁴Cu-FAPI-04. Immunohistochemical staining revealed abundant FAP expression in the stroma of xenografts. ²²⁵Ac-FAPI-04 injection showed significant tumor growth suppression in the PANC-1 xenograft mice, compared with the control mice, without a significant change in body weight. Conclusion: This proof-of-concept study showed that ⁶⁴Cu-FAPI-04 and ²²⁵Ac-FAPI-04 could be used in theranostics for the treatment of FAP-expressing pancreatic cancer. α-therapy targeting FAP in the cancer stroma is effective and will contribute to the development of a new treatment strategy.

Colombia has more internally displaced persons (IDPs) than any other country in the world, the result of a 52-year civil war. Beyond improving the lives of its 7.3 million IDPs, the country faces a number of crucial migration issues as it works to achieve stability in the wake of an historic peace accord signed in late 2016. This country profile examines historical trends and current and future migration challenges in Colombia.

When Dr. Gil Rivera became a dentist, he had no idea his career would take him to the bloodied and bruised front lines of the NHL, but nearly 18 years later, he continues to treat the ravaged mouths of professional hockey players as the team dentist of the Tampa Bay Lightning.

Rapper Ghostface Killah turns 50 and actor Noah Centineo 24, among the famous birthdays for May 9.

Maybe because there's never been a great Democrat president?  And never will be.  They're all horrible.

Two centuries ago, Napoleon Bonaparte sent his armies into Spain to overthrow a monarch who had once been a French ally. Napoleon, who believed he was touched by the hand of destiny, predicted his troops would be welcomed as liberators by ordinary Spaniards. He was wrong. The resulting Peninsular War from 1808 to 1814 seriously undermined French prestige, handed Napoleon a stinging defeat and produced a raft of unanticipated consequences that included the outbreak of deadly civil wars....

I love Christmas my all time favourite time of year. It's also a great time for awesome summer sweet produce. Muscovado brown sugar is a treacle like flavour and makes a welcome texture to a traditional pavlova.

honeycomb 40 g (11/2 oz) honey 70 g (21/2 oz) glucose syrup 200 g (7 oz) caster (superfine) sugar 1 teaspoon bicarbonate of soda (baking soda), sifted mousse 200 g (7 oz/11/3 cups) chopped good-quality dark chocolate, such as couverture (see note, page 235) 40 g (11/2 oz) unsalted butter, chopped 4 eggs, separated 150 g (51/2 oz/2/3 heaped cup) sugar espresso sauce 250 ml (9 fl oz/1 cup) espresso coffee 100 g (31/2 oz/1/2 cup) sugar 2 tablespoons kahlua

Keeping up with students’ growing mental-health needs was a concern for districts long before the pandemic began. It’s even harder now, educators and psychologists say.

Keeping up with students’ growing mental-health needs was a concern for districts long before the pandemic began. It’s even harder now, educators and psychologists say.

Officials in Illinois, Nevada, and Pennsylvania are proposing to close online charter schools over concerns that they're producing subpar academic results for students.

Keeping up with students’ growing mental-health needs was a concern for districts long before the pandemic began. It’s even harder now, educators and psychologists say.

Keeping up with students’ growing mental-health needs was a concern for districts long before the pandemic began. It’s even harder now, educators and psychologists say.

Officials in Illinois, Nevada, and Pennsylvania are proposing to close online charter schools over concerns that they're producing subpar academic results for students.

Keeping up with students’ growing mental-health needs was a concern for districts long before the pandemic began. It’s even harder now, educators and psychologists say.

Only to follow it up by getting advice from Jimmy Garoppolo, the San Francisco 49ers' starting quarterback in last season's Super Bowl. Eastern Illinois coaches and players have enjoyed those opportunities recently, while also getting the chance to connect with a plethora of other famous alumni from its football program. Similar experiences are occurring across FCS college football.

"This study contributes to the limited evidence available on how invitational narrative approaches are used in the domestic and family violence field. It focused on invitational narrative ways of engaging and working with men who perpetrate domestic and family violence. Focusing on the processes and skills of practice embedded in invitational narrative ideas enabled the examination of different ways of engaging men that have the potential to lead to sustained change. Accordingly, the main aim of this study was to explore invitational narrative ways of working in order to build an understanding of the processes and skills that engage men and enable behavioural and attitudinal change." --Executive summary (page 6).

Aurora Australis (Ship) -- History.

Intellectual property -- History.

Psychoanalysis.

The state's courts said the additional $548 million the legislature provided its schools this year is still not enough to ensure a constitutionally adequate education.

Edinburgh : Young J. Pentland, 1886.

London : Macmillan, 1875.

[Edinburgh] : [publisher not identified], [1890]

London : Printed by Mary Clark, and are to be sold by John Clark, at Mercers Chappel at the Lower End of Cheapside, MDCLXXVIII. [1678]

([Rome] : Raffaelle Jacomini impresse)

[1856]

London (6, Pall Mall) : Published ... by Henry Graves, & Comp.y, May 10th, 1856.

[London?]

Liverpool (82, Duke Street) ; And in London (13 St. James's Place, Hampstead Road) : Published ... by the artist, April 10th. 1854.

Liverpool (82, Duke Street) ; And in London (13 St. James's Place, Hampstead Road) : Published ... by the artist, April 10th. 1854.

[Rome?]

[Dresden?], [1754?]

[1990-1999?]

Paris, [France] : J.B. Baillière, Libraire de l'Académie Impériale de Médicine, 1854.

Sabrina Ionescu wins the Wooden Award for the second year in a row, becoming the fifth in the trophy's history to win in back-to-back seasons. With the honor, she completes a complete sweep of the national postseason player of the year awards. As a senior, Ionescu matched her own single-season mark with eight triple-doubles in 2019-20, and she was incredibly efficient from the field with a career-best 51.8 field goal percentage.

Flávio B. Gonçalves, Bárbara C. C. Dias.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 4, 782--800.

Abstract:
Educational assessment usually considers a contextual questionnaire to extract relevant information from the applicants. This may include items related to socio-economical profile as well as items to extract other characteristics potentially related to applicant’s performance in the test. A careful analysis of the questionnaires jointly with the test’s results may evidence important relations between profiles and test performance. The most coherent way to perform this task in a statistical context is to use the information from the questionnaire to help explain the variability of the abilities in a joint model-based approach. Nevertheless, the responses to the questionnaire typically present missing values which, in some cases, may be missing not at random. This paper proposes a statistical methodology to model the abilities in dichotomous IRT models using the information of the contextual questionnaires via linear regression. The proposed methodology models the missing data jointly with the all the observed data, which allows for the estimation of the former. The missing data modelling is flexible enough to allow the specification of missing not at random structures. Furthermore, even if those structures are not assumed a priori, they can be estimated from the posterior results when assuming missing (completely) at random structures a priori. Statistical inference is performed under the Bayesian paradigm via an efficient MCMC algorithm. Simulated and real examples are presented to investigate the efficiency and applicability of the proposed methodology.

Sibylle Béchet
Apr 8, 2020; 40:3104-3118
Neurobiology of Disease

Michele Bellesi
May 24, 2017; 37:5263-5273
Cellular

Joshua A. Gordon
May 15, 1996; 16:3274-3286
Articles

Chang-Jin Jeon
Nov 1, 1998; 18:8936-8946
Articles

Cristopher M. Niell
Jul 23, 2008; 28:7520-7536
BehavioralSystemsCognitive