up Supporting NHS Cybersecurity During COVID-19 is Vital By feedproxy.google.com Published On :: Thu, 02 Apr 2020 12:09:33 +0000 2 April 2020 Joyce Hakmeh Senior Research Fellow, International Security Programme; Co-Editor, Journal of Cyber Policy @joycehakmeh LinkedIn The current crisis is an opportunity for the UK government to show agility in how it deals with cyber threats and how it cooperates with the private sector in creating cyber resilience. 2020-04-02-NHS-nurse-tech-cyber Nurse uses a wireless electronic tablet to order medicines from the pharmacy at The Queen Elizabeth Hospital, Birmingham, England. Photo by Christopher Furlong/Getty Images. The World Health Organization, US Department of Health and Human Services, and hospitals in Spain, France and the Czech Republic have all suffered cyberattacks during the ongoing COVID-19 crisis.In the Czech Republic, a successful attack targeted a hospital with one of the country’s biggest COVID-19 testing laboratories, forcing its entire IT network to shut down, urgent surgical operations to be rescheduled, and patients to be moved to nearby hospitals. The attack also delayed dozens of COVID-19 test results and affected the hospital’s data transfer and storage, affecting the healthcare the hospital could provide.In the UK, the National Health Service (NHS) is already in crisis mode, focused on providing beds and ventilators to respond to one of the largest peacetime threats ever faced. But supporting the health sector goes beyond increasing human resources and equipment capacity.Health services ill-preparedCybersecurity support, both at organizational and individual level, is critical so health professionals can carry on saving lives, safely and securely. Yet this support is currently missing and the health services may be ill-prepared to deal with the aftermath of potential cyberattacks.When the NHS was hit by the Wannacry ransomware attack in 2017 - one of the largest cyberattacks the UK has witnessed to date – it caused massive disruption, with at least 80 of the 236 trusts across England affected and thousands of appointments and operations cancelled. Fortunately, a ‘kill-switch’ activated by a cybersecurity researcher quickly brought it to a halt.But the UK’s National Cyber Security Centre (NCSC), has been warning for some time against a cyber attack targeting national critical infrastructure sectors, including the health sector. A similar attack, known as category one (C1) attack, could cripple the UK with devastating consequences. It could happen and we should be prepared.Although the NHS has taken measures since Wannacry to improve cybersecurity, its enormous IT networks, legacy equipment and the overlap between the operational and information technology (OT/IT) does mean mitigating current potential threats are beyond its ability.And the threats have radically increased. More NHS staff with access to critical systems and patient health records are increasingly working remotely. The NHS has also extended its physical presence with new premises, such as the Nightingale hospital, potentially the largest temporary hospital in the world.Radical change frequently means proper cybersecurity protocols are not put in place. Even existing cybersecurity processes had to be side-stepped because of the outbreak, such as the decision by NHS Digital to delay its annual cybersecurity audit until September. During this audit, health and care organizations submit data security and protection toolkits to regulators setting out their cybersecurity and cyber resilience levels.The decision to delay was made to allow the NHS organizations to focus capacity on responding to COVID-19, but cybersecurity was highlighted as a high risk, and the importance of NHS and Social Care remaining resilient to cyberattacks was stressed.The NHS is stretched to breaking point. Expecting it to be on top of its cybersecurity during these exceptionally challenging times is unrealistic, and could actually add to the existing risk.Now is the time where new partnerships and support models should be emerging to support the NHS and help build its resilience. Now is the time where innovative public-private partnerships on cybersecurity should be formed.Similar to the economic package from the UK chancellor and innovative thinking on ventilator production, the government should oversee a scheme calling on the large cybersecurity capacity within the private sector to step in and assist the NHS. This support can be delivered in many different ways, but it must be mobilized swiftly.The NCSC for instance has led the formation of the Cyber Security Information Sharing Partnership (CiSP)— a joint industry and UK government initiative to exchange cyber threat information confidentially in real time with the aim of reducing the impact of cyberattacks on UK businesses.CiSP comprises organizations vetted by NCSC which go through a membership process before being able to join. These members could conduct cybersecurity assessment and penetration testing for NHS organizations, retrospectively assisting in implementing key security controls which may have been overlooked.They can also help by making sure NHS remote access systems are fully patched and advising on sensible security systems and approved solutions. They can identify critical OT and legacy systems and advise on their security.The NCSC should continue working with the NHS to enhance provision of public comprehensive guidance on cyber defence and response to potential attack. This would show they are on top of the situation, projecting confidence and reassurance.It is often said in every crisis lies an opportunity. This is an opportunity for the UK government to show agility in how it deals with cyber threats and how it cooperates with the private sector in creating cyber resilience.It is an opportunity to lead a much-needed cultural change showing cybersecurity should never be an afterthought. Full Article
up Online Study Group: All Lukashenka’s Men: The Belarusian Ruling Elite and Why It Matters By feedproxy.google.com Published On :: Thu, 16 Apr 2020 07:50:01 +0000 Invitation Only Research Event 22 April 2020 - 2:30pm to 4:00pm Event participants Ryhor Astapenia, Robert Bosch Stiftung Academy Fellow, Russia and Eurasia Programme, Chatham HouseChair: James Nixey, Programme Director, Russia and Eurasia, Chatham House Soon after assuming power in 1994, President Aliaksandr Lukashenka turned his back on democratic norms and overpowered the Belarusian political elite. However, the influence of the governing elite in Belarus is growing again. It seems likely that the current governing class could rule the country after Lukashenka leaves. It is thus important to study Belarusian elites not only to understand the current regime, but also to better forecast and navigate the political system that will one day replace it. This study group aims to disentangle how the Belarusian political system works, outline the types of individuals that make up the Belarusian ruling elite, assess the interaction of the elite and institutions with the West, and suggest changes that Western political actors might make to their approach to the Belarusian ruling class. Event attributes Chatham House Rule Department/project Russia and Eurasia Programme Anna Morgan Administrator, Ukraine Forum +44 (0)20 7389 3274 Email Full Article
up Virtual Roundtable: Re-integration or Dis-integration: What Does the Future Hold for Occupied Donbas? By feedproxy.google.com Published On :: Tue, 21 Apr 2020 22:55:01 +0000 Invitation Only Research Event 28 April 2020 - 4:00pm to 5:30pm Event participants Paul D’anieri, Professor of Public Policy and Political Science, University of California, RiversideVlad Mykhnenko, Associate Professor of Sustainable Urban Development, St Peter’s College, University of OxfordChair: Orysia Lutsevych, Research Fellow and Manager, Ukraine Forum, Chatham House The armed conflict in Donbas has now entered its seventh year. President Zelenskyy, who came to power in May 2019, promised to end the war with Russia and bring peace to Ukraine.Since assuming office, Zelenskyy has managed to revive the Normandy Format talks, complete military disengagement at three points along the line of contact and negotiate the release of over a hundred Ukrainians held as prisoners of war in Russia. However, ceasefire violations continue to occur frequently.Looking at the origins of the armed conflict in Donbas and the region’s economic role in Ukraine’s economy, this event discusses the prospects for conflict resolution. Do the recent events signify an opportunity for peace? Does Zelenskyy have a viable plan for re-integrating Donbas or will the region be cut off from mainland Ukraine for the foreseeable future?The speakers assess the strategy and track record of the Ukrainian government and its Western allies in bringing parts of the occupied Donbas under Kyiv’s control. They also review possible policy implications of the COVID-19 pandemic for the conflict. Department/project Russia and Eurasia Programme, Ukraine Forum Anna Morgan Administrator, Ukraine Forum +44 (0)20 7389 3274 Email Full Article
up Webinar: European Democracy in the Last 100 Years: Economic Crises and Political Upheaval By feedproxy.google.com Published On :: Thu, 23 Apr 2020 10:25:01 +0000 Members Event Webinar 6 May 2020 - 1:00pm to 2:00pm Event participants Pepijn Bergsen, Research Fellow, Europe Programme, Chatham HouseDr Sheri Berman, Professor of Political Science, Barnard CollegeChair: Hans Kundnani, Senior Research Fellow, Europe Programme, Chatham House In the last 100 years, global economic crises from the Great Depression of the 1930s to the 2008 financial crash have contributed to significant political changes in Europe, often leading to a rise in popularity for extremist parties and politics. As Europe contends with a perceived crisis of democracy - now compounded by the varied responses to the coronavirus outbreak - how should we understand the relationship between externally-driven economic crises, political upheaval and democracy?The panellists will consider the parallels between the political responses to some of the greatest economic crises Europe has experienced in the last century. Given that economic crises often transcend borders, why does political disruption vary between democracies? What can history tell us about the potential political impact of the unfolding COVID-19-related economic crisis? And will the unprecedented financial interventions by governments across Europe fundamentally change the expectations citizens have of the role government should play in their lives?This event is based on a recent article in The World Today by Hans Kundnani and Pepijn Bergsen who are both researchers in Chatham House's Europe Programme. 'Crawling from the Wreckage' is the first in a series of articles that look at key themes in European political discourse from the last century. You can read the article here. This event is open to Chatham House Members. Not a member? Find out more. Full Article
up Lebanese Women and the Politics of Disruption By feedproxy.google.com Published On :: Thu, 30 Apr 2020 11:00:01 +0000 Research Event 6 May 2020 - 1:00pm to 2:00pm Event participants Carmen Geha, Assistant Professor of Public Administration, Leadership and Organisational Development, American University of BeirutModerator: Lina Khatib, Director, Middle East and North Africa Programme, Chatham House Lebanese women have been at the forefront of the protest movement that has shaken Lebanon since October 2019. The active participation by women and their visibility in Lebanon's protest movement has challenged the gender norms prevalent in Lebanese society and politics. However, the COVID-19 pandemic and the nationwide lockdown that ensued has disrupted women's ability to organize, and is threatening the fragile progress towards female inclusion in the political process. In a recent article, Carmen Geha discussed the politics of representation in the context of women's participation in public life in Lebanon and argued that the country's political system is maintained through tightly-knit informal power relations among sectarian politicians, making women's participation in politics virtually impossible. The article explained how the October 2019 revolution challenged that norm by creating inclusive spaces where women activists could confront politicians and thus, transform the way women participate in politics and public life. In this webinar, part of the Chatham House project on the future of the state in the Middle East and North Africa, the article's author will discuss how women's activism in Lebanon has been affected by the coronavirus-induced lockdown. The speaker will consider how, under current circumstances, women activists can speak up collectively and bring back a movement to contest gender norms in order to build an alternative political model that can better represent women's priorities. You can express your interest in attending by following this link. You will receive a Zoom confirmation email should your registration be successful. Alternatively, you can watch the event live on the MENA Programme Facebook page. Department/project Middle East and North Africa Programme, The Future of the State in the Middle East Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email Full Article
Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email
up Webinar: Coronavirus, Globalization and Global Supply Chains By feedproxy.google.com Published On :: Wed, 06 May 2020 17:15:01 +0000 Corporate Members Event Webinar 2 June 2020 - 1:00pm to 2:00pmAdd to CalendariCalendar Outlook Google Yahoo Professor Ian Goldin, Professor of Globalisation and Development, University of Oxford; Director, Oxford Martin Programme on Technological and Economic ChangeFurther speakers to be announced. The COVID-19 pandemic has exacerbated the implications of pre-existing global trends such as rising protectionism and mounting trade tensions for the future of economic globalization. The global health crisis has since led to widespread lockdowns, paralysed supply chains and interrupted shipments of medical equipment between trade partners thereby further exposing the vulnerabilities of an integrated global economyAgainst this backdrop, the panellists will assess the impact of the coronavirus on economic globalization and global supply chains. To what extent might the health emergency encourage a re-evaluation of economic integration? How should governments and industries prepare for a resumption of activities under the auspices of a ‘new normal’ where ‘just-in-time’ methods of production may not be resilient enough to systemic shocks and challenges? Can a globalized supply and demand system become more resilient to shocks? And with China beginning to recover from the crisis, what might be the role of Chinese industry in rebooting global supply chains?This event is part of a fortnightly series of 'Business in Focus' webinars reflecting on the impact of COVID-19 on areas of particular professional interest for our corporate members and giving circles.Not a corporate member? Find out more. Full Article
up Why Turkey’s Disapproval of the West’s Response to the Coup Has Limited Merit By feedproxy.google.com Published On :: Wed, 10 Aug 2016 15:09:37 +0000 10 August 2016 Fadi Hakura Consulting Fellow, Europe Programme LinkedIn Although Turks across the political and ideological spectrum are seething at the West’s apparently lukewarm condemnation of the abortive coup on 15 July, there are valid reasons behind the response. 2016-08-10-Turkey-coup-fallout.jpg A Turkish flag attached to helium balloons as people gather to protest at Konak Square, Izmir during the July 15 failed military coup attempt. Photo by Getty Images Signs of growing anger at the restrained denunciation of Pennsylvania-based Muslim cleric Fethullah Gulen - whose followers are thought to have played a key role in the attempted coup - are being vocalised more and more, but this criticism only shows part of the true picture.It is true that prominent liberal Turkish intellectual Soli Ozel spoke for many when he criticised EU politicians and Western media for failing to recognise the “invaluable democratic resistance shown by all political parties in a parliament bombed by war planes”, as well as demonstrating “a lack of sensitivity, empathy and solidarity that cannot be easily digested” by not sending anyone from an EU institution to offer solidarity with the Turkish parliament.The criticism is reasonable - officials from Western governments and regional institutions such as the Council of Europe exhibited unconditional solidarity with Ukraine during its bitter feud with Russia, which leads some to believe that Muslim-majority Turkey does not apparently deserve the same treatment as its neighbours also experiencing an unlawful attempt to seize control of the state.Moral authority at riskIt is also right that the West should have censured the coup plotters more forcefully and built upon Turkey’s fragile unity to encourage the country to pursue further democratic reform. To quote former Swedish Prime Minister and Foreign Minister Carl Bildt: “Europe risks losing its moral authority if it does not appear particularly engaged in dealing with the coup itself.”In addition, the EU’s strong criticism of Turkey but not France, for imposing a state of emergency and for temporarily suspending the European Convention on Human Rights, undeniably, smacks of double-standards.However, some of the criticism falls short. To begin with, the West’s tepidity can be explained (though not wholly justified) by Erdogan’s abrasive behaviour at home and towards Western and international media.Just three days after the coup, Erdogan threatened in his characteristically defiant tone to revive the controversial construction plans that sparked the 2013 Gezi Park protests, saying: “If we want to preserve our history, we must rebuild this historic [Ottoman-era barracks] structure, [and] we will rebuild it.”It is also fair for Turkey to be reproached for the widespread crackdown against tens of thousands of suspected Gulenists in the aftermath of the coup. Even if it is conceivable that all 1,577 university deans who were forced to resign were Gulenists, this action will also have a lasting negative impact on the reputations and career prospects of academics unconnected to Gulen.Fervour against GulenismThe vigilance by the West is understandable given the Turkish government’s fervour against Gulenism in the immediate post-coup period. It would make no sense for the West to attack the coup and yet, at the same time, equivocate on flagrant violations of due process and human rights. Both efforts are mutually inclusive and identifying such violations has the greatest potential to encourage policy reversals or corrective measures.Similarly understandable is the attention on Erdogan himself. He is the most formidable and powerful figure in a hierarchical and top-down political system, able to make fateful decisions with few effective checks and balances. He single-handedly replaced Ahmet Davutoglu as prime minister with Binali Yildirim in a clear breach of the Turkish constitution.Despite Erdogan’s tactical attempts at embracing all the opposition parties apart from the pro-Kurdish Peoples’ Democratic Party (HDP), his refusal to renounce his ambition to transform Turkey into a powerful executive presidency indicates that this fragile political unity will not last.Only the West has the wherewithal to moderate his policies by continuing to express its friendship with Turkey, whilst not shying away from closely monitoring, scrutinising and commenting on the post-coup developments.Want to comment on this article?Contact Chatham House FeedbackJoin the conversation about this piece on Facebook Full Article
up Writing Groups Part 2 By mythicscribes.com Published On :: Sun, 19 Jan 2020 22:31:53 +0000 In my previous article on writing groups (which you can read here), I talked about some popular ways writers connect. From online forums like the Mythic Scribes writing forums to community workshops, there’s no shortage of ways writers find each other, and just as many reasons they’re out there searching in the first place. In this follow-up article I’d like to explore some ways to start a writing group, and to keep a good group running by avoiding common pitfalls that lead to trouble. What’s the Point? Whether you’ve been searching for an established group and have had zero luck finding the right one, or you’re trying to start a specific group to fill a niche, the first thing to consider when starting a group is the scope—what you’re hoping to get from it. Writing solo can work for years, until one day…it just doesn’t, and it helps to know what you’re looking for in a writers’ group. Motivation, accountability, advice, feedback, critique, support—you name it, there’s a group for it, or at least other folks looking for the same thing. Are you searching for a relaxed place for people to share their journey as writers? Continue reading Writing Groups Part 2 at Mythic Scribes. Full Article Miscellaneous Writing Life writing groups
up Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, an HDL receptor that mediates selective lipid uptake By feedproxy.google.com Published On :: 1997-07-01 S XuJul 1, 1997; 38:1289-1298Articles Full Article
up Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death By feedproxy.google.com Published On :: 2006-12-01 Nica M. BorradaileDec 1, 2006; 47:2726-2737Research Articles Full Article
up The human ATP-binding cassette (ABC) transporter superfamily By feedproxy.google.com Published On :: 2001-07-01 Michael DeanJul 1, 2001; 42:1007-1017Thematic Reviews Full Article
up Chile After the October Uprising By feedproxy.google.com Published On :: Fri, 07 Feb 2020 15:10:01 +0000 Invitation Only Research Event 13 February 2020 - 8:00am to 9:30am Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Andrés Velasco, Dean of the School of Public Policy, London School of Economics and Political ScienceRobert Funk, Assistant Professor of Political Science, University of Chile; Visiting Senior Fellow at the School of Public Policy, London School of Economics and Political ScienceChair: Melissa MacEwen, Manager, Energy, Environment and Resources Programme The outbreak of popular discontent in Chile in October of last year caught many observers by surprise. What began as a protest against a metro fare hike has transformed into widespread rejection of the economic and political model in place since the return to democracy in 1990, accompanied with unprecedented violence which raises questions about the state's ability to maintain rule of law. Professor Andrés Velasco, Dean of the School of Public Policy at the LSE, and Dr Robert Funk, Assistant Professor of Political Science at the University of Chile will join us for a discussion on the causes of the current protest.What are the prospects for reform and a return to normality? Is this the end of the much-lauded Chilean model? Event attributes Chatham House Rule Department/project US and the Americas Programme, Latin America Initiative US and Americas Programme Email Full Article
up US 2020: Super Tuesday and Implications for the General Election By feedproxy.google.com Published On :: Mon, 17 Feb 2020 10:10:01 +0000 Invitation Only Research Event 5 March 2020 - 12:00pm to 1:30pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Dr Lindsay Newman, Senior Research Fellow, US and the Americas Programme, Chatham HouseProfessor Peter Trubowitz, Professor of International Relations, London School of Economics and Political Science; Associate Fellow, US and the Americas Programme, Chatham HouseAmy Pope, Associate Fellow, US and the Americas Programme, Chatham House; Deputy Homeland Security Advisor, US National Security Council, 2015-17Chair: Dr Leslie Vinjamuri, Director, US and the Americas Programme, Chatham House The US 2020 election season enters a potentially decisive next phase with the Super Tuesday primaries on 3 March. With these fifteen, simultaneously-held state elections, the Democrats hope to have greater clarity about their party’s likely nominee for the general race against President Donald Trump in November. Concerns around intraparty divisions in the Democratic party between progressives (represented by Senators Elizabeth Warren and Bernie Sanders) and moderates (represented by former Vice President Joe Biden and former mayor Pete Buttigieg) have surrounded the primary races so far, and are unlikely to dissipate even if one candidate emerges from the field on 3 March.Against this backdrop, Chatham House brings together a panel of experts to discuss the state of the Democratic primary race, implications for the general election, and the Trump campaign’s priorities ahead of its re-election bid. Will the Democratic party resolve its divisions and unite behind a progressive or moderate in light of the Super Tuesday election results? How is Trump positioned to fair against the Democratic candidates left in the race? Did Former Mayor of New York Michael Bloomberg’s primary gamble to focus on Super Tuesday pay off? And what policy priorities are likely to be pursued under either a Trump 2.0 or a Democratic administration? Event attributes Chatham House Rule Department/project US and the Americas Programme, Chatham House US 2020 Election Series US and Americas Programme Email Full Article
up Lebanese Women and the Politics of Disruption By feedproxy.google.com Published On :: Thu, 30 Apr 2020 11:00:01 +0000 Research Event 6 May 2020 - 1:00pm to 2:00pm Event participants Carmen Geha, Assistant Professor of Public Administration, Leadership and Organisational Development, American University of BeirutModerator: Lina Khatib, Director, Middle East and North Africa Programme, Chatham House Lebanese women have been at the forefront of the protest movement that has shaken Lebanon since October 2019. The active participation by women and their visibility in Lebanon's protest movement has challenged the gender norms prevalent in Lebanese society and politics. However, the COVID-19 pandemic and the nationwide lockdown that ensued has disrupted women's ability to organize, and is threatening the fragile progress towards female inclusion in the political process. In a recent article, Carmen Geha discussed the politics of representation in the context of women's participation in public life in Lebanon and argued that the country's political system is maintained through tightly-knit informal power relations among sectarian politicians, making women's participation in politics virtually impossible. The article explained how the October 2019 revolution challenged that norm by creating inclusive spaces where women activists could confront politicians and thus, transform the way women participate in politics and public life. In this webinar, part of the Chatham House project on the future of the state in the Middle East and North Africa, the article's author will discuss how women's activism in Lebanon has been affected by the coronavirus-induced lockdown. The speaker will consider how, under current circumstances, women activists can speak up collectively and bring back a movement to contest gender norms in order to build an alternative political model that can better represent women's priorities. You can express your interest in attending by following this link. You will receive a Zoom confirmation email should your registration be successful. Alternatively, you can watch the event live on the MENA Programme Facebook page. Department/project Middle East and North Africa Programme, The Future of the State in the Middle East Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email Full Article
Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email
up Webinar: Coronavirus, Globalization and Global Supply Chains By feedproxy.google.com Published On :: Wed, 06 May 2020 17:15:01 +0000 Corporate Members Event Webinar 2 June 2020 - 1:00pm to 2:00pmAdd to CalendariCalendar Outlook Google Yahoo Professor Ian Goldin, Professor of Globalisation and Development, University of Oxford; Director, Oxford Martin Programme on Technological and Economic ChangeFurther speakers to be announced. The COVID-19 pandemic has exacerbated the implications of pre-existing global trends such as rising protectionism and mounting trade tensions for the future of economic globalization. The global health crisis has since led to widespread lockdowns, paralysed supply chains and interrupted shipments of medical equipment between trade partners thereby further exposing the vulnerabilities of an integrated global economyAgainst this backdrop, the panellists will assess the impact of the coronavirus on economic globalization and global supply chains. To what extent might the health emergency encourage a re-evaluation of economic integration? How should governments and industries prepare for a resumption of activities under the auspices of a ‘new normal’ where ‘just-in-time’ methods of production may not be resilient enough to systemic shocks and challenges? Can a globalized supply and demand system become more resilient to shocks? And with China beginning to recover from the crisis, what might be the role of Chinese industry in rebooting global supply chains?This event is part of a fortnightly series of 'Business in Focus' webinars reflecting on the impact of COVID-19 on areas of particular professional interest for our corporate members and giving circles.Not a corporate member? Find out more. Full Article
up Egypt in 2018: Elections, Divisions and Suppression By feedproxy.google.com Published On :: Mon, 09 Apr 2018 00:00:00 +0100 Full Article
up Should the Super-Rich Pay for a Universal Basic Income? By feedproxy.google.com Published On :: Tue, 10 Apr 2018 00:00:00 +0100 Full Article
up Iraq’s Future: Elections, Corruption and the Struggle for a State By feedproxy.google.com Published On :: Wed, 30 May 2018 00:00:00 +0100 Full Article
up Undercurrents: Episode 15 - Brexit Update, and Corruption in the World of the Global Super-Rich By feedproxy.google.com Published On :: Thu, 23 Aug 2018 00:00:00 +0100 Full Article
up Undercurrents: Episode 19 - Green Building Projects in Jordan, and Qatar's Football World Cup By feedproxy.google.com Published On :: Thu, 18 Oct 2018 00:00:00 +0100 Full Article
up Icebreaker Lecture: China’s Financial Sector – Reform and Opening Up By feedproxy.google.com Published On :: Tue, 12 Mar 2019 00:00:00 +0000 Full Article
up Protection of the Wounded and Medical Care-Givers in Armed Conflict: Is the Law Up to the Job? By feedproxy.google.com Published On :: Thu, 16 May 2019 00:00:00 +0100 Full Article
up Disrupting the Humanitarian Enterprise By feedproxy.google.com Published On :: Tue, 18 Jun 2019 00:00:00 +0100 Full Article
up In Conversation With Bob Dudley, Group Chief Executive, BP By feedproxy.google.com Published On :: Wed, 10 Jul 2019 00:00:00 +0100 Full Article
up Challenges and Opportunities in the Fight Against Corruption By feedproxy.google.com Published On :: Mon, 09 Dec 2019 00:00:00 +0000 Full Article
up A comprehensive evaluation of a typical plant telomeric G-quadruplex (G4) DNA reveals the dynamics of G4 formation, rearrangement, and unfolding [Plant Biology] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 Telomeres are specific nucleoprotein structures that are located at the ends of linear eukaryotic chromosomes and play crucial roles in genomic stability. Telomere DNA consists of simple repeats of a short G-rich sequence: TTAGGG in mammals and TTTAGGG in most plants. In recent years, the mammalian telomeric G-rich repeats have been shown to form G-quadruplex (G4) structures, which are crucial for modulating telomere functions. Surprisingly, even though plant telomeres are essential for plant growth, development, and environmental adaptions, only few reports exist on plant telomeric G4 DNA (pTG4). Here, using bulk and single-molecule assays, including CD spectroscopy, and single-molecule FRET approaches, we comprehensively characterized the structure and dynamics of a typical plant telomeric sequence, d[GGG(TTTAGGG)3]. We found that this sequence can fold into mixed G4s in potassium, including parallel and antiparallel structures. We also directly detected intermediate dynamic transitions, including G-hairpin, parallel G-triplex, and antiparallel G-triplex structures. Moreover, we observed that pTG4 is unfolded by the AtRecQ2 helicase but not by AtRecQ3. The results of our work shed light on our understanding about the existence, topological structures, stability, intermediates, unwinding, and functions of pTG4. Full Article
up Crystallographic and kinetic analyses of the FdsBG subcomplex of the cytosolic formate dehydrogenase FdsABG from Cupriavidus necator [Molecular Biophysics] By feedproxy.google.com Published On :: 2020-05-08T03:41:14-07:00 Formate oxidation to carbon dioxide is a key reaction in one-carbon compound metabolism, and its reverse reaction represents the first step in carbon assimilation in the acetogenic and methanogenic branches of many anaerobic organisms. The molybdenum-containing dehydrogenase FdsABG is a soluble NAD+-dependent formate dehydrogenase and a member of the NADH dehydrogenase superfamily. Here, we present the first structure of the FdsBG subcomplex of the cytosolic FdsABG formate dehydrogenase from the hydrogen-oxidizing bacterium Cupriavidus necator H16 both with and without bound NADH. The structures revealed that the two iron-sulfur clusters, Fe4S4 in FdsB and Fe2S2 in FdsG, are closer to the FMN than they are in other NADH dehydrogenases. Rapid kinetic studies and EPR measurements of rapid freeze-quenched samples of the NADH reduction of FdsBG identified a neutral flavin semiquinone, FMNH•, not previously observed to participate in NADH-mediated reduction of the FdsABG holoenzyme. We found that this semiquinone forms through the transfer of one electron from the fully reduced FMNH−, initially formed via NADH-mediated reduction, to the Fe2S2 cluster. This Fe2S2 cluster is not part of the on-path chain of iron-sulfur clusters connecting the FMN of FdsB with the active-site molybdenum center of FdsA. According to the NADH-bound structure, the nicotinamide ring stacks onto the re-face of the FMN. However, NADH binding significantly reduced the electron density for the isoalloxazine ring of FMN and induced a conformational change in residues of the FMN-binding pocket that display peptide-bond flipping upon NAD+ binding in proper NADH dehydrogenases. Full Article
up Seventh Meeting of the New Petroleum Producers Discussion Group By feedproxy.google.com Published On :: Mon, 06 Jan 2020 13:50:01 +0000 Research Event 11 November 2019 - 9:00am to 15 November 2019 - 6:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE The seventh annual meeting of the New Petroleum Producers Discussion Group brings together people from the group's member countries. The meeting includes an international discussion, a national seminar and a range of policy-relevant courses which have been specially tailored to the priorities of the group. This year’s international discussion focused on ‘Building Capacity and Institutions’.The New Petroleum Producers Discussion Group was first established in 2012 and provides a unique forum which brings together governments from over 30 new and prospective oil and gas producers to share their ideas and experiences. The group is jointly coordinated by Chatham House, the Commonwealth Secretariat, and the Natural Resource Governance Institute (NRGI).This event was hosted by the Ministry of Energy of Uganda. Department/project Energy, Environment and Resources Programme, New Petroleum Producers Discussion Group Full Article
up Episode 28: The Place Beyond the Pines/From Up On Poppy Hill By feedproxy.google.com Published On :: Fri, 19 Apr 2013 06:42:00 +0000 The Place Beyond the Pines ReviewFrom Up On Poppy Hill ReviewMovie Homework: Beasts of the Southern Wild/ShameWhat We Watched: Evil Dead, Game of Thrones, The Staircase & A Dangerous MethodYou can download the episode here. (right click to save) Next Episode: Oblivion/Trance Full Article
up Episode 33: Upstream Color/The Kings of Summer/Blackfish By feedproxy.google.com Published On :: Thu, 26 Sep 2013 04:52:00 +0000 Upstream Color reviewThe Kings of Summer reviewBlackfish reviewWhat We Watched: Fruitvale Station, At World's End, The Spectacular Now, Elysium, Only God Forgives, and The ABCs of DeathGrand Theft Auto 5 talkYou can download the episode here. (right click to save) Full Article
up SSO and other putative inhibitors of FA transport across membranes by CD36 disrupt intracellular metabolism, but do not affect FA translocation [Research Articles] By feedproxy.google.com Published On :: 2020-05-01T00:05:28-07:00 Membrane-bound proteins have been proposed to mediate the transport of long-chain FA (LCFA) transport through the plasma membrane (PM). These proposals are based largely on reports that PM transport of LCFAs can be blocked by a number of enzymes and purported inhibitors of LCFA transport. Here, using the ratiometric pH indicator (2',7'-bis-(2-carboxyethyl)-5-(and-6-)-carboxyfluorescein and acrylodated intestinal FA-binding protein-based dual fluorescence assays, we investigated the effects of nine inhibitors of the putative FA transporter protein CD36 on the binding and transmembrane movement of LCFAs. We particularly focused on sulfosuccinimidyl oleate (SSO), reported to be a competitive inhibitor of CD36-mediated LCFA transport. Using these assays in adipocytes and inhibitor-treated protein-free lipid vesicles, we demonstrate that rapid LCFA transport across model and biological membranes remains unchanged in the presence of these purported inhibitors. We have previously shown in live cells that CD36 does not accelerate the transport of unesterified LCFAs across the PM. Our present experiments indicated disruption of LCFA metabolism inside the cell within minutes upon treatment with many of the "inhibitors" previously assumed to inhibit LCFA transport across the PM. Furthermore, using confocal microscopy and a specific anti-SSO antibody, we found that numerous intracellular and PM-bound proteins are SSO-modified in addition to CD36. Our results support the hypothesis that LCFAs diffuse rapidly across biological membranes and do not require an active protein transporter for their transmembrane movement. Full Article
up Commentary on SSO and other putative inhibitors of FA transport across membranes by CD36 disrupt intracellular metabolism, but do not affect fatty acid translocation [Commentaries] By feedproxy.google.com Published On :: 2020-05-01T00:05:27-07:00 Full Article
up The Democrats have set themselves up to fail in November's election — and they don't seem to realize it By feedproxy.google.com Published On :: Mon, 24 Feb 2020 14:52:24 +0000 Source The Independent URL https://www.independent.co.uk/voices/democrats-buttigieg-sanders-trump-biden-str... Release date 21 February 2020 Expert Dr Lindsay Newman In the news type Op-ed Hide date on homepage Full Article
up Trump’s Strikes Risk Upending Iraqi Politics By feedproxy.google.com Published On :: Fri, 06 Mar 2020 16:26:01 +0000 Source Foreign Affairs URL https://www.foreignaffairs.com/articles/iran/2020-01-27/trumps-strikes-risk-upen... Release date 27 March 2020 Expert Dr Renad Mansour In the news type Op-ed Hide date on homepage Full Article
up A Balancing Act for Europe: Stop the Migrants, Support Greece, Assuage Turkey By feedproxy.google.com Published On :: Fri, 06 Mar 2020 16:30:44 +0000 Source The New York Times URL https://www.nytimes.com/2020/03/04/world/europe/europe-migrants-turkey-greece.ht... Release date 04 March 2020 Expert Robin Niblett In the news type Op-ed Hide date on homepage Full Article
up For China’s coronavirus diplomacy to succeed, Beijing must dial up generosity and downplay ideology By feedproxy.google.com Published On :: Wed, 06 May 2020 17:31:39 +0000 Source South China Morning Post URL https://www.scmp.com/comment/opinion/article/3079971/chinas-coronavirus-diplomac... Release date 16 April 2020 Expert Dr Yu Jie In the news type Op-ed Hide date on homepage Full Article
up On the existence of an operator group generated by the one-dimensional Dirac system By www.ams.org Published On :: Fri, 10 Apr 2020 08:09 EDT A. M. Savchuk and I. V. Sadovnichaya Trans. Moscow Math. Soc. 80 (2020), 235-250. Abstract, references and article information Full Article
up Weakly homoclinic groups of ergodic actions By www.ams.org Published On :: Fri, 10 Apr 2020 08:09 EDT V. V. Ryzhikov Trans. Moscow Math. Soc. 80 (2020), 83-94. Abstract, references and article information Full Article
up Com que roupa eu vou? Dicas de qual roupa usar By saudeprospera.com.br Published On :: Fri, 03 Nov 2017 16:25:57 +0000 Com que roupa eu vou? Todos os dias nós, mulheres, enfrentamos o dilema de decidir o que vestir. Veja algumas dicas para lhe ajudar a escolher qual roupa usar… A… The post Com que roupa eu vou? Dicas de qual roupa usar appeared first on Saúde Próspera. Full Article Dicas de Saúde
up Firefox 76.0 released with critical security patches – update now By feedproxy.google.com Published On :: Wed, 06 May 2020 14:58:01 +0000 Firefox's latest version is out, with new password management features and a raft of security fixes. Full Article Firefox Mozilla Exploit Patches Tor update vulnerability
up How Polarized India Erupted Into Violence By feedproxy.google.com Published On :: Thu, 27 Feb 2020 13:52:32 +0000 27 February 2020 Dr Gareth Price Senior Research Fellow, Asia-Pacific Programme @DrGarethPrice Google Scholar Growing social divisions, stoked by the BJP-led government, have mixed dangerously with a slowing economy. 2020-02-27-Delhi.jpg A woman sits on the terrace of a damaged building following clashes between people supporting and opposing the amendment to India's citizenship law, in New Delhi on 27 February. Photo: Getty Images. The outbreak of communal violence in Delhi this week is the worst in India’s capital for decades. It both reflects and will reinforce India’s polarization.That polarization is between the view that India represents homogeneity, grounded on the fact that its citizens are overwhelmingly (around four-fifths) Hindu (the view of the ruling Bharatiya Janata Party [BJP] of Narendra Modi), and the alternative that India represents diversity – its population includes hundreds of millions of non-Hindus and speakers of dozens if not hundreds of different languages.India’s polarization is reflected in the reaction to the three days of violence in northeast Delhi, which left hundreds injured and, at the time of writing, 34 dead. The government and its supporters portray the protesters as almost exclusively Muslim fifth-columnists, their actions facilitated by Islamist extremists or Pakistan or even the opposition Congress Party.The alternative view is that violence has been initiated by state-supported thugs, with the police turning a blind eye. In this view the protesters reflect a broader spectrum of Indian society, with a shared aversion to communalism and a commitment to India’s secular ideals.Delhi recently held a state election, and while the BJP lost, some of the rhetoric used by its politicians was vitriolic. One compared protesters to rapists and murderers. Another led his supporters in chants of ‘shoot the nation's traitors’, referring to the protestors.In such an environment, in which Hindu vigilantes feel empowered and India’s Muslims feel defenceless, Delhi’s worst communal violence for decades erupted.Some have drawn parallels between events in Delhi with the violence in Gujarat in 2002 when at least 1,000 people – the majority Muslim – were killed. There, the accusation against Modi, then chief minister of the state, was that the state turned a blind eye to violence.In general, past outbreaks of communal violence in India have been dampened by the rapid imposition of a curfew and deployment of substantial security forces to enforce it. Such an approach was notably absent in both Gujarat and, thus far, Delhi.The BJP, emboldenedThe violence takes place in the wake of two controversial actions the BJP has taken since its re-election in 2019.First, the BJP-led government revoked the special status of the state of Jammu and Kashmir. To the BJP, the special status accorded to Jammu and Kashmir, India’s only Muslim-majority state, was simply the most egregious example of their long-held view that other parties pandered to the Muslim community.While the move gained some international criticism, the general response in India to the crackdown that followed – including the restriction of internet access and arrest of a number of politicians – was muted.Then, the government put forward the Citizenship Amendment Act (CAA).In 2013, a year before the BJP’s first term in office, India’s Supreme Court ordered that the National Register of Citizens (NRC) be updated in the northeast Indian state of Assam.Migration from what is now Bangladesh has been a contentious issue in northeast India region since colonial times and was the cause of widespread agitation, and conflict, in the region from the late 1970s.While militancy continued thereafter, tension was partly resolved by the 1985 Assam Accord, which stated that people who had moved into Assam after 1971 (after the creation of Bangladesh) should be deported. However, this provision was not acted upon until the 2013 order.In August 2019, the final NRC was published. Just under 2 million people were found to be non-citizens. A substantial proportion of these, however, appear to have been Hindus, a dilemma for the BJP.To solve this, the government put forward the CAA, under which Hindus (along with followers of several other religions) could become Indian citizens. Muslims, however, were excluded. The BJP argued that the act was a generous gesture to illegal immigrants who faced persecution in neighbouring countries, and not a discriminatory gesture.Unlike moves in Kashmir, the CAA sparked nationwide protests across India. While Assam is something of a special case, concern over the possible nationwide rollout of the CAA caused alarm. The government has recently been ambiguous over its intentions, though had earlier directed states to establish at least one detention centre.The economy, creakingThat this is all taking place during an economic slowdown provides additional cause for concern. Many of India’s long-running internal conflicts subsided in recent years as the economy grew rapidly. But for the past year and a half, growth has slowed each quarter, to just 4.5% year on year.The common assumption has been that India needs to grow at 8% to stand still, given the need to create millions of jobs. Unemployment currently stands at a 45-year high. Among 20 to 24-year olds, unemployment stands at 37%. India’s demographic dividend is being wasted.For now, India seems trapped in a self-created vicious circle. The more it focuses on social and religious division, the more its economy will suffer. And while its economy worsens, the need to double-down on division as a distraction for its underemployed young men will intensify. Full Article
up Sustaining the Supply Chain - Part 1 By www.ams.org Published On :: Tue, 12 Jul 2011 14:35:33 -0400 It.s often a challenge to get from Point A to Point B in normal circumstances, but after a disaster it can be almost impossible to transport food, water, and clothing from the usual supply points to the people in desperate need. A new mathematical model employs probability and nonlinear programming to design supply chains that have the best chance of functioning after a disaster. For each region or country, the model generates a robust chain of supply and delivery points that can respond to the combination of disruptions in the network and increased needs of the population. Math also helps medical agencies operate more efficiently during emergencies, such as an infectious outbreak. Fluid dynamics and combinatorial optimization are applied to facility layout and epidemiological models to allocate resources and improve operations while minimizing total infection within dispensing facilities. This helps ensure fast, effective administering of vaccines and other medicines. Furthermore, solution times are fast enough that officials can input up-to-the-minute data specific to their situation and make any necessary redistribution of supplies or staff in real time. For More Information: Supply Chain Network Economics: Dynamics of Prices, Flows, and Profits, Anna Nagurney, 2006. Full Article
up Freeing Up Architecture: Part 1 By www.ams.org Published On :: Thu, 25 Jul 2013 15:10:01 -0400 Many of today.s most striking buildings are nontraditional freeform shapes. A new field of mathematics, discrete differential geometry, makes it possible to construct these complex shapes that begin as designers. digital creations. Since it.s impossible to fashion a large structure out of a single piece of glass or metal, the design is realized using smaller pieces that best fit the original smooth surface. Triangles would appear to be a natural choice to represent a shape, but it turns out that using quadrilaterals.which would seem to be more difficult.saves material and money and makes the structure easier to build. One of the primary goals of researchers is to create an efficient, streamlined process that integrates design and construction parameters so that early on architects can assess the feasibility of a given idea. Currently, implementing a plan involves extensive (and often expensive) interplay on computers between subdivision.breaking up the entire structure into manageable manufacturable pieces.and optimization.solving nonlinear equations in high-dimensional spaces to get as close as possible to the desired shape. Designers and engineers are seeking new mathematics to improve that process. Thus, in what might be characterized as a spiral with each field enriching the other, their needs will lead to new mathematics, which makes the shapes possible in the first place. For More Information: .Geometric computing for freeform architecture,. J. Wallner and H. Pottmann. Journal of Mathematics in Industry, Vol. 1, No. 4, 2011. Full Article
up Working Up a Lather : Part 1 By www.ams.org Published On :: Tue, 20 Aug 2013 14:30:44 -0400 James Sethian and Frank Morgan talk about their research investigating bubbles. Full Article
up Letter from the Chairwoman of the Supervisory Board, Evelyne Freitag, to shareholders By www.euromicron.de Published On :: Fri, 19 Jul 2019 13:19:00 +0200 Dear Shareholders, As Chairwoman of the Supervisory Board, I am contacting you personally today in advance of the Annual General Meeting to ask for your continued trust and support. Full Article
up euromicron AG’s Annual General Meeting adopts all agenda items and elects new Supervisory Board By www.euromicron.de Published On :: Fri, 30 Aug 2019 14:46:00 +0200 euromicron AG, a medium-sized technology group and expert on digital networking of business and production processes, held its Annual General Meeting 2019 in Frankfurt/Main on August 29, 2019. 42 percent of the share capital was represented. At the Annual General Meeting, the Executive Board reported on the operating performance in fiscal year 2018 and in the first half of 2019 and gave an outlook on the current fiscal year. One focus was on the implementation of the measures initiated to focus on and further develop the business model. Full Article
up Barnes saw it coming... but coach 'disappointed' he was cut ahead of Gold Cup By sportsjamaica.com Published On :: GIVEN the financial position of the Jamaica Football Federation (JFF), John Barnes had resigned Full Article
up The Startup Pay Premium By www8.gsb.columbia.edu Published On :: Thu, 16 Jan 2020 00:00:00 -0500 Research from Chazen Senior Scholar Christian Moser suggests that who gets hired and how much they get paid could make the difference between a startup’s success and its failure. Full Article
up Your Slow Website is Killing Your Business- Level up with our affordable VPS server By forums.digitalpoint.com Published On :: Sat, 09 May 2020 09:28:51 +0000 Full Article
up How to build and setup outstream video player on my site? By forums.digitalpoint.com Published On :: Sat, 09 May 2020 11:15:50 +0000 Full Article